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Papers by ORHAN KOCAMAN

Research paper thumbnail of Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA

Southern Medical Journal, 2006

Letters to the Editor are welcomed. They may report new clinical or laboratory observations and n... more Letters to the Editor are welcomed. They may report new clinical or laboratory observations and new developments in medical care or may contain comments on recent contents of the Journal. They will be published, if found suitable, as space permits. Like other material ...

Research paper thumbnail of Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD

Research paper thumbnail of Endothelial Dysfunction in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases, 2006

Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show ... more Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show microvascular endothelial dysfunction. Whether generalized endothelial dysfunction could associate with UC has not been explored yet. Our aim was to assess the endothelial function in the patients with different UC activity and to hypothesize about the relationship of endothelial function to activity-related extraintestinal complications (AREC) of UC.Methods: Twelve patients with mild UC, 14 patients with moderate UC, 16 patients with severe UC, and 24 healthy subjects were included in the study. The activity of UC is calculated according to the Seo Index. Endothelial functions of the brachial artery were evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate.Results: EDD was significantly worse in patients with severe UC as compared with patients with mild UC (8.7 ± 1.6% versus 17.3 ± 5.6%, P < 0.05) and even in patients with moderate UC as compared with patients with mild UC (13.1 ± 3.2% versus 17.3 ± 5.6%, P < 0.05). EDD was not significantly worse in patients with mild UC as compared with healthy subjects (17.3 ± 5.6% versus 18.1 ± 8.1%, P > 0.05). EID was significantly worse in patients with severe UC compared with patients with moderate UC (10.5 ± 2.9% versus 13.4 ± 3.7%, P < 0.05) and even in patients with mild UC compared with healthy subjects (20 ± 6.7% versus 31.1 ± 12.6%, P < 0.05). EDD and EID were significantly worse in patients with AREC compared with patients with no AREC (9.5 ± 2.5% versus 14.9 ± 5.1%, P < 0.05; 11.6 ± 4.3% versus 16 ± 6.1%, P < 0.05, respectively).Conclusions: Increased activity of UC is associated with significant endothelial dysfunction, which may relate to the pathophysiology of AREC of UC.

Research paper thumbnail of Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease

Internal Medicine Journal, 2008

Background: The components of the metabolic syndrome are closely related with endothelial dysfun... more Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.

Research paper thumbnail of Severe migraine attacks during treatment of chronic hepatitis C

European Journal of Internal Medicine, 2009

Research paper thumbnail of Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis

European Journal of Internal Medicine, 2008

Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolon... more Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolones for

Research paper thumbnail of Evaluation of Metabolic Syndrome Frequency and Carotid Artery Intima-media Thickness as Risk Factors for Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

Digestive Diseases and Sciences, 2008

Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery ... more Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Methods A case-control study was conducted on 40 biopsy-proven NAFLD patients and 40 age-matched healthy control subjects. Common carotid artery IMT and MetS criteria [according to the Third Report of the National Cholesterol Education Expert Panel on Detection, evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII), the International Diabetes Federation (IDF), the American Heart Association in conjunction with the National Heart, Lung, and Blood Institute (AHA/NHLBI)] were evaluated for all study subjects. Results MetS according to NCEP-ATPIII, IDF and AHA/NHLBI criteria was present in 55, 67.5 and 62.5% of NAFLD patients, respectively. The mean IMT was significantly higher in NAFLD patients (0.646 ± 0.091 mm) than control subjects (0.544 ± 0.067 mm), (P < 0.001). Among the vascular risk factors evaluated, the diagnosis of NAFLD and increased body mass index were significant independent predictors of increased IMT. Conclusions As cardiovascular risk factors, both MetS and increased IMT occur frequently among NAFLD patients. Screening for both conditions might be beneficial for assessment of future atherosclerotic complications.

Research paper thumbnail of Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA

Southern Medical Journal, 2006

Letters to the Editor are welcomed. They may report new clinical or laboratory observations and n... more Letters to the Editor are welcomed. They may report new clinical or laboratory observations and new developments in medical care or may contain comments on recent contents of the Journal. They will be published, if found suitable, as space permits. Like other material ...

Research paper thumbnail of Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD

Research paper thumbnail of Endothelial Dysfunction in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases, 2006

Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show ... more Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show microvascular endothelial dysfunction. Whether generalized endothelial dysfunction could associate with UC has not been explored yet. Our aim was to assess the endothelial function in the patients with different UC activity and to hypothesize about the relationship of endothelial function to activity-related extraintestinal complications (AREC) of UC.Methods: Twelve patients with mild UC, 14 patients with moderate UC, 16 patients with severe UC, and 24 healthy subjects were included in the study. The activity of UC is calculated according to the Seo Index. Endothelial functions of the brachial artery were evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate.Results: EDD was significantly worse in patients with severe UC as compared with patients with mild UC (8.7 ± 1.6% versus 17.3 ± 5.6%, P < 0.05) and even in patients with moderate UC as compared with patients with mild UC (13.1 ± 3.2% versus 17.3 ± 5.6%, P < 0.05). EDD was not significantly worse in patients with mild UC as compared with healthy subjects (17.3 ± 5.6% versus 18.1 ± 8.1%, P > 0.05). EID was significantly worse in patients with severe UC compared with patients with moderate UC (10.5 ± 2.9% versus 13.4 ± 3.7%, P < 0.05) and even in patients with mild UC compared with healthy subjects (20 ± 6.7% versus 31.1 ± 12.6%, P < 0.05). EDD and EID were significantly worse in patients with AREC compared with patients with no AREC (9.5 ± 2.5% versus 14.9 ± 5.1%, P < 0.05; 11.6 ± 4.3% versus 16 ± 6.1%, P < 0.05, respectively).Conclusions: Increased activity of UC is associated with significant endothelial dysfunction, which may relate to the pathophysiology of AREC of UC.

