Katalin Rajczy - Academia.edu (original) (raw)
Papers by Katalin Rajczy
European Journal of Gastroenterology Hepatology, Mar 1, 2011
Hereditary angioedema due to C1-inhibitor deficiency is a life-threatening condition, which manif... more Hereditary angioedema due to C1-inhibitor deficiency is a life-threatening condition, which manifests as edematous attacks involving subcutaneous tissues and/or the upper airway/gastrointestinal mucosa. Celiac disease is a gluten-sensitive small intestinal disorder that can lead to severe villous atrophy, malabsorption, and malignancy. Both hereditary angioedema and celiac disease may present with abdominal symptoms. Our aim was to study the occurrence of celiac disease in the hereditary angioedema population, as well as to analyze the clinical course of cases with both diseases. One hundred and twenty-eight patients with hereditary angioedema were screened for celiac disease, using serological methods [antiendomysial antibodies-immunoglobulin A (IgA), antiendomysial antibodies-IgG and tissue transglutaminase-IgA, tissue transglutaminase-IgG]. Clinical data of a child with hereditary angioedema and celiac disease diagnosed earlier were added to the dataset to be analyzed. Thus, the total number of patients was 129, comprising 107 adults and 22 pediatric patients. In patients with celiac disease, molecular genetics analysis (human leukocyte antigen-DQA1, human leukocyte antigen-DQB1) was carried out along with the introduction of a gluten-free diet and regular follow-up. Four out of the 22 children were diagnosed with celiac disease in our hereditary angioedema population. The prevalence of celiac disease among our pediatric patients with hereditary angioedema (22 children) was higher than in the general population (18.1 vs. 1.2%). Switching from the wheat starch-containing tranexamic acid product to danazol and introducing a gluten-free diet mitigated abdominal symptoms of hereditary angioedema. Similarities between the symptoms of hereditary angioedema and celiac disease may cause difficulties in differential diagnosis, as well as in choosing the appropriate therapy. In our opinion, screening hereditary angioedema patients for celiac disease is warranted if abdominal attacks or neurological symptoms persist despite adequate management. Complement testing is recommended whenever abdominal symptoms persist despite the histological and serological remission of gluten-sensitive enteropathy after the introduction of a gluten-free diet.
Transplantation, 2004
In a retrospective study we examined the differences between Caucasian (Group A) and Gypsy (Group... more In a retrospective study we examined the differences between Caucasian (Group A) and Gypsy (Group B) renal allograft recipients transplanted in Hungary. From 1983, 1918 transplants were performed in Budapest (1825 Caucasian and 93 Gypsy recipients). Group B patients were younger (34 Ϯ 12 vs 42 Ϯ 14 years of age; P Ͻ .01) and Group A had more polycystic kidney disease (12% vs 3%; P Ͻ .025). Blood group B was more common in Group B (27% vs 19%; P ϭ NS) than in Group A patients, and Group A had seemingly more diabetes (5% vs 1%; P ϭ NS) than did Group B. There were no differences in HLA mismatches or panel reactive antibodies (PRA). No differences were seen in Group A vs Group B patient survivals at 1, 3, 5, or 10 years' posttransplant (98% vs 95%; 90% vs 93%; 85% vs 88%; and 74% vs 82%, respectively). However, Group A graft survivals were significantly better than Group B at 1, 3, 5, and 10 years' posttransplant (89% vs 77%; 82% vs 66%; 76% vs 54%; and 57% vs 34%; each comparison P Ͻ .01). Group B recipients experienced a greater number of acute rejection episodes (66% vs 49%; P Ͻ .01), irreversible acute rejections (15% vs 6%; P Ͻ .001), chronic rejections (34% vs 18%; P Ͻ .001), and graft loss due to immunosuppression noncompliance (5% vs 1%; P Ͻ .05) than did Group A recipients. As has been previously described for other non-Caucasian ethnic groups (eg, African-Americans), Hungarian Gypsies appear to be at a greater immunological risk for rejection and poorer long-term graft survival.
Zeitschrift für Gerontologie
A population of 228 healthy elderly subjects was studied for immunoglobulin levels, titers of ant... more A population of 228 healthy elderly subjects was studied for immunoglobulin levels, titers of antibacterial antibodies and the prevalence of auto-antibodies, to determine the possible associations between these humoral parameters and age. Serum levels of IgG and especially IgA and the incidence of auto-antibodies (antinuclear antibody and rheumatoid factor) were increased in aged subjects. Some differences were found between males and females. The levels of IgA and natural antibodies were significantly higher in males: the changes of prevalence of auto-antibodies with age were different in males and females; furthermore the correlation between the level of IgG and that of natural antibodies was significant in males. There was a slight positive relationship between the prevalence of auto-antibodies and the level of natural antibodies.
