Junaid Ansari - Academia.edu (original) (raw)

Papers by Junaid Ansari

Organizacija, 2021

Background: Despite extensive research on employee turnover intention in the existing literature.... more Background: Despite extensive research on employee turnover intention in the existing literature. Previous studies have paid rare attention to the role of workload (WL), nepotism (N), job satisfaction (JS), and organization politics (OP) on turnover intention, especially, mediating the effect of harassment between WL, N, JS and OP on turnover intention in the Pakistani context. This study is using Hobfoll’s conservation of resources (COR) theory. Methods: Data were collected from 189 female employees (doctors and nurses) working in public and private hospitals in the province of Sindh, Pakistan, by adopting a purposive sampling technique. SmartPLS and SPPS were used to analyze the data. Results: The results demonstrated that workload and job satisfaction are positively related to harassment. At the same time, harassment has a direct effect on turnover intention. More importantly, harassment partially mediated the effect between workload and job satisfaction on turnover intention. In...

… and thoracic surgery, 2009

Life expectancy has increased during recent decades leading to a growing number of older populati... more Life expectancy has increased during recent decades leading to a growing number of older population. The objective of this study was to evaluate the outcomes of coronary artery bypass grafting (CABG) in octogenarians and to compare the outcomes of the emergent CABG ...

Lahore Journal of Business

One of the reasons affecting job satisfaction is the leadership style that engages the employees ... more One of the reasons affecting job satisfaction is the leadership style that engages the employees on a daily basis. Although perceived leadership has been studied well in the past, but there are fewer studies focusing on the mediating effect of employee empowerment. The key objective of this research is to study the relationship of perceived leadership, employee empowerment and job satisfaction of the employees, and also to study the mediating role of employee empowerment on the relationship between perceived leadership, and job satisfaction of the employee. A sample of 200 professionals from different banks was selected for the purpose of this study. Moreover, the Smart PLS 3.0 software was used to analyze whether the model was fit by referring to the PLS-SEM. The results of this study revealed that the independent variable (perceived Leadership) has a significant and positive influence on job satisfaction. All the hypotheses were accepted, and there were none that could be rejected...

Blood

Background and Purpose: Niclosamide is an anthelminthic drug which has been used for the treatmen... more Background and Purpose: Niclosamide is an anthelminthic drug which has been used for the treatment of human parasitic infections for many years. Niclosamide interacts with lysosomes and induces autophagy. In recent years, it has demonstrated anti-cancer potential in leukemia, breast cancer, colon cancer, myeloma, ovarian, prostate and lung cancer models. Multiple pathways like Wnt/β-catenin, mTORC1, STAT3, NF-κB and notch signaling were reported to be involved. Only limited studies were done in lymphoma models. We hypothesized that niclosamide may also have in vitro and in vivo activities in lymphomas. Non-Hodgkin lymphomas generally respond well to chemotherapy and/ or immunotherapy, however many patients relapse and ultimately become refractory. Relapses are often caused by tumor stem cells not eliminated by cytostatic drugs. Therefore new treatment approaches and new targets are desirable. Materials and Methods: Established B lymphoma cell lines were exposed to different concentr...

Translational Lung Cancer Research, 2016

Lung cancer remains the number one cause of cancer-related deaths worldwide with 221,200 estimate... more Lung cancer remains the number one cause of cancer-related deaths worldwide with 221,200 estimated new cases and 158,040 estimated deaths in 2015. Approximately 80% of cases are non-small cell lung cancer (NSCLC). The diagnosis is usually made at an advanced stage where the prognosis is poor and therapeutic options are limited. The evolution of lung cancer is a multistep process involving genetic, epigenetic, and environmental factor interactions that result in the dysregulation of key oncogenes and tumor suppressor genes, culminating in activation of cancer-related signaling pathways. The past decade has witnessed the discovery of multiple molecular aberrations that drive lung cancer growth, among which are epidermal growth factor receptor (EGFR) mutations and translocations involving the anaplastic lymphoma kinase (ALK) gene. This has translated into therapeutic agent developments that target these molecular alterations. The absence of targetable mutations in 50% of NSCLC cases and targeted therapy resistance development underscores the importance for developing alternative therapeutic strategies for treating lung cancer. Among these strategies, pharmacologic modulation of the epigenome has been used to treat lung cancer. Epigenetics approaches may circumvent the problem of tumor heterogeneity by affecting the expression of multiple tumor suppression genes (TSGs), halting tumor growth and survival. Moreover, it may be effective for tumors that are not driven by currently recognized druggable mutations. This review summarizes the molecular pathology of lung cancer epigenetic aberrations and discusses current efforts to target the epigenome with different pharmacological approaches. Our main focus will be on hypomethylating agents, histone deacetylase (HDAC) inhibitors, microRNA modulations, and the role of novel epigenetic biomarkers. Last, we will address the challenges that face this old-new strategy in treating lung cancer.

