Julio Enders - Academia.edu (original) (raw)
Papers by Julio Enders
A104. CHRONIC OBSTRUCTIVE PULMONARY DISEASE: MANAGEMENT OF ACUTE EXACERBATIONS AND COMORBIDITIES, 2010
Exacerbation rate in past 12M* 1 3 ... FEV1 Mild: 2 (16%), moderate: 6 (46%), severe: 5 (38%). Mi... more Exacerbation rate in past 12M* 1 3 ... FEV1 Mild: 2 (16%), moderate: 6 (46%), severe: 5 (38%). Mild: 3 (8%), moderate: 10 (27%), severe: 24 (65%). ... Social Alone: 5 (38%), partner: 2 (16%), family: 6 (46%). Alone: 21 (57%), partner: 13 (35%), family: 3 (8%).
Abstract: Objectives: To determine the validity and reliability of the instrument, assess HRQL, ... more Abstract: Objectives: To determine the validity and reliability of the instrument, assess HRQL, determine the presence and intensity of cervical pain, and analyze the relationship between pain and quality of life in the studied population. Material and methods: Observational, cross sectional study in students from the School of Medicine, National University of Cordoba, using the SF-36 Survey and the Analogue Visual Scale for pain intensity. Continuous and categorical variables were analyzed with significance level of 0.05. Results: The population (n= 465) was 20.8 (± 0.11) years old, mostly women (57.73%). The SF-36 showed construct reliability and validity. The population presented better values for the physical summing component; with the dimensions physical function, pain, vitality, and mental health being greater in men (p < 0.05). The 86.06% of the population presented pain, women perceived it with greater intensity (p=0.0001) and correlated to pain dimension from SF-36. Co...
La asociacion entre el dolor cronico y los trastornos mentales es un factor determinante para la ... more La asociacion entre el dolor cronico y los trastornos mentales es un factor determinante para la evolucion de la enfermedad y requiere un abordaje integral en los pacientes. Objetivo: Evaluar la prevalencia de trastornos mentales en pacientes con dolor cronico que consultan al servicio de Neurologia del Hospital Nacional de Clinicas, Cordoba, Argentina. Metodologia: El estudio incluyo pacientes con dolor cronico del servicio de neurologia del Hospital Nacional de Clinicas de Cordoba, Argentina, seleccionados a partir de una planilla validada que contiene los criterios clinicos adecuados. Los trastornos mentales fueron evaluados en los 351 pacientes de la muestra a traves de la version CIDI 3.0. Los entrevistadores fueron debidamente entrenados para su aplicacion. Los datos fueron analizados a partir del software estadistico InfoStat® Resultados: La media de edad de la muestra fue de 41,94±2,02 anos, con un rango de 20 a 65 anos, siendo el 88,32% mujeres. Se evidencio que el 50,98% d...
Aim: In view of the 4th Millennium Development Goal set by the UN, this study aimed at analyzing ... more Aim: In view of the 4th Millennium Development Goal set by the UN, this study aimed at analyzing the epidemiology of mortality of children under age 1 and under age 5 in Argentina between 1990 and 2011, and describing measles vaccination coverage in oneyear-old children between 1990 and 2009. Methods: Epidemiological indicators were measured using national data from secondary sources: Infant mortality rate and mortality rate in children under 5; and percentage of coverage in measles vaccination in Argentina. Results: Results show a 54.2% decrease in infant mortality rate, and 54.5% in mortality of children under 5. The most common causes of death during the first five years of life are usually associated to perinatal problems and congenital anomalies. In relation to measles vaccination coverage, there is a positive evolution of this indicator, reaching 100% coverage in 2009. Conclusions: Infant mortality represents an undeniable indicator of avoidable and unnecessary deaths that can...
Revista de Salud Pública, 2016
El sistema de remuneración e incentivos en la salud.../ GOMEZ, Patricia Fabiana. ENDERS Julio Enr... more El sistema de remuneración e incentivos en la salud.../ GOMEZ, Patricia Fabiana. ENDERS Julio Enrique. público tiene un salario mayor que el privado (p<0,0001). Los incentivos que reciben, se concentran en la capacitación y los premios. Existe correlación entre las variables IACC, IACU y IARM con respecto a, la Antigüedad (p<0,01), al monto del salario (p<0,0001), el incentivo económico (p<0,0001), a la naturaleza jurídica (p<0,05) y a la situación de revista (p<0,01).
