Kan Wu - Academia.edu (original) (raw)
Papers by Kan Wu
PloS one, 2016
Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell ... more Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell lung cancer (LS-SCLC). However, the optimal radiation dose/fractionation remains elusive. This study reviewed current evidence and explored the dose-response relationship in patients with LS-SCLC who were treated with radiochemotherapy. A quantitative analysis was performed through a systematic search of PubMed, Web of Science, and the Cochrane Library. The correlations between the biological effective dose (BED) and median overall survival (mOS), median progression-free survival (mPFS), 1-, 3-, and 5-year overall survival (OS) as well as local relapse (LR) were evaluated. In all, 2389 patients in 19 trials were included in this study. Among these 19 trials, seven were conducted in Europe, eight were conducted in Asia and four were conducted in the United States. The 19 trials that were included consisted of 29 arms with 24 concurrent and 5 sequential TRT arms. For all included studies, ...
Scientific reports, 2016
Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultraf... more Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultrafast sciences, material science, and biology, etc. In this paper, two types of carbon nano-materials, i.e. single-wall carbon nanotube (SWNT) and graphene oxide (GO), are investigated as efficient saturable absorbers (SAs) to achieve low phase noise mode-locked fiber lasers. Various properties of these wall-paper SAs, such as saturable intensity, optical absorption and degree of purity, are found to be key factors determining the performance of the ultrafast pulses. Reduced-noise femtosecond fiber lasers based on such carbon-based SAs are experimentally demonstrated, for which the phase noise has been reduced by more than 10 dB for SWNT SAs and 8 dB for GO SAs at 10 kHz. To the best of our knowledge, this is the first investigation on the relationship between different carbon material based SAs and the phase noise of mode-locked lasers. This work paves the way to generate high-quality low...
Molecular cancer therapeutics, Jan 2, 2016
Lung cancer is a leading cause of cancer mortality worldwide, and concurrent chemoradiotherapy ha... more Lung cancer is a leading cause of cancer mortality worldwide, and concurrent chemoradiotherapy has been explored as a therapeutic option. However, the chemotherapeutic agents cannot be administered for most patients at full doses safely with radical doses of thoracic radiation, and further optimizations of chemotherapy regimen to be given with radiation are needed. In this study, we examined the effects of suberoylanilide hydroxamic acid (SAHA) and cisplatin on DNA damage repairs, and determined the combination effects of SAHA and cisplatin on human non-small-cell lung cancer (NSCLC) cells in response to treatment of ionizing radiation (IR), and on tumor growth of lung cancer H460 xenograft receiving radiotherapy. We also investigated the potential differentiation effect of SAHA and its consequences on cancer cell invasion. Our results showed that SAHA and cisplatin compromise distinct DNA damage repair pathways, and treatment with SAHA enhanced synergistic radiosensitization effect...
Pathology oncology research : POR, Jan 9, 2015
Anti-PD-1/PD-L1 antibodies showed satisfactory efficacy in treating non-small-cell lung cancer. W... more Anti-PD-1/PD-L1 antibodies showed satisfactory efficacy in treating non-small-cell lung cancer. We conducted this meta-analysis to explore the advantage subtypes and best therapeutic modalities of Anti-PD-1/PD-L1 therapy on NSCLC. A quantitative meta-analysis was performed through a systematic search in PubMed, Web of Science, and the Cochrane Library. The pooled ORR, 6-month progression-free survival rate (PFSR6m), and 1-year overall survival rate (OSR1y) were calculated and compared. 15 trials were included in this meta-analysis. Our analyses demonstrated the pooled ORR of 1st line and 2nd or more line anti-PD-1/PD-L1 therapy were 36.5 % (21.9-51.0 %) and 17.0 % (14.3-19.7 %), respectively. While the difference was significant (Z = 3.31, p < 0.001). The pooled ORR for non-squamous and squamous cell lung cancer were 18.5 % (16.0-21.1 %) and 17.9 % (14.4-21.5 %), respectively. The difference was not significant (Z = 0.27, p = 0.791). The pooled ORR for PD-L1 positive and negative...
