Kamrul Ahsan Khan - Academia.edu (original) (raw)

Uploads

Papers by Kamrul Ahsan Khan

Research paper thumbnail of Pattern of infantile skin problems in a tertiary care hospital

Research paper thumbnail of Cranial Ultra-sonographic Findings in Preterm Low Birth Weight and Very Low Birth Weight Infant

Research paper thumbnail of Validity of Naked Eye Single Tube Red Cell Osmotic Fragility Test in Screening of ß-Thalassemia Trait

Research paper thumbnail of Spectrum of Pediatric Diseases at Upozilla Health Complex, Tungipara, Bangladesh

Research paper thumbnail of Drug Response in Childhood Typhoid Fever A Comparative Analysis of Ciprofloxacine Ceftriaxone and Azithromycin

Research paper thumbnail of Factors associated with Facebook addiction among university students amid the COVID-19 pandemic: Findings from an online cross-sectional survey

PLOS ONE

Background Facebook addiction (FA) has been suggested as a potential behavioral addiction. There ... more Background Facebook addiction (FA) has been suggested as a potential behavioral addiction. There is a severe lack of research evidence regarding the Facebook addiction behavior among university students during the ongoing COVID-19 pandemic. The aim of this study was to determine factors associated with Facebook addiction among Bangladeshi university students. Methods A cross-sectional online survey was conducted among 2,161 Bangladeshi university students during the COVID-19 pandemic from June 2021 to September 2021. A well fitted regression model in R programming language was used for this study. Results Female respondents and those whose family monthly income was <25,000 BDT were more addicted to Facebook than other respondents. Respondents who lost a family member or a relative to COVID-19, engaged in physical activities (exercise) during the pandemic, used Facebook for work purposes or used Facebook to relieve daily stress were more addicted to Facebook. Conclusion Overuse of...

Research paper thumbnail of Oral Vs Subcutaneous Erythropoietin in Prevention of Anemia of Prematurity

Research paper thumbnail of Role of Hydroxyurea in Reducing Transfusion Requirements in Patients with β-Thalassaemia Major

Research paper thumbnail of Prevention and Management of Respiratory Distress Syndrome: Current Practice in Bangladesh

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitaminE level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was do...

Research paper thumbnail of Predicting Neonatal Hyperbilirubinemia Using First Day Serum Bilirubin Level in Late Preterm and Term Healthy Newborn

Mymensingh medical journal : MMJ, 2017

Hyperbilirubinemia is a common problem during the neonatal period and is the most common reason f... more Hyperbilirubinemia is a common problem during the neonatal period and is the most common reason for readmission after early hospital discharge of the healthy near term and term infants. This early discharge policy along with limited follow-up facilities in developing countries and inadequate communication between physicians and parents necessitates a prognostic test to predict hyperbilirubinemia in these newborns; for early and effective management and prevention of potential complication before it occurred. This observational analytical study was done to determine the predictability of day1 total serum bilirubin (TSB) level as a screening test and identify the best cutoff value which would predict neonates likely to develop significant hyperbilirubinemia. The study was carried out in the Department of Neonatology and Department of Gynecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from 1st April 2013 to 31st March 2014. A TSB level of ...

Research paper thumbnail of Communicable Diseases of Grass Root Level Students in A Selected Madrasah

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitamin-E level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was done by a qualified ophthalmologist by binocular indirect ophthalmoscope. Data was analyzed by SPSS software version 20. Level of significance was tested by appropriate statistical tests. Result: Among 75 enrolled infants, parents of 5 infants refused to give blood and thus excluded. Finally 70 neonates were available for vitamin E estimation and among them 40 preterm infants were advised for ROP screening. Vitamin E level in preterm newborns was 0.3773 ± 0.2447 mg/dl and in term newborns it was 0.8038 ± 0.4257 mg/dl and the difference was statistically significant (P<0.001). Among the 40 preterm infants 12(30%) were found to have ROP. Step wise logistic regression showed that vitamin E deficiency is a significant risk factor for the development of ROP (RR: 4.71; p<0.05). Conclusion: Serum vitamin E level was found significantly lower in preterm newborns in comparison to term newborns and vitamin E deficiency was significantly related with the development of ROP.

