Juan Perez - Academia.edu (original) (raw)
Papers by Juan Perez
Cognition and …, 2007
This paper presents a comprehensive investigation of the criterion and incremental validity of tr... more This paper presents a comprehensive investigation of the criterion and incremental validity of trait emotional intelligence (trait EI or trait emotional self-efficacy), which is defined as a constellation of emotion-related self-perceptions and dispositions located at the lower levels of personality hierarchies . In Studies 1 and 2 (N 0/166 and 354, respectively) trait EI is shown to be related to measures of rumination, life satisfaction, depression, dysfunctional attitudes, and coping. Most relationships remained statistically significant even after controlling for Big Five variance. In Study 3 (N 0/212) trait EI is shown to be related to depression and nine distinct personality disorders. Most relationships remained significant, even after controlling for positive and negative affectivity (mood). It is concluded that trait EI has a role to play in personality, clinical, and social psychology, often with effects that are incremental over the basic dimensions of personality and mood.
Zeitschrift für …, 2006
The Bilbao Crystallographic Server is a web site with crystallographic databases and programs ava... more The Bilbao Crystallographic Server is a web site with crystallographic databases and programs available on-line at www.cryst.ehu.es. It has been operating for about six years and new applications are being added regularly. The programs available on the server do not need a local installation and can be used free of charge. The only requirement is an Internet connection and a web browser.
Journal of Biological Chemistry, 1999
Mucins are major glycoprotein components of the mucous that coats the surfaces of cells lining th... more Mucins are major glycoprotein components of the mucous that coats the surfaces of cells lining the respiratory, digestive, and urogenital tracts, and in some amphibia, the skin. They function to protect epithelial cells from infection, dehydration, and physical or chemical injury, as ...
Ophthalmology, 1999
Objective: To perform a prospective, clinical trial to determine the potential cumulative complic... more Objective: To perform a prospective, clinical trial to determine the potential cumulative complications of patients implanted with angle-supported phakic intraocular lenses (PIOLs) for the correction of myopia.
… ophthalmology & visual …, 2000
PURPOSE. Despite the rapidly growing popularity of laser in situ keratomileusis (LASIK) in correc... more PURPOSE. Despite the rapidly growing popularity of laser in situ keratomileusis (LASIK) in correction of myopia, the tissue responses have not been thoroughly investigated. The aim was to characterize morphologic changes induced by myopic LASIK in human corneal stroma. Sixty-two myopic eyes were examined once at 3 days to 2 years after LASIK using in vivo confocal microscopy for measurement of flap thickness, keratocyte response zones, and objective grading of haze. Confocal microscopy revealed corneal flap interface particles in 100% of eyes and microfolds at the Bowman's layer in 96.8%. The flaps were thinner (112 +/- 25 microm) than intended (160 microm). The keratocyte activation in the stromal bed was greatest on the third postoperative day. Patients with increased interface reflectivity due to abnormal extracellular matrix or activated keratocytes at > or = 1 month (n = 9) had significantly thinner flaps than patients with normal interface reflectivity (n = 18; 114 +/- 12 versus 132 +/- 22 microm, P = 0.027). After 6 months the mean density of the most anterior layer of flap keratocytes was decreased. Keratocyte activation induced by LASIK was of short duration compared with that reported after photorefractive keratectomy. The flaps were thinner than expected, and microfolds and interface particles were common complications. The new findings such as increased interface reflectivity associated with thin flaps and the apparent loss of keratocytes in the most anterior flap 6 months to 2 years after surgery may have important clinical relevance.
Journal of clinical …, 2003
R115777 is an orally active farnesyl transferase inhibitor that specifically blocks farnesylation... more R115777 is an orally active farnesyl transferase inhibitor that specifically blocks farnesylation of proteins involved in growth-factor-dependent cell-signal-transduction pathways. We conducted a phase II study in 76 patients with advanced breast cancer. Two cohorts of patients were recruited sequentially. The first cohort (n = 41) received a continuous dosing [CD] regimen of R115777 400 or 300 mg bid. The second cohort (n = 35) received 300 mg bid in a cyclical regimen of 21 days of treatment followed by 7 days of rest (intermittent dosing [ID]). In the CD cohort, four patients (10%) had a partial response (PR) and six patients (15%) had stable disease at > or = 24 weeks (SD). In the ID cohort, five patients (14%) had a PR and three patients (9%) had prolonged SD. The first six patients in the CD cohort treated at 400 mg bid all developed grade 3 to 4 neutropenia, so the subsequent 35 patients were treated at 300 mg bid. The incidence of hematologic toxicity was significantly lower in the ID than in the CD (300-mg bid) cohort: grade 3 to 4 neutropenia (14% v 43%; P =.016) and grade 3 to 4 thrombocytopenia (3% v 26%; P =.013). One patient in the ID cohort developed grade 2 to 3 neurotoxicity compared with 15 patients in the CD cohort (3% v 37%; P =.0004). The farnesyl transferase inhibitor R115777 has demonstrated clinical activity in patients with metastatic breast cancer, and the ID regimen has a significantly improved therapeutic index compared with the CD regimen.