The Australasian journal of dermatology, Jan 27, 2015
We describe two rarely documented cases of telangiectasia macularis multiplex acquisita (TMMA) wi... more We describe two rarely documented cases of telangiectasia macularis multiplex acquisita (TMMA) with a history of hepatitis B infection. Both patients presented with multiple erythematous macules and telangiectasia on bilateral upper arms and the upper part of the trunk. Patient 1 also had spider naevi on the upper part of the chest and palmar erythema; thus we inferred that TMMA, like spider naevi and palmar erythema, might belong to the spectrum of vascular changes of liver diseases.
We demonstrate a novel bidirectional fiber laser mode-locked with two semiconductor saturable abs... more We demonstrate a novel bidirectional fiber laser mode-locked with two semiconductor saturable absorber mirrors (SESAMs) incorporated into the laser cavity through a four-port circulator. The laser allows the generation of two independent countercirculating mode-locked pulse trains, each with individual fundamental repetition. In the experiment, two countercirculating pulse trains, with repetition rate of 21.3 MHz and 15.2 MHz, respectively, are obtained simultaneously. By controlling the intracavity loss imposed on these two pulse trains, either one of the two pulse trains can be switched on or off.
Optics express, Jan 4, 2015
Two-dimensional (2D) nanomaterials, especially the transition metal sulfide semiconductors, have ... more Two-dimensional (2D) nanomaterials, especially the transition metal sulfide semiconductors, have drawn great interests due to their potential applications in viable photonic and optoelectronic devices. In this work, 2D tungsten disulfide…
Optics express, Jan 12, 2015
We investigate the timing phase noise of fiber lasers mode locked by graphene oxide (GO) and carb... more We investigate the timing phase noise of fiber lasers mode locked by graphene oxide (GO) and carbon nanotubes (CNTs), respectively, integrated in a linear cavity fiber laser in the reflecting operation. Due to the shorter decay time of the GO and CNTs, weaker slow saturable absorber effects are expected and mode-locked lasers based on these two saturable absorbers exhibit low excess timing phase noise coupled from the laser intensity noise. Compared with a reference laser mode locked by semiconductor saturable absorber mirror (SESAM), GO based laser obtains a timing phase noise reduction of 7 dB at 1 kHz and a timing jitter reduction of 45% experimentally whereas CNTs based laser obtains a timing phase noise reduction of 3 dB and a timing jitter reduction of 29%. This finding suggests that saturable absorbers with short decay time have the potential for achieving mode locking operation with low timing phase noise, which is important for applications including frequency metrology, hi...
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010
CLEO:2011 - Laser Applications to Photonic Applications, 2011
The noise conversion from the relative intensity noise to the phase noise in the microwave synthe... more The noise conversion from the relative intensity noise to the phase noise in the microwave synthesis (photodetection process) from mode-locked lasers is investigated and is found to decrease as 1/f with the noise frequency. OCIS codes: (140.4050) Mode-locked lasers; (270.2500) Fluctuations, relaxations, and noise; Mode-locked lasers with low relative intensity noise (RIN) and phase noise attract intense interest for various
International journal of clinical and experimental pathology, 2014
Glyoxalase 1 (Glo1) gene aberrations is associated with tumorigenesis and progression in numerous... more Glyoxalase 1 (Glo1) gene aberrations is associated with tumorigenesis and progression in numerous cancers. In this study, we explored the role of Glo1 genetic amplification and expression in Chinese patients with hepatocellular carcinoma (HCC), and Glo1 genetic amplification as potential therapeutic target for HCC. We used fluorescence in situ hybridization (FISH) analysis and qRT-PCR to examine Glo1 genetic aberrations and Glo1 mRNA expression in paired tumor samples obtained from HCC patients. Glo1 genetic amplification was identified in a subset of HCC patient (6%, 3/50), and up-regulation of Glo1 expression was found in 48% (24/50) of tumor tissues compared with adjacent non-tumorous tissues. Statistic analysis showed that Glo1-upregulation significantly correlated with high serum level of alpha-fetoprotein (AFP). Interfering Glo1 expression with shRNA knocking-down led to significant inhibition of cell growth and induced apoptosis in primarily cultured HCC cells carrying geneti...
