Kapil Kanwar - Academia.edu (original) (raw)

Papers by Kapil Kanwar

Der Pharmacia Lettre, 2013

The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac)... more The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac) on 5aminosalicylic acid and prednisolone release from tablets to optimize the coating concentration for colonic delivery. Coating formulation was designed based on the full factorial design. Two indecent variables were used in different concentrations by factorial design. In-vitro dissolution studies, it was found that formulation G4 showed 99.26% of 5-ASA in 18 hours and 99.48% of prednisolone in 24 hours, which lies within the acceptance criteria of 80%. That study conclude that the 1% coating concentration of shellac on inner and 10% coating concentration of Eudragit S100 shows the complete release of drugs to colon for treatment of ulcerative colitis.

Der Pharmacia Lettre, 2013

The present investigation was undertaken to fabricate modified transport psoralen transdermal spr... more The present investigation was undertaken to fabricate modified transport psoralen transdermal spray using ethyl cellulose as film-forming polymer and to carry out in vitro characterization of an optimized formulation. Formulated Topical spray was evaluated by pH, clarity of solution, spray pattern, area covered by each spray, dermal adhesion of film, flexibility of film, water washability of film, leakage from container, average weight of formulation per metered dose (or per spray), drug content per spray, film formation time, in vitro drug transport, drug content uniformity after 10 th spray, 15 th spray, 30 th spray, 40 th spray and viscosity. Batch F1 containing ethyl cellulose (4%) and polyethylene glycol (0.25%) was found to give good clarity of solution, evaporation rate, spray pattern, and tackiness of the film. Diffusion studies of the optimized formulation through the semipermeable membrane showed the release of drug to the extent 50% over a period of 6 hours. Stability studies were conducted as per ICH guidelines and indicated that formulation was stable. Skin irritation studies were performed using rat as an animal model. The results obtained show that the transdermal spray can be a promising and innovative therapeutic system for the transdermal administration of psoralen.

Grocery shopping can be a hassle, and remembering exactly what to buy can be even more trying. Th... more Grocery shopping can be a hassle, and remembering exactly what to buy can be even more trying. This project developed the technology behind an Internet of Things enabled pantry. Integrated with cloud computing, the technology would monitor the pantry and alert the user, either via text or a webapp, about shortages and recommend products for a grocery list. The system uses an Arduino microcontroller to collect weight information about products in the pantry, a Raspberry Pi microcomputer equipped with a camera to take pictures of the pantry, and a gateway server to process this information to be sent to the central server. Smart pantry uses various Python libraries such as PiCamera to operate the camera, ZBar to read and recognize barcodes, and OpenCV to process the images. Smart pantry also uses application programming interfaces (APIs) such as Twilio to text the user and Walmart’s API to get information to recommend products. For an initial $300 for a home smart pantry and gateway a...

In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosa... more In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosage forms. Disputes like patient consistence, drug focusing on, neighborhood reactions, successive organization and vacillations in blood fixation levels, connected with their partners, the routine measurements structures were amended. Several of the pharmaceutical dosage form are formulated as controlled release dosage form to delay the release of a therapeutic agent such that its appearance in the systemic course is delayed and its plasma profile is managed in term. Tablets offer the least cost way to deal with controlled sustained release dosage forms. Matrix tablet as controlled discharge has given another leap forward for novel medication conveyance framework in the field of pharmaceutical innovation. This review concentrates on the different sorts of lattice frameworks in light of polymer utilized and porosity of network framework i.e. hydrophilic, hydrophobic, fat wax, permeable, n...

