İrfan KÜÇÜK - Academia.edu (original) (raw)

Papers by İrfan KÜÇÜK

Eskisehir Medical Journal Eskisehir City Hospital, Oct 19, 2023

Journal of Clinical Oncology, 2015

e15107 Background: Epstein-Barr virus (EBV) causes gastric adenocarcinoma besides other etiologic... more e15107 Background: Epstein-Barr virus (EBV) causes gastric adenocarcinoma besides other etiologic factors. EBV prevalence among gastric cancers has been reported in several countries. EBV-positive gastric cancer frequency has not been known in Turkey. We aimed to investigate EBV positivity and describe associated clinicopathologic parameters in north-west region of Turkey. Methods: Eighty-five gastric cancer patients and 50 control patients with HP negative chronic gastritis were admitted to the study. Epstein–Barr virus-encoded small RNAs (EBER) in situ hybridization was used for EBV positivity. Results: ISH-EBER was positive in tumor tissues from 2 cancer patients. First EBER positive patient was a 56 years old-woman (in diagnose). Tumor was intermediate-differentiated intestinal type adenocarcinoma in antrum (T3N1M0). After adjuvant chemoradiotherapy, she has been followed up without relapse for over 9 years. Second patient was a 71 years-old man. T3N0M0 tumor was diffuse type, intermediate-differentia...

Konuralp Tip Dergisi, Dec 9, 2023

Scottish Medical Journal, Sep 10, 2023

DergiPark (Istanbul University), Jul 27, 2023

Gulhane Medical Journal, 2014

We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance ... more We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance of multiple hypercoagulable conditions. The patient was admitted to our hospital for assesment of hepatosplenomegaly and ascites. By doppler ultrasonography, computed tomography and vena cavagraphy, Budd-Chiari syndrome was diagnosed. Results of diagnostic tests exhibited decreased activity, decreased antigenic concentration of Antithrombin, low protein C activity, heterozygote Factor V Leiden mutation. In clinical progress, acute severe hepatic failure with encephalopathy occured and the patient was transferred to an another medical center for liver transplantation.

Gulhane Medical Journal, 2014

We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance ... more We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance of multiple hypercoagulable conditions. The patient was admitted to our hospital for assesment of hepatosplenomegaly and ascites. By doppler ultrasonography, computed tomography and vena cavagraphy, Budd-Chiari syndrome was diagnosed. Results of diagnostic tests exhibited decreased activity, decreased antigenic concentration of Antithrombin, low protein C activity, heterozygote Factor V Leiden mutation. In clinical progress, acute severe hepatic failure with encephalopathy occured and the patient was transferred to an another medical center for liver transplantation.

PubMed, 2013

To our knowledge, there has also been no report in the literature about mild hypoxemia caused by ... more To our knowledge, there has also been no report in the literature about mild hypoxemia caused by food impaction in the esophagus, as seen in this case. Because of the patient’s psychiatric disorder, the discomfort caused by the impacted food may have resulted in the hypoxemia, but the physical examination at presentation revealed no inhalation problems and the thoracic CT showed no external compression of the airway tract.

The American Journal of Gastroenterology, Oct 1, 2011

Background/Aims: We aimed to investigate the alterations in serum lipid levels due to biliary obs... more Background/Aims: We aimed to investigate the alterations in serum lipid levels due to biliary obstruction associated with benign and malignant cases. Also, we aimed to examine the possibility of the theory that extremely high serum lipid levels can predict the malignant biliary obstruction in the differantial diagnosis. Methodology: Three hundred twenty two patients who were performed endoscopic retrograde cholangiopancreatography with the intrahepatic and extrahepatic cholestasis were reviewed in the period from September 2007 to October 2010. Results:In the malignant obstruction group, meaningfully higher total cholesterol (p 0.05) and triglycerides (p<0.05) were observed but high-density lipoprotein (p<0.05) levels were lower. The receiver operating characteristic analysis showed that total cholesterol (246.74mg/dL or less), sensitivity (84.3%), specificity (83.3%) area under the curve (0.705, range 0.6200.790; p<0.001) and high-density lipoprotein cholesterol area under the curve (0.577, range 0.444-0.710) were predictors of malignant biliary obstruction. Conclusions: Serum lipid profile may be used as an applicant marker to identify malignant reasons of the obstructive jaundice.