Zeitschrift für Gerontologie
To investigate the harmful effect of smoking three groups of CBA/Ca male mice of different ages w... more To investigate the harmful effect of smoking three groups of CBA/Ca male mice of different ages were subjected to smoking for different time durations. Body weight changes and acute cold tolerance were measured throughout the experiment. Thyroid hormone levels (T4, T3), TSH and lipid peroxidation products (as malondialdehyde and lipofuscin) were determined from either the blood or some organs. There was a decrease in body weight related to aging and it was most pronounced in the oldest animals (Group III). However, significant body-weight loss due to smoking was found in the youngest animals (Group I). Similarly, smoking resulted in a body-weight loss of the other two older groups (Groups II and III) as well. The greatest change in withstanding cold stress was measured in Group I and less so in Group II, as a consequence of smoking. Simultaneously, the youngest animals (Group I) showed the most remarkable changes in thyroxine (T4) and 3,3,4-triiodothyronine (T3) serum concentrations...
Clinical and experimental rheumatology
Juvenile idiopathic arthritis (JIA) is a complex immune-mediated disease characterized by environ... more Juvenile idiopathic arthritis (JIA) is a complex immune-mediated disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The present study was undertaken to investigate the association of polymorphisms in two candidate genes for autoimmunity, human leukocyte antigen (HLA) DRB1 and protein tyrosine phosphatase N22 (PTPN22) with JIA in Hungarian patients. A case-control study including 150 Hungarian JIA patients and 200 sex and ethnically matched healthy controls was conducted. Genotyping for HLA-DRB1 and PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601) was carried out by group-specific PCR amplification and by real-time PCR allelic discrimination, respectively. In Hungarian patients JIA was associated with HLA-DRB1*01, DRB1*08, DRB1*13 (p=0.048, p=0.002, p=0.019, respectively) with marked differences between the disease subtypes classified according to the ILAR criteria. There was no association of the PTPN22 C1858T S...
Interdisciplinary Topics in Gerontology and Geriatrics, 1990
American Journal of Forensic Medicine & Pathology
Studies of human population genetics in Hungary have revealed relevant heterogeneity in the major... more Studies of human population genetics in Hungary have revealed relevant heterogeneity in the major histocompatibility complex. In the present studies, two isolated ethnic groups were chosen: people living in the Káli Basin westward from the Danube River, and those living in Opusztaszer, a village eastward from Danube, who are known as native ancient Hungarians. Blood samples were collected from 70 people in the Káli Basin and from 45 people in Opusztaszer. The frequency of HLA-Cw alleles was determined by serology as well as by DNA typing in 46 and 32 samples of the two populations, respectively, and in 44 randomly selected subjects of Hungarian origin. Compared with a random population of cadaver donors (the deaths having resulted mostly from accidents or, in a smaller number, strokes or heart infarcts) and voluntary bone marrow donors (typed in the last 10 years) recruited from all parts of Hungary and representing the mixed Hungarian population, remarkable differences were found i...
Orvosi Hetilap
Authors present a rare history of a family with accumulation of autoimmune diseases. From eight s... more Authors present a rare history of a family with accumulation of autoimmune diseases. From eight siblings four had rheumatoid arthritis, one systemic lupus erythematodes, one primary Sjögren syndrome, and one Reiter disease. Interestingly, neither the parents nor the offsprings were affected. Because of the possible genetic background, the authors performed HLA serologic and DNA investigations in nine members of the family. The results showed, in agreement with data from the literature, the accumulation of HLA-DQ7 (DQB1*0301), DR4, B27 and DR6 (DR13) risk factors. This observation confirms, that the clinical and immunogenetic features are different in familiar and sporadic forms of rheumatoid arthritis. Authors summarize the genetic background of rheumatoid arthritis in connection with this family tree.
The Journal of Rheumatology
We describe a unique family where each of the 5 siblings in the second generation has rheumatoid ... more We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family. HLA-DRB1* alleles were determined by polymerase chain reaction using the sequence-specific primer-Olerup method. The most common alleles in the 6 persons with RA were HLA-DRB1*07 and DRB1*15, which are known to be protective and neutral in RA. No patient or family member carried any HLA-DR4 alleles. HLA-DRB1*07 and DRB1*15 alleles are thought to be protective or neutral in RA. However, the majority of RA patients in the family and nearly ...