Oncotarget, Jan 21, 2015
Afatinib is a second-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibi... more Afatinib is a second-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and has shown a significant clinical benefit in non-small cell lung cancer (NSCLC) patients with EGFR-activating mutations. However, the potential therapeutic effects of afatinib combining with other modalities, including ionizing radiation (IR), are not well understood. In this study, we developed a gefitinib-resistant cell subline (PC-9-GR) with a secondary EGFR mutation (T790M) from NSCLC PC-9 cells after chronic exposures to increasing doses of gefitinib. The presence of afatinib significantly increases the cell killing effect of radiation in PC-9-GR cells harboring acquired T790M, but not in H1975 cells with de novo T790M or in H460 cells that express wild-type EGFR. In PC-9-GR cells, afatinib remarkable blocks baseline of EGFR and ERK phosphorylations, and causes delay of IR-induced AKT phosphorylation. Afatinib treatment also leads to increased apoptosis and suppressed DNA dam...
Phase noise is very important for the ultrafast pulse application in telecommunication, ultrafast... more Phase noise is very important for the ultrafast pulse application in telecommunication, ultrafast diagnose, material science, and biology. In this paper, two types of carbon nano-materials, single-wall carbon nanotube and graphene oxide, are investigated for noise suppression in ultrafast photonics. Various properties of the wall-paper SAs, such as saturable intensity, optical absorption and degree of purity, are found to be key factors determining the phase noise of the ultrafast pulses. A reduced-noise femtosecond fiber laser is experimentally demonstrated by optimizing the above parameters of carbon material based SAs.
Physical Review X, 2015
Measurement of a topological edge invariant in a microwave network JASON C. PILLAY, WENCHAO HU, N... more Measurement of a topological edge invariant in a microwave network JASON C. PILLAY, WENCHAO HU, Nanyang Technological University, KAN WU, Shanghai Jiao Tong University, MICHAEL PASEK, PERRY PING SHUM, YIDONG CHONG, Nanyang Technological University -We report on the experimental measurement of topological edge invariants in an electromagnetic analog of a topological insulator, realized by a classical microwave network. This experiment serves as a classical electromagnetic realization of Laughlin's "topological pumping" thought experiment for the quantum Hall effect. The experiment consists of determining the electromagnetic scattering matrix, based on the input and output wave amplitudes measured at the edges of the network via a network analyzer. The winding on the scattering matrix eigenvalues, resulting from a tunable phase shift built into the network, forms a topological invariant. We demonstrate the existence of a topologically trivial phase, where the winding is zero (no edge states), as well as a topologically nontrivial phase, where the winding is non-zero (topological edge states present). Unlike most other systems used to study topological insulator physics, the full complex scattering parameters can be measured in this setup. As in most microwave experiments, however, our system is susceptible to losses. We show that topological behavior can be meaningfully defined in the experiment despite the effects of loss.
PLoS ONE, 2013
Histone deacetylase inhibitors (HDIs) have shown promise as candidate radiosensitizer for many ty... more Histone deacetylase inhibitors (HDIs) have shown promise as candidate radiosensitizer for many types of cancers. However, the mechanisms of action are not well understood, and whether they could have clinical impact on radiotherapy for leukemia is unclear. In this study, we demonstrate that suberoylanilide hydroxamic acid (SAHA) can increase radiosensitivity of acute myeloid leukemia (AML) cells through posttranslational modification of Rad51 protein responses and selective inhibition of the homology-directed repair (HDR) pathway. Our data also showed that AML cells with mutant, constitutively active FMS-like tyrosine kinase-3 (FLT3) were more radiation sensitive, caused by compromised non-homologous end joining (NHEJ) repair. Furthermore, SAHA-induced radiosensitization were enhanced in AML cells with expression of these FLT3 mutants. The results of this study suggest that SAHA, a recently approved HDI in clinical trials, may act as a candidate component for novel conditioning regimens to improve efficacy for AML patients undergoing radiotherapy and chemotherapy.