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Research paper thumbnail of Neonatal Pneumonia in NICU of a Tertiary Care Center

Background: Pneumonia is one of the causes of neonatal infection and responsible for significant ... more Background: Pneumonia is one of the causes of neonatal infection and responsible for significant morbidity and mortality, especially in developing countries. The study was aimed to reveal frequency and outcome of pneumonia among hospitalized sick newborn of neonatal intensive care unit. Methodology: This observational study was carried out in the NICU of Bangabandhu Sheikh Mujib Medical University (BSMMU) on 94 neonates with the diagnosis of pneumonia admitted from July 2012 to June 2014. All studied neonates were subjected to history taking, clinical examination, routine investigations, chest radiography and blood culture and sensitivity. Results: Incidence of neonatal pneumonia was 43% among admitted neonates with respiratory distress. Mean birth weight and gestational age were 2392±854 and 33±3.9 weeks respectively. Of enrolled infants with pneumonia, 38 (40.4%) were early onset, 24 (25%) were hospital acquired pneumonia and community acquired pneumonia was documented in 14 (14.8 %) and the rest 18 (19%) were ventilator associated pneumonia. Blood culture was positive in 18 (19%) of cases with neonatal pneumonia; most common pathogen isolated was acinetobacter. Mean duration of hospital stay was 19±8 days. Most of the neonatal pneumonia were cured 72 (76%) with therapy, whereas 17 (18%) died during their hospital course. Conclusion: Overall incidence among admitted sick neonates was 8.4% which constituted 34% of distressed neonate.

Research paper thumbnail of Comparison of Serum Bilirubin with Transcutaneous Bilirubinometry in Late Preterm and Term Newborn

Research paper thumbnail of A Comparative Analysis of Ceftriaxone and Azithromycin in the Treatment of Uncomplicated Typhoid Fever in Children

Research paper thumbnail of Newborn Sepsis- Clinical Presentation, Bacterial Pathogens and Their Sensitivity Pattern

Research paper thumbnail of Effect of Oral Erythropoietin in Prevention of Anemia of Prematurity

Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Bl... more Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Blood transfusion is a necessity when it occurs in moderate to severe form putting the child in to the risk of transfusion related complications. Erythropoietin, a potent stimulator of hemopoesis is available in breast milk in good amount and absorbed intact under physiologic condition. In this background oral recombinant human erythropoietin (rhEPO) can be a useful alternative to its subcutaneous administration in prevention of AOP. Objective: To evaluate the efficacy of oral rhEPO in the prevention of AOP in very low birth weight (VLBW) neonates. Methods: This randomized controlled study conducted in the NICU of BSMMU over one year. Total 60 preterm (<34 weeks)VLBW (<1500g) infants were enrolled and randomly divided into Control (group-I), Oral (group-II) and Subcutaneous (group III). Experimental groups (group-II & group-III) received rhEPO 400 IU/Kg, 3 times weekly in oral and subcutaneous (S/C) route respectively and continued for 2 weeks (Total 6 doses). Therapy was initiated 14 days after birth when the baby achieved oral feeding of at least 50 ml/kg/day of breast milk. All infants received oral iron and folic acid supplementation up to 12 weeks of postnatal age. Transfusion data were recorded. Anthropometric and hematological assessments were done at 2, 4, 6 and 12 weeks of age. Results: Baseline clinical characteristics and hematological values were almost similar in all groups. Mean hemoglobin were 11.34±0.68gm/dl, 11.88±0.54gm/dl& 12.12±1.32 gm/dl, the mean hematocrit were 34.11±2.03%, 35.66±1.65% & 36.38±3.97% and the mean reticulocyte were 7.56±2.48%, 9.85±1.50% & 9.22±3.11% in the control, oral and subcutaneous group respectively and the differences are statistically significant (p<0.05).Weight gain was higher in the intervention group at 6 and 12 weeks follow up than the control group(p<0.05).Only 2 (5.25%) infants, one in each of the intervention groups required blood transfusion, compared to 6 (31.5%) infants in control group (p<0.01). Conclusion: Oral EPO is as good as subcutaneous use of EPO in stimulating erythropoesis, maintaining HCT and Hb at high level and is safe in preterm baby.