Interdisciplinary Topics in Gerontology and Geriatrics, 1990
Annales immunologiae Hungaricae, 1979
Serum samples were taken serially from three nonimmunized sheep over a long period of time. Antib... more Serum samples were taken serially from three nonimmunized sheep over a long period of time. Antibodies to human serum albumin (HSA), ovalbumin (OA) and FITC were separated from the samples. Than, two of the animals were injected with HSA+ complete Freund's adjuvant, the third with adjuvant without antigen. Serial postimmunization serum samples were subjected to the same procedures as the pre-immunization ones. The specific antibodies increased in concentration, and only the postimmunization antibody population was able to precipitate. In the presence of the antigen, the postimmunization antibodies bound to the Fc receptors of lymphocytes to an increased degree. There was no difference between pre- and postimmunizaton antibody populations either in complement-activating capacity or in the quantity of antigen necessary for reaching antigen-antibody equivalence. Isoelectro-focusing showed no new bands which would indicate antibodies different from the pre-existing ones. However, ch...
Interventional Medicine and Applied Science, 2010
Abstract: Malignant diseases are considered as great challenges in clinical transplantation. It i... more Abstract: Malignant diseases are considered as great challenges in clinical transplantation. It is well known that the incidence of malignancy is higher in the transplanted population if compared with the normal population. It is important to distinguish between neoplastic diseases ...
Orvosi hetilap, Jan 6, 2005
Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow e... more Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetic and autoimmune examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IV...
Orvosi hetilap, Jan 5, 2004
The review paper summarizes the advantages of the living donor kidney transplantation aiming that... more The review paper summarizes the advantages of the living donor kidney transplantation aiming that this kind of activity should get more support in Hungary. It is a general phenomenon overall the world, that there is no more possibility to increase the number of cadaver transplantations, and the outcome of them is also worsening because of the accumulation of aged patients with long time period of dialysis treatment. The paper points out the better results of living donor kidney transplantation underlining that the kidney long term survival, in general, is 10% over the cadaver kidney survival with significant less complication. The indication of living related and unrelated donor kidney transplantation is reported and the harmless of donor kidney removal demonstrated. An important part of the review contains the ethical, legal and social issue of the living donation, moreover, its economical benefit. It shows that in certain countries the living donation becomes in the forefront of t...
Bone marrow transplantation, 1998
Bone marrow transplantation, 1998
Twenty eight Hungarian patients lacking a compatible related donor and their 61 HLA-A,B,DR serolo... more Twenty eight Hungarian patients lacking a compatible related donor and their 61 HLA-A,B,DR serologically identical potential unrelated donors (selected from BMDW) were investigated in this study. Out of the 61 donor-recipient pairs only 7 (11,5%) proved to be HLA-identical at DNA level. Thirty one pairs (50,8%) differed in DP alleles, 1 pair (1,6%) has a DQ mismatch only and 22 (36,1%) pairs differed in more alleles. More than one potential donor was found for 26 patients and 5 of them have several donors with DP mismatches only. Among the 31 donor-recipient pairs differing only in DP alleles, 0, 1 and 2 mismatches were observed in GvH direction in 7, 10 and 14 cases, respectively. In the MLC assay no proliferative response was observed when no DP mismatch has been found. Among the 1 and 2 DP mismatched cases 11 (35,5%) gave negative and 13 (41,9%) gave positive MLR results. We have found a large scatter in RR values. On the basis of the DNA typing and MLR results we have found that...
British journal of haematology, 1997
Zeitschrift für Gerontologie und Geriatrie
The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy indiv... more The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy individuals between 50-89 years of age and that of centenarians were compared. The examination showed that in healthy elderly subjects and centenarians most of the clinical laboratory findings were in the normal range. However, age-related changes could be observed in erythrocyte sedimentation rate, in serum albumin level, and in the frequency of rheuma factor. Gender difference could be seen in the HDL-cholesterol level. Age and sex differences were observed in the hematocrit-, and hemoglobin-values, in serum creatinine-, total cholesterol-, serum IgG, IgA, IgM-levels, and in the frequency of the occurrence of antinuclear factor. The examinations demonstrated that lower hemoglobin and hematocrit values, elevated total-cholesterol level, the presence of antinuclear and rheuma factor, and elevated systolic blood pressure were more frequent in females than in males. It could be stated, however,...