Mouth dissolving tablets are increasing more conspicu-ousness as a novel medication conveyance fr... more Mouth dissolving tablets are increasing more conspicu-ousness as a novel medication conveyance framework and develops as one of the prevalent and broadly acknowledged measurement shapes, particularly for pe-diatric patients in light of fragmented advancement of solid and sensory system and if there should be an occurrence of geriatric patients experiencing Parkinson's issue or hand tremors, frames like tablets and cases are presently days confronting the issues like dysphagia, bringing about the high incidence of rebelliousness and making the treatment incapable. From both pharmaceutical commercial enterprises as well as patients since they are advantageous to be fabricated and controlled, free of side impacts, offering quick discharge and improve bioavailability, in order to accomplish better patient compliance. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late analys...

Traditional Medicines derived from therapeutic plants are utilized by around 60% of the total pop... more Traditional Medicines derived from therapeutic plants are utilized by around 60% of the total populace. This review focuses on Herbal medications and plants utilized as a part of the treatment of diabetes, particularly in India. Plants have dependably been a wellspring of medications for people since time immemorial. The Indian customary arrangement of pharmaceutical is packed with the utilization of plants for the administration of diabetic conditions. The World Health Organization (WHO) has recorded 21,000 plants, which are utilized for therapeutic purposes far and wide. Natural meds have been exceedingly regarded source of prescription all through the mankind's history. Various studies have affirmed the advantages of therapeutic plants with hostile to hyper-glycemic impacts in the administration of diabetes mellitus. History demonstrated that therapeutic plants have been utilized as a part of customary recuperating far and wide for quite a while to treat diabetes; this is on ...

In this era of innovation and advancement in drug delivery for better clinical effects convention... more In this era of innovation and advancement in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated automation in manufacturing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In-lay tablet,

Various types of lipid based vesicular systems have been developed in controlled and targeted dru... more Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery. Self assembled nanoparticles (SAN) has advantages over traditional colloidal vesicular systems and also avoids some of their major disadvantages. SAN made of solid lipids are submicron colloidal carriers (50-1000nm). These consist of a solid hydrophobic core having a monolayer of phospholipid coating. The solid core contains drug dissolved or dispersed in the solid high melting fat matrix. The hydrophobic chains of phospholipids are embedded in the fat matrix. The outstanding characteristic of SAN is that they are nearly or wholly composed of ampiphillic prodrug. Serious drawbacks of the drugs could be effectively circumvented by covalent linkage of the drug to fatty acids. These lipidic prodrugs, if provided with some surface active property, tend to form supramolecular assemblages in aqueous media. They provide an efficient method for delivery of drugs directly to the targe...

Indian Journal of Pharmacy and Pharmacology, 2021

Proton pump inhibitors (PPIs) were clinically introduced a few years ago and have since become an... more Proton pump inhibitors (PPIs) were clinically introduced a few years ago and have since become an important, safe, and successful treatment for a variety of corrosive-related issues. To specifically overcome these limitations, longer-acting PPIs and innovation to draw out ordinary PPI action have been created, which may improve clinical outcomes. PPIs are identified by their pharmacokinetic properties, digestion, and clinical indications that have been approved by the Food and Drug Administration (FDA).

The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac)... more The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac) on 5- aminosalicylic acid and prednisolone release from tablets to optimize the coating concentration for colonic delivery. Coating formulation was designed based on the full factorial design. Two indecent variables were used in different concentrations by factorial design. In-vitro dissolution studies, it was found that formulation G4 showed 99.26% of 5-ASA in 18 hours and 99.48% of prednisolone in 24 hours, which lies within the acceptance criteria of 80%. That study conclude that the 1% coating concentration of shellac on inner and 10% coating concentration of Eudragit S100 shows the complete release of drugs to colon for treatment of ulcerative colitis.

Excipients are additives used to convert active pha rmaceutical ingredients into dosage forms sui... more Excipients are additives used to convert active pha rmaceutical ingredients into dosage forms suitable for administration to patients. New and mo dified excipients continue to emerge with better drug delivery performance. Synthetic polymer s offer a broad range of properties that can be reasonably well “built-in” by design and modifie d by altering polymer characteristics. Excipients of natural origin are of particular inte rest to us for reasons of reliability, sustainability and avoiding reliance upon materials derived from fossil fuels. Plant products are therefore attractive alternatives to synthetic prod ucts because of biocompatibility, low toxicity, environmental “friendliness”, and low price compare d to synthetic products. Excipients from natural products are also generally non-polluting r enewable sources for the sustainable supply of economical pharmaceutical products.