Research paper thumbnail of Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease

Internal Medicine Journal, 2008

Background: The components of the metabolic syndrome are closely related with endothelial dysfun... more Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.

Research paper thumbnail of Severe migraine attacks during treatment of chronic hepatitis C

European Journal of Internal Medicine, 2009

Research paper thumbnail of Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis

European Journal of Internal Medicine, 2008

Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolon... more Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolones for

Research paper thumbnail of Evaluation of Metabolic Syndrome Frequency and Carotid Artery Intima-media Thickness as Risk Factors for Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

Digestive Diseases and Sciences, 2008

Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery ... more Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Methods A case-control study was conducted on 40 biopsy-proven NAFLD patients and 40 age-matched healthy control subjects. Common carotid artery IMT and MetS criteria [according to the Third Report of the National Cholesterol Education Expert Panel on Detection, evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII), the International Diabetes Federation (IDF), the American Heart Association in conjunction with the National Heart, Lung, and Blood Institute (AHA/NHLBI)] were evaluated for all study subjects. Results MetS according to NCEP-ATPIII, IDF and AHA/NHLBI criteria was present in 55, 67.5 and 62.5% of NAFLD patients, respectively. The mean IMT was significantly higher in NAFLD patients (0.646 ± 0.091 mm) than control subjects (0.544 ± 0.067 mm), (P < 0.001). Among the vascular risk factors evaluated, the diagnosis of NAFLD and increased body mass index were significant independent predictors of increased IMT. Conclusions As cardiovascular risk factors, both MetS and increased IMT occur frequently among NAFLD patients. Screening for both conditions might be beneficial for assessment of future atherosclerotic complications.

Research paper thumbnail of Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA

Southern Medical Journal, 2006

Letters to the Editor are welcomed. They may report new clinical or laboratory observations and n... more Letters to the Editor are welcomed. They may report new clinical or laboratory observations and new developments in medical care or may contain comments on recent contents of the Journal. They will be published, if found suitable, as space permits. Like other material ...

Research paper thumbnail of Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD

Research paper thumbnail of Endothelial Dysfunction in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases, 2006

Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show ... more Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show microvascular endothelial dysfunction. Whether generalized endothelial dysfunction could associate with UC has not been explored yet. Our aim was to assess the endothelial function in the patients with different UC activity and to hypothesize about the relationship of endothelial function to activity-related extraintestinal complications (AREC) of UC.Methods: Twelve patients with mild UC, 14 patients with moderate UC, 16 patients with severe UC, and 24 healthy subjects were included in the study. The activity of UC is calculated according to the Seo Index. Endothelial functions of the brachial artery were evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate.Results: EDD was significantly worse in patients with severe UC as compared with patients with mild UC (8.7 ± 1.6% versus 17.3 ± 5.6%, P < 0.05) and even in patients with moderate UC as compared with patients with mild UC (13.1 ± 3.2% versus 17.3 ± 5.6%, P < 0.05). EDD was not significantly worse in patients with mild UC as compared with healthy subjects (17.3 ± 5.6% versus 18.1 ± 8.1%, P > 0.05). EID was significantly worse in patients with severe UC compared with patients with moderate UC (10.5 ± 2.9% versus 13.4 ± 3.7%, P < 0.05) and even in patients with mild UC compared with healthy subjects (20 ± 6.7% versus 31.1 ± 12.6%, P < 0.05). EDD and EID were significantly worse in patients with AREC compared with patients with no AREC (9.5 ± 2.5% versus 14.9 ± 5.1%, P < 0.05; 11.6 ± 4.3% versus 16 ± 6.1%, P < 0.05, respectively).Conclusions: Increased activity of UC is associated with significant endothelial dysfunction, which may relate to the pathophysiology of AREC of UC.

Research paper thumbnail of Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease

Internal Medicine Journal, 2008

Background: The components of the metabolic syndrome are closely related with endothelial dysfun... more Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.

