Katrina Jolliffe - Academia.edu (original) (raw)
Papers by Katrina Jolliffe
Acta Crystallographica Section E-structure Reports Online, Dec 6, 2006
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Journal of Cell Science, 2021
The lipid content of mammalian cells varies greatly between cell type. Current methods for analys... more The lipid content of mammalian cells varies greatly between cell type. Current methods for analysing lipid components of cells are technically challenging and destructive. Here, we report a facile, inexpensive method to identify lipid content – intracellular flow cytometric lipid analysis (IFCLA). Distinct lipid classes can be distinguished by Nile Blue fluorescence, Nile Red fluorescence or violet autofluorescence. Nile Blue is fluorescent in the presence of unsaturated fatty acids with a carbon chain length greater than 16. Cis-configured fatty acids induce greater Nile Blue fluorescence than their trans-configured counterparts. In contrast, Nile Red exhibits greatest fluorescence in the presence of cholesterol, cholesteryl esters, some triglycerides and phospholipids. Multiparametric spanning-tree progression analysis for density-normalized events (SPADE) analysis of hepatic cellular lipid distribution, including vitamin A autofluorescence, is presented. This flow cytometric syst...
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Chemistry – A European Journal, 2020
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Chemistry (Weinheim an der Bergstrasse, Germany), Jan 8, 2018
Fluorescent sensors that illuminate specific molecules and chemical events allow the selective an... more Fluorescent sensors that illuminate specific molecules and chemical events allow the selective and sensitive study of the cellular environment. At the centre of this technology lies the fluorescent reporter molecule, and it is therefore crucial to provide a breadth of fluorophores with varying photophysical and biological behaviour. 4-Amino-1,8-naphthalimides are commonly employed in fluorescent sensors, but the narrow range of structural derivatives limits versatility of application. Here we report the synthesis and investigation of a set of twelve 4-amino-1,8-naphthalimides bearing an additional substituent on the aromatic core. Photophysical characterisation and Time-Dependent Density Functional Theory studies provided insights into the structure-photophysical property relationships of these derivatives, which show an expanded range of emission wavelengths and other photophysical properties. These compounds could all be visualised within cells by confocal microscopy, showing cyto...
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Australian Journal of Chemistry
ABSTRACT
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Australian Journal of Chemistry, 2015
Two tripodal ligands, each derived from 1,1,1-tris(hydroxymethyl)ethane and terminated respective... more Two tripodal ligands, each derived from 1,1,1-tris(hydroxymethyl)ethane and terminated respectively by 4-pyridyl (L1) and 2-pyridyl groups (L2), have been synthesised. Competitive seven-metal extraction studies (H2O/CHCl3) incorporating equal concentrations of cobalt(ii), nickel(ii), copper(ii), zinc(ii), silver(i), cadmium(ii), and lead(ii) in the aqueous phase and L1 or L2 in the organic phase showed selective extraction of silver(i) in each case. A parallel solvent extraction experiment involving a related tripodal tris-pyridyl ligand (L3) based on a 1,3,5-substituted aryl ring scaffold and incorporating thioether sulfurs in each tripod arm also showed extraction selectivity for silver(i); extraction efficiencies towards this metal ion fall in the order L3 > L1 > L2. Physical data are in accord with L1 forming a capsule-like complex of type [Ag3L12]3+ in which silver ions link pairs of pyridyl groups from different ligands. In contrast, L2 yields a complex of type [Ag2L2(NO...
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ChemInform, 2005
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Tetrahedron, 2004
ABSTRACT
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Synlett, 2009
ABSTRACT
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Polyhedron, 2007
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Journal of the American Chemical Society, 1999
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The Journal of Organic Chemistry, 2004
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Journal of Medicinal Chemistry, 2006
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Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2011
... bis-b-diketones Jack K. Clegg Bianca Antonioli David J. Bray Karsten Gloe Kerstin Glo... more ... bis-b-diketones Jack K. Clegg Bianca Antonioli David J. Bray Karsten Gloe Kerstin Gloe Katrina A. Jolliffe Olga N. Kataeva George V. Meehan Marco Wenzel Received: 9 March 2011 / Accepted: 21 March 2011 Ó Springer Science+Business Media BV 2011 ...