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2015
The severe and chronic mental illnesses such as schizophrenia are associated with very complex pr... more The severe and chronic mental illnesses such as schizophrenia are associated with very complex problems that are not confined to the symptoms but also affect psychosocial functioning and community integration. To evaluate the reliability (in terms of internal consistency) of the WHODAS 2.0 for analyzing the psychosocial functioning of people with schizophrenia living in the community and using mental health services, and report the WHODAS 2.0 results from the same sample. The sample comprised 100 users diagnosed with schizophrenia (F20 to F29 of ICD 10) living in the community and in contact with mental health services in Córdoba, Buenos Aires and San Luis in Argentina. Interviewers were trained in the use of the WHODAS 2.0. For the overall internal consistency of the WHODAS 2.0: Cronbach's alpha = 0.78. WHODAS 2.0 results for these service users were: Domain 1, 57% none, 19.4% mild, 20.4% moderate, 3.2% severe. Domain 2, 60.2% none, 18.3% mild, 17.2% moderate, 3.2% severe. Doma...
![Research paper thumbnail of [Prevalence of mental health disorders among patientswho attendeda service of neurology for chronic pain]](https://attachments.academia-assets.com/105944100/thumbnails/1.jpg)
](Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2015
The association between chronic pain and mental disorders is a determining factor of the disease ... more The association between chronic pain and mental disorders is a determining factor of the disease evolution and requires a comprehensive approach in patients. evaluate the prevalence of mental disorders in patients with chronic pain who use the service of Neurology at the National Clinical Hospital, Cordoba, Argentina. the study included patients with chronic pain who used the Neurology service, National Clinical Hospital in Cordoba, Argentina, selected from a validated form that contains the appropriate clinical criteria. Mental disorders were evaluated in a sample of 351 patients through the CIDI 3.0. The interviewers were properly trained to implement it. Data were analyzed using InfoStat® statistical software. The mean age of the sample was 41.94±2.02 years, ranging from 20 to 65, 88.32% being women. It showed that 50.98% of the consultants for chronic pain had an episode of mental disorders throughout their life. Thus, the lifetime prevalence for affective disorders was 29.4% an...
Introducción La Facultad de Ciencias Médicas (FCM) de la UNC para mejorar los procesos educativos... more Introducción La Facultad de Ciencias Médicas (FCM) de la UNC para mejorar los procesos educativos, crea el Departamento de Admisión y propuso ejecutar el Programa de Mejoramiento Académico (2001) para abordar aspectos de la vida académica, la orientación vocacional y la articulación con la escuela media. En este contexto, se efectúa el proyecto “Los Ciclos de Nivelación de las Carreras de la Facultad de Ciencias Médicas: un abordaje a los procesos evaluativos y su relación con el rendimiento académico de los alumnos”. Al respecto este trabajo focaliza en el análisis de los materiales impresos de los Ciclos de Nivelación. Objetivo Efectuar un análisis pedagógico de los materiales impresos de los Ciclos de Nivelación. Materiales y métodos En una primera etapa se elaboró una grilla (Martínez Bonafé: 2002, Mora Vargas: 2001) conformada por dimensiones e indicadores para el análisis de los materiales impresos de Biología, Química y Física de los Ciclos de Nivelación de la FCM, a fin de e...
Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina), 2008
Although most usual admissions to hospital are in rooms in general wards, there are not scores to... more Although most usual admissions to hospital are in rooms in general wards, there are not scores to predict the number of hospitalization days in this area. The patients are located based on diagnosis at admission. to make scores who predict the number of hospitalization days in the general wards. We studied all the patients who were admitted to the Italiano Hospital from march of 2004 to may of 2005 in Cordoba city (Argentina). The inclusion criteria were: more than 18 years old patients who were admitted for more than 24 hours due to clinical or surgical conditions in general wards. We evaluated 53 variables including background, toxics, physiologic and demographic data, social reports, nutritional condition, out patients previous consultations at the admission day. Died patients were not included in this score analysis. The number of patients included was 1003. Short hospitalization was considered when the number of the days of the hospitalization was less than 4 days and long hosp...