European Journal of Gastroenterology Hepatology, Mar 1, 2011
Hereditary angioedema due to C1-inhibitor deficiency is a life-threatening condition, which manif... more Hereditary angioedema due to C1-inhibitor deficiency is a life-threatening condition, which manifests as edematous attacks involving subcutaneous tissues and/or the upper airway/gastrointestinal mucosa. Celiac disease is a gluten-sensitive small intestinal disorder that can lead to severe villous atrophy, malabsorption, and malignancy. Both hereditary angioedema and celiac disease may present with abdominal symptoms. Our aim was to study the occurrence of celiac disease in the hereditary angioedema population, as well as to analyze the clinical course of cases with both diseases. One hundred and twenty-eight patients with hereditary angioedema were screened for celiac disease, using serological methods [antiendomysial antibodies-immunoglobulin A (IgA), antiendomysial antibodies-IgG and tissue transglutaminase-IgA, tissue transglutaminase-IgG]. Clinical data of a child with hereditary angioedema and celiac disease diagnosed earlier were added to the dataset to be analyzed. Thus, the total number of patients was 129, comprising 107 adults and 22 pediatric patients. In patients with celiac disease, molecular genetics analysis (human leukocyte antigen-DQA1, human leukocyte antigen-DQB1) was carried out along with the introduction of a gluten-free diet and regular follow-up. Four out of the 22 children were diagnosed with celiac disease in our hereditary angioedema population. The prevalence of celiac disease among our pediatric patients with hereditary angioedema (22 children) was higher than in the general population (18.1 vs. 1.2%). Switching from the wheat starch-containing tranexamic acid product to danazol and introducing a gluten-free diet mitigated abdominal symptoms of hereditary angioedema. Similarities between the symptoms of hereditary angioedema and celiac disease may cause difficulties in differential diagnosis, as well as in choosing the appropriate therapy. In our opinion, screening hereditary angioedema patients for celiac disease is warranted if abdominal attacks or neurological symptoms persist despite adequate management. Complement testing is recommended whenever abdominal symptoms persist despite the histological and serological remission of gluten-sensitive enteropathy after the introduction of a gluten-free diet.
Transplantation, 2004
In a retrospective study we examined the differences between Caucasian (Group A) and Gypsy (Group... more In a retrospective study we examined the differences between Caucasian (Group A) and Gypsy (Group B) renal allograft recipients transplanted in Hungary. From 1983, 1918 transplants were performed in Budapest (1825 Caucasian and 93 Gypsy recipients). Group B patients were younger (34 Ϯ 12 vs 42 Ϯ 14 years of age; P Ͻ .01) and Group A had more polycystic kidney disease (12% vs 3%; P Ͻ .025). Blood group B was more common in Group B (27% vs 19%; P ϭ NS) than in Group A patients, and Group A had seemingly more diabetes (5% vs 1%; P ϭ NS) than did Group B. There were no differences in HLA mismatches or panel reactive antibodies (PRA). No differences were seen in Group A vs Group B patient survivals at 1, 3, 5, or 10 years' posttransplant (98% vs 95%; 90% vs 93%; 85% vs 88%; and 74% vs 82%, respectively). However, Group A graft survivals were significantly better than Group B at 1, 3, 5, and 10 years' posttransplant (89% vs 77%; 82% vs 66%; 76% vs 54%; and 57% vs 34%; each comparison P Ͻ .01). Group B recipients experienced a greater number of acute rejection episodes (66% vs 49%; P Ͻ .01), irreversible acute rejections (15% vs 6%; P Ͻ .001), chronic rejections (34% vs 18%; P Ͻ .001), and graft loss due to immunosuppression noncompliance (5% vs 1%; P Ͻ .05) than did Group A recipients. As has been previously described for other non-Caucasian ethnic groups (eg, African-Americans), Hungarian Gypsies appear to be at a greater immunological risk for rejection and poorer long-term graft survival.
Zeitschrift für Gerontologie
A population of 228 healthy elderly subjects was studied for immunoglobulin levels, titers of ant... more A population of 228 healthy elderly subjects was studied for immunoglobulin levels, titers of antibacterial antibodies and the prevalence of auto-antibodies, to determine the possible associations between these humoral parameters and age. Serum levels of IgG and especially IgA and the incidence of auto-antibodies (antinuclear antibody and rheumatoid factor) were increased in aged subjects. Some differences were found between males and females. The levels of IgA and natural antibodies were significantly higher in males: the changes of prevalence of auto-antibodies with age were different in males and females; furthermore the correlation between the level of IgG and that of natural antibodies was significant in males. There was a slight positive relationship between the prevalence of auto-antibodies and the level of natural antibodies.
