Karen Fernandes - Academia.edu (original) (raw)

Papers by Karen Fernandes

Cosmetics

Evidence has supported the use of leucine as a promising agent for the maintenance of muscle tone... more Evidence has supported the use of leucine as a promising agent for the maintenance of muscle tone. This study aimed to assess the combined effect of leucine and cream-based lactic acid (novel cosmetic product), associated with the use of surface electrical stimulation to improve contour and facial tonus in women. A total of 23 women were randomly allocated into two groups: Experimental (EG)—use of the leucine-based cream and lactic acid + electrostimulation for facial toning (mean intensity 13 Hz and protocol in progression); and placebo (GP)—use of the placebo cream (without the addition of leucine and lactic acid) + stimulation with the same protocol as the EG. Each group used their cream daily and underwent the intervention protocol three x/week with stimulation for 40 min, for a total of 8 weeks. Three main outcomes were reported: angular variation of facial contour by means of photogrammetry, muscle tone through the electromyographic activity of the masseter and zygomatic muscl...

Research, Society and Development

The objective of this review was to verify the available scientific evidence on allocation and co... more The objective of this review was to verify the available scientific evidence on allocation and concealment methods, and the statistical analyses used in randomized clinical trials (RCTs) on bilateral CTS. An integrative literature review was conducted, based on searches of databases for the period from 2014 to 2021. One-hundred-and-ten articles were found, of which 22 were considered eligible for inclusion. The statistical analyses methods used in the presence of bilateral pathologies was not clear in six (27.27%) cases and was inappropriate in another six (27.27%). A further five (22.72%) articles included only the most severely affected wrist for evaluation, while data from the right and left wrist were analyzed and described separately in four (18.18%) reports. Finally, only one (4.54%) RCT showed an adequate statistical approach. RCTs on clinical and surgical therapy of CTS do not use statistical models that include data repetition due to bilaterality when assessing outcomes.

Saúde: Referencial médico, clínico e/ou epidemiológico 2

Fisioterapia em Movimento

Introduction: Fibromyalgia (FM) is a syndrome of unknown origin characterized by several symptoms... more Introduction: Fibromyalgia (FM) is a syndrome of unknown origin characterized by several symptoms, and although its pathogenesis has not been completely elucidated, it seems to be related to inflammatory path-ways and neurochemical changes in the brain. Objective: To evaluate the association between BsmI, ApaI and FokI polymorphisms of the vitamin D receptor (VDR) gene, their polymorphisms, and clinical variables in women with and without FM. Methods: This is a case-control study composed of a group of 53 women with FM and another with 40 women without the disease. The McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire, Pain Visual Analogue Scale and the sit-up test were applied. Real-time PCR was performed to analyze the ApaI and FokI polymorphism. Results: There was a statistical association between race, comorbidity and FM, where 78.4% of the individuals were white and had FM (p < 0.002) and 96.1% had some comorbidity (p < 0.001). Seventy-six point five percent (7...

Topics in Regional Anesthesia

Optimal postoperative pain management presents a challenge for healthcare providers across all su... more Optimal postoperative pain management presents a challenge for healthcare providers across all surgical specialties, since it is estimated that many patients submitted to major surgeries do not receive an adequate analgesic treatment, increasing the risk of complications, length-of-stay and costs for health assistance. The development of new agents for postoperative pain control creates possibilities for better combinations in preventive and multimodal analgesia. Recently, the use of gabapentinoids (gabapentin and pregabalin) in the perioperative period has become more popular. Several clinical studies and meta-analyses reveal that perioperative gabapentinoids may evoke a significant opioid-sparing effect and probably decrease the postoperative pain score. Gabapentinoids may be a good strategy for preventive and multimodal analgesia in major surgeries, particularly pregabalin, considering its pharmacokinetics profile. Situations where there are limitations of regional anesthesia tec...