Modificación de algunos componentes del sistema ß-adrenérgico cardíaco durante la infección exper... more Modificación de algunos componentes del sistema ß-adrenérgico cardíaco durante la infección experimental con Trypanosoma cruzi Lo Presti M.
Stress, 2004
Maternal separation can interfere with growth and development of the brain and represents a signi... more Maternal separation can interfere with growth and development of the brain and represents a significant risk factor for adult psychopathology. In rodents, prolonged separation from the mother affects the behavioral and endocrine responses to stress for the lifetime of the animal. Limbic structures such as the anterodorsal thalamic nuclei (ADTN) play an important role in the control of neuroendocrine and sympathetic-adrenal function. In view of these findings we hypothesized that the function of the ADTN may be affected in an animal model of maternal deprivation. To test this hypothesis female rats were isolated 4.5 h daily, during the first 3 weeks of life and tested as adults. We evaluated plasma epinephrine (E) and norepinephrine (NE), cardiac adrenoreceptors and anxiety responses after maternal deprivation and variable chronic stress (VCS) in ADTN-lesioned rats. Thirty days after ADTN lesion, in non-maternally deprived rats basal plasma NE concentration was greater and cardiac beta-adrenoreceptor density was lower than that in the sham-lesioned group. Maternal deprivation induced a significant increase in basal plasma NE concentration, which was greater in lesioned rats, and cardiac beta-adrenoreceptor density was decreased in lesioned rats. After VCS plasma catecholamine concentration was much greater in non-maternally deprived rats than in maternally-deprived rats; cardiac beta-adrenoreceptor density was decreased by VCS in both maternally-deprived and non-deprived rats, but more so in non-deprived rats, and further decreased by the ADTN lesion. In the plus maze test, the number of open arm entries was greater in the maternally deprived and in the stressed rats. Thus, sympathetic-adrenal medullary activation produced by VCS was much greater in non-deprived rats, and was linked to a down regulation of myocardial beta-adrenoceptors. The ADTN are not responsible for the reduced catecholamine responses to stress in maternally-deprived rats. Maternal deprivation or chronic stress also induced a long term anxiolytic effect, which was also not affected by ADTN lesion.
Experientia, 1981
Tissue injury (laparotomy) produces an increase in plasma fibrinogen. This increase is inhibited ... more Tissue injury (laparotomy) produces an increase in plasma fibrinogen. This increase is inhibited by the removal of the adrenal medulla, but injection of epinephrine in laparotomized-medullectomized rats returns fibrinogen levels to values similar to those observed in only laparotomized rats. Epinephrine administration to laparotomized rats increases the fibrinogen compared with the group of laparotomized rats without treatment, but epinephrine by itself does not modify plasma fibrinogen levels in uninjured rats. Epinephrine is apparently responsible for the increase of plasma fibrinogen in rats subjected to tissue injury, probably through beta adrenergic stimulation.
In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac fun... more In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac function by evaluating: ventricle contractile force and norepinephrine response, affinity and density of β-adrenergic receptors, dynamic properties of myocardial membranes, and electrocardiography. Albino swiss mice (n = 250) were infected with 55 trypomastigotes, Tulahuen strain and studied at 35, 75, and 180 days post-infection, that correspond to the acute, indeterminate, and chronic phase respectively. Cardiac β-adrenergic receptors' affinity, myocardial contractility, and norepinephrine response progressively decreased from the acute to the chronic phase of the disease (p < 0.01). The density (expressed as fmol/mg.prot) of the receptors was similar to non-infected mice (71.96 ± 0.36) in both the acute (78.24 ± 1.67) and indeterminate phases (77.28 ± 0.91), but lower in the chronic disease (53.32 ± 0.71). Electrocardiographic abnormalities began in the acute phase and were found ...
