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Papers by Kranti Tekulapally

Vorapaxar, a novel oral antiplatelet drug

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022

Introduction: COVID-19 pandemic has impacted the mental health of medical students due to multipl... more Introduction: COVID-19 pandemic has impacted the mental health of medical students due to multiple factors like the fear of getting infected, the stress of maintaining the preventive measures, the demands of the online classes, and the uncertainty of the future. Aim: To assess the anxiety levels of the medical students and strategies, they used to cope up with the anxiety during the pandemic. Materials and Methods: A cross-sectional study was carried out among all the first and final year MBBS students of a Women’s Medical College and Teaching Hospital in Hyderabad, Telangana, India. The questionnaire contained a total of 25 questions- three questions to collect the demographic data, a 7-item Generalised Anxiety Disorder Scale (GAD), and 15 questions assessing their coping strategies; was distributed to all the study participants as a Google form. Data from completed questionnaires were entered into an excel sheet and analysed using Jamovi software version 1.6.23.0. Results: A total...

Indian Journal of Pharmacy and Pharmacology

Medical and Dental students are exposed to online classes for the first time during the COVID pan... more Medical and Dental students are exposed to online classes for the first time during the COVID pandemic. The current study was planned to understand their perceptions about these online classes in contrast to classroom teaching and suggest strategies to improve them.A cross-sectional study was carried out among all the students of Malla Reddy Medical College for Women and Malla Reddy Dental College for Women during September 2020. The study questionnaire containing 20 questions was prepared, prevalidated and distributed to all the study participants as google form. Data from completed questionnaires was entered into an excel sheet and analyzed using descriptive statistics.Analysis of data from 279 students revealed that the 69% of the students used smartphones to attend online classes, 96% of them reported having internet problems and 42% of the students enjoyed the online classes. Understanding of the topic and knowledge gained during online classes were rated average and above aver...

International journal of pharma and bio sciences, 2014

Curcumin is the active coloring principle of Turmeric. In the present study, the anticonvulsive e... more Curcumin is the active coloring principle of Turmeric. In the present study, the anticonvulsive effect of Curcumin was studied in albino Wistar rats in two methods. First, Curcumin in a dose of 100mg/kg was tested in comparison to Phenytoin sodium by Maximal Electroshock Seizure (MES) method in which the Duration of Tonic hind limb extension was observed. Secondly, antiepileptic effect of Curcumin was compared to Diazepam in Pentylenetetrazol (PTZ) induced convulsions in which onset and severity of convulsions was observed. Results obtained were analyzed statistically by Kruskal Wallis test and Mann Whitney U test using SPSS 20.0.0 software. The results showed that Curcumin significantly reduced the duration of tonic hind limb extension with a p < 0.05 in MES model and In PTZ test, it increased the latency to the onset of seizures with p< 0.01. The anticonvulsive effect of Curcumin was thus comparable to the standard antiepileptic drugs.

Aims & Objectives: To evaluate the anticonvulsive activity of piroxicam and diclofenac sodium in ... more Aims & Objectives: To evaluate the anticonvulsive activity of piroxicam and diclofenac sodium in Wistar rats by Maximal Electroshock Seizure (MES) method and Pentylenetetrazole (PTZ) induced kindling method in comparison to standard antiepileptic drugs, phenytoin sodium and d iazepam respectively.Materials and methods: Diclofenac 45mg/kg and piroxicam 5mg/kg were tested in comparison to phenytoin sodium 20mg/kg by Maximal Electroshock Seizure (MES) method in which a current of 150mA was delivered for 0.2 sec using ear electrodes. Duration of tonic hind limb extension (THLE) and percentage protection accorded by the drugs was observed. PTZ induced kindling was the second method in which Pentylenetetrazol (PTZ) 30mg/kg was given intraperitoneally 3 times a week for 9 weeks . Test drugs were injected one hour before giving PTZ and their effect was compared to diazepam 3mg/kg. The latency to the onset, intensity of seizures, and number of seizures in one hour was calculated. Results wer...

National Journal of Physiology, Pharmacy and Pharmacology, 2020

Background: The use of animals in research and education evokes an emotional response in students... more Background: The use of animals in research and education evokes an emotional response in students that may impact their learning outcomes. Having knowledge about animal welfare regulations may assure them that animals are well-taken care off and that may influence their attitude. Aim and Objective: The present study was, therefore, initiated to assess the knowledge and attitude of medical students toward animal research and welfare. Materials and Methods: A cross-sectional study was carried out among 210 second and final MBBS students of Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of a pre-validated questionnaire used in previous studies consisting of 19 questions were administered to the students after obtaining informed consent. The primary outcomes – knowledge and attitude were measured in percentages and compared using SPSS version 20. Results: Only 17% of the students felt that animal research cannot be justified and should be stopped. The majority of...

