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Papers by K. Amoako-gyampah

Research paper thumbnail of A robust R&D project portfolio optimization model for pharmaceutical contract research organizations

International Journal of Production Economics, 2014

Pharmaceutical drug Research and Development (R&D) outsourcing to contract research organizations... more Pharmaceutical drug Research and Development (R&D) outsourcing to contract research organizations (CROs) has experienced a significant growth in recent decades and the trend is expected to continue. A key question for CROs and firms in similar environments is which projects should be included in the firm's portfolio of projects. As a distinctive contribution to the literature this paper develops and evaluates a business support tool to help a CRO decide on clinical R&D project opportunities and revise its portfolio of R&D projects given the existing constraints, and financial and resource capabilities. A new mathematical programming model in the form of a capital budgeting problem is developed to help revising and rescheduling of the project portfolio. The uncertainty of pharmaceutical R&D cost estimates in drug development stages is captured to mimic a more realistic representation of pharmaceutical R&D projects, and a robust optimization approach is used to tackle the uncertain formulation. An illustrative example is presented to demonstrate the proposed approach.

Research paper thumbnail of Resilience in family and nonfamily firms: an examination of the relationships between manufacturing strategy, competitive strategy and firm performance

Economic recessions that affect firms regardless of location, increased competition and changes i... more Economic recessions that affect firms regardless of location, increased competition and changes in customer expectations, all contribute to disruptions that require firms to be resilient. Building resilience is a long-term strategic initiative that changes the way a firm operates by aligning linkages between functional strategies and competitive strategy. This article compares the relationship between manufacturing strategy and competitive strategy, and

Research paper thumbnail of Failure rate distributions for flexible manufacturing systems: An empirical study

To aid researchers in the simulation and testing of maintenance policies for complex, computer co... more To aid researchers in the simulation and testing of maintenance policies for complex, computer controlled technological equipment this paper presents a description of failure and repair rate characteristics as well as distribution data for a typical flexible manufacturing system (FMS) that is in use in a mid-western (USA) manufacturing plant. Separate data are included for mechanical, hydraulic, electrical, electronic, software

Research paper thumbnail of Operations strategy in an emerging economy: the case of the Ghanaian manufacturing industry

Operations strategy and its development have received a lot of attention in the operations manage... more Operations strategy and its development have received a lot of attention in the operations management literature. However, as noted by Ward et al. (1995), an understanding of the factors that influence operations strategy development has not been widely studied. Further, how managers of firms in underdeveloped countries develop operations strategy has yet to receive any significant attention among researchers. This paper takes a look at the development of operations strategy in an underdeveloped economy, Ghana. Specifically, the paper examines the relationships between the business environment and the operations strategy choices made by firms in Ghana. The paper seeks to understand the influence that specific business environmental factors have on the operations strategy choices of low cost, quality, flexibility, and delivery dependability.A survey of manufacturing firms was carried out in 1998. The respondents (production managers in those firms) were asked to indicate the extent to which business costs, labor availability, competitive hostility, and environmental dynamism were of concern to them. They were also asked to indicate their extent of emphasis on the operations strategy choices of quality, cost, flexibility and delivery dependability. This paper presents the result of the analysis of the relationships between the environmental factors and the operations strategy choices. The data indicate that, among firms in Ghana, the two strongest factors that influence the degree of emphasis placed on operations strategy choices are perceived business costs and competitive hostility. Results are presented for both large and small firms, and for firms that are completely locally owned as well as for joint venture firms.

Research paper thumbnail of Application of a Hybrid Induction-Based Approach for Exploring Cumulative Abnormal Returns

Research paper thumbnail of The adoption of flexible manufacturing systems: strategic considerations

Technovation, 1989

This paper discusses the motivating factors contributing to firms' decisions to adopt flexible ma... more This paper discusses the motivating factors contributing to firms' decisions to adopt flexible manufacturing systems (FMS). Many studies have investigated the adoption of new technology by examining the characteristics which differentiate adopting firms from non-adopting firms. This study takes a different approach by analyzing specijic decisions made by firms. Interviews were conducted with managers associated with firms' FMS adoption decisions. In this paper it is suggested that strategic objectives play an important role in firms ' decisions to adopt and implernen t FMS.

Research paper thumbnail of The operations management research agenda: An update

Journal of Operations Management, 1989

An agenda for operations management (OM) research was first proposed by Miller et al. in 1981. Ho... more An agenda for operations management (OM) research was first proposed by Miller et al. in 1981. However, until Hill et al. examined recent Ph.D. dissertations in 1987, no other work on the agenda had been done. We take another look at the status of the OM research ...

