Duygu Karakaş Aydın - Academia.edu (original) (raw)

Papers by Duygu Karakaş Aydın

Journal of Materials Science: Materials in Electronics

Clean Technologies and Environmental Policy, 2021

The effect of several parameters, such as different Co 2+ ratios, burning temperatures, and burni... more The effect of several parameters, such as different Co 2+ ratios, burning temperatures, and burning times, was examined by using defatted spent coffee grounds (DSCG) as organic waste to obtain the most effective catalyst for producing hydrogen. Under optimum conditions, the most active catalyst/metal ratio was obtained by burning 50% Co 2+ at 400 °C for 90 min. To measure the time-dependent amounts of hydrogen, 0.1 g of DSCG-Co catalyst was dissolved in 10 mL of a methanol solution containing 0.25 g sodium borohydride (NaBH 4) at 30 °C. The maximum hydrogen generation rate obtained from the methanolysis of NaBH 4 at 30 and 60 °C was found to be 8749 and 17,283 mL min −1 gcat −1 , respectively, and the activation energy of the catalyst was found to be 23.2 kJ mol −1. FTIR, ICP-OES, XRD, BET, and SEM-EDX analyses were performed for the characterization of the prepared DSCG-Co-Cat catalyst. Furthermore, a supercapacitor cell was constructed by using this catalyst as an active substance for electricity storage. The specific capacitance of the electrode at the current density of 1 A/g was calculated as 67 F/g for two-electrode systems. The results of electrochemical analysis of the prepared supercapacitor were found to be similar to the ideal supercapacitor curves. The obtained capacitance values are at very good levels in terms of the capacity and cost factors. The results indicated that the multifunctional capacitor-catalyst material produced by Co-doped waste coffee could constitute an important element in a hybrid system that includes capacitor and catalyst systems that can be installed in the future.

SSRN Electronic Journal, 2021

The main problem in this study is related to the lack of creativity of educators in using learnin... more The main problem in this study is related to the lack of creativity of educators in using learning media, especially in the manufacture and development of media in the learning process. Where the media used by educators during the learning process does not attract students' interest in learning so that it affects the learning outcomes of these students. Thus, it is necessary to have a learning media that can be used by educators and students, namely in the form of learning media using STEM-based Lectora Inspire Software. The purpose of this study is to determine the learning media using STEM-based Lectora Inspire on valid and practical thermochemical material. The type of research used is research and development (Research and Development) with a 4D design model. This research consists of four stages, namely: define, design, development and disseminate stage. However, this research was only carried out until the development stage due to the limited time required Based on the results of the study, it was shown that the product in the form of learning media using STEM-based Lectora Inspire that was developed was valid and practical. The results of product validity obtained a percentage of 98.8% with very valid criteria, and the percentage of practicality through student response questionnaires obtained a percentage of 73.1% with practical criteria. Based on these data, the STEMbased Lectora Inspire learning media is feasible and can be used as a medium in the learning process

Bu calismada, katalizor uretimi icin misir sapi ilk kez dogrudan destek malzemesi olarak kullanil... more Bu calismada, katalizor uretimi icin misir sapi ilk kez dogrudan destek malzemesi olarak kullanilmistir. Amac, dusuk maliyetli organik atiklardan hidrojen uretimi icin kullanilabilecek yuksek etkinlige sahip bir metal iceren katalizorler sentezlemektir. Katalizor hazirlanmasinda farkli metal oranlari (% 10, % 20, % 30, % 40), farkli asit konsantrasyonlari (1M, 3M, 5M ve 7M) farkli yanma sicakliklari (300 oC, 400 oC, 500 oC ve 600 oC) ve farkli yanma surelerinde (15 dak., 30 dak., 45 dak. ve 60 dak.) deneyler yapilarak hidrojen uretim hizi (HGR) acisindan en etkili katalizor hazirlanmistir. Sodyum borhidrurun metanoliz reaksiyonundan hidrojen uretimi icin katalizor destek maddesi olarak kullanilacak misir sapinin protonlanmasi icin hidroklorik asit (3M HCl) kullanilmistir. Performans acisindan HCl ile muamele edilmis misir sapi destekli-Zn katalizorunun (MS-HCl-Zn katalizoru) optimum sartlari; en etkili katalizor % 10 Zn+2 ilavesinden sonra 500 o C’de 15 dakika yakilmasi sonucu elde ...