New Indian Journal of Surgery, 2016

2011 International Conference on Multimedia, Signal Processing and Communication Technologies, 2011

In this paper, a dual frequency resonance antenna is achieved by L-strip fed semi-circular disk p... more In this paper, a dual frequency resonance antenna is achieved by L-strip fed semi-circular disk patch antenna with parasitic elements. It is analyzed by using circuit theory concept in which theoretical results are compared with IE3D simulation. It is found that, the bandwidth of lower and upper resonance frequency of simulated result are 6.61% and 6.02 %, whereas for theoretical result are 10.64 % and 9.06 % respectively.

Transplant infectious disease : an official journal of the Transplantation Society, 2014

Cytomegalovirus (CMV) is the most common cause of viral infection, causing morbidity and mortalit... more Cytomegalovirus (CMV) is the most common cause of viral infection, causing morbidity and mortality among renal transplant recipients (RTRs). Cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and interferon-gamma (IFN-γ) have been shown to possess antiviral properties, and their polymorphisms are associated with disease outcome. The aim was to investigate the association of gene polymorphisms in IL-10, IFN-γ, and TNF-α with CMV infection in RTRs. IL-10 -1082 A>G, -592 A>C; TNF-α -308 A>G; and IFN-γ +874 A>T gene polymorphisms were studied in 247 Hispanic RTRs (52 RTRs with CMV infection and 195 without CMV infection), using DNA-based polymerase chain reaction with sequence-specific primers and restriction. Median time to CMV infection was 8 months, with a mean peak CMV viral load of 25,314 copies/mL. Patients with donor-positive/recipient-negative (D+/R-) serostatus were found to be associated with a high risk of CMV infection (P = 0.001). A s...

2008 Second International Conference on Sensor Technologies and Applications (sensorcomm 2008), 2008

A wide range of wireless sensor network applications are characterized by local processing of the... more A wide range of wireless sensor network applications are characterized by local processing of the sensed data and only meager data communication requirements. Indeed, because sensor nodes are battery powered and wireless communication bears a high energy cost, data transmission can be traded for on-the-node computation to extend node and network lifetime. Furthermore, the energy consumption can be reduced significantly

Proceedings of the 16th ACM international conference on Modeling, analysis & simulation of wireless and mobile systems - MSWiM '13, 2013

2007 IEEE 18th International Symposium on Personal, Indoor and Mobile Radio Communications, 2007

... This approach allows our WSN based tracking framework to handle non-linear motion even in the... more ... This approach allows our WSN based tracking framework to handle non-linear motion even in the presence of non-Gaussian measurement ... tracking algorithm is based on a Bayesian filtering tech-nique known as particle filtering that uses Sequential Monte Carlo (SMC) method ...

2011 IEEE 22nd International Symposium on Personal, Indoor and Mobile Radio Communications, 2011

We empirically study problems of online estimation and modeling of radio activity (ON/OFF) patter... more We empirically study problems of online estimation and modeling of radio activity (ON/OFF) patterns and their duty cycles. We consider performance of two algorithms that analyze power spectrum samples in time domain as sensed by WARP SDR boards placed at different indoor locations. The first algorithm utilizes density function of the marginal distribution of the received readings to perform clustering

Proceedings of the 10th international conference on Mobile systems, applications, and services - MobiSys '12, 2012

2013 IEEE International Conference on Sensing, Communications and Networking (SECON), 2013

2008 Annual IEEE India Conference, 2008

Abstract Theoretical investigations of a gap-coupled stacked microstrip antenna is presented usin... more Abstract Theoretical investigations of a gap-coupled stacked microstrip antenna is presented using equivalent circuit concept. It is found that the antenna operates with dual frequency band characteristics with resonances at 4.76 GHz and 6.79 GHz. The dual nature of the ...

