Juli Newells - Academia.edu (original) (raw)

Papers by Juli Newells

Research paper thumbnail of NEUROSCIENCE CALENDAR JULY, 2005

Research paper thumbnail of Body Condition of Feral Cats and the Effect of Neutering

Journal of Applied Animal Welfare Science, 2002

Research paper thumbnail of Fas engagement accelerates liver regeneration after partial hepatectomy

Research paper thumbnail of Newly discovered role for Fas ligand in the cell-cycle arrest of CD4 + T cells

Research paper thumbnail of The effect of under-storey palms and cyclanths on the growth and survival of Inga seedlings

Seedlings of Inga fagifolia (L.) Willd. and I. pezizifera Benth. were planted into the understory... more Seedlings of Inga fagifolia (L.) Willd. and I. pezizifera Benth. were planted into the understory of a Costa Rican rain forest to test whether the proximity of large-leaved dwarf palms and cyclanths affects seedling growth and survival and if so, whether that effect is primarily due ...

Research paper thumbnail of Book Review:Cracking Rocks and Defending Democracy: Kirtley Fletcher Mather: Scientist, Teacher, Social Activist, 1888-1978 Kennard Baker Bork

Research paper thumbnail of Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6 -Substituted Guanine Derivatives

Journal of Medicinal Chemistry, 2002

O(6)-substituted guanines are adenosine 5&amp... more O(6)-substituted guanines are adenosine 5'-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site. Fifty-eight O(6)-substituted guanines were prepared to probe the ribose pocket, and the structures of four representative compounds bound to monomeric CDK2 were determined by X-ray crystallography. Optimum binding occurs with a moderately sized aliphatic O(6) substituent that packs tightly against the hydrophobic patch presented by the glycine loop, centered on Val18, an interaction promoted by the conformational restraints imposed in a cyclohexylmethyl or cyclohexenylmethyl ring. Structure-based design generated (R)-(2-amino-9H-purin-6-yloxymethyl)pyrrolidin-2-one (56), which reproduces the reported hydrogen bonds formed between ATP and Asp86 and Gln131 but failed to improve inhibitory potency. Thus, the parent compound O(6)-cyclohexylmethylguanine (NU2058, 25) is the preferred starting point for exploring other areas of the kinase active site.

Research paper thumbnail of Prospective Study of Spinal Anomalies in Children with Infantile Hemangiomas of the Lumbosacral Skin

Journal of Pediatrics, 2010

To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacr... more To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacral region for spinal anomalies to determine the positive predictive value of infantile hemangioma for occult spinal anomalies and to make evidence-based recommendations for screening. A multicenter prospective cohort study was performed at 9 Hemangioma Investigator Group sites. Intraspinal abnormalities were detected in 21 of 41 study participants with a lumbosacral infantile hemangioma who underwent a magnetic resonance imaging evaluation. The relative risk for all patients with lumbosacral infantile hemangiomas for spinal anomalies was 640 (95% confidence interval [CI], 404-954), and the positive predictive value of infantile hemangioma for spinal dysraphism was 51.2%. Ulceration of the hemangioma was associated with a higher risk of having spinal anomalies. The presence of additional cutaneous anomalies also was associated with a higher likelihood of finding spinal anomalies; however, 35% of the infants with isolated lumbosacral infantile hemangiomas had spinal anomalies, with a relative risk of 438 (95% CI, 188-846). The sensitivity for ultrasound scanning to detect spinal anomalies in this high-risk group was poor at 50% (95% CI, 18.7%-81.3%), with a specificity rate of 77.8% (95% CI, 40%-97.2%). Infants and children with midline lumbosacral infantile hemangiomas are at increased risk for spinal anomalies. Screening magnetic resonance imaging is recommended for children with these lesions.