The purpose of the present study was to prepare & characterize the colon targeted matrix tablet o... more The purpose of the present study was to prepare & characterize the colon targeted matrix tablet of dexamethasone for treatment and management of inflammation in colon cancer. The matrix tablet was prepared by wet granulation method. The matrix tablet was then coated with different concentration of shellac solution by dip coating method to prevent drug release in stomach. The prepared matrix tablets were evaluated for hardness, weight variation, friability and (in-vitro) dissolution. The in-vitro drug release of different formulation was found to be minimum 84.84±2.16 and maximum 99.41 ±0.96. The formulation F5 shows best result in in-vitro drug release.

INTRODUCTION Cancer is one of the major public health problems worldwide prevalence of cancer is ... more INTRODUCTION Cancer is one of the major public health problems worldwide prevalence of cancer is known to vary from region to region. The idea behind Microspheres forColon specific drug delivery system is intended because it may reduce the Systemic side effect because of low dose of the drug. The absorption of the poorly absorbed drug is increase because of increase retention time in the colon. (Vyas S.Pet al, 2002,CherukuriSowmyaet al., 2012). Dexamethasone is used in reducing the inflammation in colon cancer.The aim of the study was to develop colon targeted Matrix tablets of dexamethsone using Chitosan and xanthan gum as carriers in the treatment of colon cancer. Significance of this Research Investigation Increase the absorption and bioavailability of the drug via delayed release formulation.Utilize the nontoxic and biodegradable nature of Chitosan and Xanthan gum that makes it safer for patients as compared to other synthetic polymers it is also economical. Reduce the dose and administration frequency.Reduce the incidences of adverse drug reaction. MATERIALS AND METHODS Dexamethasone, Chitosan and Xanthan Gum was purchased from the balaji pharmaceutical Pvt.Ltd. The Shellac was obtained from the central drug store.

Journal of Pharmaceutical Research International, 2021

Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics ... more Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics for Esomeprazole magnesium; to establish its inherent properties qualitatively & quantitatively. Methods: Esomeprazole magnesium was analyzed using various traditional & modern analytical and investigative tools viz FTIR, HPLC, UV spectroscopy, X-ray diffraction, zetasizer. Results: The absorption maxima were found at 301 nm with UV Spectrophotometric and HPLC analysis. The particle size of the drug was analyzed through Malvern zetasizer employing water as diluent and found to be 11.818 µm. The quantitative solubility of Esomeprazole magnesium was predicted in various solvents at 25 0C and found that it was most soluble in methanol and was least soluble in distilled water. Solubility was also found to be pH-dependent. Solubility increases with an increase in pH. The order of solubility determined was; Methanol (1.214 mg/ml) > Phosphate buffer pH- 7.4 (0.521 mg/ml) > Simulated Intes...

Colors are capable of influencing many aspects of our lives, including our mood, mental state and... more Colors are capable of influencing many aspects of our lives, including our mood, mental state and energy level. According to color therapy, each color is thought to be associated with one of seven energy centers. The method of color therapy is based on the law of resonant colors interaction, conterminous to frequency characteristics of body. Colored light can be used directly on the body's health and immune strength, affecting the body and the emotions. It does not alter the material make up of the body, but rather the vibrational aspect, similar to homeopathy. The treatment itself involves the application of colored light to the acupuncture points on the skin with an instrument that resembles a simple penlight. Treatment by color can be performed on finger meridians, on chakras, painting the certain points by the certain color following the laws of colors interaction (and consequently, energies) and thus changing the energy potential (balance) both in the point, and in all meri...

