Kareem Gamal - Academia.edu (original) (raw)

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Research paper thumbnail of Effect of oral ursodeoxycholic acid on cholelithiasis following laparoscopic sleeve gastrectomy for morbid obesity

Surgery for Obesity and Related Diseases, 2019

Background: Laparoscopic sleeve gastrectomy (LSG) is a definitive solution for morbid obesity and... more Background: Laparoscopic sleeve gastrectomy (LSG) is a definitive solution for morbid obesity and its related comorbidities. Cholelithiasis is a postoperative complication of LSG. The use of ursodeoxycholic acid (UDCA) after LSG is a proposed solution to reduce the incidence of cholelithiasis. Objective: To evaluate the effect of UDCA prophylaxis on cholelithiasis following LSG in morbidly obese patients. Setting: Two University hospitals in Egypt, Cairo and BeniSuef Universities hospitals. Methods: This prospective study was conducted between July 2015 and March 2018 and included 200 patients scheduled for LSG. They were randomly divided into two groups. UDCA Group received a postoperative prophylaxis regimen for prevention of cholelithiasis in the form of 250 mg twice daily of UDCA for six months. Control Group did not receive prophylactic treatment. Abdominal ultrasound was done at 3, 6, 9 and 12 months for all patients to detect cholelithiasis. The primary outcome measure was cholelithiasis. Results: Only 6% of the UDCA group developed cholelithiasis compared to 40% in the control group (p < 0.001). Age, gender, initial body mass index and excess body weight loss at six months didn't significantly affect cholelithiasis. Conclusion: UDCA treatment for six months after LSG is effective in the prevention of cholelithiasis.

Research paper thumbnail of Effect of oral ursodeoxycholic acid on cholelithiasis following laparoscopic sleeve gastrectomy for morbid obesity

Surgery for Obesity and Related Diseases, 2019

Background: Laparoscopic sleeve gastrectomy (LSG) is a definitive solution for morbid obesity and... more Background: Laparoscopic sleeve gastrectomy (LSG) is a definitive solution for morbid obesity and its related comorbidities. Cholelithiasis is a postoperative complication of LSG. The use of ursodeoxycholic acid (UDCA) after LSG is a proposed solution to reduce the incidence of cholelithiasis. Objective: To evaluate the effect of UDCA prophylaxis on cholelithiasis following LSG in morbidly obese patients. Setting: Two University hospitals in Egypt, Cairo and BeniSuef Universities hospitals. Methods: This prospective study was conducted between July 2015 and March 2018 and included 200 patients scheduled for LSG. They were randomly divided into two groups. UDCA Group received a postoperative prophylaxis regimen for prevention of cholelithiasis in the form of 250 mg twice daily of UDCA for six months. Control Group did not receive prophylactic treatment. Abdominal ultrasound was done at 3, 6, 9 and 12 months for all patients to detect cholelithiasis. The primary outcome measure was cholelithiasis. Results: Only 6% of the UDCA group developed cholelithiasis compared to 40% in the control group (p < 0.001). Age, gender, initial body mass index and excess body weight loss at six months didn't significantly affect cholelithiasis. Conclusion: UDCA treatment for six months after LSG is effective in the prevention of cholelithiasis.

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