Jyoti Gupta - Academia.edu (original) (raw)

Papers by Jyoti Gupta

Research paper thumbnail of Language, education and development planning

Prospects Quarterly Review of Education, 1976

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Research paper thumbnail of Protective role of green tea extract against genotoxic damage induced by anabolic steroids in cultured human lymphocytes

Biology and Medicine, 2009

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Research paper thumbnail of Further records of a new and one known species of Drosophila from Arunachal Pradesh, India

Entomon, 1989

... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""&#x27... more ... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'"'J of Zoology, Bañaras Hindu University, Varanasi, India and Department of ... of the genus Drosophila wherein it somewhat resembles the members of the inornata group in showing reduced arista and in not ...

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Research paper thumbnail of Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore

Molecular Membrane Biology, 2003

Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator... more Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently unclear. As a result, comparisons between CFTR and other classes of Cl(-) channel of known structure are difficult. We compare here the effects of point mutations at each of eight consecutive amino acid residues (arginine 334-serine 341) in the crucial sixth transmembrane region (TM6) of CFTR. Anion selectivity was determined using patch-clamp recording from inside-out membrane patches excised from transiently transfected mammalian cell lines. The results suggest that selectivity is predominantly controlled by a single site involving adjacent residues phenylalanine 337 and threonine 338, and that the selectivity conferred by this 'filter' region is modified by anion binding to flanking sites involving the more extracellular arginine 334 and the more intracellular serine 341. Other residues within this part of the pore play only minor roles in controlling anion permeability and conductance. Our results support a model in which specific TM6 residues make important contributions to a single, localized anion selectivity filter in the CFTR pore, and also contribute to multiple anion binding sites both within and on either side of the filter region.

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Research paper thumbnail of Validity of Prediction Methods Under Population Stress in Composite and Varietal Hybrids in Maize (Zea Mays L.)

The Indian Journal of Genetics and Plant Breeding, 1989

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Research paper thumbnail of Defense Centers of Excellence: Limited Budget and Performance Information on the Center for Psychological Health and Traumatic Brain Injury

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Research paper thumbnail of Antigenotoxic Effect of Genistein and Gingerol on Genotoxicity Induced by Norethandrolone and Oxandrolone in Cultured Human Lymphocytes

Int J Pharmacol, 2008

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Research paper thumbnail of Mental Retardation and Mental Health: Paradigm Shifts in Genetic, Clinical and Behavioural Research

Journal of Medical Sciences, 2008

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Research paper thumbnail of Codependence in spouses of alcohol and opioid dependent men

Http Dx Doi Org 10 1080 17542863 2013 868502, Dec 19, 2013

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Research paper thumbnail of Anticancer potentials of Green tea polyphenols in human cancer cell lines

ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents... more ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents in colon cancer prevention which include isoflavones, curcumin, calcium, vitamin D and more recently Green tea polyphenols. These compounds are relatively non-toxic, are of low cost and can be taken orally or as a part of the daily diet. Historical references of tea date back to 5,000 years. Tea was consumed even earlier by the indigenous peoples of India and China, to improve their health. Present study, therefore, is directed towards investigation of the anticancer action of Green tea polyphenols in vitro. Gas Chromatography and Mass Spectrometry of Green tea extract was performed for detection of polyphenolic contents in the Green tea extract. Cytotoxicity of the (methanolic) Green tea extract (GTE) was then evaluated by the assessment of its in vitro impact on the Human Breast cancer cell line (MCF-7) and Human Embryonic Kidney cell line (HEK 293). The results revealed that the methanolic extract of Green tea had a significant cytotoxic impact on MCF-7 cells and HEK 293 cells with the half maximal inhibitory concentration (IC 50 mean value) of 592.6 μg/ml and 1041.35 μg/ml, respectively, on both the cell lines. Keywords: Green tea polyphenols, Cellular metabolic MTT Assay, Neutral Red (NR) uptake Assay, Half maximal inhibitory concentration (IC 50 mean value).

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Research paper thumbnail of Pyramiding of Family-owned Banks in Emerging Markets

Ssrn Electronic Journal, Sep 1, 2006

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Research paper thumbnail of Optimum Size of Plots for Experiments on the Weight of Onion Bulbs

Indian Journal of Horticulture, 1971

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Research paper thumbnail of Nutritive Vaule of Exbucklandia (Symingtonia populnea) Leaves for Goats

Indian Journal of Animal Nutrition, 1991

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Research paper thumbnail of Effects of phosphorus, lime and farmyard manure on the yield and uptake of calcium and magnesium at different growth stages in late sown wheat in an acid Alfisol of Himalayan region

Journal of the Indian Society of Soil Science, 1994

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Research paper thumbnail of Response of Feeding Chelated Mineral Product on Nutrient Utilization and Growth in Pigs

Indian Journal of Animal Nutrition, 1997

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Research paper thumbnail of Coin tossing and Laplace inversion

Proc Indian Acad Sci Math Sci, 2000

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Research paper thumbnail of Bangladesh, in blood and tears

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Research paper thumbnail of ChemInform Abstract: Chemical Constituents of Boerhavia diffusa Linn. roots

Cheminform, Mar 2, 2010

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Research paper thumbnail of New Pentacyclic Triterpenic Esters from the Roots of Calotropis Gigantea

Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 1999

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Research paper thumbnail of Synthesis, Analgesic and Ulcerogenic Activity of Novel Pyrimidine Derivative of Coumarin Moiety

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Research paper thumbnail of Language, education and development planning

Prospects Quarterly Review of Education, 1976

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Research paper thumbnail of Protective role of green tea extract against genotoxic damage induced by anabolic steroids in cultured human lymphocytes

Biology and Medicine, 2009

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Research paper thumbnail of Further records of a new and one known species of Drosophila from Arunachal Pradesh, India

Entomon, 1989

... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""&#x27... more ... Deposited in the M^tÂ^- "Drosophila Collection" of the Department ""'"'J of Zoology, Bañaras Hindu University, Varanasi, India and Department of ... of the genus Drosophila wherein it somewhat resembles the members of the inornata group in showing reduced arista and in not ...