INTRODUCTION: Diabetic individuals have several complications, such as diabetic retinopathy and n... more INTRODUCTION: Diabetic individuals have several complications, such as diabetic retinopathy and nephropathy as well as an increased mortality risk and impairment in health-related quality of life. Despite some authors have suggested that pulmonary function reduction might be a chronic complication of diabetes mellitus (DM), there are doubts whether the pulmonary function decrease is really caused by DM itself or if it represents a deleterious impact of ageing process. AIMS: This study aimed to compare respiratory muscle strength and pulmonary function in diabetic and nondiabetic elderly patients as well as to evaluate a possible correlation of this effect with glycemic control. METHHODS: For this case-control study, older adults (age over 60 years old) were randomly selected from an ageing study (EELO project) and they were separated in Diabetic (DG) and non-diabetic group (referred ascontrol group, CG). Respiratory muscle strength was assessed by measuring maximum static inspirator...

International Journal of Radiology & Radiation Therapy, 2020

Objective: to analyze the prevalence of psychological disorders (anxiety, depression, stress) and... more Objective: to analyze the prevalence of psychological disorders (anxiety, depression, stress) and the relationship of these factors with functional disability in patients with chronic low back pain. Study design: cross-sectional descriptive and observational study. Setting: the physiotherapy outpatient clinic of the Northen University of Paraná, Londrina, Paraná, Brazil. Methods: 84 individuals were recruited, being 43 elderly (20 with low back pain and 23 control subjects) and 41 adults (21 with low back pain and 20 control subjects). In order to assess the psychological aspects, Beck Inventories of Depression and anxiety as well as Lipp Stress Inventory were used. To evaluate the funcionality, Roland Morris Questionnaire was chosen. The evaluation of the pressure pain threshold was performed using algometer emg systems®. To analyse was considered a significance level of 5% (p<0.05). Results: It was observed that people with low back pain have higher scores of depression, anxiet...

Research, Society and Development, 2021

This article aims to evaluate the preoperative use of gabapentin in the control of intra- and pos... more This article aims to evaluate the preoperative use of gabapentin in the control of intra- and postoperative pain in patients with idiopathic bilateral carpal tunnel syndrome (CTS). A prospective, randomised, double-blind study involving 45 subjects with severe CTS, 23 receiving treatment (gabapentin 600 mg) and 22 receiving placebo (control), who underwent an open surgical approach in one hand under local anaesthesia. Information related to the patients’ profile, safety of the surgical procedure, history of pain, adverse effects, numbness, and medications used were collected during the 14 days of the procedure and evaluated by Generalised Estimated Equations and Generalised Linear Mixed Models. The treatment and control groups were homogeneous regarding the patients’ profile and surgical procedure data. The patients who used gabapentin 600 mg had a better evaluation during surgery (d = 0.655), anaesthesia (d = 0.854), and on the first night of sleep (d = 1.323), and they reported a ...

Introducao: A osteoartrite e uma doenca cronico-degenerativa muito prevalente em idosos, a qual d... more Introducao: A osteoartrite e uma doenca cronico-degenerativa muito prevalente em idosos, a qual desencadeia limitacoes funcionais e pior qualidade de vida. Embora existam questionarios para avaliacao da funcionalidade destes pacientes, a busca por instrumentos especifi cos para avaliacao de membros inferiores apresenta relevância na pratica fi sioterapeutica. Objetivos: Avaliar a correlacao do Lower Extremity Functional Scale (LEFS) com a funcionalidade e componentes fisicos e mentais da qualidade de vida em idosos com osteoartrite. Metodo: Estudo transversal, no qual a funcionalidade foi avaliada pelos questionarios WOMAC, Lequesne e LEFS e a qualidade de vida foi avaliada pelo questionario SF-36. Resultados: Participaram do estudo 105 idosos (Idade: 68,80± 6,3 anos) com osteoartrite de joelho ou quadril, sendo 31homens e 74 mulheres. Nao foi observada associacao entre a idade (p>0,05) e o comprometimento funcional avaliado tanto pelo indice WOMAC quanto Lequesne (p>0,05) na ...

Fisioterapia e Pesquisa, 2015

O objetivo deste estudo foi analisar a influencia do genero, idade e farmacoterapia da osteoartri... more O objetivo deste estudo foi analisar a influencia do genero, idade e farmacoterapia da osteoartrite (OA) sobre a funcionalidade de idosos. Trata-se de um estudo transversal com 105 idosos de ambos os generos (Idade: 70,73±6,0 anos) e portadores de OA de quadril e/ou joelho, confirmado por analise radiografica. A funcionalidade foi avaliada por dois instrumentos: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) e Indice Algofuncional de Lequesne. As analises dos dados apresentaram pior funcionalidade tanto no questionario Lequesne (p=0,007) como no WOMAC (p=0,013) e em seus dominios Intensidade da Dor (p=0,013), Rigidez (p=0,032) e Funcionalidade (p=0,018). Contudo, nao foram verificadas diferencas nos instrumentos avaliados quanto a diferentes faixas etarias ou comprometimento da articulacao segundo alteracoes radiograficas (p>;0,05). Foi observado que os medicados apresentavam pior funcionalidade em comparacao aos que nao utilizavam medicamentos para OA (Le...

Advances in Rheumatology, 2019

Background Fibromyalgia (FM) is a chronic pain syndrome characterized by generalized skeletal mus... more Background Fibromyalgia (FM) is a chronic pain syndrome characterized by generalized skeletal muscle chronic pain. Its etiology is not well defined, because there are several factors that may trigger it such as physical and/or emotional stresses, or a genetic susceptibility, involving serotonergic, dopaminergic and catecholaminergic paths. The objective of this study was to investigate the association between the strength of the lower limb, genetic polymorphism of the serotonin receptor gene HTR2A in women with fibromyalgia. Methods In this observational study of case-control type 48 women were evaluated who belonged to the group with FM (52 ± 12 years) and 100 women in the control group (58 ± 11 years). Socio demographic and anthropometric data were collected and peripheral blood samples for DNA extraction; genotypic analyzes were performed by means of PCR in real time by TaqMan® system. The lower limb muscle strength was assessed through the test of sitting down and standing up fo...

Brazilian Journal of Kinanthropometry and Human Performance, 2016

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p20 The aim of the study was to compare BMD amo... more DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p20 The aim of the study was to compare BMD among physically independent elderly women with different physical-functional profiles and vitamin D receptor gene (VDR) polymorphisms, as well as to analyze the effect of the interaction between these last two aspects on BMD. Overall, 165 elderly women had BMD assessed by bone densitometry. Handgrip and lower limb strength and functional exercise capacity (6MWT) were also assessed. VDR polymorphisms (TaqI, BsmI, ApaI and FokI) were analyzed by polymerase chain reaction. For analyses, elderly women were categorized according to their performance on physical-functional tests into low performance (LP; <25th percentile), normal performance (NP; 25th percentile ≤ NP ≤ 75thpercentile) and high performance (HP;> 75th percentile). Regarding functional exercise capacity, LP group showed lower BMD compared to HP and NP groups (p=0,003). With respect to handgrip strength, there was a trend for ...

PloS one, 2018

Postural instability is a common problem among older people, and it is associated with mobility i... more Postural instability is a common problem among older people, and it is associated with mobility impairments, activity limitation and fear of falling. The evaluation of postural control can contribute to the early detection of balance deficits and help health professionals to manage this problem to prevent falls in older adults. The aim of this study was to identify center of pressure cut-offs to differentiate between older adults with and without falls in the past 12 months. The participants were 170 older adults (mean age 67 years, 50 fallers and 120 non-fallers). Center of pressure area and sway velocity in the anterior-posterior and medio-lateral directions were assessed using a force platform during three 30s one-legged stance trials with eyes open. The mean across trials was used for analysis. The time-limit (how long the participant was able to stay in one-legged stance, up to 30s) was also assessed. Fallers had poorer postural control than non-fallers (effect size ≥ 0.52, P &...

Respiratory care, Jan 7, 2017

The terms sedentary behavior and physical inactivity have been confusingly mixed. Although the as... more The terms sedentary behavior and physical inactivity have been confusingly mixed. Although the association between physical inactivity and mortality has been shown previously in subjects with COPD, this association had not yet been investigated with regard to sedentarism. The aim of this work was to investigate the impact of sedentary behavior on mortality of subjects with COPD and to propose a cutoff point of sedentarism with prognostic value. In this retrospective cohort study, sedentary behavior was assessed with 2 activity monitors (DynaPort and Sensewear armband) in 101 subjects with COPD from 2006 to 2011. Vital status was then ascertained in 2015. The following 6 variables of sedentary behavior were analyzed: average of metabolic equivalent of task (MET)/d (reflecting intensity); time spent/d lying, sitting, and lying + sitting (reflecting duration of sedentary postures); and time spent/d in activities requiring <1.5 MET and <2 MET (reflecting intensity and duration of ...

Fisioterapia e Pesquisa, 2016

RESUMO Objetivou-se verificar a influência das variáveis de pressão plantar e amplitude de movime... more RESUMO Objetivou-se verificar a influência das variáveis de pressão plantar e amplitude de movimento (ADM) de quadril, joelho e tornozelo sobre o risco de quedas em idosas. Participaram 39 idosas, avaliando-se a Pressão Máxima e Média sobre a plataforma de baropodometria. Em seguida, realizou-se o teste Timed Up and Go (TUG) e posteriormente a avaliação da ADM de flexão de quadril e joelho e flexão plantar e dorsal de tornozelo por meio de um goniômetro. As variáveis baropodométricas (Pressão Máxima e Pressão Média) tenderam a influenciar os valores do TUG conforme valor do teste de hipótese (p=0,051), demonstrando correlação moderada (r=0,487), com destaque para a Pressão Máxima, que apresentou correlação significativa com o TUG (p<0,005). Entretanto, a ADM articular de quadril, joelho e tornozelo não apresentaram correlações significativas entre as variáveis baropodométricas e risco de quedas. Sobre a análise da associação entre o TUG, categorizado em baixo e médio risco de que...

Respiratory care, Jan 2, 2016

Studies have shown that individuals with COPD have impaired body balance, probably caused by the ... more Studies have shown that individuals with COPD have impaired body balance, probably caused by the disease's multisystemic manifestations plus age-related decline in balance, potentially increasing the risk of falling and its consequences. However, little is known about the profile of individuals with COPD who present balance impairments, especially related to sex and disease severity stages. The aim of this work was to compare static and functional balance between subjects with COPD and healthy controls and to check possible differences according to sex and degrees of disease severity. Forty-seven subjects with COPD and 25 healthy controls were included in this study. Their static balance was assessed in one-legged stance using a force platform and functional balance with the Timed Up and Go test. Additionally, participants performed spirometry, the 6-min walk test and isometric quadriceps maximal voluntary contraction assessment. Disease severity was classified according to the ...

Revista Brasileira de Reumatologia, 2017

Revista CEFAC, 2015

Resumo: OBJETIVO: avaliar a influência do tratamento com fármacos antivertiginosos sobre a qualid... more Resumo: OBJETIVO: avaliar a influência do tratamento com fármacos antivertiginosos sobre a qualidade de vida e o equilíbrio postural de adultos e idosos com queixas de tontura. MÉTODOS: estudo transversal, com amostra de 51 indivíduos portadores de queixas de tontura, divididos em dois grupos, de acordo com o uso (grupo medicado, n=25) ou não (grupo não medicado, n=26) de fármacos antivertiginosos. Foram coletadas informações sobre: caracterização dos sintomas (ficha elaborada pelos pesquisadores), autopercepção de qualidade de vida (Dizziness Handicap Inventory),intensidade de tontura (escala visual analógica de tontura) e equilíbrio postural (plataforma de força). RESULTADOS: verificou-se intensidade moderada de tontura (Média: 4,6 ± 2,8) e impacto negativo das vestibulopatias sobre a qualidade de vida (Média: 47,3 ± 22,4) na amostra total. Quando comparados os dois grupos, não houve diferença estatisticamente significante na intensidade da tontura (p=0,74) ou qualidade de vida (p...