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Introduction Materials and Methods Results and Discussion Conclusion Bibliography IV.
The Journal of allergy and clinical immunology, Jan 3, 2018
Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal ti... more Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal tissue including eosinophil-rich inflammation, basal zone hyperplasia (BZH) and dilated intercellular spaces (DIS). The underlying molecular processes that drive the histopathologic features of EoE remain largely unexplored. To investigate the involvement of SLC9A3 in esophageal epithelial [pH] and DIS formation and the histopathological features of EoE. We examined expression of esophageal epithelial gene networks associated with regulation of intracellular pH ([pH]) in the EoE transcriptome of primary esophageal epithelial cells and an in vitro esophageal epithelial 3D model system (EPC2-ALI). Molecular and cellular analyses and ion transport assays were employed to evaluate expression and function of SLC9A3. We identified altered expression of gene networks associated with regulation of intracellular pH ([pH]) and acid protective mechanisms in esophageal biopsies from pediatric patients...
Liver Transplantation, 2011
The pediatric population has many physiological differences that can significantly alter the phar... more The pediatric population has many physiological differences that can significantly alter the pharmacokinetic and pharmacogenomic disposition in terms of Abbreviations: EBV, Epstein-Barr virus; LT, liver transplantation; MMF, mycophenolate mofetil.
Introduction Materials and Methods Results and Discussion Conclusion Bibliography IV.
The Journal of allergy and clinical immunology, Jan 3, 2018
Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal ti... more Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal tissue including eosinophil-rich inflammation, basal zone hyperplasia (BZH) and dilated intercellular spaces (DIS). The underlying molecular processes that drive the histopathologic features of EoE remain largely unexplored. To investigate the involvement of SLC9A3 in esophageal epithelial [pH] and DIS formation and the histopathological features of EoE. We examined expression of esophageal epithelial gene networks associated with regulation of intracellular pH ([pH]) in the EoE transcriptome of primary esophageal epithelial cells and an in vitro esophageal epithelial 3D model system (EPC2-ALI). Molecular and cellular analyses and ion transport assays were employed to evaluate expression and function of SLC9A3. We identified altered expression of gene networks associated with regulation of intracellular pH ([pH]) and acid protective mechanisms in esophageal biopsies from pediatric patients...
Liver Transplantation, 2011
The pediatric population has many physiological differences that can significantly alter the phar... more The pediatric population has many physiological differences that can significantly alter the pharmacokinetic and pharmacogenomic disposition in terms of Abbreviations: EBV, Epstein-Barr virus; LT, liver transplantation; MMF, mycophenolate mofetil.