K V T Gopal - Academia.edu (original) (raw)

Papers by K V T Gopal

Indian Dermatology Online Journal

Background: A few recent studies have shown fungal elements within the hair follicle epithelium, ... more Background: A few recent studies have shown fungal elements within the hair follicle epithelium, which may act as a reservoir and responsible for recurrent dermatophytosis. Objectives: To assess the clinical patterns, mycological profile, and histopathology of recurrent dermatophytosis and to determine the prevalence of fungal hyphae in the hair follicle epithelium and other appendages. Materials and Methods: One hundred and fifty clinically diagnosed cases of recurrent dermatophytic infection were included. Skin samples were taken for direct microscopy, fungal culture, and histopathological analysis. Haematoxylin and eosin and special staining with periodic acid Schiff (PAS) and Gomori's methenamine silver (GMS) were performed to detect the fungal hyphae in the skin and hair follicle epithelium. Results: The most common clinical pattern observed was tinea corporis et cruris in 64 patients (42.66%). On direct microscopy and fungal culture, positive results were obtained in 116 c...

International Journal of Research in Dermatology, Dec 26, 2022

Lichen planus is an inflammatory skin disorder which has been shown to be associated with thyroid... more Lichen planus is an inflammatory skin disorder which has been shown to be associated with thyroid disorders, hepatitis B, hepatitis C. IgA vasculitis is a form of cutaneous small vessel vasculitis (CSVV) characterized by palpable purpura, abdominal pain and joint pain usually seen in children. We report a case of 45-year-old female patient came with violaceous itchy lesions which were distributed over trunk and extremities of 1 month duration. Complete blood count (CBC) and serum biochemistry tests were normal. Histopathology of violaceous lesions showed changes of lichen planus. Purpuric lesions showed mild perivascular and transmural inflammatory infiltrate, composed mainly of neutrophils and few lymphocytes in the superficial dermis. Direct immunofluorescence was positive for IgA (granular pattern along with vessel walls of small vessels). Based on clinical, histopathological findings, a diagnosis of lichen planus with IgA vasculitis was made. The patient was treated with 30 mg prednisolone, gradually tapered over 6 weeks and anti-histamines. Satisfactory response was observed at follow-up at 6 weeks. Our case highlights the rare association of lichen planus with IgA vasculitis. Thorough evaluation of the patient helped in reaching correct diagnosis.

International Journal of Research in Dermatology, Dec 26, 2022

on dorsum of bilateral feet, legs, buttocks region and scalp. Current distribution of lesions was... more on dorsum of bilateral feet, legs, buttocks region and scalp. Current distribution of lesions was present since 3 months. No history of similar complaints in the past. Family history and drug history was not significant. Patient was well built and nourished, taking mixed diet, normal sleep, appetite,

International Journal of Research in Dermatology, Oct 27, 2022

Sarcoidosis/Mortimer's malady is a multisystem disease defined by presence of epithelioid cell gr... more Sarcoidosis/Mortimer's malady is a multisystem disease defined by presence of epithelioid cell granulomas without caseation in various organs. It involves mainly the lungs, eyes, skin, lymph node etc. We reported a 40 year old female who presented with multiple plaques over different regions of the body with past history of ulcerated lesion of scalp which healed with cicatricial alopecia. On thorough evaluation she was found to have involvement of multiple internal organs. Based on the clinical features and histopathological findings, a diagnosis of cutaneous sarcoidosis (plaque type) was made. Patient treated with systemic and topical corticosteroids resulting in marked improvement in her skin lesions were seen and pulmonary complaints also resolved.

Indian Dermatology Online Journal

International Journal of Research in Dermatology

Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-... more Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-epidermal junction. We report a 31-year-old female who presented with vesiculobullous lesions in the photo exposed areas along with vasculitic lesions over palms and soles and ulcerations in the larynx. She also had history of photosensitivity and hair loss. Investigations showed significant anaemia and high titres of antibodies (ANA, anti-ds-DNA, anti Sm) confirming SLE. Histopathology showing sub epidermal blister with neutrophils and immunofluorescence favoured diagnosis of bullous SLE. The patient responded well to high dose parenteral steroids and dapsone. In view of high probability of renal involvement, patient was referred to nephrologist and is under regular follow up.

Journal of Evolution of Medical and Dental Sciences

BACKGROUND Vitiligo is an acquired primary, usually progressive, melanocytopenia of unknown aetio... more BACKGROUND Vitiligo is an acquired primary, usually progressive, melanocytopenia of unknown aetiology clinically manifested by circumscribed achromic macules and histologically by degeneration and disappearance of melanocytes in involved skin. Childhood vitiligo deserves special attention as it has unique epidemiological features. We wanted to determine, compare and analyze the clinical and epidemiological features and autoimmune disease associations in childhood vitiligo and adult vitiligo. METHODS It was a prospective cross-sectional observational hospital-based clinical study conducted in a suburban medical college hospital over 20 months which involved 120 patients with vitiligo who were assessed using detailed history and clinical examination for demographic and clinical data. Relevant history and family history were noted. Investigations including complete hemogram, serum biochemistry profile, thyroid profile and fasting plasma glucose examination were performed in all patient...

Indian Dermatology Online Journal

Background: Many previous studies have observed an association of lichen planus (LP) with one or ... more Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. Materials and Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. After taking complete history, general examination and thorough dermatological examination were performed in all cases. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose, lipid profile, T3, T4, and thyroid-stimulating hormone levels, and anti-HCVantibodies. Metabolic syndrome was diagnosed according to 2005 revised National Cholesterol Education Programme's Adult Treatment Panel III. Two-sample Student's t-test was used for statistical analysis. Results: Increased triglyceride levels were seen in 26 cases (34.67%) compared with 14 controls (14%), which was significant (P = 0.024). Statistically significant increased prevalence of increasedlow-density lipoprotein levels (P = 0.027), low high-density lipoprotein levels (P = 0.0189), and diabetes mellitus (P = 0.0217) was also observed in LP. Metabolic syndrome (P = 0.656) and hypothyroidism (P = 0.117) were not significantly associated with LP. Strong association was observed between oral LP and hypothyroidism. All patients screened for anti-HCV antibodies were found to be negative. Conclusion: There is a clear associationof LP with dyslipidemia and diabetes mellitus. Screening for dyslipidemia and diabetes mellitus in all patients of LP will help in early detection, initiation of treatment, and prevent long-term morbidity.

Indian Dermatology Online Journal, 2020

Background: Acne scarring commonly seen in young adults causes marked psychological distress. Com... more Background: Acne scarring commonly seen in young adults causes marked psychological distress. Commonly used procedural treatments for post-acne scarring have limited efficacy. This prospective, randomized study was undertaken to evaluate the efficacy and adverse effects offractional CO2 laser, microneedling, and platelet-rich plasma (PRP) in post-acne scarring. Materials and Methods: Sixty clinically diagnosed cases of post-acne scarring of both sexes were enrolled and divided into three groups of 20 patients each. The severity of scarring was graded as per the qualitative and quantitative grading system proposed by Goodman and Baron. Group A, B, and C patients were treated with fractional CO2 laser, microneedling, and PRP,respectively, at monthly intervals for foursessions. Improve men tin quantitative and qualitative grades of scars and adverse effects were noted at each session and 1 month after the final sitting. Statistical analysis was done using Student 't' test for quantitative values and Chi square test for qualitative values. Results: At the end of foursessions, based on mean percentage of improvement in quantitative grade, the efficacy of fractional CO2 laser is significantly greater than that of PRP (P = 0.00), while CO2 laser and microneedling did not show significant difference (P = 0.106). Based on qualitative scores, fractional CO2 laser group showed statistically higher therapeutic efficacy compared to microneedling and PRP (P = 0.00).No significant adverse effects were encountered in any groups. Conclusion: Fractional CO2laser resurfacing is more efficacious than microneedling and PRP. Unsatisfactory results were obtained with PRP as monotherapy in post-acne scarring.

International Journal of Research in Dermatology, 2018

Background: Androgenetic alopecia (AGA) is commonly known as male pattern baldness has a prevalen... more Background: Androgenetic alopecia (AGA) is commonly known as male pattern baldness has a prevalence of up to 50% in men worldwide. It occurs in most patients before the age of 40 years. It is characterized by a progressive conversion of terminal hair into miniaturized hair defined by various patterns. Various studies have shown that androgenetic alopecia have significant physical and psychological morbidity and a lowered dermatological life quality index.Methods: The study included 75 patients with clinical diagnosis of AGA and 75 age and sex matched controls. After taking complete history, general examination and thorough dermatological examination was performed in all cases to grade the severity of AGA. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose and lipid profile. Metabolic syndrome (MS) was diagnosed according to 2005 revised National Cholesterol Education Programme’s Adult Treatment Panel III (NCEP ATP III). Chi square tes...

International Journal of Research in Dermatology, 2021

Background: Warts are one of the most common benign growths of skin caused by human papilloma vir... more Background: Warts are one of the most common benign growths of skin caused by human papilloma virus. No single treatment has proved to be completely effective and most therapies for palmo-plantar and periungual warts remain unsatisfactory. The present study was conducted to evaluate the therapeutic efficacy and safety of intralesional bleomycin injection in palmo-plantar and periungual warts in patients in region of south east India. Methods: Ninety patients of multiple palmo-plantar and periungual warts were included in the study. They were infiltrated with bleomycin (1 mg/ml) till blanching. The treatment was repeated after paring of eschar at 2 weeks interval in cases with partial or no response. The patients were reviewed at monthly interval for 24 weeks to note cure, adverse effects, recurrence and outcome satisfaction levels. Results: Out of total 305 warts, 103 (34%) were cured after 1st injection and 249 (82%) were cured after 2nd injection. The number of warts requiring mor...

International Journal of Research in Dermatology, 2019

Background: Comedonal acne commonly seen in adolescents and young patients which is refractory to... more Background: Comedonal acne commonly seen in adolescents and young patients which is refractory to standard treatments. This study is being undertaken to determine the efficacy and adverse effects of oral isotretinoin, electrodessication and comedone extraction in patients of comedonalacne.Methods: A total of 120 patients of comedonal acne were enrolled and randomly divided into 4 groups of 30 patients each. Group A, B, C and D patients were treated with isotretinoin (20 mg daily), electrodessication, comedone extraction (4 weeks interval) and topical antibiotic daily for 12 weeks. The response in each group was assessed based on decrease in total comedonal count after 12 weeks of treatment. Statistical analysis was done using chi square test.Results: Eighty seven (72%) cases had predominantly closed comedones and 33 (27%) cases showed open comedones. After 12 weeks of treatment, more than 75% decrease in comedonal count was seen in 60% of patients in electrodessication group followe...

Journal of Evolution of Medical and Dental Sciences, 2014

Indian Dermatology Online Journal, 2016

On general examination, there was no pallor, icterus, clubbing, cyanosis or lymphadenopathy.

Indian dermatology online journal, 2014

Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian s... more Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian studies have focused on the relation between vitiligo, autoimmune thyroid dysfunction and diabetes mellitus. This case-control study included 150 new cases of vitiligo and 100 age and sex-matched controls. A complete history and thorough dermatological examination was done. Serum samples from both patients and controls were collected and assayed for triiodothyronine, thyroxine, thyroid-stimulating hormone, anti-thyroid antibodies-anti-thyroid peroxidase and anti-thyroglobulin and fasting plasma glucose. Thyroid hormonal profile revealed autoimmune thyroid dysfunction manifesting as hypothyroidism in 30 (20%) vitiligo patients and two controls (2%). Diabetes mellitus was present in 24 (16%) vitiligo patients and five controls. Seven (4.7%) patients had both hypothyroidism and diabetes mellitus. There is a clear association between vitiligo, autoimmune hypothyroidism and diabetes mellitus. ...

International Journal of Dermatology, 2007

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Indian Journal of Dermatology, Venereology and Leprology, 2008

Background: Genital ulcerative disease is one of the risk factors for acquisition of HIV. As HSV-... more Background: Genital ulcerative disease is one of the risk factors for acquisition of HIV. As HSV-2 infection is currently the most common cause of genital ulcerative disease, it acts as a potential risk factor for HIV infection. The present study was undertaken to know the seroprevalence of antibodies to HSV-2 in HIV seropositive individuals and in the general population, and to ascertain if HSV-2 is a risk factor for developing HIV infection. Methods: The study group included one hundred new HIV seropositive persons irrespective of active genital herpes or history of genital herpes. Fifty age-and sex-matched healthy volunteers were included as controls. In all patients and controls, diagnostic serology was done for HSV-2 using HSV-2-specifi c glycoprotein IgG2 by indirect immunoassay using the ELISA test. Statistical value 'P' was calculated using the Chi-squared test. Results: Out of the 100 HIV seropositives, 66 were males and 34 were females with an age range of 20-54 years. In only 22 (19 males and 3 females) of these, positive history of genital herpes was obtained. In 49 out of the 100 HIV seropositives, IgG2 antibodies against HSV-2 were detected. In the control group, 11 out of 50 controls were seropositive for HSV-2 IgG2 antibody. There was a statistically signifi cant association between HSV-2 and HIV seropositivity with 'P' value < 0.005. Conclusion: The high prevalence of HSV-2 seropositivity in the HIV-infected group (49%) as compared to normal controls (22%) was statistically signifi cant. Prior HSV-2 infection could be an important risk factor for acquisition of HIV in our patients.

Indian Journal of Dermatology, Venereology and Leprology, 2008

Background: Tuberous sclerosis complex (TSC) is a neurocutaneous genodermatosis characterized by ... more Background: Tuberous sclerosis complex (TSC) is a neurocutaneous genodermatosis characterized by hamartoma formation in multiple organs. There are no defi nite cutaneous markers suggestive of central nervous system (CNS) involvement in TSC. Aims: To study association of forehead plaque seen in tuberous sclerosis patients and CNS involvement in TSC. Methods: This is a retrospective study of 15 cases of tuberous sclerosis in varying age groups-from 1.5 to 50 years. All the cases were thoroughly evaluated with detailed history; clinical examination; and relevant investigations like X-rays of chest, skull, hands and feet; ultrasound abdomen and computed tomography of brain. Results: Out of the 15 cases, CNS involvement was seen in 8 cases. Seizures were present in 8 cases (53.33%) and mental retardation was seen in 6 cases (40%). Computerized tomography of brain revealed subependymal nodules (SENs) in eight cases (53.33%). In addition to SENs, subependymal giant cell astrocytomas and cortical tubers were seen in 2 cases each. Out of these 8 cases having CNS involvement, in 7 cases forehead plaque was observed. In 1 case, no forehead plaque was observed (X 2 = 1.07, P<0.05). Conclusion: This study shows that there is a statistically signifi cant relationship between the presence of a forehead plaque and CNS involvement in TSC. Therefore, forehead plaque may be considered as a novel cutaneous marker to know the CNS involvement in TSC at an early stage.

Indian Dermatology Online Journal

Background: A few recent studies have shown fungal elements within the hair follicle epithelium, ... more Background: A few recent studies have shown fungal elements within the hair follicle epithelium, which may act as a reservoir and responsible for recurrent dermatophytosis. Objectives: To assess the clinical patterns, mycological profile, and histopathology of recurrent dermatophytosis and to determine the prevalence of fungal hyphae in the hair follicle epithelium and other appendages. Materials and Methods: One hundred and fifty clinically diagnosed cases of recurrent dermatophytic infection were included. Skin samples were taken for direct microscopy, fungal culture, and histopathological analysis. Haematoxylin and eosin and special staining with periodic acid Schiff (PAS) and Gomori's methenamine silver (GMS) were performed to detect the fungal hyphae in the skin and hair follicle epithelium. Results: The most common clinical pattern observed was tinea corporis et cruris in 64 patients (42.66%). On direct microscopy and fungal culture, positive results were obtained in 116 c...

International Journal of Research in Dermatology, Dec 26, 2022

Lichen planus is an inflammatory skin disorder which has been shown to be associated with thyroid... more Lichen planus is an inflammatory skin disorder which has been shown to be associated with thyroid disorders, hepatitis B, hepatitis C. IgA vasculitis is a form of cutaneous small vessel vasculitis (CSVV) characterized by palpable purpura, abdominal pain and joint pain usually seen in children. We report a case of 45-year-old female patient came with violaceous itchy lesions which were distributed over trunk and extremities of 1 month duration. Complete blood count (CBC) and serum biochemistry tests were normal. Histopathology of violaceous lesions showed changes of lichen planus. Purpuric lesions showed mild perivascular and transmural inflammatory infiltrate, composed mainly of neutrophils and few lymphocytes in the superficial dermis. Direct immunofluorescence was positive for IgA (granular pattern along with vessel walls of small vessels). Based on clinical, histopathological findings, a diagnosis of lichen planus with IgA vasculitis was made. The patient was treated with 30 mg prednisolone, gradually tapered over 6 weeks and anti-histamines. Satisfactory response was observed at follow-up at 6 weeks. Our case highlights the rare association of lichen planus with IgA vasculitis. Thorough evaluation of the patient helped in reaching correct diagnosis.

International Journal of Research in Dermatology, Dec 26, 2022

on dorsum of bilateral feet, legs, buttocks region and scalp. Current distribution of lesions was... more on dorsum of bilateral feet, legs, buttocks region and scalp. Current distribution of lesions was present since 3 months. No history of similar complaints in the past. Family history and drug history was not significant. Patient was well built and nourished, taking mixed diet, normal sleep, appetite,

International Journal of Research in Dermatology, Oct 27, 2022

Sarcoidosis/Mortimer's malady is a multisystem disease defined by presence of epithelioid cell gr... more Sarcoidosis/Mortimer's malady is a multisystem disease defined by presence of epithelioid cell granulomas without caseation in various organs. It involves mainly the lungs, eyes, skin, lymph node etc. We reported a 40 year old female who presented with multiple plaques over different regions of the body with past history of ulcerated lesion of scalp which healed with cicatricial alopecia. On thorough evaluation she was found to have involvement of multiple internal organs. Based on the clinical features and histopathological findings, a diagnosis of cutaneous sarcoidosis (plaque type) was made. Patient treated with systemic and topical corticosteroids resulting in marked improvement in her skin lesions were seen and pulmonary complaints also resolved.

Indian Dermatology Online Journal

International Journal of Research in Dermatology

Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-... more Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-epidermal junction. We report a 31-year-old female who presented with vesiculobullous lesions in the photo exposed areas along with vasculitic lesions over palms and soles and ulcerations in the larynx. She also had history of photosensitivity and hair loss. Investigations showed significant anaemia and high titres of antibodies (ANA, anti-ds-DNA, anti Sm) confirming SLE. Histopathology showing sub epidermal blister with neutrophils and immunofluorescence favoured diagnosis of bullous SLE. The patient responded well to high dose parenteral steroids and dapsone. In view of high probability of renal involvement, patient was referred to nephrologist and is under regular follow up.

Journal of Evolution of Medical and Dental Sciences

BACKGROUND Vitiligo is an acquired primary, usually progressive, melanocytopenia of unknown aetio... more BACKGROUND Vitiligo is an acquired primary, usually progressive, melanocytopenia of unknown aetiology clinically manifested by circumscribed achromic macules and histologically by degeneration and disappearance of melanocytes in involved skin. Childhood vitiligo deserves special attention as it has unique epidemiological features. We wanted to determine, compare and analyze the clinical and epidemiological features and autoimmune disease associations in childhood vitiligo and adult vitiligo. METHODS It was a prospective cross-sectional observational hospital-based clinical study conducted in a suburban medical college hospital over 20 months which involved 120 patients with vitiligo who were assessed using detailed history and clinical examination for demographic and clinical data. Relevant history and family history were noted. Investigations including complete hemogram, serum biochemistry profile, thyroid profile and fasting plasma glucose examination were performed in all patient...

Indian Dermatology Online Journal

Background: Many previous studies have observed an association of lichen planus (LP) with one or ... more Background: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. Materials and Methods: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. After taking complete history, general examination and thorough dermatological examination were performed in all cases. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose, lipid profile, T3, T4, and thyroid-stimulating hormone levels, and anti-HCVantibodies. Metabolic syndrome was diagnosed according to 2005 revised National Cholesterol Education Programme's Adult Treatment Panel III. Two-sample Student's t-test was used for statistical analysis. Results: Increased triglyceride levels were seen in 26 cases (34.67%) compared with 14 controls (14%), which was significant (P = 0.024). Statistically significant increased prevalence of increasedlow-density lipoprotein levels (P = 0.027), low high-density lipoprotein levels (P = 0.0189), and diabetes mellitus (P = 0.0217) was also observed in LP. Metabolic syndrome (P = 0.656) and hypothyroidism (P = 0.117) were not significantly associated with LP. Strong association was observed between oral LP and hypothyroidism. All patients screened for anti-HCV antibodies were found to be negative. Conclusion: There is a clear associationof LP with dyslipidemia and diabetes mellitus. Screening for dyslipidemia and diabetes mellitus in all patients of LP will help in early detection, initiation of treatment, and prevent long-term morbidity.

Indian Dermatology Online Journal, 2020

Background: Acne scarring commonly seen in young adults causes marked psychological distress. Com... more Background: Acne scarring commonly seen in young adults causes marked psychological distress. Commonly used procedural treatments for post-acne scarring have limited efficacy. This prospective, randomized study was undertaken to evaluate the efficacy and adverse effects offractional CO2 laser, microneedling, and platelet-rich plasma (PRP) in post-acne scarring. Materials and Methods: Sixty clinically diagnosed cases of post-acne scarring of both sexes were enrolled and divided into three groups of 20 patients each. The severity of scarring was graded as per the qualitative and quantitative grading system proposed by Goodman and Baron. Group A, B, and C patients were treated with fractional CO2 laser, microneedling, and PRP,respectively, at monthly intervals for foursessions. Improve men tin quantitative and qualitative grades of scars and adverse effects were noted at each session and 1 month after the final sitting. Statistical analysis was done using Student 't' test for quantitative values and Chi square test for qualitative values. Results: At the end of foursessions, based on mean percentage of improvement in quantitative grade, the efficacy of fractional CO2 laser is significantly greater than that of PRP (P = 0.00), while CO2 laser and microneedling did not show significant difference (P = 0.106). Based on qualitative scores, fractional CO2 laser group showed statistically higher therapeutic efficacy compared to microneedling and PRP (P = 0.00).No significant adverse effects were encountered in any groups. Conclusion: Fractional CO2laser resurfacing is more efficacious than microneedling and PRP. Unsatisfactory results were obtained with PRP as monotherapy in post-acne scarring.

International Journal of Research in Dermatology, 2018

Background: Androgenetic alopecia (AGA) is commonly known as male pattern baldness has a prevalen... more Background: Androgenetic alopecia (AGA) is commonly known as male pattern baldness has a prevalence of up to 50% in men worldwide. It occurs in most patients before the age of 40 years. It is characterized by a progressive conversion of terminal hair into miniaturized hair defined by various patterns. Various studies have shown that androgenetic alopecia have significant physical and psychological morbidity and a lowered dermatological life quality index.Methods: The study included 75 patients with clinical diagnosis of AGA and 75 age and sex matched controls. After taking complete history, general examination and thorough dermatological examination was performed in all cases to grade the severity of AGA. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose and lipid profile. Metabolic syndrome (MS) was diagnosed according to 2005 revised National Cholesterol Education Programme’s Adult Treatment Panel III (NCEP ATP III). Chi square tes...

International Journal of Research in Dermatology, 2021

Background: Warts are one of the most common benign growths of skin caused by human papilloma vir... more Background: Warts are one of the most common benign growths of skin caused by human papilloma virus. No single treatment has proved to be completely effective and most therapies for palmo-plantar and periungual warts remain unsatisfactory. The present study was conducted to evaluate the therapeutic efficacy and safety of intralesional bleomycin injection in palmo-plantar and periungual warts in patients in region of south east India. Methods: Ninety patients of multiple palmo-plantar and periungual warts were included in the study. They were infiltrated with bleomycin (1 mg/ml) till blanching. The treatment was repeated after paring of eschar at 2 weeks interval in cases with partial or no response. The patients were reviewed at monthly interval for 24 weeks to note cure, adverse effects, recurrence and outcome satisfaction levels. Results: Out of total 305 warts, 103 (34%) were cured after 1st injection and 249 (82%) were cured after 2nd injection. The number of warts requiring mor...

International Journal of Research in Dermatology, 2019

Background: Comedonal acne commonly seen in adolescents and young patients which is refractory to... more Background: Comedonal acne commonly seen in adolescents and young patients which is refractory to standard treatments. This study is being undertaken to determine the efficacy and adverse effects of oral isotretinoin, electrodessication and comedone extraction in patients of comedonalacne.Methods: A total of 120 patients of comedonal acne were enrolled and randomly divided into 4 groups of 30 patients each. Group A, B, C and D patients were treated with isotretinoin (20 mg daily), electrodessication, comedone extraction (4 weeks interval) and topical antibiotic daily for 12 weeks. The response in each group was assessed based on decrease in total comedonal count after 12 weeks of treatment. Statistical analysis was done using chi square test.Results: Eighty seven (72%) cases had predominantly closed comedones and 33 (27%) cases showed open comedones. After 12 weeks of treatment, more than 75% decrease in comedonal count was seen in 60% of patients in electrodessication group followe...