Research paper thumbnail of Use of fetal skeletal mineralization for prediction of parturition date in cats

Javma-journal of The American Veterinary Medical Association, 2003

To determine the relationship between parturition date and fetal skeletal mineralization detected... more To determine the relationship between parturition date and fetal skeletal mineralization detected radiographically in cats. Prospective clinical trial. 31 queens and their 49 pregnancies. Seventeen pregnant queens were radiographed with a computed radiography system every 2 to 3 days from 1 week after pregnancy was identified by abdominal palpation until parturition. Radiographs were evaluated to determine the first identifiable mineralization of 16 bony structures and teeth during each pregnancy. This information was used to establish a table of expected parturition dates on the basis of fetal mineralization. Single radiographs from an additional 32 pregnant cats were evaluated, and predictions of parturition dates were made on the basis of the mineralization table. Mineralization was first detected 25 to 29 days prior to parturition (dpp). Mineralization was determined for the spinal column (22 to 27 dpp), skull (21 to 27 dpp), ribs (20 to 25 dpp), scapula (17 to 24 dpp), humerus (20 to 24 dpp), femur (19 to 23 dpp), radius (15 to 22 dpp), tibia (15 to 21 dpp), ulna (5 to 21 dpp), pelvis (8 to 20 dpp), fibula (0 to 17 dpp), tail (8 to 16 dpp), metacarpals and metatarsals (3 to 14 dpp), phalanges (0 to 11 dpp), calcaneus (0 to 10 dpp), and teeth (1 to 6 dpp). Date of parturition was predictable within 3 days in 75% of cats. Identification of bony structures in the fetus is useful in estimating the time to parturition in queens.

Research paper thumbnail of An Epidemiologic Approach to Assessing Primary Care Needs in Rural Illinois

Journal of Rural Health, 1996

Abstract: One persistent problem that faces state and federal health policy-makers is determining... more Abstract: One persistent problem that faces state and federal health policy-makers is determining the level of primary care needs of the citizens they serve. To refine the decision-making process in Illinois, a model was developed to compare the 84 rural counties of Illinois and their potential need for additional primary care interventions. Using expert panel methods, a group of public health professionals selected a set of 31 health status indicators that were available at the county level throughout the state. Next, the panel developed a weighting system for those indicators. These weighted values were then applied to the demographic and epidemiologic data from each of the counties to rank the counties on the basis of need. Indicators having the highest correlation with the weighted sum were the percent of the population enrolled in Medicaid, lung cancer mortality rate, general population mortality rate, proportion of population at poverty level, and percent of births to teens. Data also showed that the rural counties with the greatest needs clustered in five geographic regions. The identification of these five geographic clusters may facilitate collaborative efforts in meeting the primary care needs of these populations.

Research paper thumbnail of Julian1245

Research paper thumbnail of NEUROSCIENCE CALENDAR JULY, 2005

Research paper thumbnail of Body Condition of Feral Cats and the Effect of Neutering

Journal of Applied Animal Welfare Science, 2002

Research paper thumbnail of Fas engagement accelerates liver regeneration after partial hepatectomy

Research paper thumbnail of Newly discovered role for Fas ligand in the cell-cycle arrest of CD4 + T cells

Research paper thumbnail of The effect of under-storey palms and cyclanths on the growth and survival of Inga seedlings

Seedlings of Inga fagifolia (L.) Willd. and I. pezizifera Benth. were planted into the understory... more Seedlings of Inga fagifolia (L.) Willd. and I. pezizifera Benth. were planted into the understory of a Costa Rican rain forest to test whether the proximity of large-leaved dwarf palms and cyclanths affects seedling growth and survival and if so, whether that effect is primarily due ...

Research paper thumbnail of Book Review:Cracking Rocks and Defending Democracy: Kirtley Fletcher Mather: Scientist, Teacher, Social Activist, 1888-1978 Kennard Baker Bork

Research paper thumbnail of Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6 -Substituted Guanine Derivatives

Journal of Medicinal Chemistry, 2002

O(6)-substituted guanines are adenosine 5&amp... more O(6)-substituted guanines are adenosine 5'-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site. Fifty-eight O(6)-substituted guanines were prepared to probe the ribose pocket, and the structures of four representative compounds bound to monomeric CDK2 were determined by X-ray crystallography. Optimum binding occurs with a moderately sized aliphatic O(6) substituent that packs tightly against the hydrophobic patch presented by the glycine loop, centered on Val18, an interaction promoted by the conformational restraints imposed in a cyclohexylmethyl or cyclohexenylmethyl ring. Structure-based design generated (R)-(2-amino-9H-purin-6-yloxymethyl)pyrrolidin-2-one (56), which reproduces the reported hydrogen bonds formed between ATP and Asp86 and Gln131 but failed to improve inhibitory potency. Thus, the parent compound O(6)-cyclohexylmethylguanine (NU2058, 25) is the preferred starting point for exploring other areas of the kinase active site.