Annals of Colorectal Research, Jul 6, 2019

Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting wi... more Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting with diarrhea, bloody defecation and abdominal pain. Although cardiac and/or pulmonary involvement has been reported in patients with ulcerative colitis, it rarely involves both the pleura and pericardium at the same time. Also, it is difficult to determine whether pulmonary or cardiac disease is secondary to the ulcerative colitis drugs or to the underlying disease process. Here we present a rare case of pleuropericardial effusion in a patient newly diagnosed with ulcerative colitis. In ulcerative colitis, the simultaneous involvement of the respiratory and cardiovascular systems is uncommon yet potentially dangerous.

Haydarpaşa Numune medical journal, 2023

Revista Espanola De Enfermedades Digestivas, 2022

Scandinavian Journal of Gastroenterology, Jun 10, 2014

Acute pancreatitis (AP) is defined as an inflammatory disease of the pancreas. The purpose of thi... more Acute pancreatitis (AP) is defined as an inflammatory disease of the pancreas. The purpose of this study was to examine the effectiveness of Anakinra on cerulein-induced experimental pancreatitis rat model by using the results of biochemical and histopathological findings. Cerulein was administered to induce AP in rats. Group 1 was the sham group. Subcutancerulein was injected to the rats in group 2 for experimental pancreatitis group. In groups 3 and 4, 100 and 50 mg/kg intraperitoneal Anakinra were injected after the induction of experimental pancreatitis by subcutaneous cerulein in rats, respectively. Lastly, in group 5, rats were injected with intraperitoneal saline and subcutan cerulean for placebo group. The following parameters were evaluated: histopathological score of pancreatitis, apoptotic index, amylase, lipase, TNF-α levels, IL-1β and the leukocyte count. When the results of serum amylase, lipase, TNF-α and IL-1β levels, the leukocyte count, histopathologic scores and apoptotic indices of control group compared to the results of other groups, the differences exhibited statistical significance (all p < 0.05). On the other hand, when the results of fourth group compared with the results of third group, the data demonstrated statistical insignificance (p > 0.05). However, no any significant differences were found between the results of fourth and fifth groups (p > 0.05). In the light of these results, cerulein is an appropriate agent for experimental AP rat model and Anakinra has a favorable therapeutic effect on acute experimental pancreatitis model. Moreover, Anakinra significantly decreases cerulein-related pancreatic tissue injury and pancreatic apoptosis.

The Turkish journal of gastroenterology, Nov 11, 2015

Background/Aims: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteina... more Background/Aims: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are well-known inflammatory biomarkers, with a diagnostic potential for various diseases. The aim of the present study was to determine the potential diagnostic applications of serum MMP-9 and TIMP-1 concentrations in patients with familial Mediterranean fever (FMF). Materials and Methods: A total of 66 male FMF patients and 40 age-matched healthy subjects were included in this research. TIMP-1 and MMP-9 levels with conventional inflammation markers were determined. Pearson correlation analysis was used to determine the correlation between the characteristics of patients and the laboratory data. Results: In patients with FMF, serum MMP-9 levels and MMP-9/TIMP-1 ratios were found to be significantly elevated in both acute episode and asymptomatic periods (p=0.0001 and p=0.0001, respectively). There was no significant difference between TIMP-1 levels. A significant negative correlation between patients' current age and TIMP-1 level in patients with acute episodes was detected (p=0.0008, r=−0.52). Moreover, a moderate negative correlation was noticed between erythrocyte sedimentation rate and TIMP-1 level in patients with acute episodes (p=0.01, r=−0.39). Additionally, a moderate negative correlation was found between the duration of colchicine use and MMP-9 and TIMP-1 levels during the attack period (p=0.04, r=−0.36 and p=0.02, r=−0.39, respectively). Conclusion: Our findings demonstrate that a significant MMP-9/TIMP-1 imbalance exists in patients with FMF, which reflects an ongoing inflammation in both FMF periods. Thus, the increased MMP-9 levels observed in FMF patients could rationalize therapeutic targeting to MMPs.