Der Pharmacia Lettre, 2013

The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac)... more The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac) on 5aminosalicylic acid and prednisolone release from tablets to optimize the coating concentration for colonic delivery. Coating formulation was designed based on the full factorial design. Two indecent variables were used in different concentrations by factorial design. In-vitro dissolution studies, it was found that formulation G4 showed 99.26% of 5-ASA in 18 hours and 99.48% of prednisolone in 24 hours, which lies within the acceptance criteria of 80%. That study conclude that the 1% coating concentration of shellac on inner and 10% coating concentration of Eudragit S100 shows the complete release of drugs to colon for treatment of ulcerative colitis.

Der Pharmacia Lettre, 2013

The present investigation was undertaken to fabricate modified transport psoralen transdermal spr... more The present investigation was undertaken to fabricate modified transport psoralen transdermal spray using ethyl cellulose as film-forming polymer and to carry out in vitro characterization of an optimized formulation. Formulated Topical spray was evaluated by pH, clarity of solution, spray pattern, area covered by each spray, dermal adhesion of film, flexibility of film, water washability of film, leakage from container, average weight of formulation per metered dose (or per spray), drug content per spray, film formation time, in vitro drug transport, drug content uniformity after 10 th spray, 15 th spray, 30 th spray, 40 th spray and viscosity. Batch F1 containing ethyl cellulose (4%) and polyethylene glycol (0.25%) was found to give good clarity of solution, evaporation rate, spray pattern, and tackiness of the film. Diffusion studies of the optimized formulation through the semipermeable membrane showed the release of drug to the extent 50% over a period of 6 hours. Stability studies were conducted as per ICH guidelines and indicated that formulation was stable. Skin irritation studies were performed using rat as an animal model. The results obtained show that the transdermal spray can be a promising and innovative therapeutic system for the transdermal administration of psoralen.

Grocery shopping can be a hassle, and remembering exactly what to buy can be even more trying. Th... more Grocery shopping can be a hassle, and remembering exactly what to buy can be even more trying. This project developed the technology behind an Internet of Things enabled pantry. Integrated with cloud computing, the technology would monitor the pantry and alert the user, either via text or a webapp, about shortages and recommend products for a grocery list. The system uses an Arduino microcontroller to collect weight information about products in the pantry, a Raspberry Pi microcomputer equipped with a camera to take pictures of the pantry, and a gateway server to process this information to be sent to the central server. Smart pantry uses various Python libraries such as PiCamera to operate the camera, ZBar to read and recognize barcodes, and OpenCV to process the images. Smart pantry also uses application programming interfaces (APIs) such as Twilio to text the user and Walmart’s API to get information to recommend products. For an initial $300 for a home smart pantry and gateway a...

In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosa... more In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosage forms. Disputes like patient consistence, drug focusing on, neighborhood reactions, successive organization and vacillations in blood fixation levels, connected with their partners, the routine measurements structures were amended. Several of the pharmaceutical dosage form are formulated as controlled release dosage form to delay the release of a therapeutic agent such that its appearance in the systemic course is delayed and its plasma profile is managed in term. Tablets offer the least cost way to deal with controlled sustained release dosage forms. Matrix tablet as controlled discharge has given another leap forward for novel medication conveyance framework in the field of pharmaceutical innovation. This review concentrates on the different sorts of lattice frameworks in light of polymer utilized and porosity of network framework i.e. hydrophilic, hydrophobic, fat wax, permeable, n...

Mouth dissolving tablets are increasing more conspicu-ousness as a novel medication conveyance fr... more Mouth dissolving tablets are increasing more conspicu-ousness as a novel medication conveyance framework and develops as one of the prevalent and broadly acknowledged measurement shapes, particularly for pe-diatric patients in light of fragmented advancement of solid and sensory system and if there should be an occurrence of geriatric patients experiencing Parkinson's issue or hand tremors, frames like tablets and cases are presently days confronting the issues like dysphagia, bringing about the high incidence of rebelliousness and making the treatment incapable. From both pharmaceutical commercial enterprises as well as patients since they are advantageous to be fabricated and controlled, free of side impacts, offering quick discharge and improve bioavailability, in order to accomplish better patient compliance. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late analys...