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitamin-E level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was done by a qualified ophthalmologist by binocular indirect ophthalmoscope. Data was analyzed by SPSS software version 20. Level of significance was tested by appropriate statistical tests. Result: Among 75 enrolled infants, parents of 5 infants refused to give blood and thus excluded. Finally 70 neonates were available for vitamin E estimation and among them 40 preterm infants were advised for ROP screening. Vitamin E level in preterm newborns was 0.3773 ± 0.2447 mg/dl and in term newborns it was 0.8038 ± 0.4257 mg/dl and the difference was statistically significant (P<0.001). Among the 40 preterm infants 12(30%) were found to have ROP. Step wise logistic regression showed that vitamin E deficiency is a significant risk factor for the development of ROP (RR: 4.71; p<0.05). Conclusion: Serum vitamin E level was found significantly lower in preterm newborns in comparison to term newborns and vitamin E deficiency was significantly related with the development of ROP.

Research paper thumbnail of Pattern of infantile skin problems in a tertiary care hospital

Research paper thumbnail of Cranial Ultra-sonographic Findings in Preterm Low Birth Weight and Very Low Birth Weight Infant

Research paper thumbnail of Validity of Naked Eye Single Tube Red Cell Osmotic Fragility Test in Screening of ß-Thalassemia Trait

Research paper thumbnail of Spectrum of Pediatric Diseases at Upozilla Health Complex, Tungipara, Bangladesh

Research paper thumbnail of Drug Response in Childhood Typhoid Fever A Comparative Analysis of Ciprofloxacine Ceftriaxone and Azithromycin

Research paper thumbnail of Factors associated with Facebook addiction among university students amid the COVID-19 pandemic: Findings from an online cross-sectional survey

PLOS ONE

Background Facebook addiction (FA) has been suggested as a potential behavioral addiction. There ... more Background Facebook addiction (FA) has been suggested as a potential behavioral addiction. There is a severe lack of research evidence regarding the Facebook addiction behavior among university students during the ongoing COVID-19 pandemic. The aim of this study was to determine factors associated with Facebook addiction among Bangladeshi university students. Methods A cross-sectional online survey was conducted among 2,161 Bangladeshi university students during the COVID-19 pandemic from June 2021 to September 2021. A well fitted regression model in R programming language was used for this study. Results Female respondents and those whose family monthly income was <25,000 BDT were more addicted to Facebook than other respondents. Respondents who lost a family member or a relative to COVID-19, engaged in physical activities (exercise) during the pandemic, used Facebook for work purposes or used Facebook to relieve daily stress were more addicted to Facebook. Conclusion Overuse of...

Research paper thumbnail of Oral Vs Subcutaneous Erythropoietin in Prevention of Anemia of Prematurity

Research paper thumbnail of Role of Hydroxyurea in Reducing Transfusion Requirements in Patients with β-Thalassaemia Major

Research paper thumbnail of Prevention and Management of Respiratory Distress Syndrome: Current Practice in Bangladesh

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitaminE level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was do...