The Turkish journal of gastroenterology, May 20, 2016

We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp... more We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp-2) expressions in patients with ulcerative colitis (UC) and healthy controls using the immunohistochemical (IHC) method. We also aimed to evaluate the correlations between the activity of UC and the expressions of these two proteins. Ninety-five patients with UC (82 males and 13 females) and 38 healthy controls (35 males and 3 females) were included. Clinical and endoscopic activities of UC were assessed. Conventional laboratory activation parameters and severity of inflammation measures were used for the evaluation of histological activity. IHC staining of biopsy samples for the two proteins were semi-quantitatively applied, similar to previously described methods for colon adenocarcinomas. IHC scores of Phb-2 were lower but Slp-2 scores were higher in the UC group than in the healthy controls (p<0.05 and p=0.003, respectively). Phb-2 scores were positively correlated with clinical and histological activities (r=0.364, p<0.05 and r=0.220, p<0.032, respectively). In the UC group, endoscopic activity scores, C-reactive protein levels, and sedimentation rates were also positively correlated with Phb-2 scores (r=0.279, p<0.05, r=0.216, p<0.05, and r=0.216, p<0.05, respectively). IHC scores of Slp-2 were not significantly correlated with the activity parameters of UC. However, there was a significant positive correlation between the expressions of Phb-2 and Slp-2 proteins (p<0.001). Phb-2 may serve as a valuable new biomarker for predicting the severity of all UC activity parameters. The therapeutic effectiveness of both Phb-2 and Slp-2 should be taken into consideration.

İç Anadolu tıp dergisi, May 21, 2015

Giriş Sentetik kannabinoidler (SK), insanlarda bazı marijuana benzeri etkiler oluşturan kimyasall... more Giriş Sentetik kannabinoidler (SK), insanlarda bazı marijuana benzeri etkiler oluşturan kimyasallardır (1). Sentetik kannabinoid içeren maddeler genel

Digestive Diseases and Sciences, Aug 8, 2013

Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal re... more Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF are limited. We have investigated the relationship between serum levels of fetuin-A and inflammatory markers in patients with FMF before, during, and after FMF attacks. Sixty-seven patients with FMF were enrolled in this study. Serum fetuin-A, seruloplasmin, fibrinogen, C reactive protein (CRP), white blood cell count (WBC), calcium, and erythrocyte sedimentation rate (ESR) were measured three times: during the attack-free period, 12 h after FMF attacks, and 7 days after FMF attacks. Plasma fetuin-A concentration was measured by use of an enzyme-linked immunoassay (ELISA) kit. Correlations and differentiation between the serum fetuin-A and other inflammatory markers in patients with FMF were investigated by use of the paired-samples T test and the Pearson correlation test (p < 0.01). Serum fetuin-A levels of all FMF patients in the attack period were significantly lower than in the attack-free period (p < 0.001). In contrast, serum seruloplasmin (p < 0.05), fibrinogen (p < 0.001), CRP (p < 0.05), WBC (p < 0.05), and ESR (p < 0.05) were all significantly higher than in the attack-free period. Plasma fetuin-A is significantly and inversely highly correlated with the other inflammatory markers. Fetuin-A might be a novel indicator of disease activity in patients with FMF and could be used as an adjunctive marker for differentiation of FMF attacks. The negative correlation between serum fetuin-A and other inflammatory markers may also be indicative of inflammation-dependent downregulation of fetuin-A expression in FMF patients.

American Journal of Gastroenterology, 2011

Acta Neurologica Scandinavica, 2009

Ił_ zecka J. Serum-soluble receptor for advanced glycation end product levels in patients with am... more Ił_ zecka J. Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis.