Traditional Medicines derived from therapeutic plants are utilized by around 60% of the total pop... more Traditional Medicines derived from therapeutic plants are utilized by around 60% of the total populace. This review focuses on Herbal medications and plants utilized as a part of the treatment of diabetes, particularly in India. Plants have dependably been a wellspring of medications for people since time immemorial. The Indian customary arrangement of pharmaceutical is packed with the utilization of plants for the administration of diabetic conditions. The World Health Organization (WHO) has recorded 21,000 plants, which are utilized for therapeutic purposes far and wide. Natural meds have been exceedingly regarded source of prescription all through the mankind's history. Various studies have affirmed the advantages of therapeutic plants with hostile to hyper-glycemic impacts in the administration of diabetes mellitus. History demonstrated that therapeutic plants have been utilized as a part of customary recuperating far and wide for quite a while to treat diabetes; this is on ...

In this era of innovation and advancement in drug delivery for better clinical effects convention... more In this era of innovation and advancement in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated automation in manufacturing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In-lay tablet,

Various types of lipid based vesicular systems have been developed in controlled and targeted dru... more Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery. Self assembled nanoparticles (SAN) has advantages over traditional colloidal vesicular systems and also avoids some of their major disadvantages. SAN made of solid lipids are submicron colloidal carriers (50-1000nm). These consist of a solid hydrophobic core having a monolayer of phospholipid coating. The solid core contains drug dissolved or dispersed in the solid high melting fat matrix. The hydrophobic chains of phospholipids are embedded in the fat matrix. The outstanding characteristic of SAN is that they are nearly or wholly composed of ampiphillic prodrug. Serious drawbacks of the drugs could be effectively circumvented by covalent linkage of the drug to fatty acids. These lipidic prodrugs, if provided with some surface active property, tend to form supramolecular assemblages in aqueous media. They provide an efficient method for delivery of drugs directly to the targe...

Indian Journal of Pharmacy and Pharmacology, 2021

Proton pump inhibitors (PPIs) were clinically introduced a few years ago and have since become an... more Proton pump inhibitors (PPIs) were clinically introduced a few years ago and have since become an important, safe, and successful treatment for a variety of corrosive-related issues. To specifically overcome these limitations, longer-acting PPIs and innovation to draw out ordinary PPI action have been created, which may improve clinical outcomes. PPIs are identified by their pharmacokinetic properties, digestion, and clinical indications that have been approved by the Food and Drug Administration (FDA).

The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac)... more The present work was to evaluate the effects of pH sensitive polymers (Eugragit S100 and Shellac) on 5- aminosalicylic acid and prednisolone release from tablets to optimize the coating concentration for colonic delivery. Coating formulation was designed based on the full factorial design. Two indecent variables were used in different concentrations by factorial design. In-vitro dissolution studies, it was found that formulation G4 showed 99.26% of 5-ASA in 18 hours and 99.48% of prednisolone in 24 hours, which lies within the acceptance criteria of 80%. That study conclude that the 1% coating concentration of shellac on inner and 10% coating concentration of Eudragit S100 shows the complete release of drugs to colon for treatment of ulcerative colitis.

Excipients are additives used to convert active pha rmaceutical ingredients into dosage forms sui... more Excipients are additives used to convert active pha rmaceutical ingredients into dosage forms suitable for administration to patients. New and mo dified excipients continue to emerge with better drug delivery performance. Synthetic polymer s offer a broad range of properties that can be reasonably well “built-in” by design and modifie d by altering polymer characteristics. Excipients of natural origin are of particular inte rest to us for reasons of reliability, sustainability and avoiding reliance upon materials derived from fossil fuels. Plant products are therefore attractive alternatives to synthetic prod ucts because of biocompatibility, low toxicity, environmental “friendliness”, and low price compare d to synthetic products. Excipients from natural products are also generally non-polluting r enewable sources for the sustainable supply of economical pharmaceutical products.

