Kathy Fosnaugh - Academia.edu (original) (raw)

Papers by Kathy Fosnaugh

Research paper thumbnail of Identification of Stabilized Small Interfering RNAs (siRNAs) for the Potential Treatment of Age–related Macular Degeneration (AMD)

Investigative Ophthalmology & Visual Science, 2005

Research paper thumbnail of Stabilized small interfering RNAs (siRNAs) targeting the vascular endothelial growth factor (VEGF) pathway inhibit angiogenesis in vivo in a rat corneal model

Investigative Ophthalmology & Visual Science, 2004

Research paper thumbnail of By RNA interference mediated inhibition of gene expression using sina (short interfering nucleic acid)

Research paper thumbnail of 短干渉核酸（ｓｉＮＡ）を用いる遺伝子発現のＲＮＡ干渉媒介性阻害

本発明は，種々の用途，例えば，治療，診断，標的評価およびゲノム発見用途における使用において，ヒト免疫不全ウイルス（ＨＩＶ）の遺伝子発現を調節するのに有用な方法および試薬に関する。詳細には，本発明... more 本発明は，種々の用途，例えば，治療，診断，標的評価およびゲノム発見用途における使用において，ヒト免疫不全ウイルス（ＨＩＶ）の遺伝子発現を調節するのに有用な方法および試薬に関する。詳細には，本発明は，ＨＩＶ遺伝子の発現および／または活性に対するＲＮＡ干渉（ＲＮＡｉ）を媒介しうる小核酸分子，例えば，短干渉核酸（ｓｉＮＡ），短干渉ＲＮＡ（ｓｉＲＮＡ），二本鎖ＲＮＡ（ｄｓＲＮＡ），マイクロＲＮＡ（ｍｉＲＮＡ），および短ヘアピンＲＮＡ（ｓｈＲＮＡ）分子に関する。小核酸分子は，ＨＩＶ感染，ＡＩＤＳ，およびＨＩＶの発現または活性の調節に応答する他の任意の疾病または病気の治療において有用である。

Research paper thumbnail of Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Cancer Research, 2017

Tumorigenesis is associated with increased polyamine levels and involves the induction of ornithi... more Tumorigenesis is associated with increased polyamine levels and involves the induction of ornithine decarboxylase (ODC), the initial rate-limiting enzyme in polyamine biosynthesis, and increased uptake of polyamines from the blood and diet. As well as contributing to proliferation, polyamines are reported to exert an immunosuppressive effect. Amplification of the MYC/MYCN oncogenes has been shown to directly induce ODC activity and inhibition of this enzyme by α-difluoromethylornithine (DFMO) markedly delays tumor development. Aminex Therapeutics is developing a polyamine depletion approach targeting both biosynthesis and transport of polyamines with AMX-513, a combination of the approved ODC inhibitor, DFMO, together with AMXT 1501, an alkylated polyamine mimetic which blocks polyamine uptake. In the syngeneic CT26.CL25 mouse model of colorectal cancer, AMX-513, dosed daily for four weeks, reduced tumor growth > 75% compared to vehicle-treated control in immunocompetent Balb/C m...

Research paper thumbnail of Nucleic acid compounds for inhibiting hras gene expression and uses thereof

Research paper thumbnail of Rna interference by modified short interfering nucleic acid

Research paper thumbnail of Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof

Research paper thumbnail of Nucleic Acid Compounds with Conformationally Restricted Monomers and Uses Thereof

Research paper thumbnail of RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Research paper thumbnail of Nucleic Acid Compounds for Inhibiting Survivin Gene Expression Uses Thereof

Research paper thumbnail of Delivery Molecules for Therapeutics

Research paper thumbnail of Activity Generating Delivery Molecules

Research paper thumbnail of Method and reagent for the treatment of asthma and allergic conditions

Research paper thumbnail of Nucleic Acid Compounds for Inhibiting PLK1 Gene Expression and Uses Thereof

Research paper thumbnail of Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies

Research paper thumbnail of An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

Molecular Therapy, 2011

Development of Amino Acid-based Liposomal siRNA Delivery Systems VII, apolipoprotein B100 (ApoB),... more Development of Amino Acid-based Liposomal siRNA Delivery Systems VII, apolipoprotein B100 (ApoB), and Transthyretin (TTR) genes are described.

