Kasturi Saikia - Academia.edu (original) (raw)
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Institute of Archaeology and Ethnology Polish Academy of Sciences
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Papers by Kasturi Saikia
International Journal of Surgical Pathology
Adamantinoma-like Ewing sarcoma (ALES) is a newly described rare entity, which shows EWSR1::FLI1 ... more Adamantinoma-like Ewing sarcoma (ALES) is a newly described rare entity, which shows EWSR1::FLI1 rearrangement characteristic of Ewing sarcoma. This can be diagnostically challenging as it manifests histologically with epithelial differentiation and has diffuse keratin expression as well as p40 and p60 positivity. We hereby report a case of ALES in a 33-year-old woman with a past medical history of breast carcinoma who presented with a right-sided parotid mass. CT scan of the neck showed a heterogenous mass within the superficial lobe, measuring 17 mm in diameter for which the patient underwent superficial parotidectomy. Histopathology of the mass revealed a malignant neoplasm formed of solid nests, cords and sheets of cells with minimal cytoplasm and monomorphic nuclei with granular chromatin and indistinct nucleoli. Brisk mitotic activity and tumor necrosis were also present. The tumor showed strong and diffuse reactivity for pankeratin (clone AE1/AE3) and keratin 20, both in a do...
Open Forum Infectious Diseases
Background Universal PCR and Next Generation Sequencing (uPCR/NGS) is a major advancement in micr... more Background Universal PCR and Next Generation Sequencing (uPCR/NGS) is a major advancement in microbiology. It is a highly sensitive and specific test that amplifies ribosomal RNA in samples to detect bacterial and fungal pathogens. We investigated the uPCR/NGS tests sent from Henry Ford Health (HFH) and the effect obtaining this test had on patient care. Methods We completed a retrospective, observational study assessing all consecutive uPCR/NGS tests obtained from at HFH from 2016-2021. This included uPCR/NGS for detection of bacterial, fungal, mycobacterium tuberculosis (MTB), and non-tuberculosis mycobacterium (NTM). All samples were of non-blood fluids and tissue samples. Patients concurrent tissue cultures and blood cultures from day of uPCR/NGS, and within 6 months of obtaining the uPCR/NGS sample were evaluated. Primary outcomes included if uPCR/NGS testing resulted in a change of choice or duration of antibiotic therapy. Results At HFH, 226 uPCR/NGS tests from 111 samples we...
International Journal of Science and Research (IJSR), 2017
Background: The tumors of the Central nervous system (CNS) include tumors of the brain and spinal... more Background: The tumors of the Central nervous system (CNS) include tumors of the brain and spinal cord. Primary CNS tumors are not common. However the incidence of CNS tumors has been rapidly increasing at recent times. 1 Aims and Objectives: The aims of this study were to determine the relative frequencies of tumors of central nervous system (CNS), their age and sex distribution. It was a hospital based study. Methods: The study group comprises of a total of 60 cases of tumors of CNS who have been clinically and radiologically diagnosed as such in the department of Neurosurgery, department of Pediatric surgery and department of General surgery in GMCH.The patients are of all ages and both sexes who have been operated for clinically indicated reasons. Result: CNS tumors are more common in adults with 50 cases (83%) than children with 10 cases (17%). Tumors of the CNS are more common in males than females in both children (≤19 years) and adults (>19 years) with a M:F ratio of 1.5:1 and 1.17:1 respectively. In adults meningioma was the commonest histology among all primary CNS tumors with 22 cases (44%). In children astrocytomas were found to be the commonest with 6 cases (60%). In adults the most common site of CNS tumor was found to be meninges (23 cases, 46 %). In children the most common site was cerebellum (6 cases, 60 %). Intracranial tumors were more common with 48 cases (80%) than spinal cord tumors with 12 cases (20%). Among the spinal cord tumors meningioma was the most common (8 cases, 66.7%) followed by schwannoma (3 cases, 25%) and ependymoma (1 case, 8.3%). Conclusion: CNS tumours vary considerably in their histological and gender distribution throughout childhood and adulthood. CNS tumors in adults have a relatively high frequency as compared to children. Even though most patients with high grade gliomas have a dismal prognosis, long-time survivors are seen in all histologic groups and illustrate the heterogeneity of these tumors. 2
Gynecologic Oncology Reports
International Journal of Surgical Pathology
Adamantinoma-like Ewing sarcoma (ALES) is a newly described rare entity, which shows EWSR1::FLI1 ... more Adamantinoma-like Ewing sarcoma (ALES) is a newly described rare entity, which shows EWSR1::FLI1 rearrangement characteristic of Ewing sarcoma. This can be diagnostically challenging as it manifests histologically with epithelial differentiation and has diffuse keratin expression as well as p40 and p60 positivity. We hereby report a case of ALES in a 33-year-old woman with a past medical history of breast carcinoma who presented with a right-sided parotid mass. CT scan of the neck showed a heterogenous mass within the superficial lobe, measuring 17 mm in diameter for which the patient underwent superficial parotidectomy. Histopathology of the mass revealed a malignant neoplasm formed of solid nests, cords and sheets of cells with minimal cytoplasm and monomorphic nuclei with granular chromatin and indistinct nucleoli. Brisk mitotic activity and tumor necrosis were also present. The tumor showed strong and diffuse reactivity for pankeratin (clone AE1/AE3) and keratin 20, both in a do...