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología, 1999
The limbic structures play an important role in the control of the neuroendocrine and sympathical... more The limbic structures play an important role in the control of the neuroendocrine and sympathical adrenal function in basal and stress conditions. This work was undertaken to evaluate plasma ACTH, adrenocortical activity, cardiac adrenoceptors density and affinity response to variable chronic stress (VCS) in anterodorsal thalamic nuclei (ADTN) lesioned rats. Thirty days after lesion, shamlesioned stressed animals increased plasma ACTH and corticosterone as compared to sham-lesioned unstressed animals (p < 0.05); lesioned rats increased ACTH levels after VCS (p < 0.05) as compared to unstressed-lesioned rats. Whereas in sham-lesion plasma corticosterone (C) increased after stress, in lesioned animals(C) remained unchanged as compared to unstressed-lesioned animals. In the stressed groups, adrenal C contents were below those found in unstressed rats. beta-receptors affinity, in all the experimental groups, was similar, but VCS sham-lesioned animals underwent a significant increa...
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología, 1996
Chagas' disease presents complex physiopathogenic mechanism, many of them poorly understood, ... more Chagas' disease presents complex physiopathogenic mechanism, many of them poorly understood, that in our country generally produce cardiac lesions. The acute phase related with the presence of the parasite is usually asymptomatic. This report studies if the amount of T. cruzi that induced acute infection could modify the myocardiopathy evolution. Previous works have shown that Albino Swiss mice inoculated with 45 tripomastigotes (AcL) presented alterations in the cardiac pharmacological response to adrenergic agonist and antagonist studied at 30 days post-infection (p.i). Mice inoculated with 7 x 10(4) parasites/animal showed similar behaviour at 7 days p.i. We studied the involvement of the affinity and density of cardiac beta receptors in both acute groups by binding with 3H/DHA. The AcH group presented less cardiac beta receptors number (p < 0.001), but their affinity was conserved. The AcL model presented significantly less affinity (p < 0.01) but density was not diffe...
Cadernos Saúde Coletiva, 2012
OBJETIVO: Con la finalidad de establecer un diagnóstico para detectar situaciones de riesgos fami... more OBJETIVO: Con la finalidad de establecer un diagnóstico para detectar situaciones de riesgos familiares en niños escolarizados, el objetivo propuesto fue identificar los factores de riesgo vinculados a situaciones familiares que se relacionan con la salud mental, en niños de escuela primaria, de un sector urbano aledaño a la ciudad de Córdoba, en Argentina. METODOLOGÍA: El instrumento utilizado fue el test 'Cómo es tú-su familia'. Se realizó los análisis exploratorio bivariado y lo factorial. Se entrevistaron a 146 niños escolarizados de quinto y sexto grado del nivel primario. RESULTADOS: La estructura familiar más frecuente fue la biparental y el 45% de los encuestados tenían estructuras familiares a cargo de mujeres. Más de la mitad de los niños escolarizados refirieron que sus padres nunca, o algunas veces, dedican tiempo para hablar con ellos; los integrantes de su familia no pueden expresarse fácilmente si lo desean y la posibilidad de afrontar los problemas en familia...
Revista Latino-Americana de Enfermagem, 2010
En el presente trabajo se analiza la frecuencia de experimentación y consumo de drogas, en alumno... more En el presente trabajo se analiza la frecuencia de experimentación y consumo de drogas, en alumnos de escuelas de nivel medio de Córdoba, Argentina, en relación a variables sociodemográficas. De carácter analítico, la investigación se basó en los registros de la Secretaría de Programación para la Prevención de la Drogadicción y la Lucha contra el Narcotráfico. El procesamiento estadístico fue análisis bivariado, razón de riesgo e intervalos de confianza para cada variable. El consumo de alcohol fue más frecuente en los hombres, el 12,2% de los adolescentes probó algún tipo de droga ilícita, y los tranquilizantes son los psicofármacos más utilizados. El valor del consumo de drogas aumenta según aumenta el rango de edad, año de estudio y disponibilidad de dinero. Los hallazgos del presente trabajo identificaron una realidad epidemiológica que permitirá elaborar estrategias de prevención de adicción en los adolescentes.
