Jyoti Gupta - Academia.edu (original) (raw)
Papers by Jyoti Gupta
Prospects Quarterly Review of Education, 1976
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Biology and Medicine, 2009
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Entomon, 1989
... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'... more ... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'"'J of Zoology, Bañaras Hindu University, Varanasi, India and Department of ... of the genus Drosophila wherein it somewhat resembles the members of the inornata group in showing reduced arista and in not ...
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Molecular Membrane Biology, 2003
Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator... more Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently unclear. As a result, comparisons between CFTR and other classes of Cl(-) channel of known structure are difficult. We compare here the effects of point mutations at each of eight consecutive amino acid residues (arginine 334-serine 341) in the crucial sixth transmembrane region (TM6) of CFTR. Anion selectivity was determined using patch-clamp recording from inside-out membrane patches excised from transiently transfected mammalian cell lines. The results suggest that selectivity is predominantly controlled by a single site involving adjacent residues phenylalanine 337 and threonine 338, and that the selectivity conferred by this 'filter' region is modified by anion binding to flanking sites involving the more extracellular arginine 334 and the more intracellular serine 341. Other residues within this part of the pore play only minor roles in controlling anion permeability and conductance. Our results support a model in which specific TM6 residues make important contributions to a single, localized anion selectivity filter in the CFTR pore, and also contribute to multiple anion binding sites both within and on either side of the filter region.
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The Indian Journal of Genetics and Plant Breeding, 1989
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Int J Pharmacol, 2008
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Journal of Medical Sciences, 2008
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Http Dx Doi Org 10 1080 17542863 2013 868502, Dec 19, 2013
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ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents... more ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents in colon cancer prevention which include isoflavones, curcumin, calcium, vitamin D and more recently Green tea polyphenols. These compounds are relatively non-toxic, are of low cost and can be taken orally or as a part of the daily diet. Historical references of tea date back to 5,000 years. Tea was consumed even earlier by the indigenous peoples of India and China, to improve their health. Present study, therefore, is directed towards investigation of the anticancer action of Green tea polyphenols in vitro. Gas Chromatography and Mass Spectrometry of Green tea extract was performed for detection of polyphenolic contents in the Green tea extract. Cytotoxicity of the (methanolic) Green tea extract (GTE) was then evaluated by the assessment of its in vitro impact on the Human Breast cancer cell line (MCF-7) and Human Embryonic Kidney cell line (HEK 293). The results revealed that the methanolic extract of Green tea had a significant cytotoxic impact on MCF-7 cells and HEK 293 cells with the half maximal inhibitory concentration (IC 50 mean value) of 592.6 μg/ml and 1041.35 μg/ml, respectively, on both the cell lines. Keywords: Green tea polyphenols, Cellular metabolic MTT Assay, Neutral Red (NR) uptake Assay, Half maximal inhibitory concentration (IC 50 mean value).
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Ssrn Electronic Journal, Sep 1, 2006
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Indian Journal of Horticulture, 1971
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Indian Journal of Animal Nutrition, 1991
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Journal of the Indian Society of Soil Science, 1994
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Indian Journal of Animal Nutrition, 1997
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Proc Indian Acad Sci Math Sci, 2000
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Cheminform, Mar 2, 2010
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Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 1999
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Prospects Quarterly Review of Education, 1976
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Biology and Medicine, 2009
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Entomon, 1989
... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'... more ... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'"'J of Zoology, Bañaras Hindu University, Varanasi, India and Department of ... of the genus Drosophila wherein it somewhat resembles the members of the inornata group in showing reduced arista and in not ...
Bookmarks Related papers MentionsView impact
Molecular Membrane Biology, 2003
Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator... more Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently unclear. As a result, comparisons between CFTR and other classes of Cl(-) channel of known structure are difficult. We compare here the effects of point mutations at each of eight consecutive amino acid residues (arginine 334-serine 341) in the crucial sixth transmembrane region (TM6) of CFTR. Anion selectivity was determined using patch-clamp recording from inside-out membrane patches excised from transiently transfected mammalian cell lines. The results suggest that selectivity is predominantly controlled by a single site involving adjacent residues phenylalanine 337 and threonine 338, and that the selectivity conferred by this 'filter' region is modified by anion binding to flanking sites involving the more extracellular arginine 334 and the more intracellular serine 341. Other residues within this part of the pore play only minor roles in controlling anion permeability and conductance. Our results support a model in which specific TM6 residues make important contributions to a single, localized anion selectivity filter in the CFTR pore, and also contribute to multiple anion binding sites both within and on either side of the filter region.
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The Indian Journal of Genetics and Plant Breeding, 1989
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Int J Pharmacol, 2008
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Journal of Medical Sciences, 2008
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Http Dx Doi Org 10 1080 17542863 2013 868502, Dec 19, 2013
Bookmarks Related papers MentionsView impact
ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents... more ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents in colon cancer prevention which include isoflavones, curcumin, calcium, vitamin D and more recently Green tea polyphenols. These compounds are relatively non-toxic, are of low cost and can be taken orally or as a part of the daily diet. Historical references of tea date back to 5,000 years. Tea was consumed even earlier by the indigenous peoples of India and China, to improve their health. Present study, therefore, is directed towards investigation of the anticancer action of Green tea polyphenols in vitro. Gas Chromatography and Mass Spectrometry of Green tea extract was performed for detection of polyphenolic contents in the Green tea extract. Cytotoxicity of the (methanolic) Green tea extract (GTE) was then evaluated by the assessment of its in vitro impact on the Human Breast cancer cell line (MCF-7) and Human Embryonic Kidney cell line (HEK 293). The results revealed that the methanolic extract of Green tea had a significant cytotoxic impact on MCF-7 cells and HEK 293 cells with the half maximal inhibitory concentration (IC 50 mean value) of 592.6 μg/ml and 1041.35 μg/ml, respectively, on both the cell lines. Keywords: Green tea polyphenols, Cellular metabolic MTT Assay, Neutral Red (NR) uptake Assay, Half maximal inhibitory concentration (IC 50 mean value).
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Ssrn Electronic Journal, Sep 1, 2006
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Indian Journal of Horticulture, 1971
Bookmarks Related papers MentionsView impact
Indian Journal of Animal Nutrition, 1991
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Journal of the Indian Society of Soil Science, 1994
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Indian Journal of Animal Nutrition, 1997
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Proc Indian Acad Sci Math Sci, 2000
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Bookmarks Related papers MentionsView impact
Cheminform, Mar 2, 2010
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Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 1999
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