Pattern recognition letters, 1994
Abstract Given N ordered points in the plane and a constant M&amp... more Abstract Given N ordered points in the plane and a constant M< N, an efficient algorithm is proposed to find M points, among those given, which define a polygonal curve that is a globally optimal approximation to the given points. The algorithm accommodates any ...
Like most scientific works, this book is not the sole product of the one, or in this case, two au... more Like most scientific works, this book is not the sole product of the one, or in this case, two authors to whom it is credited. It was made possible through several exchange networks all contributing to its creation. The first is the social psychology research team of the University of Geneva, and in particular, Willem Doise, who introduced us to the study of intergroup relations and with whom we developed our constructivist approach to social psychology; Stamos Papastamou, collaborator in our first book on the issue, The Power of Minorities; and Clause Kaiser and Patricia Roux, with whom so many of our studies were conducted. A second network, this time international and connected to the first, was instrumental in enabling the experiments reported in this book. Serge Moscovici played a central role here, providing initial inspiration and constant suggestions. These networks were supported from outside the University of Geneva, where we found the means to develop our research and confront our ideas with others, particularly through two conferences on minority influence, one held in Barcelona in 1980, the other in Geneva in 1985, with the assistance of the Laboratoire Europ‚en de Psychologie Sociale and the European Association of Experimental Social Psychology. Our experimental research, so fundamental to this approach, was greatly facilitated by several research grants from the Fonds National suisse de la Recherche Scientifique.
Reports are published in the HTA monograph series if (1) they have resulted from work commissione... more Reports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.
Emotional intelligence: An …, 2005
This chapter provides a brief introduction to the construct of emotional intelligence (EI), focus... more This chapter provides a brief introduction to the construct of emotional intelligence (EI), focusing on the conceptual distinction between trait EI (or emotional self-efficacy) and ability EI (or cognitive-emotional ability). The former encompasses emotion-related behavioral dispositions and self-perceived abilities measured via self-report, whereas the latter concerns actual emotion-related cognitive abilities and must be measured via maximum-performance tests. Salient measures of both types of EI are succinctly reviewed. It is argued that in terms of measurement most success has been achieved in relation to trait EI rather than ability EI. The overarching message of the chapter is that progress in the field is contingent on recognizing the fundamental differences between the two EI constructs.
Cognition and …, 2007
This paper presents a comprehensive investigation of the criterion and incremental validity of tr... more This paper presents a comprehensive investigation of the criterion and incremental validity of trait emotional intelligence (trait EI or trait emotional self-efficacy), which is defined as a constellation of emotion-related self-perceptions and dispositions located at the lower levels of personality hierarchies . In Studies 1 and 2 (N 0/166 and 354, respectively) trait EI is shown to be related to measures of rumination, life satisfaction, depression, dysfunctional attitudes, and coping. Most relationships remained statistically significant even after controlling for Big Five variance. In Study 3 (N 0/212) trait EI is shown to be related to depression and nine distinct personality disorders. Most relationships remained significant, even after controlling for positive and negative affectivity (mood). It is concluded that trait EI has a role to play in personality, clinical, and social psychology, often with effects that are incremental over the basic dimensions of personality and mood.
Zeitschrift für …, 2006
The Bilbao Crystallographic Server is a web site with crystallographic databases and programs ava... more The Bilbao Crystallographic Server is a web site with crystallographic databases and programs available on-line at www.cryst.ehu.es. It has been operating for about six years and new applications are being added regularly. The programs available on the server do not need a local installation and can be used free of charge. The only requirement is an Internet connection and a web browser.
Journal of Biological Chemistry, 1999
Mucins are major glycoprotein components of the mucous that coats the surfaces of cells lining th... more Mucins are major glycoprotein components of the mucous that coats the surfaces of cells lining the respiratory, digestive, and urogenital tracts, and in some amphibia, the skin. They function to protect epithelial cells from infection, dehydration, and physical or chemical injury, as ...
Ophthalmology, 1999
Objective: To perform a prospective, clinical trial to determine the potential cumulative complic... more Objective: To perform a prospective, clinical trial to determine the potential cumulative complications of patients implanted with angle-supported phakic intraocular lenses (PIOLs) for the correction of myopia.