A104. CHRONIC OBSTRUCTIVE PULMONARY DISEASE: MANAGEMENT OF ACUTE EXACERBATIONS AND COMORBIDITIES, 2010
Exacerbation rate in past 12M* 1 3 ... FEV1 Mild: 2 (16%), moderate: 6 (46%), severe: 5 (38%). Mi... more Exacerbation rate in past 12M* 1 3 ... FEV1 Mild: 2 (16%), moderate: 6 (46%), severe: 5 (38%). Mild: 3 (8%), moderate: 10 (27%), severe: 24 (65%). ... Social Alone: 5 (38%), partner: 2 (16%), family: 6 (46%). Alone: 21 (57%), partner: 13 (35%), family: 3 (8%).
Abstract: Objectives: To determine the validity and reliability of the instrument, assess HRQL, ... more Abstract: Objectives: To determine the validity and reliability of the instrument, assess HRQL, determine the presence and intensity of cervical pain, and analyze the relationship between pain and quality of life in the studied population. Material and methods: Observational, cross sectional study in students from the School of Medicine, National University of Cordoba, using the SF-36 Survey and the Analogue Visual Scale for pain intensity. Continuous and categorical variables were analyzed with significance level of 0.05. Results: The population (n= 465) was 20.8 (± 0.11) years old, mostly women (57.73%). The SF-36 showed construct reliability and validity. The population presented better values for the physical summing component; with the dimensions physical function, pain, vitality, and mental health being greater in men (p < 0.05). The 86.06% of the population presented pain, women perceived it with greater intensity (p=0.0001) and correlated to pain dimension from SF-36. Co...
La asociacion entre el dolor cronico y los trastornos mentales es un factor determinante para la ... more La asociacion entre el dolor cronico y los trastornos mentales es un factor determinante para la evolucion de la enfermedad y requiere un abordaje integral en los pacientes. Objetivo: Evaluar la prevalencia de trastornos mentales en pacientes con dolor cronico que consultan al servicio de Neurologia del Hospital Nacional de Clinicas, Cordoba, Argentina. Metodologia: El estudio incluyo pacientes con dolor cronico del servicio de neurologia del Hospital Nacional de Clinicas de Cordoba, Argentina, seleccionados a partir de una planilla validada que contiene los criterios clinicos adecuados. Los trastornos mentales fueron evaluados en los 351 pacientes de la muestra a traves de la version CIDI 3.0. Los entrevistadores fueron debidamente entrenados para su aplicacion. Los datos fueron analizados a partir del software estadistico InfoStat® Resultados: La media de edad de la muestra fue de 41,94±2,02 anos, con un rango de 20 a 65 anos, siendo el 88,32% mujeres. Se evidencio que el 50,98% d...
Aim: In view of the 4th Millennium Development Goal set by the UN, this study aimed at analyzing ... more Aim: In view of the 4th Millennium Development Goal set by the UN, this study aimed at analyzing the epidemiology of mortality of children under age 1 and under age 5 in Argentina between 1990 and 2011, and describing measles vaccination coverage in oneyear-old children between 1990 and 2009. Methods: Epidemiological indicators were measured using national data from secondary sources: Infant mortality rate and mortality rate in children under 5; and percentage of coverage in measles vaccination in Argentina. Results: Results show a 54.2% decrease in infant mortality rate, and 54.5% in mortality of children under 5. The most common causes of death during the first five years of life are usually associated to perinatal problems and congenital anomalies. In relation to measles vaccination coverage, there is a positive evolution of this indicator, reaching 100% coverage in 2009. Conclusions: Infant mortality represents an undeniable indicator of avoidable and unnecessary deaths that can...
