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Papers by Julia Omar

Malaysian Journal of Paediatrics and Child Health

Glycogen storage disease (GSD) type VI is one of the rare GSD variants characterised by PYGL muta... more Glycogen storage disease (GSD) type VI is one of the rare GSD variants characterised by PYGL mutation. It leads to liver phosphorylase deficiency, thus causing glycogenolysis disorder. Classic manifestations are mild hypoglycaemia, abdominal distension, growth retardation, hepatomegaly, elevated liver transaminases, hyperlipidaemia, and normal lactate and uric acid. This proband is a 14-year-old Malay girl who was the second child of non-consanguineous parents. At four years old, she was referred for the incidental finding of hepatomegaly with deranged liver enzymes. Clinically, there was hepatomegaly (4 cm below the right costal margin) without any growth retardation. Subsequently, at 11 and 13 years old, she experienced a twisted left ovarian cyst and acute colitis, respectively. Biochemically, there was significantly increased transaminases, hypertriglyceridaemia, and mild hypoglycaemia. The liver biopsy result was consistent with GSD. Next-gene sequence analysis test revealed co...

Malaysian Journal of Science Health & Technology, Sep 1, 2021

This is a case report of a 47-year old man with an unknown medical illness, presented with neurol... more This is a case report of a 47-year old man with an unknown medical illness, presented with neurological deficits typical of clinical stroke. The Magnetic Resonance Imaging (MRI) findings were an acute left middle cerebral artery (MCA) territory infarction and an incidental finding of a sellar mass likely pituitary origin. The pituitary hormones showed markedly hyperprolactinaemia with the level of 21146 ng/ml (n 4.04 – 15.2 ng/ml), low Follicle-stimulating hormone (FSH) with a level of 0.929 IU/L (n 1.5-12.4 IU/L), and low luteinizing hormone (LH) with a level of 1.11 IU/L (n 1.7-8.6 IU/L). Other investigations of serum cortisol, growth hormone (GH), thyroid-stimulating hormone (TSH), platelet count and coagulation profiles were normal. The patient was treated conservatively in the ward for acute ischaemic stroke and later was started on dopamine agonist cabergoline for hyperprolactinaemia.

International Journal of Environmental Research and Public Health, Feb 8, 2021

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Asian Pacific Journal of Cancer Prevention

was 36.2 cases per 100,000 females. In the West Bank, 513 new BC cases were registered in 2021, w... more was 36.2 cases per 100,000 females. In the West Bank, 513 new BC cases were registered in 2021, which was 15.2% of all newly registered cancer cases, while in the Gaza Strip, 363 new cases were registered, amounting to 18.6% of all new cancer cases (Ministry of Health, 2022).

Japan Health Sciences University & Japan International Cultural Exchange Foundation, Apr 1, 2020

IIUM Medical Journal Malaysia

INTRODUCTION: Analyte stability time is challenging to employ in clinical settings. The diversity... more INTRODUCTION: Analyte stability time is challenging to employ in clinical settings. The diversity of processing time may affect the accuracy of results. This study evaluates the maximum time delay permissible before sample centrifugation and analysis. MATERIALS AND METHODS: We evaluated 15 serum electrolytes in 40 samples centrifuged and analysed using an automated analyser. The time was divided into 1, 2, 6, and 24 hours. RESULTS: Most analytes studied remained stable for up to 24 hours before centrifugation. However, delayed processing affected the value of potassium, magnesium, LDH, and calcium after 2 hours up to a maximum of 6 hours at room temperature for total protein, phosphate, and sodium. CONCLUSIONS: Most analytes were unaffected by a delay in centrifugation at room temperatures, but several critical analytes were severely affected.

Bangladesh Journal of Medical Science

Background:Several decades of research have established the relationships between systemic diseas... more Background:Several decades of research have established the relationships between systemic diseases and periodontal diseases. Chronic kidney disease (CKD) is a chronic medical condition in which the homeostatic and emunctory activity of the kidneys is progressively declines. Periodontitis is a complex, polymicrobial disease that involves both the host and the environment. Tissue destruction is primarily associated with the host’s hyperresponsiveness, resulting in the release of inflammatory markers. Aim: This paper reviewed the evidence linking CKD, inflammatory markers, and periodontal disease and the effect of periodontal therapy on inflammatory markers and kidney function as well as dental parameters. Setting and Design: The sources of data were compiledand reviewed from MEDLINE, SCOPUS and Web of Sciences from 2010 to 2021. Result and Discussion: This review identifies biologically plausible bidirectional nexus between periodontitis and CKD. Periodontitis has emerged as non-trad...

Malaysian Journal of Pharmaceutical Sciences

Channa striatus, an indigenous freshwater fish, has been shown to treat knee osteoarthritis, but ... more Channa striatus, an indigenous freshwater fish, has been shown to treat knee osteoarthritis, but no study has been done to compare its effectiveness with other oral therapy. This study aimed to compare the effectiveness of oral Channa striatus extract and glucosamine sulphate in knee osteoarthritis symptoms and physical function. This is a double-blind randomised controlled trial, conducted among 78 patients with primary knee osteoarthritis. Patients were assigned to receive either 500 mg/d of Channa striatus or 1,500 mg/d of glucosamine sulphate for 6 months. The main outcome measures were pain, stiffness and physical function, as assessed by the Western Ontario and Mc Master Osteoarthritis Index (WOMAC) at baseline, 3- and 6-months post-randomisation. Seventy-three patients completed the study (Channa striatus, n = 37; glucosamine sulphate, n = 37). There was no significant between-group difference in the WOMAC index. However, the within-group comparison pointed to a significant i...