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Research paper thumbnail of Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore

Molecular Membrane Biology, 2003

Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator... more Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently unclear. As a result, comparisons between CFTR and other classes of Cl(-) channel of known structure are difficult. We compare here the effects of point mutations at each of eight consecutive amino acid residues (arginine 334-serine 341) in the crucial sixth transmembrane region (TM6) of CFTR. Anion selectivity was determined using patch-clamp recording from inside-out membrane patches excised from transiently transfected mammalian cell lines. The results suggest that selectivity is predominantly controlled by a single site involving adjacent residues phenylalanine 337 and threonine 338, and that the selectivity conferred by this 'filter' region is modified by anion binding to flanking sites involving the more extracellular arginine 334 and the more intracellular serine 341. Other residues within this part of the pore play only minor roles in controlling anion permeability and conductance. Our results support a model in which specific TM6 residues make important contributions to a single, localized anion selectivity filter in the CFTR pore, and also contribute to multiple anion binding sites both within and on either side of the filter region.

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Research paper thumbnail of Validity of Prediction Methods Under Population Stress in Composite and Varietal Hybrids in Maize (Zea Mays L.)

The Indian Journal of Genetics and Plant Breeding, 1989

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Research paper thumbnail of Defense Centers of Excellence: Limited Budget and Performance Information on the Center for Psychological Health and Traumatic Brain Injury

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Antigenotoxic Effect of Genistein and Gingerol on Genotoxicity Induced by Norethandrolone and Oxandrolone in Cultured Human Lymphocytes

Int J Pharmacol, 2008

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Research paper thumbnail of Mental Retardation and Mental Health: Paradigm Shifts in Genetic, Clinical and Behavioural Research

Journal of Medical Sciences, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Codependence in spouses of alcohol and opioid dependent men

Http Dx Doi Org 10 1080 17542863 2013 868502, Dec 19, 2013

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Research paper thumbnail of Anticancer potentials of Green tea polyphenols in human cancer cell lines

ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents... more ABSTRACT Several plant-based nutrients and non-nutrients are identified as chemopreventive agents in colon cancer prevention which include isoflavones, curcumin, calcium, vitamin D and more recently Green tea polyphenols. These compounds are relatively non-toxic, are of low cost and can be taken orally or as a part of the daily diet. Historical references of tea date back to 5,000 years. Tea was consumed even earlier by the indigenous peoples of India and China, to improve their health. Present study, therefore, is directed towards investigation of the anticancer action of Green tea polyphenols in vitro. Gas Chromatography and Mass Spectrometry of Green tea extract was performed for detection of polyphenolic contents in the Green tea extract. Cytotoxicity of the (methanolic) Green tea extract (GTE) was then evaluated by the assessment of its in vitro impact on the Human Breast cancer cell line (MCF-7) and Human Embryonic Kidney cell line (HEK 293). The results revealed that the methanolic extract of Green tea had a significant cytotoxic impact on MCF-7 cells and HEK 293 cells with the half maximal inhibitory concentration (IC 50 mean value) of 592.6 μg/ml and 1041.35 μg/ml, respectively, on both the cell lines. Keywords: Green tea polyphenols, Cellular metabolic MTT Assay, Neutral Red (NR) uptake Assay, Half maximal inhibitory concentration (IC 50 mean value).

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Research paper thumbnail of Pyramiding of Family-owned Banks in Emerging Markets

Ssrn Electronic Journal, Sep 1, 2006

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Research paper thumbnail of Optimum Size of Plots for Experiments on the Weight of Onion Bulbs

Indian Journal of Horticulture, 1971

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Research paper thumbnail of Nutritive Vaule of Exbucklandia (Symingtonia populnea) Leaves for Goats

Indian Journal of Animal Nutrition, 1991

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Effects of phosphorus, lime and farmyard manure on the yield and uptake of calcium and magnesium at different growth stages in late sown wheat in an acid Alfisol of Himalayan region

Journal of the Indian Society of Soil Science, 1994

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Response of Feeding Chelated Mineral Product on Nutrient Utilization and Growth in Pigs

Indian Journal of Animal Nutrition, 1997

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Coin tossing and Laplace inversion

Proc Indian Acad Sci Math Sci, 2000

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Bangladesh, in blood and tears

Bookmarks Related papers MentionsView impact

Research paper thumbnail of ChemInform Abstract: Chemical Constituents of Boerhavia diffusa Linn. roots

Cheminform, Mar 2, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of New Pentacyclic Triterpenic Esters from the Roots of Calotropis Gigantea

Indian Journal of Chemistry Sect B Organic Chemistry Including Medical Chemistry, 1999

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Synthesis, Analgesic and Ulcerogenic Activity of Novel Pyrimidine Derivative of Coumarin Moiety

Bookmarks Related papers MentionsView impact