Revista de Salud Pública, 2016
El sistema de remuneración e incentivos en la salud.../ GOMEZ, Patricia Fabiana. ENDERS Julio Enr... more El sistema de remuneración e incentivos en la salud.../ GOMEZ, Patricia Fabiana. ENDERS Julio Enrique. público tiene un salario mayor que el privado (p<0,0001). Los incentivos que reciben, se concentran en la capacitación y los premios. Existe correlación entre las variables IACC, IACU y IARM con respecto a, la Antigüedad (p<0,01), al monto del salario (p<0,0001), el incentivo económico (p<0,0001), a la naturaleza jurídica (p<0,05) y a la situación de revista (p<0,01).
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2015
The severe and chronic mental illnesses such as schizophrenia are associated with very complex pr... more The severe and chronic mental illnesses such as schizophrenia are associated with very complex problems that are not confined to the symptoms but also affect psychosocial functioning and community integration. To evaluate the reliability (in terms of internal consistency) of the WHODAS 2.0 for analyzing the psychosocial functioning of people with schizophrenia living in the community and using mental health services, and report the WHODAS 2.0 results from the same sample. The sample comprised 100 users diagnosed with schizophrenia (F20 to F29 of ICD 10) living in the community and in contact with mental health services in Córdoba, Buenos Aires and San Luis in Argentina. Interviewers were trained in the use of the WHODAS 2.0. For the overall internal consistency of the WHODAS 2.0: Cronbach's alpha = 0.78. WHODAS 2.0 results for these service users were: Domain 1, 57% none, 19.4% mild, 20.4% moderate, 3.2% severe. Domain 2, 60.2% none, 18.3% mild, 17.2% moderate, 3.2% severe. Doma...
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2015
The association between chronic pain and mental disorders is a determining factor of the disease ... more The association between chronic pain and mental disorders is a determining factor of the disease evolution and requires a comprehensive approach in patients. evaluate the prevalence of mental disorders in patients with chronic pain who use the service of Neurology at the National Clinical Hospital, Cordoba, Argentina. the study included patients with chronic pain who used the Neurology service, National Clinical Hospital in Cordoba, Argentina, selected from a validated form that contains the appropriate clinical criteria. Mental disorders were evaluated in a sample of 351 patients through the CIDI 3.0. The interviewers were properly trained to implement it. Data were analyzed using InfoStat® statistical software. The mean age of the sample was 41.94±2.02 years, ranging from 20 to 65, 88.32% being women. It showed that 50.98% of the consultants for chronic pain had an episode of mental disorders throughout their life. Thus, the lifetime prevalence for affective disorders was 29.4% an...
Introducción La Facultad de Ciencias Médicas (FCM) de la UNC para mejorar los procesos educativos... more Introducción La Facultad de Ciencias Médicas (FCM) de la UNC para mejorar los procesos educativos, crea el Departamento de Admisión y propuso ejecutar el Programa de Mejoramiento Académico (2001) para abordar aspectos de la vida académica, la orientación vocacional y la articulación con la escuela media. En este contexto, se efectúa el proyecto “Los Ciclos de Nivelación de las Carreras de la Facultad de Ciencias Médicas: un abordaje a los procesos evaluativos y su relación con el rendimiento académico de los alumnos”. Al respecto este trabajo focaliza en el análisis de los materiales impresos de los Ciclos de Nivelación. Objetivo Efectuar un análisis pedagógico de los materiales impresos de los Ciclos de Nivelación. Materiales y métodos En una primera etapa se elaboró una grilla (Martínez Bonafé: 2002, Mora Vargas: 2001) conformada por dimensiones e indicadores para el análisis de los materiales impresos de Biología, Química y Física de los Ciclos de Nivelación de la FCM, a fin de e...
Revista de la Facultad de Ciencias Médicas (Córdoba, Argentina), 2008
Although most usual admissions to hospital are in rooms in general wards, there are not scores to... more Although most usual admissions to hospital are in rooms in general wards, there are not scores to predict the number of hospitalization days in this area. The patients are located based on diagnosis at admission. to make scores who predict the number of hospitalization days in the general wards. We studied all the patients who were admitted to the Italiano Hospital from march of 2004 to may of 2005 in Cordoba city (Argentina). The inclusion criteria were: more than 18 years old patients who were admitted for more than 24 hours due to clinical or surgical conditions in general wards. We evaluated 53 variables including background, toxics, physiologic and demographic data, social reports, nutritional condition, out patients previous consultations at the admission day. Died patients were not included in this score analysis. The number of patients included was 1003. Short hospitalization was considered when the number of the days of the hospitalization was less than 4 days and long hosp...