The prevalence of phenylketonuria (PKU) in Malaysia to date is not known since no study has been ... more The prevalence of phenylketonuria (PKU) in Malaysia to date is not known since no study has been conducted to address the subject. The objectives of this study were to determine the prevalence of PKU among the mentally retarded children in Kelantan, to determine the feasibility of carrying out a screening programme for PKU in newborns and to establish a method for PKU screening should the need arise later on. The study was a cross-sectional survey involving all the schools with special programmes for mentally retarded children and community- and clinic-based rehabilitation centers ( CCRC) in Kelantan. All children listed and attended these two institutions were taken as the study samples. A validated questionnaire was used to obtain personal and socioeconomic information of the patients and their families. The questionnaire was collected together with the written consent for the study before the final list of respondents was recorded. Blood spots on filter papers were collected by a...

Objectives: Currently, the treatment of osteoarthritis (OA) is to provide pain relief. However, c... more Objectives: Currently, the treatment of osteoarthritis (OA) is to provide pain relief. However, concerns on the side effects with the current treatment has encouraged studies to search for natural products. Channa striatus (CS) is a freshwater fish that is proclaimed as natural remedies to various illnesses by local communities without scientific evidence. Therefore, the objective of this study was to evaluate the effect of oral administration of CS extract (500 mg/day) in knee osteoarthritis (KOA) patients on the level of chondroprotective marker—cartilage oligomeric protein (COMP) and inflammatory marker—Cyclooxgenase-2 (COX-2) and compared it with glucosamine sulphate (GS) treated patients. Methods: This was a randomised and double-blind trial comparing the effect of CS extract (500 mg/day) and GS (1,500 mg/day) treated groups. The number of patients in CS and GS groups were n = 36 and n = 37, respectively. Blood samples were collected at different-time periods (baseline and six ...

Malaysian Journal of Science Health & Technology, 2022

Ornithine transcarbamylase (OTC) deficiency (OTCD), the most common urea cycle disorder, is an X-... more Ornithine transcarbamylase (OTC) deficiency (OTCD), the most common urea cycle disorder, is an X-linked genetic disorder due to complete or partial lack of the OTC enzyme. Its clinical presentation depends on the degree of enzyme deficiency and ranges from an acute neonatal metabolic crisis with a high mortality rate through to an asymptomatic adult. We present a case of a newborn baby boy who presented with poor feeding, vomiting, lethargy, and respiratory distress. Laboratory investigations revealed severe hyperammonaemia, hyperglutaminaemia, hyperalaninaemia, absence of citrulline, and marked orotic aciduria. Family screening confirmed the presence of an OTC disease-causing mutation in his mother. It was a heterozygous mutation, c.316G>A. p. Gly106Arg in exon 4.

Malaysian Journal of Medical Sciences, 2009

A cross sectional pilot study was carried out to look into the usefulness of percent free prostat... more A cross sectional pilot study was carried out to look into the usefulness of percent free prostate specific antigen (fPSA) in the diagnosis of prostatic cancer in HUSM patients. All patients who attended surgical clinic and admitted to surgical wards with signs and symptoms of prostate problems during the study period were taken as the study subjects. Total prostate specific antigen (tPSA) was estimated by immunoassay technique and those values of 4 ng/mL or more were proceeded for estimation of fPSA. Using the cut-off value of less than 25% fPSA for diagnosing patients with prostate cancer, our study showed that majority of the prostate cancer patients have a ratio of fPSA:tPSA more than 25% and a significantly higher level of total prostate specific antigen (P<0.005) when compared with patients with benign prostatic hyperplasia (BPH). Unexpectedly, the fPSA values were high in patients diagnosed as prostate cancer compared to BPH. Ratio of percent fPSA to tPSA was found not to ...

Hypoglycemia is a common medical emergency. Insulinoma, a rare pancreatic endocrine tumour is the... more Hypoglycemia is a common medical emergency. Insulinoma, a rare pancreatic endocrine tumour is the most common cause of hypoglycemia in patients without systemic illness. Most insulinomas are small, solitary and benign, which can be treated effectively by surgical removal of the tumour. Diagnosis is based on clinical features, laboratory tests and radiological investigation to localize the tumour. However, small size of this tumour leads to difficulty in localization of the disease, especially in occult insulinoma. Intra-arterial calcium stimulation with hepatic venous sampling can be utilised for preoperative localization of the tumour. We hereby present a case of a 33-year-old woman presenting with history of recurrent hypoglycemic symptoms and morbid obesity. A thorough history, clinical examination and laboratory investigation including prolonged fasting test were conducted and diagnosis of insulinoma was made. Intra-arterial calcium stimulation with hepatic venous sampling was c...

Introduction: Magnesium is a major determinant of insulin and glucose metabolism. The lower the m... more Introduction: Magnesium is a major determinant of insulin and glucose metabolism. The lower the magnesium, the greater the amount of insulin required to metabolise the same amount of glucose load, indicating insulin insensitivity. Many studies have reported hypomagnesaemia in diabetes mellitus and its relation to poor glycaemic control. This study provides overview regarding the level of serum magnesium among patients with type 2 diabetes mellitus in the Hospital University Science Malaysia (HUSM) and correlates the level with diabetic control as measured by HbA1c. Materials and Methods: A comparative cross sectional study was conducted among 75 good control (HbA1c ≤ 7.0% in two consecutive reading or one ≤6.5%) and 75 poor glycaemic control (two HbA1c > 7.0% readings or one ≥6.5% reading over the study period) who attended the Out-Patient Department Clinic and Medical Specialist Clinic HUSM, Kelantan. The patient had been called for sampling of serum magnesium level within three...

Journal of Clinical Neuroscience, 2010

Malaysian Applied Biology, Nov 30, 2021