Wireless Personal Communications, 2013

ABSTRACT In this paper, a comparative study of co-planar gap coupled rectangular and elliptical m... more ABSTRACT In this paper, a comparative study of co-planar gap coupled rectangular and elliptical microstrip patch antenna is presented. It is analyzed by using circuit theory concept. The proposed antennas show ultra wideband operations which depend on dimensions of the patches, gap between them as well as air gap thickness. It is observed that the performance of gap coupled elliptical patch antenna is better than that of rectangular patch antenna while the area of rectangular and elliptical patches is same. The bandwidth of proposed rectangular patch antenna is found to be 50.7 % with average gain of 6.5 dBi while for elliptical patch antenna the bandwidth and gain further improves up to 57.6 % and 9.5 dBi respectively. The theoretical results are in good agreement with the simulated results obtained from IE3D simulation software.

Toxicology Mechanisms and Methods, 2012

There has been a steady increase in the epidemiology of obesity over the last 30 years with devel... more There has been a steady increase in the epidemiology of obesity over the last 30 years with developed countries leading the way. Oxidative stress was believed to be the principle contributor to the development of cardiovascular disorders that linked with obesity. To evaluate the enhancement of antioxidant defense mechanism by Pitavastatin (PTV) and Rosuvastatin (RSV) on obesity-induced oxidative stress in Wistar rats. Fifty Wistar albino rats were divided into five groups. High fat diet (HFD, 20 g/day/rat) pellets were given for 28 days to produce obesity-induced oxidative stress in Wistar rats. Oral administration of HFD along with PTV, RSV and Orlistat [(HFD for 28 days + from 8th day PTV (1 mg/kg), RSV (5 mg/kg) and Orlistat (10 mg/kg) to 28th day] were given respectively. Both PTV and RSV produced significant (p &amp;amp;amp;lt; 0.01) reduction in serum apolipoprotein-B (Apo-B), total cholesterol (TC), triglycerides (TGs), cardiac-lipid peroxides (TBARS) levels and elevation in serum high density lipoprotein (HDL-C), cardiac antioxidant enzymes [glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catase (CAT)] levels. Results were comparable with Orlistat, a standard antiobesity drug and present initial evidence that Pitavastatin and Rosuvastatin are useful for the treatment of obesity by enhancing the antioxidant defense mechanism. However, the effects of PTV were more prominent than RSV. The present findings of Pitavastatin and Rosuvastatin raise the possibility of a new application as an antiobesity therapeutic modality.

The Journal of Thoracic and Cardiovascular Surgery, 2008

A 53-year-old woman presented to the cardiology clinic with complaints of palpitations. Echocardi... more A 53-year-old woman presented to the cardiology clinic with complaints of palpitations. Echocardiographic analysis revealed a 15-mm secundum ASD. She underwent elective closure of the ASD with ASO without any complications. Her predischarge echocardiogram revealed that the ASD ...

International Journal of Wireless Information Networks, 2009

Sensor network applications are generally characterized by long idle durations and intermittent c... more Sensor network applications are generally characterized by long idle durations and intermittent communication patterns. The traffic loads are typically so low that overall idle duration energy consumption dominates. Low duty cycle MAC protocols are used in order to reduce the energy consumption in idle periods. However, lowering the duty cycle value in favour of energy consumption results in increased latency, which makes this approach undesirable for many practical applications. In this paper, we propose Radio Triggered Wake-up with Addressing Capabilities (RTWAC) that allows suppressing the idle duration current consumption. Our solution consists of an external low-cost hardware wake-up circuit attached to the microcontroller of a sensor node. In order to communicate with a sensor node, a special kind of out-of-band modulated wake-up signal is transmitted. The modulated signal contains data that enables one to distinguish between differently addressed nodes in order to avoid undesired node wake-ups. Furthermore, we advocate the idea of combining RTWAC to a MAC protocol running on the normal sensor node radio in order to simultaneously achieve low energy consumption and low latency for reliable data communication. 1