2010 Photonics Global Conference, 2010
We experimentally demonstrate an erbium-doped fiber laser which is passively mode-locked by Singl... more We experimentally demonstrate an erbium-doped fiber laser which is passively mode-locked by Single-Wall Carbon Nanotubes (SWCNTs) saturable absorber. Generating 600 fs pulses at 120 MHz repetition rate, this laser exhibits a low rms timing jitter of 35 fs [10 Hz, 10 MHz]. To the best of our knowledge, this is the lowest timing jitter observed from a fiber laser passively
Optics Communications, 2015
ABSTRACT
2008 Winter Simulation Conference, Vols 1-5, 2008
Queueing theory is a well-known method for evaluating the performance of manufacturing systems. W... more Queueing theory is a well-known method for evaluating the performance of manufacturing systems. When we want to analyze the performance of a single machine, M/M/1 queues or approximations of G/G/1 queues often are considered a proper choice. However, due to the complex nature of interruptions in manufacturing, the appropriate model should be selected carefully. This paper proposes a systematic way to classify different kinds of interruptions seen in a single machine system. Queueing models for each category are proposed, and event classifications are compared from both the SEMI E10 and queueing theory points of view.
Ieee Photonics Journal, 2011
We experimentally demonstrate an all-fiber erbium-doped fiber laser operating in the large normal... more We experimentally demonstrate an all-fiber erbium-doped fiber laser operating in the large normal dispersion regime. The laser is mode-locked by use of nonlinear polarization rotation and generates dissipative solitons (DSs) with large positive chirp and steep spectral edges. Within the cavity, there is no additional spectral filter used for self-starting and stabilizing the mode-locking of the laser. The output DSs have a duration of 30.5 ps with pulse energies up to 12 nJ, which can be compressed externally to 240 fs.
Passive Components and Fiber-Based Devices Viii, 2011
A novel ring fiber laser based on Er-doped photonic crystal fiber (EDPCF) is demonstrated. EDPCF ... more A novel ring fiber laser based on Er-doped photonic crystal fiber (EDPCF) is demonstrated. EDPCF is used as gain medium to implement stable CW operation. The laser output wavelength can be continuously tuned over the range from 1529 to 1535 nm by adjusting the polarization state of the light inside the cavity. Stable dual-wavelength CW operation is also observed with
PloS one, 2016
Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell ... more Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell lung cancer (LS-SCLC). However, the optimal radiation dose/fractionation remains elusive. This study reviewed current evidence and explored the dose-response relationship in patients with LS-SCLC who were treated with radiochemotherapy. A quantitative analysis was performed through a systematic search of PubMed, Web of Science, and the Cochrane Library. The correlations between the biological effective dose (BED) and median overall survival (mOS), median progression-free survival (mPFS), 1-, 3-, and 5-year overall survival (OS) as well as local relapse (LR) were evaluated. In all, 2389 patients in 19 trials were included in this study. Among these 19 trials, seven were conducted in Europe, eight were conducted in Asia and four were conducted in the United States. The 19 trials that were included consisted of 29 arms with 24 concurrent and 5 sequential TRT arms. For all included studies, ...
Scientific reports, 2016
Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultraf... more Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultrafast sciences, material science, and biology, etc. In this paper, two types of carbon nano-materials, i.e. single-wall carbon nanotube (SWNT) and graphene oxide (GO), are investigated as efficient saturable absorbers (SAs) to achieve low phase noise mode-locked fiber lasers. Various properties of these wall-paper SAs, such as saturable intensity, optical absorption and degree of purity, are found to be key factors determining the performance of the ultrafast pulses. Reduced-noise femtosecond fiber lasers based on such carbon-based SAs are experimentally demonstrated, for which the phase noise has been reduced by more than 10 dB for SWNT SAs and 8 dB for GO SAs at 10 kHz. To the best of our knowledge, this is the first investigation on the relationship between different carbon material based SAs and the phase noise of mode-locked lasers. This work paves the way to generate high-quality low...