Zeitschrift für Gerontologie
To investigate the harmful effect of smoking three groups of CBA/Ca male mice of different ages w... more To investigate the harmful effect of smoking three groups of CBA/Ca male mice of different ages were subjected to smoking for different time durations. Body weight changes and acute cold tolerance were measured throughout the experiment. Thyroid hormone levels (T4, T3), TSH and lipid peroxidation products (as malondialdehyde and lipofuscin) were determined from either the blood or some organs. There was a decrease in body weight related to aging and it was most pronounced in the oldest animals (Group III). However, significant body-weight loss due to smoking was found in the youngest animals (Group I). Similarly, smoking resulted in a body-weight loss of the other two older groups (Groups II and III) as well. The greatest change in withstanding cold stress was measured in Group I and less so in Group II, as a consequence of smoking. Simultaneously, the youngest animals (Group I) showed the most remarkable changes in thyroxine (T4) and 3,3,4-triiodothyronine (T3) serum concentrations...
Clinical and experimental rheumatology
Juvenile idiopathic arthritis (JIA) is a complex immune-mediated disease characterized by environ... more Juvenile idiopathic arthritis (JIA) is a complex immune-mediated disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The present study was undertaken to investigate the association of polymorphisms in two candidate genes for autoimmunity, human leukocyte antigen (HLA) DRB1 and protein tyrosine phosphatase N22 (PTPN22) with JIA in Hungarian patients. A case-control study including 150 Hungarian JIA patients and 200 sex and ethnically matched healthy controls was conducted. Genotyping for HLA-DRB1 and PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601) was carried out by group-specific PCR amplification and by real-time PCR allelic discrimination, respectively. In Hungarian patients JIA was associated with HLA-DRB1*01, DRB1*08, DRB1*13 (p=0.048, p=0.002, p=0.019, respectively) with marked differences between the disease subtypes classified according to the ILAR criteria. There was no association of the PTPN22 C1858T S...
Interdisciplinary Topics in Gerontology and Geriatrics, 1990
American Journal of Forensic Medicine & Pathology
Studies of human population genetics in Hungary have revealed relevant heterogeneity in the major... more Studies of human population genetics in Hungary have revealed relevant heterogeneity in the major histocompatibility complex. In the present studies, two isolated ethnic groups were chosen: people living in the Káli Basin westward from the Danube River, and those living in Opusztaszer, a village eastward from Danube, who are known as native ancient Hungarians. Blood samples were collected from 70 people in the Káli Basin and from 45 people in Opusztaszer. The frequency of HLA-Cw alleles was determined by serology as well as by DNA typing in 46 and 32 samples of the two populations, respectively, and in 44 randomly selected subjects of Hungarian origin. Compared with a random population of cadaver donors (the deaths having resulted mostly from accidents or, in a smaller number, strokes or heart infarcts) and voluntary bone marrow donors (typed in the last 10 years) recruited from all parts of Hungary and representing the mixed Hungarian population, remarkable differences were found i...
Orvosi Hetilap
Authors present a rare history of a family with accumulation of autoimmune diseases. From eight s... more Authors present a rare history of a family with accumulation of autoimmune diseases. From eight siblings four had rheumatoid arthritis, one systemic lupus erythematodes, one primary Sjögren syndrome, and one Reiter disease. Interestingly, neither the parents nor the offsprings were affected. Because of the possible genetic background, the authors performed HLA serologic and DNA investigations in nine members of the family. The results showed, in agreement with data from the literature, the accumulation of HLA-DQ7 (DQB1*0301), DR4, B27 and DR6 (DR13) risk factors. This observation confirms, that the clinical and immunogenetic features are different in familiar and sporadic forms of rheumatoid arthritis. Authors summarize the genetic background of rheumatoid arthritis in connection with this family tree.
The Journal of Rheumatology
We describe a unique family where each of the 5 siblings in the second generation has rheumatoid ... more We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family. HLA-DRB1* alleles were determined by polymerase chain reaction using the sequence-specific primer-Olerup method. The most common alleles in the 6 persons with RA were HLA-DRB1*07 and DRB1*15, which are known to be protective and neutral in RA. No patient or family member carried any HLA-DR4 alleles. HLA-DRB1*07 and DRB1*15 alleles are thought to be protective or neutral in RA. However, the majority of RA patients in the family and nearly ...