Eskisehir Medical Journal Eskisehir City Hospital, Oct 19, 2023

Journal of Clinical Oncology, 2015

e15107 Background: Epstein-Barr virus (EBV) causes gastric adenocarcinoma besides other etiologic... more e15107 Background: Epstein-Barr virus (EBV) causes gastric adenocarcinoma besides other etiologic factors. EBV prevalence among gastric cancers has been reported in several countries. EBV-positive gastric cancer frequency has not been known in Turkey. We aimed to investigate EBV positivity and describe associated clinicopathologic parameters in north-west region of Turkey. Methods: Eighty-five gastric cancer patients and 50 control patients with HP negative chronic gastritis were admitted to the study. Epstein–Barr virus-encoded small RNAs (EBER) in situ hybridization was used for EBV positivity. Results: ISH-EBER was positive in tumor tissues from 2 cancer patients. First EBER positive patient was a 56 years old-woman (in diagnose). Tumor was intermediate-differentiated intestinal type adenocarcinoma in antrum (T3N1M0). After adjuvant chemoradiotherapy, she has been followed up without relapse for over 9 years. Second patient was a 71 years-old man. T3N0M0 tumor was diffuse type, intermediate-differentia...

Konuralp Tip Dergisi, Dec 9, 2023

Scottish Medical Journal, Sep 10, 2023

DergiPark (Istanbul University), Jul 27, 2023

Gulhane Medical Journal, 2014

We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance ... more We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance of multiple hypercoagulable conditions. The patient was admitted to our hospital for assesment of hepatosplenomegaly and ascites. By doppler ultrasonography, computed tomography and vena cavagraphy, Budd-Chiari syndrome was diagnosed. Results of diagnostic tests exhibited decreased activity, decreased antigenic concentration of Antithrombin, low protein C activity, heterozygote Factor V Leiden mutation. In clinical progress, acute severe hepatic failure with encephalopathy occured and the patient was transferred to an another medical center for liver transplantation.

Gulhane Medical Journal, 2014

We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance ... more We present here a case of a 22-year-old male patient with Budd-Chiari syndrome owing to alliance of multiple hypercoagulable conditions. The patient was admitted to our hospital for assesment of hepatosplenomegaly and ascites. By doppler ultrasonography, computed tomography and vena cavagraphy, Budd-Chiari syndrome was diagnosed. Results of diagnostic tests exhibited decreased activity, decreased antigenic concentration of Antithrombin, low protein C activity, heterozygote Factor V Leiden mutation. In clinical progress, acute severe hepatic failure with encephalopathy occured and the patient was transferred to an another medical center for liver transplantation.

PubMed, 2013

To our knowledge, there has also been no report in the literature about mild hypoxemia caused by ... more To our knowledge, there has also been no report in the literature about mild hypoxemia caused by food impaction in the esophagus, as seen in this case. Because of the patient’s psychiatric disorder, the discomfort caused by the impacted food may have resulted in the hypoxemia, but the physical examination at presentation revealed no inhalation problems and the thoracic CT showed no external compression of the airway tract.

The American Journal of Gastroenterology, Oct 1, 2011

Background/Aims: We aimed to investigate the alterations in serum lipid levels due to biliary obs... more Background/Aims: We aimed to investigate the alterations in serum lipid levels due to biliary obstruction associated with benign and malignant cases. Also, we aimed to examine the possibility of the theory that extremely high serum lipid levels can predict the malignant biliary obstruction in the differantial diagnosis. Methodology: Three hundred twenty two patients who were performed endoscopic retrograde cholangiopancreatography with the intrahepatic and extrahepatic cholestasis were reviewed in the period from September 2007 to October 2010. Results:In the malignant obstruction group, meaningfully higher total cholesterol (p 0.05) and triglycerides (p<0.05) were observed but high-density lipoprotein (p<0.05) levels were lower. The receiver operating characteristic analysis showed that total cholesterol (246.74mg/dL or less), sensitivity (84.3%), specificity (83.3%) area under the curve (0.705, range 0.6200.790; p<0.001) and high-density lipoprotein cholesterol area under the curve (0.577, range 0.444-0.710) were predictors of malignant biliary obstruction. Conclusions: Serum lipid profile may be used as an applicant marker to identify malignant reasons of the obstructive jaundice.