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Journal of Antimicrobial Chemotherapy, 2013
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Fungal Genetics and Biology, 2014
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Fungal Genetics and Biology, 2013
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Antimicrobial Agents and Chemotherapy, 2010
Ten bis(alkylpyridinium)alkane compounds were tested for antifungal activity against 19 species (... more Ten bis(alkylpyridinium)alkane compounds were tested for antifungal activity against 19 species (26 isolates) of yeasts and molds. We then determined the MICs and minimum fungicidal concentrations (MFCs) of four of the most active compounds (compounds 1, 4, 5, and 8) against 80 Candida and 20 cryptococcal isolates, in comparison with the MICs of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, and caspofungin, using Clinical Laboratory and Standards Institutes broth microdulition M27-A3 (yeasts) or M38-A2 (filamentous fungi) susceptibility protocols. The compounds were more potent against Candida and Cryptococcus spp. (MIC range, 0.74 to 27.9 μg/ml) than molds (0.74 to 59.7 μg/ml). MICs against Exophiala were 0.37 to 5.9 μg/ml and as low as 1.48 μg/ml for Scedosporium but ≥25 μg/ml for zygomycetes, Aspergillus , and Fusarium spp. Compounds 1, 4, 5, and 8 exhibited good fungicidal activity against Candida and Cryptococcus , except for Candida parapsilosis (MICs ...
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Antimicrobial Agents and Chemotherapy, 2007
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecan... more The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 μg/ml, respectively. MI was more active than ITC ( P < 0.001).
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Angewandte Chemie International Edition, 1998
The high affinity of Ag ions for aromatic π donors and cyano groups is exploited in a novel MALDI... more The high affinity of Ag ions for aromatic π donors and cyano groups is exploited in a novel MALDI-TOF mass spectrometric method for the identification of hydrogen-bonded assemblies. The interaction with the Ag ions-which, for example, can be complexed by two phenyl groups in a sandwich-type manner (see drawing on the right)-provides positively charged assemblies in a nondestructive way.
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Acta Crystallographica Section E-structure Reports Online, Dec 6, 2006
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Journal of Cell Science, 2021
The lipid content of mammalian cells varies greatly between cell type. Current methods for analys... more The lipid content of mammalian cells varies greatly between cell type. Current methods for analysing lipid components of cells are technically challenging and destructive. Here, we report a facile, inexpensive method to identify lipid content – intracellular flow cytometric lipid analysis (IFCLA). Distinct lipid classes can be distinguished by Nile Blue fluorescence, Nile Red fluorescence or violet autofluorescence. Nile Blue is fluorescent in the presence of unsaturated fatty acids with a carbon chain length greater than 16. Cis-configured fatty acids induce greater Nile Blue fluorescence than their trans-configured counterparts. In contrast, Nile Red exhibits greatest fluorescence in the presence of cholesterol, cholesteryl esters, some triglycerides and phospholipids. Multiparametric spanning-tree progression analysis for density-normalized events (SPADE) analysis of hepatic cellular lipid distribution, including vitamin A autofluorescence, is presented. This flow cytometric syst...
Bookmarks Related papers MentionsView impact
Chemistry – A European Journal, 2020
Bookmarks Related papers MentionsView impact
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 8, 2018
Fluorescent sensors that illuminate specific molecules and chemical events allow the selective an... more Fluorescent sensors that illuminate specific molecules and chemical events allow the selective and sensitive study of the cellular environment. At the centre of this technology lies the fluorescent reporter molecule, and it is therefore crucial to provide a breadth of fluorophores with varying photophysical and biological behaviour. 4-Amino-1,8-naphthalimides are commonly employed in fluorescent sensors, but the narrow range of structural derivatives limits versatility of application. Here we report the synthesis and investigation of a set of twelve 4-amino-1,8-naphthalimides bearing an additional substituent on the aromatic core. Photophysical characterisation and Time-Dependent Density Functional Theory studies provided insights into the structure-photophysical property relationships of these derivatives, which show an expanded range of emission wavelengths and other photophysical properties. These compounds could all be visualised within cells by confocal microscopy, showing cyto...
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Australian Journal of Chemistry
ABSTRACT
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Australian Journal of Chemistry, 2015
Two tripodal ligands, each derived from 1,1,1-tris(hydroxymethyl)ethane and terminated respective... more Two tripodal ligands, each derived from 1,1,1-tris(hydroxymethyl)ethane and terminated respectively by 4-pyridyl (L1) and 2-pyridyl groups (L2), have been synthesised. Competitive seven-metal extraction studies (H2O/CHCl3) incorporating equal concentrations of cobalt(ii), nickel(ii), copper(ii), zinc(ii), silver(i), cadmium(ii), and lead(ii) in the aqueous phase and L1 or L2 in the organic phase showed selective extraction of silver(i) in each case. A parallel solvent extraction experiment involving a related tripodal tris-pyridyl ligand (L3) based on a 1,3,5-substituted aryl ring scaffold and incorporating thioether sulfurs in each tripod arm also showed extraction selectivity for silver(i); extraction efficiencies towards this metal ion fall in the order L3 > L1 > L2. Physical data are in accord with L1 forming a capsule-like complex of type [Ag3L12]3+ in which silver ions link pairs of pyridyl groups from different ligands. In contrast, L2 yields a complex of type [Ag2L2(NO...
Bookmarks Related papers MentionsView impact
ChemInform, 2005
Bookmarks Related papers MentionsView impact
Tetrahedron, 2004
ABSTRACT
Bookmarks Related papers MentionsView impact
Synlett, 2009
ABSTRACT
Bookmarks Related papers MentionsView impact
Polyhedron, 2007
Bookmarks Related papers MentionsView impact
Journal of the American Chemical Society, 1999
Bookmarks Related papers MentionsView impact
The Journal of Organic Chemistry, 2004
Bookmarks Related papers MentionsView impact
Journal of Medicinal Chemistry, 2006
Bookmarks Related papers MentionsView impact
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2011
... bis-b-diketones Jack K. Clegg Bianca Antonioli David J. Bray Karsten Gloe Kerstin Glo... more ... bis-b-diketones Jack K. Clegg Bianca Antonioli David J. Bray Karsten Gloe Kerstin Gloe Katrina A. Jolliffe Olga N. Kataeva George V. Meehan Marco Wenzel Received: 9 March 2011 / Accepted: 21 March 2011 Ó Springer Science+Business Media BV 2011 ...
Bookmarks Related papers MentionsView impact
Journal of Antimicrobial Chemotherapy, 2013
Bookmarks Related papers MentionsView impact
Fungal Genetics and Biology, 2014
Bookmarks Related papers MentionsView impact
Fungal Genetics and Biology, 2013
Bookmarks Related papers MentionsView impact
Antimicrobial Agents and Chemotherapy, 2010
Ten bis(alkylpyridinium)alkane compounds were tested for antifungal activity against 19 species (... more Ten bis(alkylpyridinium)alkane compounds were tested for antifungal activity against 19 species (26 isolates) of yeasts and molds. We then determined the MICs and minimum fungicidal concentrations (MFCs) of four of the most active compounds (compounds 1, 4, 5, and 8) against 80 Candida and 20 cryptococcal isolates, in comparison with the MICs of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, and caspofungin, using Clinical Laboratory and Standards Institutes broth microdulition M27-A3 (yeasts) or M38-A2 (filamentous fungi) susceptibility protocols. The compounds were more potent against Candida and Cryptococcus spp. (MIC range, 0.74 to 27.9 μg/ml) than molds (0.74 to 59.7 μg/ml). MICs against Exophiala were 0.37 to 5.9 μg/ml and as low as 1.48 μg/ml for Scedosporium but ≥25 μg/ml for zygomycetes, Aspergillus , and Fusarium spp. Compounds 1, 4, 5, and 8 exhibited good fungicidal activity against Candida and Cryptococcus , except for Candida parapsilosis (MICs ...
Bookmarks Related papers MentionsView impact
Antimicrobial Agents and Chemotherapy, 2007
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecan... more The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 μg/ml, respectively. MI was more active than ITC ( P < 0.001).
Bookmarks Related papers MentionsView impact
Angewandte Chemie International Edition, 1998
The high affinity of Ag ions for aromatic π donors and cyano groups is exploited in a novel MALDI... more The high affinity of Ag ions for aromatic π donors and cyano groups is exploited in a novel MALDI-TOF mass spectrometric method for the identification of hydrogen-bonded assemblies. The interaction with the Ag ions-which, for example, can be complexed by two phenyl groups in a sandwich-type manner (see drawing on the right)-provides positively charged assemblies in a nondestructive way.
Bookmarks Related papers MentionsView impact