Interdisciplinary Topics in Gerontology and Geriatrics, 1990
Annales immunologiae Hungaricae, 1979
Serum samples were taken serially from three nonimmunized sheep over a long period of time. Antib... more Serum samples were taken serially from three nonimmunized sheep over a long period of time. Antibodies to human serum albumin (HSA), ovalbumin (OA) and FITC were separated from the samples. Than, two of the animals were injected with HSA+ complete Freund's adjuvant, the third with adjuvant without antigen. Serial postimmunization serum samples were subjected to the same procedures as the pre-immunization ones. The specific antibodies increased in concentration, and only the postimmunization antibody population was able to precipitate. In the presence of the antigen, the postimmunization antibodies bound to the Fc receptors of lymphocytes to an increased degree. There was no difference between pre- and postimmunizaton antibody populations either in complement-activating capacity or in the quantity of antigen necessary for reaching antigen-antibody equivalence. Isoelectro-focusing showed no new bands which would indicate antibodies different from the pre-existing ones. However, ch...
Interventional Medicine and Applied Science, 2010
Abstract: Malignant diseases are considered as great challenges in clinical transplantation. It i... more Abstract: Malignant diseases are considered as great challenges in clinical transplantation. It is well known that the incidence of malignancy is higher in the transplanted population if compared with the normal population. It is important to distinguish between neoplastic diseases ...
Orvosi hetilap, Jan 6, 2005
Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow e... more Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetic and autoimmune examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IV...
Orvosi hetilap, Jan 5, 2004
The review paper summarizes the advantages of the living donor kidney transplantation aiming that... more The review paper summarizes the advantages of the living donor kidney transplantation aiming that this kind of activity should get more support in Hungary. It is a general phenomenon overall the world, that there is no more possibility to increase the number of cadaver transplantations, and the outcome of them is also worsening because of the accumulation of aged patients with long time period of dialysis treatment. The paper points out the better results of living donor kidney transplantation underlining that the kidney long term survival, in general, is 10% over the cadaver kidney survival with significant less complication. The indication of living related and unrelated donor kidney transplantation is reported and the harmless of donor kidney removal demonstrated. An important part of the review contains the ethical, legal and social issue of the living donation, moreover, its economical benefit. It shows that in certain countries the living donation becomes in the forefront of t...
Bone marrow transplantation, 1998
Bone marrow transplantation, 1998
Twenty eight Hungarian patients lacking a compatible related donor and their 61 HLA-A,B,DR serolo... more Twenty eight Hungarian patients lacking a compatible related donor and their 61 HLA-A,B,DR serologically identical potential unrelated donors (selected from BMDW) were investigated in this study. Out of the 61 donor-recipient pairs only 7 (11,5%) proved to be HLA-identical at DNA level. Thirty one pairs (50,8%) differed in DP alleles, 1 pair (1,6%) has a DQ mismatch only and 22 (36,1%) pairs differed in more alleles. More than one potential donor was found for 26 patients and 5 of them have several donors with DP mismatches only. Among the 31 donor-recipient pairs differing only in DP alleles, 0, 1 and 2 mismatches were observed in GvH direction in 7, 10 and 14 cases, respectively. In the MLC assay no proliferative response was observed when no DP mismatch has been found. Among the 1 and 2 DP mismatched cases 11 (35,5%) gave negative and 13 (41,9%) gave positive MLR results. We have found a large scatter in RR values. On the basis of the DNA typing and MLR results we have found that...
British journal of haematology, 1997
Zeitschrift für Gerontologie und Geriatrie
The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy indiv... more The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy individuals between 50-89 years of age and that of centenarians were compared. The examination showed that in healthy elderly subjects and centenarians most of the clinical laboratory findings were in the normal range. However, age-related changes could be observed in erythrocyte sedimentation rate, in serum albumin level, and in the frequency of rheuma factor. Gender difference could be seen in the HDL-cholesterol level. Age and sex differences were observed in the hematocrit-, and hemoglobin-values, in serum creatinine-, total cholesterol-, serum IgG, IgA, IgM-levels, and in the frequency of the occurrence of antinuclear factor. The examinations demonstrated that lower hemoglobin and hematocrit values, elevated total-cholesterol level, the presence of antinuclear and rheuma factor, and elevated systolic blood pressure were more frequent in females than in males. It could be stated, however,...