Kunnathur Murugesan Sakthivel - Academia.edu (original) (raw)

Papers by Kunnathur Murugesan Sakthivel

A Scientific Review, 2013

Journal of Advanced Pharmaceutical Technology & Research, 2012

Cancer disease is a leading cause of death worldwide. The main reason for such high mortality fro... more Cancer disease is a leading cause of death worldwide. The main reason for such high mortality from cancer is due to the highly invasive behavior of cancer cells, which usually results in metastasis. Metastasis is a process by which cancer cells spread to other parts of the body through blood circulation and lymphatic system. Metastasis is an extremely complex process that remains to be a major problem in the management of cancer. Countering metastatic cancer and development of novel with effective therapies were always in the priority list of cancer researchers. Therapeutic goals are the prevention of an initial metastasis in high-risk patients, shrinkage of established lesions and prevention of additional metastases in patients with limited disease. Though many pathways have been hypothesized, regulation of metastasis by oncogenes is considered as an important one. Role of oncogenes in inducing metastasis is becoming stronger day by day. Oncogenes induced replication stress and associated DNA damage results in genomic instability that alter the gene regulation which regulates metastatic potential of cancer cells. Since most of the oncogenes also functions as transcription factors, they are able to modify the genomic regulation in favor of metastasis. In this review we have focused on recent findings about important oncogenes and how they regulate metastasis.

A Scientific Review, 2013

Journal of Advanced Pharmaceutical Technology & Research, 2012

Cancer disease is a leading cause of death worldwide. The main reason for such high mortality fro... more Cancer disease is a leading cause of death worldwide. The main reason for such high mortality from cancer is due to the highly invasive behavior of cancer cells, which usually results in metastasis. Metastasis is a process by which cancer cells spread to other parts of the body through blood circulation and lymphatic system. Metastasis is an extremely complex process that remains to be a major problem in the management of cancer. Countering metastatic cancer and development of novel with effective therapies were always in the priority list of cancer researchers. Therapeutic goals are the prevention of an initial metastasis in high-risk patients, shrinkage of established lesions and prevention of additional metastases in patients with limited disease. Though many pathways have been hypothesized, regulation of metastasis by oncogenes is considered as an important one. Role of oncogenes in inducing metastasis is becoming stronger day by day. Oncogenes induced replication stress and associated DNA damage results in genomic instability that alter the gene regulation which regulates metastatic potential of cancer cells. Since most of the oncogenes also functions as transcription factors, they are able to modify the genomic regulation in favor of metastasis. In this review we have focused on recent findings about important oncogenes and how they regulate metastasis.