International Journal of Health & Allied Sciences, 2017

CONTEXT: Reviewing the teaching programs by taking feedback from the students at regular interval... more CONTEXT: Reviewing the teaching programs by taking feedback from the students at regular intervals gives us input into the strength of the pharmacology curriculum so that necessary reforms can be undertaken to improve students' performance. AIMS: This study aims to obtain feedback from 2nd year Bachelor of Dental Surgery (BDS) students regarding their preferred teaching method and their perception about pharmacology. SETTING: A study done at Mallareddy Dental College for Women (MRMCW), Hyderabad. DESIGN: A cross-sectional survey. SUBJECTS AND METHODS: A prevalidated questionnaire containing 17 questions with 2–6 options each were administered to 73 2nd year BDS students studying at MRMCW, Hyderabad. The data so obtained were entered into Microsoft Excel and statistical analysis was done. STATISTICAL ANALYSIS USED: Descriptive statistics were used for analysis of the data. RESULTS: The majority (84%) of students preferred lecture as their preferred teaching method in Pharmacology...

Pregnancy is associated with physiological changes in the pharmacokinetics and pharmacodynamics o... more Pregnancy is associated with physiological changes in the pharmacokinetics and pharmacodynamics of the drugs. Also, use of drugs in pregnancy poses great risk to the mother and fetus. It therefore requires special care to prescribe drugs to pregnant women. The main objective of this study was to explore drug utilization in pregnant women attending a private sector tertiary healthcare institution. This was a cross-sectional case study in women attending outpatient clinic, Unit I, Department of Obstetrics and Gynecology, Malla Reddy Institute of Medical Sciences. The required information obtained from their prescriptions and 174 case notes was collected in a structured data collection sheets and the results were analysed using microsoft office. There were 80 (45.9%) primigravidae, 94 (54%) multigravidae and 69 (39.6%) women were in the second trimester of pregnancy. Most women (57.4%) were between 21−25 years of age. Average number of drugs prescribed per prescription was 2.4, encount...

Background: Online teaching and assessments have been introduced in dental education for the 1st ... more Background: Online teaching and assessments have been introduced in dental education for the 1st time during the corona pandemic. Formative assessments not only improve students understanding of the subject but also their self-assessment ability. There are less reported data on how students felt about the online formative assessments. Aim and Objective: The present study was planned to understand the dental students’ perceptions on the online formative assessments and their preferences in receiving feedback. Materials and Methods: A cross-sectional study was carried out among the 2nd year students of Malla Reddy Dental College for Women. Students who have attended 50% of the online formative assessments were included in the study. A pre-validated questionnaire containing 16 questions was distributed to all the study participants as Google Forms. Data from completed questionnaires were entered into an Excel sheet and analyzed using descriptive statistics. Results: Majority of the stu...

Background: Rational use of drugs significantly impacts the treatment outcomes and the cost of he... more Background: Rational use of drugs significantly impacts the treatment outcomes and the cost of health care. Most of the medical students are exposed to rational use of medicines and prescription writing during their second year but it is only during internship that they actually start prescribing under expert guidance. Aims and Objective: This study was planned to assess the rational prescribing practices of Interns in a tertiary care teaching hospital. Materials and Methods: With prior approval from Institutional Ethics Committee, a cross sectional study was conducted among 2014 batch of Interns from Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of prevalidated questionnaire consisting of 23 questions including a question on writing a prescription for a patient suffering from cold and fever was administered to the students after taking oral informed consent. Data from completed questionnaires was entered into excel sheet and analysed using descriptive stati...

PERSPECTIVES IN MEDICAL RESEARCH

INTRODUCTION An internship orientation program is conducted in most of the medical colleges befor... more INTRODUCTION An internship orientation program is conducted in most of the medical colleges before the beginning of internship program to facilitate the transition between medical student and intern. The present study was initiated to assess the preparedness of interns for the internship program and identifying the areas that require additional training and education. MATERIALS AND METHODS A cross sectional study was carried out among 2014 batch interns of Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of the study questionnaire prepared and validated by expert panel was administered to the interns before and after the two-day internship orientation program. The outcomes were measured on 5-point quantitative scale. The raw scores obtained by each student were converted to percentages.The scores less than or equal to 49% were considered low, the scores between 50% to 70% were considered as average and scores above 71% were considered high with respect to level...