Research paper thumbnail of Predicting Neonatal Hyperbilirubinemia Using First Day Serum Bilirubin Level in Late Preterm and Term Healthy Newborn

Mymensingh medical journal : MMJ, 2017

Hyperbilirubinemia is a common problem during the neonatal period and is the most common reason f... more Hyperbilirubinemia is a common problem during the neonatal period and is the most common reason for readmission after early hospital discharge of the healthy near term and term infants. This early discharge policy along with limited follow-up facilities in developing countries and inadequate communication between physicians and parents necessitates a prognostic test to predict hyperbilirubinemia in these newborns; for early and effective management and prevention of potential complication before it occurred. This observational analytical study was done to determine the predictability of day1 total serum bilirubin (TSB) level as a screening test and identify the best cutoff value which would predict neonates likely to develop significant hyperbilirubinemia. The study was carried out in the Department of Neonatology and Department of Gynecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from 1st April 2013 to 31st March 2014. A TSB level of ...

Research paper thumbnail of Communicable Diseases of Grass Root Level Students in A Selected Madrasah

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitamin-E level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was done by a qualified ophthalmologist by binocular indirect ophthalmoscope. Data was analyzed by SPSS software version 20. Level of significance was tested by appropriate statistical tests. Result: Among 75 enrolled infants, parents of 5 infants refused to give blood and thus excluded. Finally 70 neonates were available for vitamin E estimation and among them 40 preterm infants were advised for ROP screening. Vitamin E level in preterm newborns was 0.3773 ± 0.2447 mg/dl and in term newborns it was 0.8038 ± 0.4257 mg/dl and the difference was statistically significant (P<0.001). Among the 40 preterm infants 12(30%) were found to have ROP. Step wise logistic regression showed that vitamin E deficiency is a significant risk factor for the development of ROP (RR: 4.71; p<0.05). Conclusion: Serum vitamin E level was found significantly lower in preterm newborns in comparison to term newborns and vitamin E deficiency was significantly related with the development of ROP.

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Research paper thumbnail of Neonatal Pneumonia in NICU of a Tertiary Care Center

Background: Pneumonia is one of the causes of neonatal infection and responsible for significant ... more Background: Pneumonia is one of the causes of neonatal infection and responsible for significant morbidity and mortality, especially in developing countries. The study was aimed to reveal frequency and outcome of pneumonia among hospitalized sick newborn of neonatal intensive care unit. Methodology: This observational study was carried out in the NICU of Bangabandhu Sheikh Mujib Medical University (BSMMU) on 94 neonates with the diagnosis of pneumonia admitted from July 2012 to June 2014. All studied neonates were subjected to history taking, clinical examination, routine investigations, chest radiography and blood culture and sensitivity. Results: Incidence of neonatal pneumonia was 43% among admitted neonates with respiratory distress. Mean birth weight and gestational age were 2392±854 and 33±3.9 weeks respectively. Of enrolled infants with pneumonia, 38 (40.4%) were early onset, 24 (25%) were hospital acquired pneumonia and community acquired pneumonia was documented in 14 (14.8 %) and the rest 18 (19%) were ventilator associated pneumonia. Blood culture was positive in 18 (19%) of cases with neonatal pneumonia; most common pathogen isolated was acinetobacter. Mean duration of hospital stay was 19±8 days. Most of the neonatal pneumonia were cured 72 (76%) with therapy, whereas 17 (18%) died during their hospital course. Conclusion: Overall incidence among admitted sick neonates was 8.4% which constituted 34% of distressed neonate.

Research paper thumbnail of Comparison of Serum Bilirubin with Transcutaneous Bilirubinometry in Late Preterm and Term Newborn

Research paper thumbnail of A Comparative Analysis of Ceftriaxone and Azithromycin in the Treatment of Uncomplicated Typhoid Fever in Children

Research paper thumbnail of Newborn Sepsis- Clinical Presentation, Bacterial Pathogens and Their Sensitivity Pattern

Research paper thumbnail of Effect of Oral Erythropoietin in Prevention of Anemia of Prematurity

Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Bl... more Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Blood transfusion is a necessity when it occurs in moderate to severe form putting the child in to the risk of transfusion related complications. Erythropoietin, a potent stimulator of hemopoesis is available in breast milk in good amount and absorbed intact under physiologic condition. In this background oral recombinant human erythropoietin (rhEPO) can be a useful alternative to its subcutaneous administration in prevention of AOP. Objective: To evaluate the efficacy of oral rhEPO in the prevention of AOP in very low birth weight (VLBW) neonates. Methods: This randomized controlled study conducted in the NICU of BSMMU over one year. Total 60 preterm (<34 weeks)VLBW (<1500g) infants were enrolled and randomly divided into Control (group-I), Oral (group-II) and Subcutaneous (group III). Experimental groups (group-II & group-III) received rhEPO 400 IU/Kg, 3 times weekly in oral and subcutaneous (S/C) route respectively and continued for 2 weeks (Total 6 doses). Therapy was initiated 14 days after birth when the baby achieved oral feeding of at least 50 ml/kg/day of breast milk. All infants received oral iron and folic acid supplementation up to 12 weeks of postnatal age. Transfusion data were recorded. Anthropometric and hematological assessments were done at 2, 4, 6 and 12 weeks of age. Results: Baseline clinical characteristics and hematological values were almost similar in all groups. Mean hemoglobin were 11.34±0.68gm/dl, 11.88±0.54gm/dl& 12.12±1.32 gm/dl, the mean hematocrit were 34.11±2.03%, 35.66±1.65% & 36.38±3.97% and the mean reticulocyte were 7.56±2.48%, 9.85±1.50% & 9.22±3.11% in the control, oral and subcutaneous group respectively and the differences are statistically significant (p<0.05).Weight gain was higher in the intervention group at 6 and 12 weeks follow up than the control group(p<0.05).Only 2 (5.25%) infants, one in each of the intervention groups required blood transfusion, compared to 6 (31.5%) infants in control group (p<0.01). Conclusion: Oral EPO is as good as subcutaneous use of EPO in stimulating erythropoesis, maintaining HCT and Hb at high level and is safe in preterm baby.

Research paper thumbnail of Newborns Vitamin E Level and Its Relationship with Retinopathy of Prematurity

Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitam... more Introduction: Vitamin E status in newborn is not well established. Many studies showed that vitamin-E level is low in premature babies and without supplementation complications may occur including retinopathy of prematurity (ROP). So this study was aimed to estimate serum tocopherol (vitamin-E) level in infants and to find out the relationship of low serum vitamin E level with the development of ROP. Method: This cross sectional analytic study was performed in the department of Neonatology, BSMMU over a period of 6 months. Total 75 stable term (38-42wk) and preterm (30-35wk) newborn infants admitted in BSMMU were consecutively enrolled. Newborns of <30 weeks and 36-37 weeks of gestation, hemodynamically unstable or with major congenital anomalies were excluded. After informed written consent from parents, 3 ml free flow venous blood was collected at 3-5 days of life. Serum Vitamin E level estimation was done by high performance liquid chromatography (HPLC) and ROP screening was done by a qualified ophthalmologist by binocular indirect ophthalmoscope. Data was analyzed by SPSS software version 20. Level of significance was tested by appropriate statistical tests. Result: Among 75 enrolled infants, parents of 5 infants refused to give blood and thus excluded. Finally 70 neonates were available for vitamin E estimation and among them 40 preterm infants were advised for ROP screening. Vitamin E level in preterm newborns was 0.3773 ± 0.2447 mg/dl and in term newborns it was 0.8038 ± 0.4257 mg/dl and the difference was statistically significant (P<0.001). Among the 40 preterm infants 12(30%) were found to have ROP. Step wise logistic regression showed that vitamin E deficiency is a significant risk factor for the development of ROP (RR: 4.71; p<0.05). Conclusion: Serum vitamin E level was found significantly lower in preterm newborns in comparison to term newborns and vitamin E deficiency was significantly related with the development of ROP.