Annals of Colorectal Research, Jul 6, 2019

Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting wi... more Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting with diarrhea, bloody defecation and abdominal pain. Although cardiac and/or pulmonary involvement has been reported in patients with ulcerative colitis, it rarely involves both the pleura and pericardium at the same time. Also, it is difficult to determine whether pulmonary or cardiac disease is secondary to the ulcerative colitis drugs or to the underlying disease process. Here we present a rare case of pleuropericardial effusion in a patient newly diagnosed with ulcerative colitis. In ulcerative colitis, the simultaneous involvement of the respiratory and cardiovascular systems is uncommon yet potentially dangerous.

Haydarpaşa Numune medical journal, 2023

Revista Espanola De Enfermedades Digestivas, 2022

Scandinavian Journal of Gastroenterology, Jun 10, 2014

Acute pancreatitis (AP) is defined as an inflammatory disease of the pancreas. The purpose of thi... more Acute pancreatitis (AP) is defined as an inflammatory disease of the pancreas. The purpose of this study was to examine the effectiveness of Anakinra on cerulein-induced experimental pancreatitis rat model by using the results of biochemical and histopathological findings. Cerulein was administered to induce AP in rats. Group 1 was the sham group. Subcutancerulein was injected to the rats in group 2 for experimental pancreatitis group. In groups 3 and 4, 100 and 50 mg/kg intraperitoneal Anakinra were injected after the induction of experimental pancreatitis by subcutaneous cerulein in rats, respectively. Lastly, in group 5, rats were injected with intraperitoneal saline and subcutan cerulean for placebo group. The following parameters were evaluated: histopathological score of pancreatitis, apoptotic index, amylase, lipase, TNF-α levels, IL-1β and the leukocyte count. When the results of serum amylase, lipase, TNF-α and IL-1β levels, the leukocyte count, histopathologic scores and apoptotic indices of control group compared to the results of other groups, the differences exhibited statistical significance (all p < 0.05). On the other hand, when the results of fourth group compared with the results of third group, the data demonstrated statistical insignificance (p > 0.05). However, no any significant differences were found between the results of fourth and fifth groups (p > 0.05). In the light of these results, cerulein is an appropriate agent for experimental AP rat model and Anakinra has a favorable therapeutic effect on acute experimental pancreatitis model. Moreover, Anakinra significantly decreases cerulein-related pancreatic tissue injury and pancreatic apoptosis.

The Turkish journal of gastroenterology, Nov 11, 2015

Background/Aims: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteina... more Background/Aims: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are well-known inflammatory biomarkers, with a diagnostic potential for various diseases. The aim of the present study was to determine the potential diagnostic applications of serum MMP-9 and TIMP-1 concentrations in patients with familial Mediterranean fever (FMF). Materials and Methods: A total of 66 male FMF patients and 40 age-matched healthy subjects were included in this research. TIMP-1 and MMP-9 levels with conventional inflammation markers were determined. Pearson correlation analysis was used to determine the correlation between the characteristics of patients and the laboratory data. Results: In patients with FMF, serum MMP-9 levels and MMP-9/TIMP-1 ratios were found to be significantly elevated in both acute episode and asymptomatic periods (p=0.0001 and p=0.0001, respectively). There was no significant difference between TIMP-1 levels. A significant negative correlation between patients' current age and TIMP-1 level in patients with acute episodes was detected (p=0.0008, r=−0.52). Moreover, a moderate negative correlation was noticed between erythrocyte sedimentation rate and TIMP-1 level in patients with acute episodes (p=0.01, r=−0.39). Additionally, a moderate negative correlation was found between the duration of colchicine use and MMP-9 and TIMP-1 levels during the attack period (p=0.04, r=−0.36 and p=0.02, r=−0.39, respectively). Conclusion: Our findings demonstrate that a significant MMP-9/TIMP-1 imbalance exists in patients with FMF, which reflects an ongoing inflammation in both FMF periods. Thus, the increased MMP-9 levels observed in FMF patients could rationalize therapeutic targeting to MMPs.