Molecular cancer therapeutics, Jan 2, 2016
Lung cancer is a leading cause of cancer mortality worldwide, and concurrent chemoradiotherapy ha... more Lung cancer is a leading cause of cancer mortality worldwide, and concurrent chemoradiotherapy has been explored as a therapeutic option. However, the chemotherapeutic agents cannot be administered for most patients at full doses safely with radical doses of thoracic radiation, and further optimizations of chemotherapy regimen to be given with radiation are needed. In this study, we examined the effects of suberoylanilide hydroxamic acid (SAHA) and cisplatin on DNA damage repairs, and determined the combination effects of SAHA and cisplatin on human non-small-cell lung cancer (NSCLC) cells in response to treatment of ionizing radiation (IR), and on tumor growth of lung cancer H460 xenograft receiving radiotherapy. We also investigated the potential differentiation effect of SAHA and its consequences on cancer cell invasion. Our results showed that SAHA and cisplatin compromise distinct DNA damage repair pathways, and treatment with SAHA enhanced synergistic radiosensitization effect...
Pathology oncology research : POR, Jan 9, 2015
Anti-PD-1/PD-L1 antibodies showed satisfactory efficacy in treating non-small-cell lung cancer. W... more Anti-PD-1/PD-L1 antibodies showed satisfactory efficacy in treating non-small-cell lung cancer. We conducted this meta-analysis to explore the advantage subtypes and best therapeutic modalities of Anti-PD-1/PD-L1 therapy on NSCLC. A quantitative meta-analysis was performed through a systematic search in PubMed, Web of Science, and the Cochrane Library. The pooled ORR, 6-month progression-free survival rate (PFSR6m), and 1-year overall survival rate (OSR1y) were calculated and compared. 15 trials were included in this meta-analysis. Our analyses demonstrated the pooled ORR of 1st line and 2nd or more line anti-PD-1/PD-L1 therapy were 36.5 % (21.9-51.0 %) and 17.0 % (14.3-19.7 %), respectively. While the difference was significant (Z = 3.31, p < 0.001). The pooled ORR for non-squamous and squamous cell lung cancer were 18.5 % (16.0-21.1 %) and 17.9 % (14.4-21.5 %), respectively. The difference was not significant (Z = 0.27, p = 0.791). The pooled ORR for PD-L1 positive and negative...
The Australasian journal of dermatology, Jan 27, 2015
We describe two rarely documented cases of telangiectasia macularis multiplex acquisita (TMMA) wi... more We describe two rarely documented cases of telangiectasia macularis multiplex acquisita (TMMA) with a history of hepatitis B infection. Both patients presented with multiple erythematous macules and telangiectasia on bilateral upper arms and the upper part of the trunk. Patient 1 also had spider naevi on the upper part of the chest and palmar erythema; thus we inferred that TMMA, like spider naevi and palmar erythema, might belong to the spectrum of vascular changes of liver diseases.
We demonstrate a novel bidirectional fiber laser mode-locked with two semiconductor saturable abs... more We demonstrate a novel bidirectional fiber laser mode-locked with two semiconductor saturable absorber mirrors (SESAMs) incorporated into the laser cavity through a four-port circulator. The laser allows the generation of two independent countercirculating mode-locked pulse trains, each with individual fundamental repetition. In the experiment, two countercirculating pulse trains, with repetition rate of 21.3 MHz and 15.2 MHz, respectively, are obtained simultaneously. By controlling the intracavity loss imposed on these two pulse trains, either one of the two pulse trains can be switched on or off.
Optics express, Jan 4, 2015
Two-dimensional (2D) nanomaterials, especially the transition metal sulfide semiconductors, have ... more Two-dimensional (2D) nanomaterials, especially the transition metal sulfide semiconductors, have drawn great interests due to their potential applications in viable photonic and optoelectronic devices. In this work, 2D tungsten disulfide…
Optics express, Jan 12, 2015
We investigate the timing phase noise of fiber lasers mode locked by graphene oxide (GO) and carb... more We investigate the timing phase noise of fiber lasers mode locked by graphene oxide (GO) and carbon nanotubes (CNTs), respectively, integrated in a linear cavity fiber laser in the reflecting operation. Due to the shorter decay time of the GO and CNTs, weaker slow saturable absorber effects are expected and mode-locked lasers based on these two saturable absorbers exhibit low excess timing phase noise coupled from the laser intensity noise. Compared with a reference laser mode locked by semiconductor saturable absorber mirror (SESAM), GO based laser obtains a timing phase noise reduction of 7 dB at 1 kHz and a timing jitter reduction of 45% experimentally whereas CNTs based laser obtains a timing phase noise reduction of 3 dB and a timing jitter reduction of 29%. This finding suggests that saturable absorbers with short decay time have the potential for achieving mode locking operation with low timing phase noise, which is important for applications including frequency metrology, hi...
