Juan Caturelli - Academia.edu (original) (raw)
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King AbdulAziz University (KAU) Jeddah, Saudi Arabia
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Papers by Juan Caturelli
Journal of Molecular Structure, Nov 1, 2018
The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of bio... more The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of biological properties to different derivatives. Thus, synthetic methods have been developed to obtain such molecules. Herein, we describe the heterocyclization process to obtain imidazolidine-2,4-diones (hydantoin compounds) from methylcyclobutyl ketones and cyclobutanones derived from (-)-(1S)--pinene and (-)-(1S)-verbenone through the Bucherer-Berg reaction. The methylcyclobutyl hydantoins and the spirohydantoin obtained were fully characterized, determining their absolute stereochemistry by nuclear magnetic resonance experiments and theoretical calculations.
Journal of Molecular Structure, Nov 1, 2018
The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of bio... more The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of biological properties to different derivatives. Thus, synthetic methods have been developed to obtain such molecules. Herein, we describe the heterocyclization process to obtain imidazolidine-2,4-diones (hydantoin compounds) from methylcyclobutyl ketones and cyclobutanones derived from (-)-(1S)--pinene and (-)-(1S)-verbenone through the Bucherer-Berg reaction. The methylcyclobutyl hydantoins and the spirohydantoin obtained were fully characterized, determining their absolute stereochemistry by nuclear magnetic resonance experiments and theoretical calculations.