Karuza Pereira - Academia.edu (original) (raw)

Papers by Karuza Pereira

Aos meus colegas de turma do mestrado, nossa que turma... Faltam palavras para descrever as pesso... more Aos meus colegas de turma do mestrado, nossa que turma... Faltam palavras para descrever as pessoas que contribuíram para meu crescimento e amadurecimento profissional ao longo desses dois anos. Ao Cassiano, sempre prestativo e atencioso, pela ajuda e aprendizagem científica compartilhada, que nos motiva a aprender cada vez mais. Obrigada Japa!!! Ao George, sempre alegre e brincalhão, pela sua forma extrovertida e compromissada de dividir seus conhecimentos. Valeu George!!! Ao amigo João, autêntico e amável, que mesmo com nossas diferenças e dificuldades, tenho certeza que crescemos muito, tanto no campo profissional, quanto no pessoal. Valeu Joaozinho!!! E à Amiga Danielle, jovem sempre convicta de seus ideais, pelo seu jeito sincero e acolhedor, por nossas brincadeiras, pelos momentos partilhados e ajuda mútua que tivemos ao longo deste curso. Obrigada Dani!!!! À colega de Doutorado e grande amiga Roberta Cavalcante, exemplo garra, perseverança e simplicidade, com quem tive o imenso prazer de conviver ao longo desses dois anos, realmente, nossa convivência foi ímpar. Pelo apoio incondicional, incentivo constante, não só agora no mestrado, mas deste a graduação e por acreditar no meu potencial, pois com você aprendi que tudo é possível se tivermos força de vontade. Meu profundo agradecimento. Ao colega de Doutorado e amigo Gustavo Godoy, com sua alegria contagiante e bom humor inigualável, transforma o ambiente com suas gargalhadas. Pelo acolhimento, compreensão, por tudo que você me ensinou, e acima de tudo pela sua sincera amizade. 9 Aos colegas do doutorado: Rosilene e Márcio, com quem eu despertei para "gostar" do HPV, pela ajuda de forma desinteressada e efetiva, pois esse trabalho é continuação do projeto iniciado por vocês.

Frontiers in physiology, 2017

Periodontitis is very prevalent worldwide and is one of the major causes of tooth loss in adults.... more Periodontitis is very prevalent worldwide and is one of the major causes of tooth loss in adults. About 80% of the worldwide population use medicinal plants for their health care. Stemodia maritima L. (S. maritima) antioxidant and antimicrobial effects in vitro as well as anti-inflammatory properties. Herein, the potential therapeutic effect of S. maritima was assessed in rats subjected to experimental periodontitis (EP). EP was induced in female Wistar rats by nylon thread ligature around 2nd upper left molars for 11 days. Animals received (per os) S. maritima (0.2; 1 or 5 mg/kg) or vehicle (saline + DMSO) 1 h before ligature and then once daily for 11 days. The naive group had no manipulation. After this time-point, the animals were terminally anesthetized, and the maxillae were removed for morphometric and histological analyzes (HE). Gingival tissues were dissected to cytokine levels detection (TNF-α, IL1-β, CINC-1, and IL-10), enzymes superoxide dismutase (SOD), and catalase (CA...

Journal of …, 2010

Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Journal of Cranio... more Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Journal of Craniofacial Surgery. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed ...

Archives of Oral Biology, Aug 1, 2011

Asian Pacific journal of cancer prevention : APJCP, 2016

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of ... more Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early sta...

Rev Cir Traumatol Buco Maxilo Fac, Sep 1, 2009

Current Pharmaceutical Design, 2016

Lectins are a heterogeneous group of proteins and glycoproteins with potential role as therapeuti... more Lectins are a heterogeneous group of proteins and glycoproteins with potential role as therapeutic and diagnostic tools to combat various diseases, besides some functions on human organism. Abelmoschus esculentus (Okra), a horticultural plant of African origin, is cultivated in northeastern Brazil, and used for different medicinal purposes. This work is aimed to elucidate the action mechanisms of Abelmoschus esculentus lectin (AEL) gastro protective effect on gastropathy induced by ethanol. Fasted mice treated with Ethanol 99.9% (0.2 ml/animal, p.o.) received previously AEL (0.01, 0.1, 1.0, 10 or 50 mg/kg, i.v.), saline (5 ml/kg; i.v.) or ranitidine (80 mg/kg, p.o.) in four experimental series, in which pharmacological tools (yohimbine, naloxone, L-NAME or indomethacin), were administered with the purpose of make clear possible molecular action mechanisms. Mice were euthanized 30 min after ethanol challenge to verify the stomach damages. Establishment of gastric oxidative stress, tissue hemoglobin (Hb) content and microscopic features (H&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;E) were taken in order to characterize the AEL gastro protective effect. AEL (1 mg/kg) was capable of protect mucosa against ethanol damages in presence of two (L-NAME and indomethacin) of four antagonists/inhibitors used. The AEL effect was reversed by naloxone and yohimbine, showing the involvement of opioids and Αlpha-2 adrenergic receptors on gastric protective effect of this lectin. Evaluation of microscopic features, oxidative stress, and Hb levels pointed the protective effects of AEL. This activity seems to be mediated by alpha-2 adrenergic and opioid receptors activation. Nitric oxide or prostaglandins were not involved. AEL simultaneously showed antioxidant effect that is probably implicated in its intricate defensive mechanism of action.