National Journal of Physiology, Pharmacy and Pharmacology

National Journal of Physiology, Pharmacy and Pharmacology

Indian Journal of Pharmacy and Pharmacology

International Journal of Basic & Clinical Pharmacology, 2015

International Journal of Basic & Clinical Pharmacology, 2015

Vorapaxar, a novel oral antiplatelet drug

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022

Introduction: COVID-19 pandemic has impacted the mental health of medical students due to multipl... more Introduction: COVID-19 pandemic has impacted the mental health of medical students due to multiple factors like the fear of getting infected, the stress of maintaining the preventive measures, the demands of the online classes, and the uncertainty of the future. Aim: To assess the anxiety levels of the medical students and strategies, they used to cope up with the anxiety during the pandemic. Materials and Methods: A cross-sectional study was carried out among all the first and final year MBBS students of a Women’s Medical College and Teaching Hospital in Hyderabad, Telangana, India. The questionnaire contained a total of 25 questions- three questions to collect the demographic data, a 7-item Generalised Anxiety Disorder Scale (GAD), and 15 questions assessing their coping strategies; was distributed to all the study participants as a Google form. Data from completed questionnaires were entered into an excel sheet and analysed using Jamovi software version 1.6.23.0. Results: A total...

Indian Journal of Pharmacy and Pharmacology

Medical and Dental students are exposed to online classes for the first time during the COVID pan... more Medical and Dental students are exposed to online classes for the first time during the COVID pandemic. The current study was planned to understand their perceptions about these online classes in contrast to classroom teaching and suggest strategies to improve them.A cross-sectional study was carried out among all the students of Malla Reddy Medical College for Women and Malla Reddy Dental College for Women during September 2020. The study questionnaire containing 20 questions was prepared, prevalidated and distributed to all the study participants as google form. Data from completed questionnaires was entered into an excel sheet and analyzed using descriptive statistics.Analysis of data from 279 students revealed that the 69% of the students used smartphones to attend online classes, 96% of them reported having internet problems and 42% of the students enjoyed the online classes. Understanding of the topic and knowledge gained during online classes were rated average and above aver...

International journal of pharma and bio sciences, 2014

Curcumin is the active coloring principle of Turmeric. In the present study, the anticonvulsive e... more Curcumin is the active coloring principle of Turmeric. In the present study, the anticonvulsive effect of Curcumin was studied in albino Wistar rats in two methods. First, Curcumin in a dose of 100mg/kg was tested in comparison to Phenytoin sodium by Maximal Electroshock Seizure (MES) method in which the Duration of Tonic hind limb extension was observed. Secondly, antiepileptic effect of Curcumin was compared to Diazepam in Pentylenetetrazol (PTZ) induced convulsions in which onset and severity of convulsions was observed. Results obtained were analyzed statistically by Kruskal Wallis test and Mann Whitney U test using SPSS 20.0.0 software. The results showed that Curcumin significantly reduced the duration of tonic hind limb extension with a p < 0.05 in MES model and In PTZ test, it increased the latency to the onset of seizures with p< 0.01. The anticonvulsive effect of Curcumin was thus comparable to the standard antiepileptic drugs.

Aims & Objectives: To evaluate the anticonvulsive activity of piroxicam and diclofenac sodium in ... more Aims & Objectives: To evaluate the anticonvulsive activity of piroxicam and diclofenac sodium in Wistar rats by Maximal Electroshock Seizure (MES) method and Pentylenetetrazole (PTZ) induced kindling method in comparison to standard antiepileptic drugs, phenytoin sodium and d iazepam respectively.Materials and methods: Diclofenac 45mg/kg and piroxicam 5mg/kg were tested in comparison to phenytoin sodium 20mg/kg by Maximal Electroshock Seizure (MES) method in which a current of 150mA was delivered for 0.2 sec using ear electrodes. Duration of tonic hind limb extension (THLE) and percentage protection accorded by the drugs was observed. PTZ induced kindling was the second method in which Pentylenetetrazol (PTZ) 30mg/kg was given intraperitoneally 3 times a week for 9 weeks . Test drugs were injected one hour before giving PTZ and their effect was compared to diazepam 3mg/kg. The latency to the onset, intensity of seizures, and number of seizures in one hour was calculated. Results wer...

National Journal of Physiology, Pharmacy and Pharmacology, 2020

Background: The use of animals in research and education evokes an emotional response in students... more Background: The use of animals in research and education evokes an emotional response in students that may impact their learning outcomes. Having knowledge about animal welfare regulations may assure them that animals are well-taken care off and that may influence their attitude. Aim and Objective: The present study was, therefore, initiated to assess the knowledge and attitude of medical students toward animal research and welfare. Materials and Methods: A cross-sectional study was carried out among 210 second and final MBBS students of Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of a pre-validated questionnaire used in previous studies consisting of 19 questions were administered to the students after obtaining informed consent. The primary outcomes – knowledge and attitude were measured in percentages and compared using SPSS version 20. Results: Only 17% of the students felt that animal research cannot be justified and should be stopped. The majority of...