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010
CLEO:2011 - Laser Applications to Photonic Applications, 2011
The noise conversion from the relative intensity noise to the phase noise in the microwave synthe... more The noise conversion from the relative intensity noise to the phase noise in the microwave synthesis (photodetection process) from mode-locked lasers is investigated and is found to decrease as 1/f with the noise frequency. OCIS codes: (140.4050) Mode-locked lasers; (270.2500) Fluctuations, relaxations, and noise; Mode-locked lasers with low relative intensity noise (RIN) and phase noise attract intense interest for various
International journal of clinical and experimental pathology, 2014
Glyoxalase 1 (Glo1) gene aberrations is associated with tumorigenesis and progression in numerous... more Glyoxalase 1 (Glo1) gene aberrations is associated with tumorigenesis and progression in numerous cancers. In this study, we explored the role of Glo1 genetic amplification and expression in Chinese patients with hepatocellular carcinoma (HCC), and Glo1 genetic amplification as potential therapeutic target for HCC. We used fluorescence in situ hybridization (FISH) analysis and qRT-PCR to examine Glo1 genetic aberrations and Glo1 mRNA expression in paired tumor samples obtained from HCC patients. Glo1 genetic amplification was identified in a subset of HCC patient (6%, 3/50), and up-regulation of Glo1 expression was found in 48% (24/50) of tumor tissues compared with adjacent non-tumorous tissues. Statistic analysis showed that Glo1-upregulation significantly correlated with high serum level of alpha-fetoprotein (AFP). Interfering Glo1 expression with shRNA knocking-down led to significant inhibition of cell growth and induced apoptosis in primarily cultured HCC cells carrying geneti...
Oncotarget, Jan 21, 2015
Afatinib is a second-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibi... more Afatinib is a second-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and has shown a significant clinical benefit in non-small cell lung cancer (NSCLC) patients with EGFR-activating mutations. However, the potential therapeutic effects of afatinib combining with other modalities, including ionizing radiation (IR), are not well understood. In this study, we developed a gefitinib-resistant cell subline (PC-9-GR) with a secondary EGFR mutation (T790M) from NSCLC PC-9 cells after chronic exposures to increasing doses of gefitinib. The presence of afatinib significantly increases the cell killing effect of radiation in PC-9-GR cells harboring acquired T790M, but not in H1975 cells with de novo T790M or in H460 cells that express wild-type EGFR. In PC-9-GR cells, afatinib remarkable blocks baseline of EGFR and ERK phosphorylations, and causes delay of IR-induced AKT phosphorylation. Afatinib treatment also leads to increased apoptosis and suppressed DNA dam...
Phase noise is very important for the ultrafast pulse application in telecommunication, ultrafast... more Phase noise is very important for the ultrafast pulse application in telecommunication, ultrafast diagnose, material science, and biology. In this paper, two types of carbon nano-materials, single-wall carbon nanotube and graphene oxide, are investigated for noise suppression in ultrafast photonics. Various properties of the wall-paper SAs, such as saturable intensity, optical absorption and degree of purity, are found to be key factors determining the phase noise of the ultrafast pulses. A reduced-noise femtosecond fiber laser is experimentally demonstrated by optimizing the above parameters of carbon material based SAs.