Research paper thumbnail of RNA interfernece mediated inhibition of gene expression by chemically modified short interfering nucleic acids

Research paper thumbnail of RNA interference mediated inhibition of prostaglandin D2 receptor (PTGDR) and prostaglandin D2 synthetase (PTGDS) gene expression using short interfering RNA

Research paper thumbnail of Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid

Research paper thumbnail of Identification of Stabilized Small Interfering RNAs (siRNAs) for the Potential Treatment of Age–related Macular Degeneration (AMD)

Investigative Ophthalmology & Visual Science, 2005

Research paper thumbnail of Stabilized small interfering RNAs (siRNAs) targeting the vascular endothelial growth factor (VEGF) pathway inhibit angiogenesis in vivo in a rat corneal model

Investigative Ophthalmology & Visual Science, 2004

Research paper thumbnail of By RNA interference mediated inhibition of gene expression using sina (short interfering nucleic acid)

Research paper thumbnail of 短干渉核酸（ｓｉＮＡ）を用いる遺伝子発現のＲＮＡ干渉媒介性阻害

本発明は，種々の用途，例えば，治療，診断，標的評価およびゲノム発見用途における使用において，ヒト免疫不全ウイルス（ＨＩＶ）の遺伝子発現を調節するのに有用な方法および試薬に関する。詳細には，本発明... more 本発明は，種々の用途，例えば，治療，診断，標的評価およびゲノム発見用途における使用において，ヒト免疫不全ウイルス（ＨＩＶ）の遺伝子発現を調節するのに有用な方法および試薬に関する。詳細には，本発明は，ＨＩＶ遺伝子の発現および／または活性に対するＲＮＡ干渉（ＲＮＡｉ）を媒介しうる小核酸分子，例えば，短干渉核酸（ｓｉＮＡ），短干渉ＲＮＡ（ｓｉＲＮＡ），二本鎖ＲＮＡ（ｄｓＲＮＡ），マイクロＲＮＡ（ｍｉＲＮＡ），および短ヘアピンＲＮＡ（ｓｈＲＮＡ）分子に関する。小核酸分子は，ＨＩＶ感染，ＡＩＤＳ，およびＨＩＶの発現または活性の調節に応答する他の任意の疾病または病気の治療において有用である。

Research paper thumbnail of Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Cancer Research, 2017

Tumorigenesis is associated with increased polyamine levels and involves the induction of ornithi... more Tumorigenesis is associated with increased polyamine levels and involves the induction of ornithine decarboxylase (ODC), the initial rate-limiting enzyme in polyamine biosynthesis, and increased uptake of polyamines from the blood and diet. As well as contributing to proliferation, polyamines are reported to exert an immunosuppressive effect. Amplification of the MYC/MYCN oncogenes has been shown to directly induce ODC activity and inhibition of this enzyme by α-difluoromethylornithine (DFMO) markedly delays tumor development. Aminex Therapeutics is developing a polyamine depletion approach targeting both biosynthesis and transport of polyamines with AMX-513, a combination of the approved ODC inhibitor, DFMO, together with AMXT 1501, an alkylated polyamine mimetic which blocks polyamine uptake. In the syngeneic CT26.CL25 mouse model of colorectal cancer, AMX-513, dosed daily for four weeks, reduced tumor growth > 75% compared to vehicle-treated control in immunocompetent Balb/C m...

Research paper thumbnail of Nucleic acid compounds for inhibiting hras gene expression and uses thereof

Research paper thumbnail of Rna interference by modified short interfering nucleic acid

Research paper thumbnail of Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof

Research paper thumbnail of Nucleic Acid Compounds with Conformationally Restricted Monomers and Uses Thereof

Research paper thumbnail of RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Research paper thumbnail of Nucleic Acid Compounds for Inhibiting Survivin Gene Expression Uses Thereof

Research paper thumbnail of Delivery Molecules for Therapeutics

Research paper thumbnail of Activity Generating Delivery Molecules

Research paper thumbnail of Method and reagent for the treatment of asthma and allergic conditions

Research paper thumbnail of Nucleic Acid Compounds for Inhibiting PLK1 Gene Expression and Uses Thereof

Research paper thumbnail of Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies

Research paper thumbnail of An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

Molecular Therapy, 2011

Development of Amino Acid-based Liposomal siRNA Delivery Systems VII, apolipoprotein B100 (ApoB),... more Development of Amino Acid-based Liposomal siRNA Delivery Systems VII, apolipoprotein B100 (ApoB), and Transthyretin (TTR) genes are described.

Research paper thumbnail of RNA interfernece mediated inhibition of gene expression by chemically modified short interfering nucleic acids

Research paper thumbnail of RNA interference mediated inhibition of prostaglandin D2 receptor (PTGDR) and prostaglandin D2 synthetase (PTGDS) gene expression using short interfering RNA

Research paper thumbnail of Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid