Karen Vaneunen - Academia.edu (original) (raw)
Papers by Karen Vaneunen
SEB experimental biology series, 2008
1. SEB Exp Biol Ser. 2008;61:65-91. Vertical systems biology: from DNA to flux and back. Bevilacq... more 1. SEB Exp Biol Ser. 2008;61:65-91. Vertical systems biology: from DNA to flux and back. Bevilacqua A, Wilkinson SJ, Dimelow R, Murabito E, Rehman S, Nardelli M, van Eunen K, Rossell S, Bruggeman FJ, Blüthgen N, De Vos D, Bouwman J, Bakker BM, Westerhoff HV. Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, UK. PMID: 18709737 [PubMed - indexed for MEDLINE]. Publication Types: Research Support, Non-US Gov't. MeSH Terms. ...
Biochemical Society Transactions, 2010
Biology and medicine have become 'big science', even though we may not always like this: genomics... more Biology and medicine have become 'big science', even though we may not always like this: genomics and the subsequent analysis of what the genomes encode has shown that interesting living organisms require many more than 300 gene products to interact. We once thought that somewhere in this jungle of interacting macromolecules was hidden the molecule that constitutes the secret of Life, and therewith of health and disease. Now we know that, somehow, the secret of Life is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come out. In the present paper, we review two strategies, which look at control and regulation. We discuss the difference between control and regulation and prove a relationship between them. To whom correspondence should be addressed (email Hans.Westerhoff@manchester. ac.uk). and the information about the individual trees has been growing exponentially. Reasons are the enormous complexity of the subject matter and, perhaps, a wrong approach to that complexity. Systems biology more than the biology of living systems should help get us out of this predicament. It should perhaps utilize the natural organization of living systems to develop analysis methods that thereby deviate from those of chemistry and physics and help clarify the mysteries of Life.
... Hans V. Westerhoff*1, Malkhey Verma*, Maria Nardelli*, Malgorzata Adamczyk*, Karen van Eunen... more ... Hans V. Westerhoff*1, Malkhey Verma*, Maria Nardelli*, Malgorzata Adamczyk*, Karen van Eunen, Evangelos Simeonidis* and Barbara M. Bakker *Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, 131 ...
SEB experimental biology series, 2008
1. SEB Exp Biol Ser. 2008;61:65-91. Vertical systems biology: from DNA to flux and back. Bevilacq... more 1. SEB Exp Biol Ser. 2008;61:65-91. Vertical systems biology: from DNA to flux and back. Bevilacqua A, Wilkinson SJ, Dimelow R, Murabito E, Rehman S, Nardelli M, van Eunen K, Rossell S, Bruggeman FJ, Blüthgen N, De Vos D, Bouwman J, Bakker BM, Westerhoff HV. Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, UK. PMID: 18709737 [PubMed - indexed for MEDLINE]. Publication Types: Research Support, Non-US Gov't. MeSH Terms. ...
Biochemical Society Transactions, 2010
Biology and medicine have become 'big science', even though we may not always like this: genomics... more Biology and medicine have become 'big science', even though we may not always like this: genomics and the subsequent analysis of what the genomes encode has shown that interesting living organisms require many more than 300 gene products to interact. We once thought that somewhere in this jungle of interacting macromolecules was hidden the molecule that constitutes the secret of Life, and therewith of health and disease. Now we know that, somehow, the secret of Life is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come out. In the present paper, we review two strategies, which look at control and regulation. We discuss the difference between control and regulation and prove a relationship between them. To whom correspondence should be addressed (email Hans.Westerhoff@manchester. ac.uk). and the information about the individual trees has been growing exponentially. Reasons are the enormous complexity of the subject matter and, perhaps, a wrong approach to that complexity. Systems biology more than the biology of living systems should help get us out of this predicament. It should perhaps utilize the natural organization of living systems to develop analysis methods that thereby deviate from those of chemistry and physics and help clarify the mysteries of Life.
... Hans V. Westerhoff*1, Malkhey Verma*, Maria Nardelli*, Malgorzata Adamczyk*, Karen van Eunen... more ... Hans V. Westerhoff*1, Malkhey Verma*, Maria Nardelli*, Malgorzata Adamczyk*, Karen van Eunen, Evangelos Simeonidis* and Barbara M. Bakker *Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, 131 ...