Physical Review X, 2015
Measurement of a topological edge invariant in a microwave network JASON C. PILLAY, WENCHAO HU, N... more Measurement of a topological edge invariant in a microwave network JASON C. PILLAY, WENCHAO HU, Nanyang Technological University, KAN WU, Shanghai Jiao Tong University, MICHAEL PASEK, PERRY PING SHUM, YIDONG CHONG, Nanyang Technological University -We report on the experimental measurement of topological edge invariants in an electromagnetic analog of a topological insulator, realized by a classical microwave network. This experiment serves as a classical electromagnetic realization of Laughlin's "topological pumping" thought experiment for the quantum Hall effect. The experiment consists of determining the electromagnetic scattering matrix, based on the input and output wave amplitudes measured at the edges of the network via a network analyzer. The winding on the scattering matrix eigenvalues, resulting from a tunable phase shift built into the network, forms a topological invariant. We demonstrate the existence of a topologically trivial phase, where the winding is zero (no edge states), as well as a topologically nontrivial phase, where the winding is non-zero (topological edge states present). Unlike most other systems used to study topological insulator physics, the full complex scattering parameters can be measured in this setup. As in most microwave experiments, however, our system is susceptible to losses. We show that topological behavior can be meaningfully defined in the experiment despite the effects of loss.
PLoS ONE, 2013
Histone deacetylase inhibitors (HDIs) have shown promise as candidate radiosensitizer for many ty... more Histone deacetylase inhibitors (HDIs) have shown promise as candidate radiosensitizer for many types of cancers. However, the mechanisms of action are not well understood, and whether they could have clinical impact on radiotherapy for leukemia is unclear. In this study, we demonstrate that suberoylanilide hydroxamic acid (SAHA) can increase radiosensitivity of acute myeloid leukemia (AML) cells through posttranslational modification of Rad51 protein responses and selective inhibition of the homology-directed repair (HDR) pathway. Our data also showed that AML cells with mutant, constitutively active FMS-like tyrosine kinase-3 (FLT3) were more radiation sensitive, caused by compromised non-homologous end joining (NHEJ) repair. Furthermore, SAHA-induced radiosensitization were enhanced in AML cells with expression of these FLT3 mutants. The results of this study suggest that SAHA, a recently approved HDI in clinical trials, may act as a candidate component for novel conditioning regimens to improve efficacy for AML patients undergoing radiotherapy and chemotherapy.
2010 Photonics Global Conference, 2010
We experimentally demonstrate an erbium-doped fiber laser which is passively mode-locked by Singl... more We experimentally demonstrate an erbium-doped fiber laser which is passively mode-locked by Single-Wall Carbon Nanotubes (SWCNTs) saturable absorber. Generating 600 fs pulses at 120 MHz repetition rate, this laser exhibits a low rms timing jitter of 35 fs [10 Hz, 10 MHz]. To the best of our knowledge, this is the lowest timing jitter observed from a fiber laser passively
Optics Communications, 2015
ABSTRACT
2008 Winter Simulation Conference, Vols 1-5, 2008
Queueing theory is a well-known method for evaluating the performance of manufacturing systems. W... more Queueing theory is a well-known method for evaluating the performance of manufacturing systems. When we want to analyze the performance of a single machine, M/M/1 queues or approximations of G/G/1 queues often are considered a proper choice. However, due to the complex nature of interruptions in manufacturing, the appropriate model should be selected carefully. This paper proposes a systematic way to classify different kinds of interruptions seen in a single machine system. Queueing models for each category are proposed, and event classifications are compared from both the SEMI E10 and queueing theory points of view.
Ieee Photonics Journal, 2011
We experimentally demonstrate an all-fiber erbium-doped fiber laser operating in the large normal... more We experimentally demonstrate an all-fiber erbium-doped fiber laser operating in the large normal dispersion regime. The laser is mode-locked by use of nonlinear polarization rotation and generates dissipative solitons (DSs) with large positive chirp and steep spectral edges. Within the cavity, there is no additional spectral filter used for self-starting and stabilizing the mode-locking of the laser. The output DSs have a duration of 30.5 ps with pulse energies up to 12 nJ, which can be compressed externally to 240 fs.
Passive Components and Fiber-Based Devices Viii, 2011
A novel ring fiber laser based on Er-doped photonic crystal fiber (EDPCF) is demonstrated. EDPCF ... more A novel ring fiber laser based on Er-doped photonic crystal fiber (EDPCF) is demonstrated. EDPCF is used as gain medium to implement stable CW operation. The laser output wavelength can be continuously tuned over the range from 1529 to 1535 nm by adjusting the polarization state of the light inside the cavity. Stable dual-wavelength CW operation is also observed with