Revista Brasileira De Otorrinolaringologia, 2008

Odontol Clin Cient, Sep 24, 2007

ABSTRACT

Inflammation Research, 2015

Wide biotechnological investigations of only a limited number of seaweed lectins have been perfor... more Wide biotechnological investigations of only a limited number of seaweed lectins have been performed. We previously demonstrated the anti-nociceptive and anti-inflammatory effects of a lectin isolated from the green seaweed Caulerpa cupressoides var. lycopodium (CcL). Herein, we further studied the mechanisms of action of CcL. Classical acute inflammation models induced by different flogistic agents were used to evaluate the anti-inflammatory action of CcL. CcL was injected locally into the rat paw to verify a possible pro-inflammatory outcome. CcL (0.1, 1 or 10 mg/kg; i.v.) reduced the carrageenan-induced rat paw edema and neutrophilic infiltration, which was not altered by either mucin (inhibitor of CcL carbohydrate-binding site) or ZnPP-IX (specific HO-1 inhibitor). Immunohistochemical analyses showed that CcL (1 mg/kg) reduced the expression of the cytokines IL-1β, TNF-α, IL-6 and COX-2. CcL (0.1, 1 or 10 mg/kg) inhibited dextran, and CcL (1 mg/kg) inhibited histamine-induced rat paw edema. Both effects were reversed by mucin inhibition. CcL (1 mg/kg) was ineffective for the treatment of serotonin- and bradykinin-induced rat paw edema. When injected via the i.pl. route, CcL (10 mg/kg) elicited rat paw edema involving a wide range of mediators. The anti-inflammatory action of CcL involves the inhibition of IL-1β, TNF-α, IL-6 and COX-2 expression and histamine H1 receptors. When locally administered, CcL exerts pro-inflammatory actions.

Journal of the American Geriatrics Society, 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015

The Journal of the American Dental Association, 2015

Case Reports in Dentistry, 2015

Lymphoepithelial cyst is a rare lesion of the oral cavity, with the mouth floor being the most co... more Lymphoepithelial cyst is a rare lesion of the oral cavity, with the mouth floor being the most common site of occurrence. The therapeutic approach of choice is the surgical treatment, which has rare cases of postoperative complications. The aim of this study is to report the case of a 53-year-old patient who came to Dental Service in the Federal University of Ceará complaining of a small nodular lesion (0.5 cm) located in the ventral tongue. Excisional biopsy was performed and the surgical specimen was submitted for anatomopathological analysis, which found that there was an oral lymphoepithelial cyst. The patient returned after seven days for suture removal and reported loss of sensitivity around the ventral tongue. We prescribed Citoneurin for ten days; however, there was not any significant improvement of the sensitivity. Low frequency laser therapy sessions were applied. The only postoperative symptom was dysesthesia, where there is only a sensitivity decrease. Currently, the patient has a postoperative period of 1 year without recurrence of the lesion. Although previous reports have no described tongue sensorineural disorders associated with this lesion, the occurrence of this event may be related to an unexpected anatomical variation of the lingual nerve.

Brazilian journal of otorhinolaryngology

... Cisto Epidermóide em região submentoniana: Relato de caso clínico. RBPO 2005;4(2): 90-3. 2. Y... more ... Cisto Epidermóide em região submentoniana: Relato de caso clínico. RBPO 2005;4(2): 90-3. 2. Yilmaz I, Yilmazer C, Yavuz H, Bal N, Ozluoglu L. Giant sublingual epidermoid cyst: a report of two cases. J Laryng Otol 2005;19:1-4. 3. Baredes S, Lee HJ, Eloy JA. ...