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2020

Bu calismada, organik atik kaynaklarindan olan nar kabugu, katalizor uretimi icin ilk kez dogruda... more Bu calismada, organik atik kaynaklarindan olan nar kabugu, katalizor uretimi icin ilk kez dogrudan destek malzemesi olarak kullanilmistir. Amac, yenilenebilir bir enerji kaynagi olan hidrojen uretimi icin kullanilabilecek metal iceren katalizorlerde kullanilacak olan destek maddesini dogrudan kullanarak yuksek etkinlige sahip bir katalizor sentezlemektir. Calisma kapsaminda toz haline getirilmis nar kabugu uzerine etanol eklenerek, daha sonra uzerine sirasiyla belirli oranlarda (0.3 Pd (mg metal/g katalizor)), (0.15 Mn ( mg metal/g katalizor)), (0.075 Ag ( mg metal/g katalizor)) ve 3-aminopropiltrimetoksisilan ilave edilerek katalizor sentezlenmistir. Son olarak, elde edilen katalizor sodyum bor hidrurun metanoliz reaksiyonunda hidrojen uretiminde kullanilmak uzere performansi test edilmistir. Yapilan deneylerde Nar Kabugu-NH2/PdMnAg (PP-NH2/PdMnAg) katalizorunun farkli NaBH4 miktari (%1, %2.5, %5, ve %7.5), farkli katalizor miktarlari (0.05, 0.1, 0.15, ve 0.25 g) ve farkli sica...

In this study, pomegranate peel, one of the organic waste sources, was used for the first time as... more In this study, pomegranate peel, one of the organic waste sources, was used for the first time as a direct support material for catalyst production. The aim is to synthesize a high efficiency catalyst using directly the support material to be used in metal containing catalysts that can be used for the production of hydrogen. Within the scope of the study, the catalyst was synthesized by adding ethanol on the powdered pomegranate peel and adding certain proportions (0.3 Pd (mg metal/g catalyst)), (0.15 Mn ( mg metal/g catalyst)), (0.075 Ag ( mg metal/g catalystr)) and 3-aminopropyltrimethoxysilane respectively. Finally, the performance of the obtained catalyst sodium boron hydride for the production of hydrogen by the methanolis reaction was tested. The effect of the amount of NaBH4 was investigated with 1%, 2.5%, 5%, and 7.5% ratio of NaBH4 while the influence of the concentration of catalyst was carried-out at 0.05, 0.1, 0.15, and 0.25 g catalysts. Four different temperatures were ...

International Journal of Hydrogen Energy, 2021

Fuel, 2021

Abstract In the present study, Spirulina Platensis waste-supported Pd-Co (SPW-Pd-Co) catalyst was... more Abstract In the present study, Spirulina Platensis waste-supported Pd-Co (SPW-Pd-Co) catalyst was used as an efficient catalyst for the methanolysis reaction of sodium borohydride (NaBH4); moreover, the produced SPW-Pd-Co catalyst was tested as a supercapacitor electrode material for the first time. In this context, the SPW-Pd-Co catalyst was synthesized by the treatment of the Spirulina Platensis waste (SPW) with 1–7 M HCl, 1 mL PdCl2 solution (2% w/w) and 1, 2, 3, 4, and 5 mL CoCI2·6H2O solution (5% w/w). Under optimum conditions, the most active catalyst was obtained by burning with 3 M HCl-Pd-4 mL Co2+ solution at 600 °C for 90 min. The maximum rate of hydrogen generation (HGR) obtained at 30 °C from the NaBH4 methanolysis reaction was found to be 5497.7 mLmin-1gcat−1, and the catalyst activation energy was found to be 10.32 kJ mol−1. The gravimetric capacitance of the prepared electrode was calculated as 50 F/g at 2 A/g current density. The capacitance values of the supercapacitor are at a significant level in terms of capacity and the cost.