… ophthalmology & visual …, 2000
PURPOSE. Despite the rapidly growing popularity of laser in situ keratomileusis (LASIK) in correc... more PURPOSE. Despite the rapidly growing popularity of laser in situ keratomileusis (LASIK) in correction of myopia, the tissue responses have not been thoroughly investigated. The aim was to characterize morphologic changes induced by myopic LASIK in human corneal stroma. Sixty-two myopic eyes were examined once at 3 days to 2 years after LASIK using in vivo confocal microscopy for measurement of flap thickness, keratocyte response zones, and objective grading of haze. Confocal microscopy revealed corneal flap interface particles in 100% of eyes and microfolds at the Bowman's layer in 96.8%. The flaps were thinner (112 +/- 25 microm) than intended (160 microm). The keratocyte activation in the stromal bed was greatest on the third postoperative day. Patients with increased interface reflectivity due to abnormal extracellular matrix or activated keratocytes at > or = 1 month (n = 9) had significantly thinner flaps than patients with normal interface reflectivity (n = 18; 114 +/- 12 versus 132 +/- 22 microm, P = 0.027). After 6 months the mean density of the most anterior layer of flap keratocytes was decreased. Keratocyte activation induced by LASIK was of short duration compared with that reported after photorefractive keratectomy. The flaps were thinner than expected, and microfolds and interface particles were common complications. The new findings such as increased interface reflectivity associated with thin flaps and the apparent loss of keratocytes in the most anterior flap 6 months to 2 years after surgery may have important clinical relevance.
Journal of clinical …, 2003
R115777 is an orally active farnesyl transferase inhibitor that specifically blocks farnesylation... more R115777 is an orally active farnesyl transferase inhibitor that specifically blocks farnesylation of proteins involved in growth-factor-dependent cell-signal-transduction pathways. We conducted a phase II study in 76 patients with advanced breast cancer. Two cohorts of patients were recruited sequentially. The first cohort (n = 41) received a continuous dosing [CD] regimen of R115777 400 or 300 mg bid. The second cohort (n = 35) received 300 mg bid in a cyclical regimen of 21 days of treatment followed by 7 days of rest (intermittent dosing [ID]). In the CD cohort, four patients (10%) had a partial response (PR) and six patients (15%) had stable disease at > or = 24 weeks (SD). In the ID cohort, five patients (14%) had a PR and three patients (9%) had prolonged SD. The first six patients in the CD cohort treated at 400 mg bid all developed grade 3 to 4 neutropenia, so the subsequent 35 patients were treated at 300 mg bid. The incidence of hematologic toxicity was significantly lower in the ID than in the CD (300-mg bid) cohort: grade 3 to 4 neutropenia (14% v 43%; P =.016) and grade 3 to 4 thrombocytopenia (3% v 26%; P =.013). One patient in the ID cohort developed grade 2 to 3 neurotoxicity compared with 15 patients in the CD cohort (3% v 37%; P =.0004). The farnesyl transferase inhibitor R115777 has demonstrated clinical activity in patients with metastatic breast cancer, and the ID regimen has a significantly improved therapeutic index compared with the CD regimen.
Pattern recognition letters, 1994
Abstract Given N ordered points in the plane and a constant M&amp... more Abstract Given N ordered points in the plane and a constant M< N, an efficient algorithm is proposed to find M points, among those given, which define a polygonal curve that is a globally optimal approximation to the given points. The algorithm accommodates any ...
Like most scientific works, this book is not the sole product of the one, or in this case, two au... more Like most scientific works, this book is not the sole product of the one, or in this case, two authors to whom it is credited. It was made possible through several exchange networks all contributing to its creation. The first is the social psychology research team of the University of Geneva, and in particular, Willem Doise, who introduced us to the study of intergroup relations and with whom we developed our constructivist approach to social psychology; Stamos Papastamou, collaborator in our first book on the issue, The Power of Minorities; and Clause Kaiser and Patricia Roux, with whom so many of our studies were conducted. A second network, this time international and connected to the first, was instrumental in enabling the experiments reported in this book. Serge Moscovici played a central role here, providing initial inspiration and constant suggestions. These networks were supported from outside the University of Geneva, where we found the means to develop our research and confront our ideas with others, particularly through two conferences on minority influence, one held in Barcelona in 1980, the other in Geneva in 1985, with the assistance of the Laboratoire Europ‚en de Psychologie Sociale and the European Association of Experimental Social Psychology. Our experimental research, so fundamental to this approach, was greatly facilitated by several research grants from the Fonds National suisse de la Recherche Scientifique.
Reports are published in the HTA monograph series if (1) they have resulted from work commissione... more Reports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.
Emotional intelligence: An …, 2005
This chapter provides a brief introduction to the construct of emotional intelligence (EI), focus... more This chapter provides a brief introduction to the construct of emotional intelligence (EI), focusing on the conceptual distinction between trait EI (or emotional self-efficacy) and ability EI (or cognitive-emotional ability). The former encompasses emotion-related behavioral dispositions and self-perceived abilities measured via self-report, whereas the latter concerns actual emotion-related cognitive abilities and must be measured via maximum-performance tests. Salient measures of both types of EI are succinctly reviewed. It is argued that in terms of measurement most success has been achieved in relation to trait EI rather than ability EI. The overarching message of the chapter is that progress in the field is contingent on recognizing the fundamental differences between the two EI constructs.