The Turkish journal of gastroenterology, May 20, 2016

We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp... more We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp-2) expressions in patients with ulcerative colitis (UC) and healthy controls using the immunohistochemical (IHC) method. We also aimed to evaluate the correlations between the activity of UC and the expressions of these two proteins. Ninety-five patients with UC (82 males and 13 females) and 38 healthy controls (35 males and 3 females) were included. Clinical and endoscopic activities of UC were assessed. Conventional laboratory activation parameters and severity of inflammation measures were used for the evaluation of histological activity. IHC staining of biopsy samples for the two proteins were semi-quantitatively applied, similar to previously described methods for colon adenocarcinomas. IHC scores of Phb-2 were lower but Slp-2 scores were higher in the UC group than in the healthy controls (p<0.05 and p=0.003, respectively). Phb-2 scores were positively correlated with clinical and histological activities (r=0.364, p<0.05 and r=0.220, p<0.032, respectively). In the UC group, endoscopic activity scores, C-reactive protein levels, and sedimentation rates were also positively correlated with Phb-2 scores (r=0.279, p<0.05, r=0.216, p<0.05, and r=0.216, p<0.05, respectively). IHC scores of Slp-2 were not significantly correlated with the activity parameters of UC. However, there was a significant positive correlation between the expressions of Phb-2 and Slp-2 proteins (p<0.001). Phb-2 may serve as a valuable new biomarker for predicting the severity of all UC activity parameters. The therapeutic effectiveness of both Phb-2 and Slp-2 should be taken into consideration.

İç Anadolu tıp dergisi, May 21, 2015

Giriş Sentetik kannabinoidler (SK), insanlarda bazı marijuana benzeri etkiler oluşturan kimyasall... more Giriş Sentetik kannabinoidler (SK), insanlarda bazı marijuana benzeri etkiler oluşturan kimyasallardır (1). Sentetik kannabinoid içeren maddeler genel

Digestive Diseases and Sciences, Aug 8, 2013

Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal re... more Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF are limited. We have investigated the relationship between serum levels of fetuin-A and inflammatory markers in patients with FMF before, during, and after FMF attacks. Sixty-seven patients with FMF were enrolled in this study. Serum fetuin-A, seruloplasmin, fibrinogen, C reactive protein (CRP), white blood cell count (WBC), calcium, and erythrocyte sedimentation rate (ESR) were measured three times: during the attack-free period, 12 h after FMF attacks, and 7 days after FMF attacks. Plasma fetuin-A concentration was measured by use of an enzyme-linked immunoassay (ELISA) kit. Correlations and differentiation between the serum fetuin-A and other inflammatory markers in patients with FMF were investigated by use of the paired-samples T test and the Pearson correlation test (p < 0.01). Serum fetuin-A levels of all FMF patients in the attack period were significantly lower than in the attack-free period (p < 0.001). In contrast, serum seruloplasmin (p < 0.05), fibrinogen (p < 0.001), CRP (p < 0.05), WBC (p < 0.05), and ESR (p < 0.05) were all significantly higher than in the attack-free period. Plasma fetuin-A is significantly and inversely highly correlated with the other inflammatory markers. Fetuin-A might be a novel indicator of disease activity in patients with FMF and could be used as an adjunctive marker for differentiation of FMF attacks. The negative correlation between serum fetuin-A and other inflammatory markers may also be indicative of inflammation-dependent downregulation of fetuin-A expression in FMF patients.

American Journal of Gastroenterology, 2011

Acta Neurologica Scandinavica, 2009

Ił_ zecka J. Serum-soluble receptor for advanced glycation end product levels in patients with am... more Ił_ zecka J. Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis.