Kaitlyn Hall - Academia.edu (original) (raw)
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Papers by Kaitlyn Hall
Society for Information Technology & Teacher Education International Conference, Mar 5, 2017
This article describes a collaboration between engineering and teacher education departments from... more This article describes a collaboration between engineering and teacher education departments from two universities in Virginia in the 2015-2016 semesters. Accounts by the professor and the student teacher author are interspersed to describe how this collaboration between engineering students and teacher education students enhanced the skill sets of the students in science, technology, engineering, and math (STEM) in elementary classrooms. Engineering students observed and participated as student teachers taught STEM units. Teacher education students observed and participated as engineering students conducted short STEM hands-on sessions. The outcome was mutually beneficial as engineering students learned teaching techniques and skills, while teacher education students learned STEM knowledge and engineering practices. Future idea include co-designing engineering challenges and cooperation in summer STEM camps.
Antibody reduction phenomenon, although only sporadically observed at large scale cell culture ha... more Antibody reduction phenomenon, although only sporadically observed at large scale cell culture harvests, can be devastating for the entire production campaign. In such an event, the disulfide bonds of the antibody molecules are cleaved due to enzymes like thioredoxin 1 present in cell culture harvest resulting in heavy and light chain antibody fragments1,2. Occurrence of such a phenomenon might lead to the rejection of the entire large scale batch as the product will fail to meet its specifications. Thus, it is important to get an early-read on the cell culture harvest’s tendency to cause antibody reduction at smaller scale prior to the process scale-up. A scale down model that can reproduce the antibody reduction phenomenon can not only allow screening different cell culture systems for the tendency of antibody reduction but can also provide higher experimental throughput in case the tendency is observed. This will allow one to evaluate all the mitigation strategies and choose the ...
Society for Information Technology & Teacher Education International Conference, Mar 5, 2017
This article describes a collaboration between engineering and teacher education departments from... more This article describes a collaboration between engineering and teacher education departments from two universities in Virginia in the 2015-2016 semesters. Accounts by the professor and the student teacher author are interspersed to describe how this collaboration between engineering students and teacher education students enhanced the skill sets of the students in science, technology, engineering, and math (STEM) in elementary classrooms. Engineering students observed and participated as student teachers taught STEM units. Teacher education students observed and participated as engineering students conducted short STEM hands-on sessions. The outcome was mutually beneficial as engineering students learned teaching techniques and skills, while teacher education students learned STEM knowledge and engineering practices. Future idea include co-designing engineering challenges and cooperation in summer STEM camps.
Antibody reduction phenomenon, although only sporadically observed at large scale cell culture ha... more Antibody reduction phenomenon, although only sporadically observed at large scale cell culture harvests, can be devastating for the entire production campaign. In such an event, the disulfide bonds of the antibody molecules are cleaved due to enzymes like thioredoxin 1 present in cell culture harvest resulting in heavy and light chain antibody fragments1,2. Occurrence of such a phenomenon might lead to the rejection of the entire large scale batch as the product will fail to meet its specifications. Thus, it is important to get an early-read on the cell culture harvest’s tendency to cause antibody reduction at smaller scale prior to the process scale-up. A scale down model that can reproduce the antibody reduction phenomenon can not only allow screening different cell culture systems for the tendency of antibody reduction but can also provide higher experimental throughput in case the tendency is observed. This will allow one to evaluate all the mitigation strategies and choose the ...