International Journal of Health & Allied Sciences, 2017

CONTEXT: Reviewing the teaching programs by taking feedback from the students at regular interval... more CONTEXT: Reviewing the teaching programs by taking feedback from the students at regular intervals gives us input into the strength of the pharmacology curriculum so that necessary reforms can be undertaken to improve students' performance. AIMS: This study aims to obtain feedback from 2nd year Bachelor of Dental Surgery (BDS) students regarding their preferred teaching method and their perception about pharmacology. SETTING: A study done at Mallareddy Dental College for Women (MRMCW), Hyderabad. DESIGN: A cross-sectional survey. SUBJECTS AND METHODS: A prevalidated questionnaire containing 17 questions with 2–6 options each were administered to 73 2nd year BDS students studying at MRMCW, Hyderabad. The data so obtained were entered into Microsoft Excel and statistical analysis was done. STATISTICAL ANALYSIS USED: Descriptive statistics were used for analysis of the data. RESULTS: The majority (84%) of students preferred lecture as their preferred teaching method in Pharmacology...

Pregnancy is associated with physiological changes in the pharmacokinetics and pharmacodynamics o... more Pregnancy is associated with physiological changes in the pharmacokinetics and pharmacodynamics of the drugs. Also, use of drugs in pregnancy poses great risk to the mother and fetus. It therefore requires special care to prescribe drugs to pregnant women. The main objective of this study was to explore drug utilization in pregnant women attending a private sector tertiary healthcare institution. This was a cross-sectional case study in women attending outpatient clinic, Unit I, Department of Obstetrics and Gynecology, Malla Reddy Institute of Medical Sciences. The required information obtained from their prescriptions and 174 case notes was collected in a structured data collection sheets and the results were analysed using microsoft office. There were 80 (45.9%) primigravidae, 94 (54%) multigravidae and 69 (39.6%) women were in the second trimester of pregnancy. Most women (57.4%) were between 21−25 years of age. Average number of drugs prescribed per prescription was 2.4, encount...

Background: Online teaching and assessments have been introduced in dental education for the 1st ... more Background: Online teaching and assessments have been introduced in dental education for the 1st time during the corona pandemic. Formative assessments not only improve students understanding of the subject but also their self-assessment ability. There are less reported data on how students felt about the online formative assessments. Aim and Objective: The present study was planned to understand the dental students’ perceptions on the online formative assessments and their preferences in receiving feedback. Materials and Methods: A cross-sectional study was carried out among the 2nd year students of Malla Reddy Dental College for Women. Students who have attended 50% of the online formative assessments were included in the study. A pre-validated questionnaire containing 16 questions was distributed to all the study participants as Google Forms. Data from completed questionnaires were entered into an Excel sheet and analyzed using descriptive statistics. Results: Majority of the stu...

Background: Rational use of drugs significantly impacts the treatment outcomes and the cost of he... more Background: Rational use of drugs significantly impacts the treatment outcomes and the cost of health care. Most of the medical students are exposed to rational use of medicines and prescription writing during their second year but it is only during internship that they actually start prescribing under expert guidance. Aims and Objective: This study was planned to assess the rational prescribing practices of Interns in a tertiary care teaching hospital. Materials and Methods: With prior approval from Institutional Ethics Committee, a cross sectional study was conducted among 2014 batch of Interns from Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of prevalidated questionnaire consisting of 23 questions including a question on writing a prescription for a patient suffering from cold and fever was administered to the students after taking oral informed consent. Data from completed questionnaires was entered into excel sheet and analysed using descriptive stati...

PERSPECTIVES IN MEDICAL RESEARCH

INTRODUCTION An internship orientation program is conducted in most of the medical colleges befor... more INTRODUCTION An internship orientation program is conducted in most of the medical colleges before the beginning of internship program to facilitate the transition between medical student and intern. The present study was initiated to assess the preparedness of interns for the internship program and identifying the areas that require additional training and education. MATERIALS AND METHODS A cross sectional study was carried out among 2014 batch interns of Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of the study questionnaire prepared and validated by expert panel was administered to the interns before and after the two-day internship orientation program. The outcomes were measured on 5-point quantitative scale. The raw scores obtained by each student were converted to percentages.The scores less than or equal to 49% were considered low, the scores between 50% to 70% were considered as average and scores above 71% were considered high with respect to level...

National Journal of Physiology, Pharmacy and Pharmacology

National Journal of Physiology, Pharmacy and Pharmacology

Indian Journal of Pharmacy and Pharmacology

International Journal of Basic & Clinical Pharmacology, 2015

International Journal of Basic & Clinical Pharmacology, 2015