Journal of Evolution of Medical and Dental Sciences, 2014

Indian Dermatology Online Journal, 2016

On general examination, there was no pallor, icterus, clubbing, cyanosis or lymphadenopathy.

Indian dermatology online journal, 2014

Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian s... more Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian studies have focused on the relation between vitiligo, autoimmune thyroid dysfunction and diabetes mellitus. This case-control study included 150 new cases of vitiligo and 100 age and sex-matched controls. A complete history and thorough dermatological examination was done. Serum samples from both patients and controls were collected and assayed for triiodothyronine, thyroxine, thyroid-stimulating hormone, anti-thyroid antibodies-anti-thyroid peroxidase and anti-thyroglobulin and fasting plasma glucose. Thyroid hormonal profile revealed autoimmune thyroid dysfunction manifesting as hypothyroidism in 30 (20%) vitiligo patients and two controls (2%). Diabetes mellitus was present in 24 (16%) vitiligo patients and five controls. Seven (4.7%) patients had both hypothyroidism and diabetes mellitus. There is a clear association between vitiligo, autoimmune hypothyroidism and diabetes mellitus. ...

International Journal of Dermatology, 2007

Skip to Main Content. ...

Indian Journal of Dermatology, Venereology and Leprology, 2008

Background: Genital ulcerative disease is one of the risk factors for acquisition of HIV. As HSV-... more Background: Genital ulcerative disease is one of the risk factors for acquisition of HIV. As HSV-2 infection is currently the most common cause of genital ulcerative disease, it acts as a potential risk factor for HIV infection. The present study was undertaken to know the seroprevalence of antibodies to HSV-2 in HIV seropositive individuals and in the general population, and to ascertain if HSV-2 is a risk factor for developing HIV infection. Methods: The study group included one hundred new HIV seropositive persons irrespective of active genital herpes or history of genital herpes. Fifty age-and sex-matched healthy volunteers were included as controls. In all patients and controls, diagnostic serology was done for HSV-2 using HSV-2-specifi c glycoprotein IgG2 by indirect immunoassay using the ELISA test. Statistical value 'P' was calculated using the Chi-squared test. Results: Out of the 100 HIV seropositives, 66 were males and 34 were females with an age range of 20-54 years. In only 22 (19 males and 3 females) of these, positive history of genital herpes was obtained. In 49 out of the 100 HIV seropositives, IgG2 antibodies against HSV-2 were detected. In the control group, 11 out of 50 controls were seropositive for HSV-2 IgG2 antibody. There was a statistically signifi cant association between HSV-2 and HIV seropositivity with 'P' value < 0.005. Conclusion: The high prevalence of HSV-2 seropositivity in the HIV-infected group (49%) as compared to normal controls (22%) was statistically signifi cant. Prior HSV-2 infection could be an important risk factor for acquisition of HIV in our patients.

Indian Journal of Dermatology, Venereology and Leprology, 2008

Background: Tuberous sclerosis complex (TSC) is a neurocutaneous genodermatosis characterized by ... more Background: Tuberous sclerosis complex (TSC) is a neurocutaneous genodermatosis characterized by hamartoma formation in multiple organs. There are no defi nite cutaneous markers suggestive of central nervous system (CNS) involvement in TSC. Aims: To study association of forehead plaque seen in tuberous sclerosis patients and CNS involvement in TSC. Methods: This is a retrospective study of 15 cases of tuberous sclerosis in varying age groups-from 1.5 to 50 years. All the cases were thoroughly evaluated with detailed history; clinical examination; and relevant investigations like X-rays of chest, skull, hands and feet; ultrasound abdomen and computed tomography of brain. Results: Out of the 15 cases, CNS involvement was seen in 8 cases. Seizures were present in 8 cases (53.33%) and mental retardation was seen in 6 cases (40%). Computerized tomography of brain revealed subependymal nodules (SENs) in eight cases (53.33%). In addition to SENs, subependymal giant cell astrocytomas and cortical tubers were seen in 2 cases each. Out of these 8 cases having CNS involvement, in 7 cases forehead plaque was observed. In 1 case, no forehead plaque was observed (X 2 = 1.07, P<0.05). Conclusion: This study shows that there is a statistically signifi cant relationship between the presence of a forehead plaque and CNS involvement in TSC. Therefore, forehead plaque may be considered as a novel cutaneous marker to know the CNS involvement in TSC at an early stage.