The purpose of the present study was to prepare & characterize the colon targeted matrix tablet o... more The purpose of the present study was to prepare & characterize the colon targeted matrix tablet of dexamethasone for treatment and management of inflammation in colon cancer. The matrix tablet was prepared by wet granulation method. The matrix tablet was then coated with different concentration of shellac solution by dip coating method to prevent drug release in stomach. The prepared matrix tablets were evaluated for hardness, weight variation, friability and (in-vitro) dissolution. The in-vitro drug release of different formulation was found to be minimum 84.84±2.16 and maximum 99.41 ±0.96. The formulation F5 shows best result in in-vitro drug release.

INTRODUCTION Cancer is one of the major public health problems worldwide prevalence of cancer is ... more INTRODUCTION Cancer is one of the major public health problems worldwide prevalence of cancer is known to vary from region to region. The idea behind Microspheres forColon specific drug delivery system is intended because it may reduce the Systemic side effect because of low dose of the drug. The absorption of the poorly absorbed drug is increase because of increase retention time in the colon. (Vyas S.Pet al, 2002,CherukuriSowmyaet al., 2012). Dexamethasone is used in reducing the inflammation in colon cancer.The aim of the study was to develop colon targeted Matrix tablets of dexamethsone using Chitosan and xanthan gum as carriers in the treatment of colon cancer. Significance of this Research Investigation Increase the absorption and bioavailability of the drug via delayed release formulation.Utilize the nontoxic and biodegradable nature of Chitosan and Xanthan gum that makes it safer for patients as compared to other synthetic polymers it is also economical. Reduce the dose and administration frequency.Reduce the incidences of adverse drug reaction. MATERIALS AND METHODS Dexamethasone, Chitosan and Xanthan Gum was purchased from the balaji pharmaceutical Pvt.Ltd. The Shellac was obtained from the central drug store.

Journal of Pharmaceutical Research International, 2021

Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics ... more Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics for Esomeprazole magnesium; to establish its inherent properties qualitatively & quantitatively. Methods: Esomeprazole magnesium was analyzed using various traditional & modern analytical and investigative tools viz FTIR, HPLC, UV spectroscopy, X-ray diffraction, zetasizer. Results: The absorption maxima were found at 301 nm with UV Spectrophotometric and HPLC analysis. The particle size of the drug was analyzed through Malvern zetasizer employing water as diluent and found to be 11.818 µm. The quantitative solubility of Esomeprazole magnesium was predicted in various solvents at 25 0C and found that it was most soluble in methanol and was least soluble in distilled water. Solubility was also found to be pH-dependent. Solubility increases with an increase in pH. The order of solubility determined was; Methanol (1.214 mg/ml) > Phosphate buffer pH- 7.4 (0.521 mg/ml) > Simulated Intes...

Colors are capable of influencing many aspects of our lives, including our mood, mental state and... more Colors are capable of influencing many aspects of our lives, including our mood, mental state and energy level. According to color therapy, each color is thought to be associated with one of seven energy centers. The method of color therapy is based on the law of resonant colors interaction, conterminous to frequency characteristics of body. Colored light can be used directly on the body's health and immune strength, affecting the body and the emotions. It does not alter the material make up of the body, but rather the vibrational aspect, similar to homeopathy. The treatment itself involves the application of colored light to the acupuncture points on the skin with an instrument that resembles a simple penlight. Treatment by color can be performed on finger meridians, on chakras, painting the certain points by the certain color following the laws of colors interaction (and consequently, energies) and thus changing the energy potential (balance) both in the point, and in all meri...