International Journal of Energy Research, 2021

Turist Rehberliği Dergisi (TURED), 2018

Amaç ve Önem: Bu çalışma, sağlık turizmi için turist rehberliği mesleğinde uzmanlaşma konusuna od... more Amaç ve Önem: Bu çalışma, sağlık turizmi için turist rehberliği mesleğinde uzmanlaşma konusuna odaklanmaktadır. Bu kapsamda giderek gelişen ve ileride daha da yaygınlaşacağı düşünülen sağlık turizmi için sağlık turizmi rehberliğini tartışmaya açmayı amaçlamaktadır. Sağlık turizmi kapsamında uzman sağlık turizmi rehberlerinin istihdam edilmesinin ülke ve sektör açısından konuya verilen önemi ve hizmet kalitesinin arttırılma çabasını destekleyen önemli bir konu olduğu düşünülmektedir. Yöntem: Araştırmanın amacı ve temel soruları için uygun olduğu düşünülen betimsel araştırma yöntemlerinden tarama modeli kullanılmıştır. Bulgular: Araştırma sonucunda sağlık turizmi rehberliği ile uyumlu olduğu düşünülen derslerin kısıtlı olduğu, mevcut derslerin ilkyardım ve temel sağlık bilgisi kapsamlı olduğu görülmektedir. 'Sağlık Turizmi' adındaki ders ise sadece üç üniversitenin turizm rehberliği müfredatında yer almaktadır. Özgünlük/Bilimsel Katkı: Profesyonel turist rehberliği eğitiminde uzmanlaşma konusu gündeme yeni gelen bir konudur. Literatürde konuyla ilgili yapılan çalışmaların kısıtlı olduğu, özellikle sağlık

Chemical Papers, 2020

Lung cancer is one of the major causes of cancer-related deaths in the world. Non-small-cell lung... more Lung cancer is one of the major causes of cancer-related deaths in the world. Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, and small-cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Proper therapies for SCLC have not yet been developed. However, new molecules have been designed and big innovation in treating SCLC has been achieved. Platinum-based antitumor drugs like cisplatin and carboplatin have several disadvantages including side effects, cisplatin-resistant tumors and limited solubility in aqueous media. Thus, two novel chiral aminoalcohol-based bis(phosphinite) ligands containing (η 6 -p-cymene)-Ru(II)-phosphinite and bis(phosphinite)–Pd(II) complexes were synthesized and evaluated for anticancer activity. In this study, the results showed that complex 1 has the strongest cytotoxic effects on SCLC and NSCLC cell lines. On the other hand, cisplatin, ruthenium and palladium complexes are capable to induce apoptosis. Especially, complexes 1 and 2 can induce apoptosis for both SCLC and NSCLC. When compared to the qRT-PCR and TUNEL results, we obtained a significant correlation between apoptotic index and p21, Bax gene expressions. This work revealed the potential of the synthesized complexes as anticancer agents with cytotoxic and pro-apoptotic activity as leading compounds for further anticancer researches.

Inorganica Chimica Acta, 2018

Chiral C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes have be... more Chiral C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes have been synthesized and used as catalysts in the ruthenium-catalyzed asymmetric transfer hydrogenation of aromatic, methyl alkyl and alkyl/aryl ketones using 2-propanol as both the hydrogen source and solvent in the presence of KOH. Under optimized conditions, all complexes showed high catalytic activity as catalysts in the reduction of various ketones to corresponding chiral secondary alcohols. Products were obtained with high conversions (99%) and moderate to good enantioselectivities (82% ee). Furthermore, C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes were characterized by multinuclear NMR spectroscopy, FT-IR spectroscopy, LC/MS-MS and elemental analysis.

Applied Organometallic Chemistry, 2017

Transition Metal Chemistry, 2017

Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chira... more Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chiral alcohols has recently attracted attention. Therefore, a series of methyl alkyl or alkyl/aryl ketones have been reduced by using Ru(II), Rh(I) and Ir(III) catalysts based on C 2-symmetric chiral ferrocenyl phosphinite ligands. The corresponding optically active secondary alcohols were obtained in excellent conversions and moderate-to-good enantioselectivities. The best results were obtained with an iridium catalyst, giving up to 98% conversion and 80% ee.