Modificación de algunos componentes del sistema ß-adrenérgico cardíaco durante la infección exper... more Modificación de algunos componentes del sistema ß-adrenérgico cardíaco durante la infección experimental con Trypanosoma cruzi Lo Presti M.
Stress, 2004
Maternal separation can interfere with growth and development of the brain and represents a signi... more Maternal separation can interfere with growth and development of the brain and represents a significant risk factor for adult psychopathology. In rodents, prolonged separation from the mother affects the behavioral and endocrine responses to stress for the lifetime of the animal. Limbic structures such as the anterodorsal thalamic nuclei (ADTN) play an important role in the control of neuroendocrine and sympathetic-adrenal function. In view of these findings we hypothesized that the function of the ADTN may be affected in an animal model of maternal deprivation. To test this hypothesis female rats were isolated 4.5 h daily, during the first 3 weeks of life and tested as adults. We evaluated plasma epinephrine (E) and norepinephrine (NE), cardiac adrenoreceptors and anxiety responses after maternal deprivation and variable chronic stress (VCS) in ADTN-lesioned rats. Thirty days after ADTN lesion, in non-maternally deprived rats basal plasma NE concentration was greater and cardiac beta-adrenoreceptor density was lower than that in the sham-lesioned group. Maternal deprivation induced a significant increase in basal plasma NE concentration, which was greater in lesioned rats, and cardiac beta-adrenoreceptor density was decreased in lesioned rats. After VCS plasma catecholamine concentration was much greater in non-maternally deprived rats than in maternally-deprived rats; cardiac beta-adrenoreceptor density was decreased by VCS in both maternally-deprived and non-deprived rats, but more so in non-deprived rats, and further decreased by the ADTN lesion. In the plus maze test, the number of open arm entries was greater in the maternally deprived and in the stressed rats. Thus, sympathetic-adrenal medullary activation produced by VCS was much greater in non-deprived rats, and was linked to a down regulation of myocardial beta-adrenoceptors. The ADTN are not responsible for the reduced catecholamine responses to stress in maternally-deprived rats. Maternal deprivation or chronic stress also induced a long term anxiolytic effect, which was also not affected by ADTN lesion.
Experientia, 1981
Tissue injury (laparotomy) produces an increase in plasma fibrinogen. This increase is inhibited ... more Tissue injury (laparotomy) produces an increase in plasma fibrinogen. This increase is inhibited by the removal of the adrenal medulla, but injection of epinephrine in laparotomized-medullectomized rats returns fibrinogen levels to values similar to those observed in only laparotomized rats. Epinephrine administration to laparotomized rats increases the fibrinogen compared with the group of laparotomized rats without treatment, but epinephrine by itself does not modify plasma fibrinogen levels in uninjured rats. Epinephrine is apparently responsible for the increase of plasma fibrinogen in rats subjected to tissue injury, probably through beta adrenergic stimulation.
In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac fun... more In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac function by evaluating: ventricle contractile force and norepinephrine response, affinity and density of β-adrenergic receptors, dynamic properties of myocardial membranes, and electrocardiography. Albino swiss mice (n = 250) were infected with 55 trypomastigotes, Tulahuen strain and studied at 35, 75, and 180 days post-infection, that correspond to the acute, indeterminate, and chronic phase respectively. Cardiac β-adrenergic receptors' affinity, myocardial contractility, and norepinephrine response progressively decreased from the acute to the chronic phase of the disease (p < 0.01). The density (expressed as fmol/mg.prot) of the receptors was similar to non-infected mice (71.96 ± 0.36) in both the acute (78.24 ± 1.67) and indeterminate phases (77.28 ± 0.91), but lower in the chronic disease (53.32 ± 0.71). Electrocardiographic abnormalities began in the acute phase and were found ...