Research paper thumbnail of Prospective Study of Spinal Anomalies in Children with Infantile Hemangiomas of the Lumbosacral Skin

Journal of Pediatrics, 2010

To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacr... more To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacral region for spinal anomalies to determine the positive predictive value of infantile hemangioma for occult spinal anomalies and to make evidence-based recommendations for screening. A multicenter prospective cohort study was performed at 9 Hemangioma Investigator Group sites. Intraspinal abnormalities were detected in 21 of 41 study participants with a lumbosacral infantile hemangioma who underwent a magnetic resonance imaging evaluation. The relative risk for all patients with lumbosacral infantile hemangiomas for spinal anomalies was 640 (95% confidence interval [CI], 404-954), and the positive predictive value of infantile hemangioma for spinal dysraphism was 51.2%. Ulceration of the hemangioma was associated with a higher risk of having spinal anomalies. The presence of additional cutaneous anomalies also was associated with a higher likelihood of finding spinal anomalies; however, 35% of the infants with isolated lumbosacral infantile hemangiomas had spinal anomalies, with a relative risk of 438 (95% CI, 188-846). The sensitivity for ultrasound scanning to detect spinal anomalies in this high-risk group was poor at 50% (95% CI, 18.7%-81.3%), with a specificity rate of 77.8% (95% CI, 40%-97.2%). Infants and children with midline lumbosacral infantile hemangiomas are at increased risk for spinal anomalies. Screening magnetic resonance imaging is recommended for children with these lesions.

Research paper thumbnail of Use of fetal skeletal mineralization for prediction of parturition date in cats

Javma-journal of The American Veterinary Medical Association, 2003

To determine the relationship between parturition date and fetal skeletal mineralization detected... more To determine the relationship between parturition date and fetal skeletal mineralization detected radiographically in cats. Prospective clinical trial. 31 queens and their 49 pregnancies. Seventeen pregnant queens were radiographed with a computed radiography system every 2 to 3 days from 1 week after pregnancy was identified by abdominal palpation until parturition. Radiographs were evaluated to determine the first identifiable mineralization of 16 bony structures and teeth during each pregnancy. This information was used to establish a table of expected parturition dates on the basis of fetal mineralization. Single radiographs from an additional 32 pregnant cats were evaluated, and predictions of parturition dates were made on the basis of the mineralization table. Mineralization was first detected 25 to 29 days prior to parturition (dpp). Mineralization was determined for the spinal column (22 to 27 dpp), skull (21 to 27 dpp), ribs (20 to 25 dpp), scapula (17 to 24 dpp), humerus (20 to 24 dpp), femur (19 to 23 dpp), radius (15 to 22 dpp), tibia (15 to 21 dpp), ulna (5 to 21 dpp), pelvis (8 to 20 dpp), fibula (0 to 17 dpp), tail (8 to 16 dpp), metacarpals and metatarsals (3 to 14 dpp), phalanges (0 to 11 dpp), calcaneus (0 to 10 dpp), and teeth (1 to 6 dpp). Date of parturition was predictable within 3 days in 75% of cats. Identification of bony structures in the fetus is useful in estimating the time to parturition in queens.

Research paper thumbnail of An Epidemiologic Approach to Assessing Primary Care Needs in Rural Illinois

Journal of Rural Health, 1996

Abstract: One persistent problem that faces state and federal health policy-makers is determining... more Abstract: One persistent problem that faces state and federal health policy-makers is determining the level of primary care needs of the citizens they serve. To refine the decision-making process in Illinois, a model was developed to compare the 84 rural counties of Illinois and their potential need for additional primary care interventions. Using expert panel methods, a group of public health professionals selected a set of 31 health status indicators that were available at the county level throughout the state. Next, the panel developed a weighting system for those indicators. These weighted values were then applied to the demographic and epidemiologic data from each of the counties to rank the counties on the basis of need. Indicators having the highest correlation with the weighted sum were the percent of the population enrolled in Medicaid, lung cancer mortality rate, general population mortality rate, proportion of population at poverty level, and percent of births to teens. Data also showed that the rural counties with the greatest needs clustered in five geographic regions. The identification of these five geographic clusters may facilitate collaborative efforts in meeting the primary care needs of these populations.

Research paper thumbnail of Julian1245