Research paper thumbnail of Severe migraine attacks during treatment of chronic hepatitis C

European Journal of Internal Medicine, 2009

Research paper thumbnail of Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis

European Journal of Internal Medicine, 2008

Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolon... more Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolones for

Research paper thumbnail of Evaluation of Metabolic Syndrome Frequency and Carotid Artery Intima-media Thickness as Risk Factors for Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

Digestive Diseases and Sciences, 2008

Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery ... more Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Methods A case-control study was conducted on 40 biopsy-proven NAFLD patients and 40 age-matched healthy control subjects. Common carotid artery IMT and MetS criteria [according to the Third Report of the National Cholesterol Education Expert Panel on Detection, evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII), the International Diabetes Federation (IDF), the American Heart Association in conjunction with the National Heart, Lung, and Blood Institute (AHA/NHLBI)] were evaluated for all study subjects. Results MetS according to NCEP-ATPIII, IDF and AHA/NHLBI criteria was present in 55, 67.5 and 62.5% of NAFLD patients, respectively. The mean IMT was significantly higher in NAFLD patients (0.646 ± 0.091 mm) than control subjects (0.544 ± 0.067 mm), (P < 0.001). Among the vascular risk factors evaluated, the diagnosis of NAFLD and increased body mass index were significant independent predictors of increased IMT. Conclusions As cardiovascular risk factors, both MetS and increased IMT occur frequently among NAFLD patients. Screening for both conditions might be beneficial for assessment of future atherosclerotic complications.

Research paper thumbnail of Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA

Southern Medical Journal, 2006

Letters to the Editor are welcomed. They may report new clinical or laboratory observations and n... more Letters to the Editor are welcomed. They may report new clinical or laboratory observations and new developments in medical care or may contain comments on recent contents of the Journal. They will be published, if found suitable, as space permits. Like other material ...

Research paper thumbnail of Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD

Research paper thumbnail of Endothelial Dysfunction in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases, 2006

Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show ... more Background: Human intestinal microvessels from chronically inflamed ulcerative colitis (UC) show microvascular endothelial dysfunction. Whether generalized endothelial dysfunction could associate with UC has not been explored yet. Our aim was to assess the endothelial function in the patients with different UC activity and to hypothesize about the relationship of endothelial function to activity-related extraintestinal complications (AREC) of UC.Methods: Twelve patients with mild UC, 14 patients with moderate UC, 16 patients with severe UC, and 24 healthy subjects were included in the study. The activity of UC is calculated according to the Seo Index. Endothelial functions of the brachial artery were evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate.Results: EDD was significantly worse in patients with severe UC as compared with patients with mild UC (8.7 ± 1.6% versus 17.3 ± 5.6%, P < 0.05) and even in patients with moderate UC as compared with patients with mild UC (13.1 ± 3.2% versus 17.3 ± 5.6%, P < 0.05). EDD was not significantly worse in patients with mild UC as compared with healthy subjects (17.3 ± 5.6% versus 18.1 ± 8.1%, P > 0.05). EID was significantly worse in patients with severe UC compared with patients with moderate UC (10.5 ± 2.9% versus 13.4 ± 3.7%, P < 0.05) and even in patients with mild UC compared with healthy subjects (20 ± 6.7% versus 31.1 ± 12.6%, P < 0.05). EDD and EID were significantly worse in patients with AREC compared with patients with no AREC (9.5 ± 2.5% versus 14.9 ± 5.1%, P < 0.05; 11.6 ± 4.3% versus 16 ± 6.1%, P < 0.05, respectively).Conclusions: Increased activity of UC is associated with significant endothelial dysfunction, which may relate to the pathophysiology of AREC of UC.

Research paper thumbnail of Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease

Internal Medicine Journal, 2008

Background: The components of the metabolic syndrome are closely related with endothelial dysfun... more Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.

Research paper thumbnail of Severe migraine attacks during treatment of chronic hepatitis C

European Journal of Internal Medicine, 2009

Research paper thumbnail of Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis

European Journal of Internal Medicine, 2008

Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolon... more Paz et al. have fittingly recommended a thirdgeneration cephalosporin recipe rather than quinolones for

Research paper thumbnail of Evaluation of Metabolic Syndrome Frequency and Carotid Artery Intima-media Thickness as Risk Factors for Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

Digestive Diseases and Sciences, 2008

Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery ... more Aim The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Methods A case-control study was conducted on 40 biopsy-proven NAFLD patients and 40 age-matched healthy control subjects. Common carotid artery IMT and MetS criteria [according to the Third Report of the National Cholesterol Education Expert Panel on Detection, evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII), the International Diabetes Federation (IDF), the American Heart Association in conjunction with the National Heart, Lung, and Blood Institute (AHA/NHLBI)] were evaluated for all study subjects. Results MetS according to NCEP-ATPIII, IDF and AHA/NHLBI criteria was present in 55, 67.5 and 62.5% of NAFLD patients, respectively. The mean IMT was significantly higher in NAFLD patients (0.646 ± 0.091 mm) than control subjects (0.544 ± 0.067 mm), (P < 0.001). Among the vascular risk factors evaluated, the diagnosis of NAFLD and increased body mass index were significant independent predictors of increased IMT. Conclusions As cardiovascular risk factors, both MetS and increased IMT occur frequently among NAFLD patients. Screening for both conditions might be beneficial for assessment of future atherosclerotic complications.