Open Forum Infectious Diseases
Background Universal PCR and Next Generation Sequencing (uPCR/NGS) is a major advancement in micr... more Background Universal PCR and Next Generation Sequencing (uPCR/NGS) is a major advancement in microbiology. It is a highly sensitive and specific test that amplifies ribosomal RNA in samples to detect bacterial and fungal pathogens. We investigated the uPCR/NGS tests sent from Henry Ford Health (HFH) and the effect obtaining this test had on patient care. Methods We completed a retrospective, observational study assessing all consecutive uPCR/NGS tests obtained from at HFH from 2016-2021. This included uPCR/NGS for detection of bacterial, fungal, mycobacterium tuberculosis (MTB), and non-tuberculosis mycobacterium (NTM). All samples were of non-blood fluids and tissue samples. Patients concurrent tissue cultures and blood cultures from day of uPCR/NGS, and within 6 months of obtaining the uPCR/NGS sample were evaluated. Primary outcomes included if uPCR/NGS testing resulted in a change of choice or duration of antibiotic therapy. Results At HFH, 226 uPCR/NGS tests from 111 samples we...
International Journal of Science and Research (IJSR), 2017
Background: The tumors of the Central nervous system (CNS) include tumors of the brain and spinal... more Background: The tumors of the Central nervous system (CNS) include tumors of the brain and spinal cord. Primary CNS tumors are not common. However the incidence of CNS tumors has been rapidly increasing at recent times. 1 Aims and Objectives: The aims of this study were to determine the relative frequencies of tumors of central nervous system (CNS), their age and sex distribution. It was a hospital based study. Methods: The study group comprises of a total of 60 cases of tumors of CNS who have been clinically and radiologically diagnosed as such in the department of Neurosurgery, department of Pediatric surgery and department of General surgery in GMCH.The patients are of all ages and both sexes who have been operated for clinically indicated reasons. Result: CNS tumors are more common in adults with 50 cases (83%) than children with 10 cases (17%). Tumors of the CNS are more common in males than females in both children (≤19 years) and adults (>19 years) with a M:F ratio of 1.5:1 and 1.17:1 respectively. In adults meningioma was the commonest histology among all primary CNS tumors with 22 cases (44%). In children astrocytomas were found to be the commonest with 6 cases (60%). In adults the most common site of CNS tumor was found to be meninges (23 cases, 46 %). In children the most common site was cerebellum (6 cases, 60 %). Intracranial tumors were more common with 48 cases (80%) than spinal cord tumors with 12 cases (20%). Among the spinal cord tumors meningioma was the most common (8 cases, 66.7%) followed by schwannoma (3 cases, 25%) and ependymoma (1 case, 8.3%). Conclusion: CNS tumours vary considerably in their histological and gender distribution throughout childhood and adulthood. CNS tumors in adults have a relatively high frequency as compared to children. Even though most patients with high grade gliomas have a dismal prognosis, long-time survivors are seen in all histologic groups and illustrate the heterogeneity of these tumors. 2
Gynecologic Oncology Reports