Research paper thumbnail of Research Article Three An Exploratory Study of the Contextual Factors That Influence Success of ICT Projects in Developing Nations: A Case Study of a Telecommunications Company in Ghana

Journal of Pediatric, Maternal & Family Health-Chiropractic, 2010

Research paper thumbnail of How Internet Security Breaches Harm Market Value

Research paper thumbnail of A robust R&D project portfolio optimization model for pharmaceutical contract research organizations

International Journal of Production Economics, 2014

Pharmaceutical drug Research and Development (R&D) outsourcing to contract research organizations... more Pharmaceutical drug Research and Development (R&D) outsourcing to contract research organizations (CROs) has experienced a significant growth in recent decades and the trend is expected to continue. A key question for CROs and firms in similar environments is which projects should be included in the firm's portfolio of projects. As a distinctive contribution to the literature this paper develops and evaluates a business support tool to help a CRO decide on clinical R&D project opportunities and revise its portfolio of R&D projects given the existing constraints, and financial and resource capabilities. A new mathematical programming model in the form of a capital budgeting problem is developed to help revising and rescheduling of the project portfolio. The uncertainty of pharmaceutical R&D cost estimates in drug development stages is captured to mimic a more realistic representation of pharmaceutical R&D projects, and a robust optimization approach is used to tackle the uncertain formulation. An illustrative example is presented to demonstrate the proposed approach.

Research paper thumbnail of Resilience in family and nonfamily firms: an examination of the relationships between manufacturing strategy, competitive strategy and firm performance

Economic recessions that affect firms regardless of location, increased competition and changes i... more Economic recessions that affect firms regardless of location, increased competition and changes in customer expectations, all contribute to disruptions that require firms to be resilient. Building resilience is a long-term strategic initiative that changes the way a firm operates by aligning linkages between functional strategies and competitive strategy. This article compares the relationship between manufacturing strategy and competitive strategy, and

Research paper thumbnail of Failure rate distributions for flexible manufacturing systems: An empirical study

To aid researchers in the simulation and testing of maintenance policies for complex, computer co... more To aid researchers in the simulation and testing of maintenance policies for complex, computer controlled technological equipment this paper presents a description of failure and repair rate characteristics as well as distribution data for a typical flexible manufacturing system (FMS) that is in use in a mid-western (USA) manufacturing plant. Separate data are included for mechanical, hydraulic, electrical, electronic, software

Research paper thumbnail of Operations strategy in an emerging economy: the case of the Ghanaian manufacturing industry

Operations strategy and its development have received a lot of attention in the operations manage... more Operations strategy and its development have received a lot of attention in the operations management literature. However, as noted by Ward et al. (1995), an understanding of the factors that influence operations strategy development has not been widely studied. Further, how managers of firms in underdeveloped countries develop operations strategy has yet to receive any significant attention among researchers. This paper takes a look at the development of operations strategy in an underdeveloped economy, Ghana. Specifically, the paper examines the relationships between the business environment and the operations strategy choices made by firms in Ghana. The paper seeks to understand the influence that specific business environmental factors have on the operations strategy choices of low cost, quality, flexibility, and delivery dependability.A survey of manufacturing firms was carried out in 1998. The respondents (production managers in those firms) were asked to indicate the extent to which business costs, labor availability, competitive hostility, and environmental dynamism were of concern to them. They were also asked to indicate their extent of emphasis on the operations strategy choices of quality, cost, flexibility and delivery dependability. This paper presents the result of the analysis of the relationships between the environmental factors and the operations strategy choices. The data indicate that, among firms in Ghana, the two strongest factors that influence the degree of emphasis placed on operations strategy choices are perceived business costs and competitive hostility. Results are presented for both large and small firms, and for firms that are completely locally owned as well as for joint venture firms.

Research paper thumbnail of Application of a Hybrid Induction-Based Approach for Exploring Cumulative Abnormal Returns

Research paper thumbnail of The adoption of flexible manufacturing systems: strategic considerations

Technovation, 1989

This paper discusses the motivating factors contributing to firms' decisions to adopt flexible ma... more This paper discusses the motivating factors contributing to firms' decisions to adopt flexible manufacturing systems (FMS). Many studies have investigated the adoption of new technology by examining the characteristics which differentiate adopting firms from non-adopting firms. This study takes a different approach by analyzing specijic decisions made by firms. Interviews were conducted with managers associated with firms' FMS adoption decisions. In this paper it is suggested that strategic objectives play an important role in firms ' decisions to adopt and implernen t FMS.

Research paper thumbnail of The operations management research agenda: An update

Journal of Operations Management, 1989

An agenda for operations management (OM) research was first proposed by Miller et al. in 1981. Ho... more An agenda for operations management (OM) research was first proposed by Miller et al. in 1981. However, until Hill et al. examined recent Ph.D. dissertations in 1987, no other work on the agenda had been done. We take another look at the status of the OM research ...

Research paper thumbnail of Research Article Three An Exploratory Study of the Contextual Factors That Influence Success of ICT Projects in Developing Nations: A Case Study of a Telecommunications Company in Ghana

Journal of Pediatric, Maternal & Family Health-Chiropractic, 2010

Research paper thumbnail of How Internet Security Breaches Harm Market Value