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología, 1999
The limbic structures play an important role in the control of the neuroendocrine and sympathical... more The limbic structures play an important role in the control of the neuroendocrine and sympathical adrenal function in basal and stress conditions. This work was undertaken to evaluate plasma ACTH, adrenocortical activity, cardiac adrenoceptors density and affinity response to variable chronic stress (VCS) in anterodorsal thalamic nuclei (ADTN) lesioned rats. Thirty days after lesion, shamlesioned stressed animals increased plasma ACTH and corticosterone as compared to sham-lesioned unstressed animals (p < 0.05); lesioned rats increased ACTH levels after VCS (p < 0.05) as compared to unstressed-lesioned rats. Whereas in sham-lesion plasma corticosterone (C) increased after stress, in lesioned animals(C) remained unchanged as compared to unstressed-lesioned animals. In the stressed groups, adrenal C contents were below those found in unstressed rats. beta-receptors affinity, in all the experimental groups, was similar, but VCS sham-lesioned animals underwent a significant increa...
Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología, 1996
Chagas' disease presents complex physiopathogenic mechanism, many of them poorly understood, ... more Chagas' disease presents complex physiopathogenic mechanism, many of them poorly understood, that in our country generally produce cardiac lesions. The acute phase related with the presence of the parasite is usually asymptomatic. This report studies if the amount of T. cruzi that induced acute infection could modify the myocardiopathy evolution. Previous works have shown that Albino Swiss mice inoculated with 45 tripomastigotes (AcL) presented alterations in the cardiac pharmacological response to adrenergic agonist and antagonist studied at 30 days post-infection (p.i). Mice inoculated with 7 x 10(4) parasites/animal showed similar behaviour at 7 days p.i. We studied the involvement of the affinity and density of cardiac beta receptors in both acute groups by binding with 3H/DHA. The AcH group presented less cardiac beta receptors number (p < 0.001), but their affinity was conserved. The AcL model presented significantly less affinity (p < 0.01) but density was not diffe...
Cadernos Saúde Coletiva, 2012
OBJETIVO: Con la finalidad de establecer un diagnóstico para detectar situaciones de riesgos fami... more OBJETIVO: Con la finalidad de establecer un diagnóstico para detectar situaciones de riesgos familiares en niños escolarizados, el objetivo propuesto fue identificar los factores de riesgo vinculados a situaciones familiares que se relacionan con la salud mental, en niños de escuela primaria, de un sector urbano aledaño a la ciudad de Córdoba, en Argentina. METODOLOGÍA: El instrumento utilizado fue el test 'Cómo es tú-su familia'. Se realizó los análisis exploratorio bivariado y lo factorial. Se entrevistaron a 146 niños escolarizados de quinto y sexto grado del nivel primario. RESULTADOS: La estructura familiar más frecuente fue la biparental y el 45% de los encuestados tenían estructuras familiares a cargo de mujeres. Más de la mitad de los niños escolarizados refirieron que sus padres nunca, o algunas veces, dedican tiempo para hablar con ellos; los integrantes de su familia no pueden expresarse fácilmente si lo desean y la posibilidad de afrontar los problemas en familia...
Revista Latino-Americana de Enfermagem, 2010
En el presente trabajo se analiza la frecuencia de experimentación y consumo de drogas, en alumno... more En el presente trabajo se analiza la frecuencia de experimentación y consumo de drogas, en alumnos de escuelas de nivel medio de Córdoba, Argentina, en relación a variables sociodemográficas. De carácter analítico, la investigación se basó en los registros de la Secretaría de Programación para la Prevención de la Drogadicción y la Lucha contra el Narcotráfico. El procesamiento estadístico fue análisis bivariado, razón de riesgo e intervalos de confianza para cada variable. El consumo de alcohol fue más frecuente en los hombres, el 12,2% de los adolescentes probó algún tipo de droga ilícita, y los tranquilizantes son los psicofármacos más utilizados. El valor del consumo de drogas aumenta según aumenta el rango de edad, año de estudio y disponibilidad de dinero. Los hallazgos del presente trabajo identificaron una realidad epidemiológica que permitirá elaborar estrategias de prevención de adicción en los adolescentes.