Journal of Organometallic Chemistry, 2016

Abstract Hydrogen transfer reduction methods are attracting increasing interest from synthetic ch... more Abstract Hydrogen transfer reduction methods are attracting increasing interest from synthetic chemists in view of their operational simplicity. Thus, interaction of [Rh(μ-Cl)(cod)] 2 and Ir(η 5 -C 5 Me 5 )(μ-Cl)Cl] 2 with phosphinite ligand [(Ph 2 PO)-C 7 H 11 N 2 Cl]Cl, 1 gave new monodendate (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (chloro ɳ 4 -1,5-cyclooctadiene rhodium(I))], 2 and (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (dichloro ɳ 5 -pentamethylcyclopentadienyl iridium(III))], 3 complexes, which were characterized by a combination of multinuclear NMR spectroscopy, IR spectroscopy, and elemental analysis. 1 H-{ 31 P} NMR, 1 H- 13 C HETCOR or 1 H- 1 H COSY correlation experiments were used to confirm the spectral assignments. The novel catalysts were applied to transfer hydrogenation of acetophenone derivatives using 2-propanol as a hydrogen source. The results showed that the corresponding alcohols could be obtained with high activity (up to 99%) under mild conditions. Notably, (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (chloro ɳ 4 -1,5-cyclooctadiene rhodium(I))], 2 complex is much more active than the other analogous complex, 3 in the transfer hydrogenation. Furthermore, compound, 2 acts as excellent catalysts, giving the corresponding alcohols in 97–99% conversions in 5 min (TOF ≤ 1176 h −1 ).

Journal of Organometallic Chemistry, 2016

Known Ru(II), Rh(I) and Ir(III) complexes of C2-symmetric ferrocenyl based chiral bis(phoshinite)... more Known Ru(II), Rh(I) and Ir(III) complexes of C2-symmetric ferrocenyl based chiral bis(phoshinite) ligands were catalyzed the asymmetric transfer hydrogenation of alkyl/aryl or alkyl methyl ketones. Corresponding secondary alcohols were obtained with high enantioselectivities up to 98% ee and reactivities using iso-propanol as the hydrogen source.

Journal of Materials Science: Materials in Electronics

Clean Technologies and Environmental Policy, 2021

The effect of several parameters, such as different Co 2+ ratios, burning temperatures, and burni... more The effect of several parameters, such as different Co 2+ ratios, burning temperatures, and burning times, was examined by using defatted spent coffee grounds (DSCG) as organic waste to obtain the most effective catalyst for producing hydrogen. Under optimum conditions, the most active catalyst/metal ratio was obtained by burning 50% Co 2+ at 400 °C for 90 min. To measure the time-dependent amounts of hydrogen, 0.1 g of DSCG-Co catalyst was dissolved in 10 mL of a methanol solution containing 0.25 g sodium borohydride (NaBH 4) at 30 °C. The maximum hydrogen generation rate obtained from the methanolysis of NaBH 4 at 30 and 60 °C was found to be 8749 and 17,283 mL min −1 gcat −1 , respectively, and the activation energy of the catalyst was found to be 23.2 kJ mol −1. FTIR, ICP-OES, XRD, BET, and SEM-EDX analyses were performed for the characterization of the prepared DSCG-Co-Cat catalyst. Furthermore, a supercapacitor cell was constructed by using this catalyst as an active substance for electricity storage. The specific capacitance of the electrode at the current density of 1 A/g was calculated as 67 F/g for two-electrode systems. The results of electrochemical analysis of the prepared supercapacitor were found to be similar to the ideal supercapacitor curves. The obtained capacitance values are at very good levels in terms of the capacity and cost factors. The results indicated that the multifunctional capacitor-catalyst material produced by Co-doped waste coffee could constitute an important element in a hybrid system that includes capacitor and catalyst systems that can be installed in the future.

SSRN Electronic Journal, 2021

The main problem in this study is related to the lack of creativity of educators in using learnin... more The main problem in this study is related to the lack of creativity of educators in using learning media, especially in the manufacture and development of media in the learning process. Where the media used by educators during the learning process does not attract students' interest in learning so that it affects the learning outcomes of these students. Thus, it is necessary to have a learning media that can be used by educators and students, namely in the form of learning media using STEM-based Lectora Inspire Software. The purpose of this study is to determine the learning media using STEM-based Lectora Inspire on valid and practical thermochemical material. The type of research used is research and development (Research and Development) with a 4D design model. This research consists of four stages, namely: define, design, development and disseminate stage. However, this research was only carried out until the development stage due to the limited time required Based on the results of the study, it was shown that the product in the form of learning media using STEM-based Lectora Inspire that was developed was valid and practical. The results of product validity obtained a percentage of 98.8% with very valid criteria, and the percentage of practicality through student response questionnaires obtained a percentage of 73.1% with practical criteria. Based on these data, the STEMbased Lectora Inspire learning media is feasible and can be used as a medium in the learning process

Bu calismada, katalizor uretimi icin misir sapi ilk kez dogrudan destek malzemesi olarak kullanil... more Bu calismada, katalizor uretimi icin misir sapi ilk kez dogrudan destek malzemesi olarak kullanilmistir. Amac, dusuk maliyetli organik atiklardan hidrojen uretimi icin kullanilabilecek yuksek etkinlige sahip bir metal iceren katalizorler sentezlemektir. Katalizor hazirlanmasinda farkli metal oranlari (% 10, % 20, % 30, % 40), farkli asit konsantrasyonlari (1M, 3M, 5M ve 7M) farkli yanma sicakliklari (300 oC, 400 oC, 500 oC ve 600 oC) ve farkli yanma surelerinde (15 dak., 30 dak., 45 dak. ve 60 dak.) deneyler yapilarak hidrojen uretim hizi (HGR) acisindan en etkili katalizor hazirlanmistir. Sodyum borhidrurun metanoliz reaksiyonundan hidrojen uretimi icin katalizor destek maddesi olarak kullanilacak misir sapinin protonlanmasi icin hidroklorik asit (3M HCl) kullanilmistir. Performans acisindan HCl ile muamele edilmis misir sapi destekli-Zn katalizorunun (MS-HCl-Zn katalizoru) optimum sartlari; en etkili katalizor % 10 Zn+2 ilavesinden sonra 500 o C’de 15 dakika yakilmasi sonucu elde ...

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2020

Bu calismada, organik atik kaynaklarindan olan nar kabugu, katalizor uretimi icin ilk kez dogruda... more Bu calismada, organik atik kaynaklarindan olan nar kabugu, katalizor uretimi icin ilk kez dogrudan destek malzemesi olarak kullanilmistir. Amac, yenilenebilir bir enerji kaynagi olan hidrojen uretimi icin kullanilabilecek metal iceren katalizorlerde kullanilacak olan destek maddesini dogrudan kullanarak yuksek etkinlige sahip bir katalizor sentezlemektir. Calisma kapsaminda toz haline getirilmis nar kabugu uzerine etanol eklenerek, daha sonra uzerine sirasiyla belirli oranlarda (0.3 Pd (mg metal/g katalizor)), (0.15 Mn ( mg metal/g katalizor)), (0.075 Ag ( mg metal/g katalizor)) ve 3-aminopropiltrimetoksisilan ilave edilerek katalizor sentezlenmistir. Son olarak, elde edilen katalizor sodyum bor hidrurun metanoliz reaksiyonunda hidrojen uretiminde kullanilmak uzere performansi test edilmistir. Yapilan deneylerde Nar Kabugu-NH2/PdMnAg (PP-NH2/PdMnAg) katalizorunun farkli NaBH4 miktari (%1, %2.5, %5, ve %7.5), farkli katalizor miktarlari (0.05, 0.1, 0.15, ve 0.25 g) ve farkli sica...

In this study, pomegranate peel, one of the organic waste sources, was used for the first time as... more In this study, pomegranate peel, one of the organic waste sources, was used for the first time as a direct support material for catalyst production. The aim is to synthesize a high efficiency catalyst using directly the support material to be used in metal containing catalysts that can be used for the production of hydrogen. Within the scope of the study, the catalyst was synthesized by adding ethanol on the powdered pomegranate peel and adding certain proportions (0.3 Pd (mg metal/g catalyst)), (0.15 Mn ( mg metal/g catalyst)), (0.075 Ag ( mg metal/g catalystr)) and 3-aminopropyltrimethoxysilane respectively. Finally, the performance of the obtained catalyst sodium boron hydride for the production of hydrogen by the methanolis reaction was tested. The effect of the amount of NaBH4 was investigated with 1%, 2.5%, 5%, and 7.5% ratio of NaBH4 while the influence of the concentration of catalyst was carried-out at 0.05, 0.1, 0.15, and 0.25 g catalysts. Four different temperatures were ...

International Journal of Hydrogen Energy, 2021

Fuel, 2021

Abstract In the present study, Spirulina Platensis waste-supported Pd-Co (SPW-Pd-Co) catalyst was... more Abstract In the present study, Spirulina Platensis waste-supported Pd-Co (SPW-Pd-Co) catalyst was used as an efficient catalyst for the methanolysis reaction of sodium borohydride (NaBH4); moreover, the produced SPW-Pd-Co catalyst was tested as a supercapacitor electrode material for the first time. In this context, the SPW-Pd-Co catalyst was synthesized by the treatment of the Spirulina Platensis waste (SPW) with 1–7 M HCl, 1 mL PdCl2 solution (2% w/w) and 1, 2, 3, 4, and 5 mL CoCI2·6H2O solution (5% w/w). Under optimum conditions, the most active catalyst was obtained by burning with 3 M HCl-Pd-4 mL Co2+ solution at 600 °C for 90 min. The maximum rate of hydrogen generation (HGR) obtained at 30 °C from the NaBH4 methanolysis reaction was found to be 5497.7 mLmin-1gcat−1, and the catalyst activation energy was found to be 10.32 kJ mol−1. The gravimetric capacitance of the prepared electrode was calculated as 50 F/g at 2 A/g current density. The capacitance values of the supercapacitor are at a significant level in terms of capacity and the cost.

International Journal of Energy Research, 2021

Turist Rehberliği Dergisi (TURED), 2018

Amaç ve Önem: Bu çalışma, sağlık turizmi için turist rehberliği mesleğinde uzmanlaşma konusuna od... more Amaç ve Önem: Bu çalışma, sağlık turizmi için turist rehberliği mesleğinde uzmanlaşma konusuna odaklanmaktadır. Bu kapsamda giderek gelişen ve ileride daha da yaygınlaşacağı düşünülen sağlık turizmi için sağlık turizmi rehberliğini tartışmaya açmayı amaçlamaktadır. Sağlık turizmi kapsamında uzman sağlık turizmi rehberlerinin istihdam edilmesinin ülke ve sektör açısından konuya verilen önemi ve hizmet kalitesinin arttırılma çabasını destekleyen önemli bir konu olduğu düşünülmektedir. Yöntem: Araştırmanın amacı ve temel soruları için uygun olduğu düşünülen betimsel araştırma yöntemlerinden tarama modeli kullanılmıştır. Bulgular: Araştırma sonucunda sağlık turizmi rehberliği ile uyumlu olduğu düşünülen derslerin kısıtlı olduğu, mevcut derslerin ilkyardım ve temel sağlık bilgisi kapsamlı olduğu görülmektedir. 'Sağlık Turizmi' adındaki ders ise sadece üç üniversitenin turizm rehberliği müfredatında yer almaktadır. Özgünlük/Bilimsel Katkı: Profesyonel turist rehberliği eğitiminde uzmanlaşma konusu gündeme yeni gelen bir konudur. Literatürde konuyla ilgili yapılan çalışmaların kısıtlı olduğu, özellikle sağlık

Chemical Papers, 2020

Lung cancer is one of the major causes of cancer-related deaths in the world. Non-small-cell lung... more Lung cancer is one of the major causes of cancer-related deaths in the world. Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, and small-cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Proper therapies for SCLC have not yet been developed. However, new molecules have been designed and big innovation in treating SCLC has been achieved. Platinum-based antitumor drugs like cisplatin and carboplatin have several disadvantages including side effects, cisplatin-resistant tumors and limited solubility in aqueous media. Thus, two novel chiral aminoalcohol-based bis(phosphinite) ligands containing (η 6 -p-cymene)-Ru(II)-phosphinite and bis(phosphinite)–Pd(II) complexes were synthesized and evaluated for anticancer activity. In this study, the results showed that complex 1 has the strongest cytotoxic effects on SCLC and NSCLC cell lines. On the other hand, cisplatin, ruthenium and palladium complexes are capable to induce apoptosis. Especially, complexes 1 and 2 can induce apoptosis for both SCLC and NSCLC. When compared to the qRT-PCR and TUNEL results, we obtained a significant correlation between apoptotic index and p21, Bax gene expressions. This work revealed the potential of the synthesized complexes as anticancer agents with cytotoxic and pro-apoptotic activity as leading compounds for further anticancer researches.

Inorganica Chimica Acta, 2018

Chiral C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes have be... more Chiral C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes have been synthesized and used as catalysts in the ruthenium-catalyzed asymmetric transfer hydrogenation of aromatic, methyl alkyl and alkyl/aryl ketones using 2-propanol as both the hydrogen source and solvent in the presence of KOH. Under optimized conditions, all complexes showed high catalytic activity as catalysts in the reduction of various ketones to corresponding chiral secondary alcohols. Products were obtained with high conversions (99%) and moderate to good enantioselectivities (82% ee). Furthermore, C 2-symmetric bis(phosphinite) ligands and their binuclear ruthenium(II) complexes were characterized by multinuclear NMR spectroscopy, FT-IR spectroscopy, LC/MS-MS and elemental analysis.

Applied Organometallic Chemistry, 2017

Transition Metal Chemistry, 2017

Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chira... more Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chiral alcohols has recently attracted attention. Therefore, a series of methyl alkyl or alkyl/aryl ketones have been reduced by using Ru(II), Rh(I) and Ir(III) catalysts based on C 2-symmetric chiral ferrocenyl phosphinite ligands. The corresponding optically active secondary alcohols were obtained in excellent conversions and moderate-to-good enantioselectivities. The best results were obtained with an iridium catalyst, giving up to 98% conversion and 80% ee.

Journal of Organometallic Chemistry, 2016

Abstract Hydrogen transfer reduction methods are attracting increasing interest from synthetic ch... more Abstract Hydrogen transfer reduction methods are attracting increasing interest from synthetic chemists in view of their operational simplicity. Thus, interaction of [Rh(μ-Cl)(cod)] 2 and Ir(η 5 -C 5 Me 5 )(μ-Cl)Cl] 2 with phosphinite ligand [(Ph 2 PO)-C 7 H 11 N 2 Cl]Cl, 1 gave new monodendate (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (chloro ɳ 4 -1,5-cyclooctadiene rhodium(I))], 2 and (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (dichloro ɳ 5 -pentamethylcyclopentadienyl iridium(III))], 3 complexes, which were characterized by a combination of multinuclear NMR spectroscopy, IR spectroscopy, and elemental analysis. 1 H-{ 31 P} NMR, 1 H- 13 C HETCOR or 1 H- 1 H COSY correlation experiments were used to confirm the spectral assignments. The novel catalysts were applied to transfer hydrogenation of acetophenone derivatives using 2-propanol as a hydrogen source. The results showed that the corresponding alcohols could be obtained with high activity (up to 99%) under mild conditions. Notably, (1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-yl diphenylphosphinite chloride) (chloro ɳ 4 -1,5-cyclooctadiene rhodium(I))], 2 complex is much more active than the other analogous complex, 3 in the transfer hydrogenation. Furthermore, compound, 2 acts as excellent catalysts, giving the corresponding alcohols in 97–99% conversions in 5 min (TOF ≤ 1176 h −1 ).

Journal of Organometallic Chemistry, 2016

Known Ru(II), Rh(I) and Ir(III) complexes of C2-symmetric ferrocenyl based chiral bis(phoshinite)... more Known Ru(II), Rh(I) and Ir(III) complexes of C2-symmetric ferrocenyl based chiral bis(phoshinite) ligands were catalyzed the asymmetric transfer hydrogenation of alkyl/aryl or alkyl methyl ketones. Corresponding secondary alcohols were obtained with high enantioselectivities up to 98% ee and reactivities using iso-propanol as the hydrogen source.