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Papers by Kazi Saiful Islam

Research paper thumbnail of 58 Rahman et al

Effect of early diagnosis, response to conventional therapies and possibility of recurrence of di... more Effect of early diagnosis, response to conventional therapies and possibility of recurrence of disease in different cancer patients in Bangladeshi adults

Research paper thumbnail of Maternal obstetric and morbidity factors in relation to infant birth weight

Low birth weight is an important factor that affects infant's morbidity and mortality. It is asso... more Low birth weight is an important factor that affects infant's morbidity and mortality. It is associated with infant's physiology, psychology, behavior and learning process during childhood. It is also determinant factors for future chronic health problems. The objective of this study was to investigate the association of maternal obstetric and morbidity factors with infant birth weight. In this study, a total of 343 newborns and their mothers were enrolled. The mean birth weight was 2755 ± 466 g. We found that multi-para had highest incidence of low birth weight (35.7%) and incidence of low birth weight was found higher among mothers who had started antenatal check up at 3rd trimester. Highest incidence of low birth weight (100%) was found among mothers having systolic blood pressure up to 99.9 mm Hg and lowest (16.2%) among mothers having systolic blood pressure ≥140 mm Hg. Incidence of low birth weight was 32.5% among mothers who had urinary tract infection and 24.9% who were normal. Incidence of low birth weight was highest (35.5%) when haemoglobin level was <9 g/dl and lowest (13.2%) when the level was ≥ 11. In conclusion this study we found that maternal obstetric and morbidity factors influences birth weight of newborns.

Research paper thumbnail of 76 Monirujjaman et al. Correlation between different cancers with age, sex, physiological, clinical and nutritional status in Bangladeshi adults International Journal of Biosciences (IJB)

Cancer is one of the leading causes of death all over the world including Bangladesh. Cancer inci... more Cancer is one of the leading causes of death all over the world including Bangladesh. Cancer incidence is dependent on different factors like age, sex, physiology, many other diseases and nutritional status. In this study, total 105 cancer patients aged between 20 and 79 were diagnosed; among them 41 patients were male and 64 were female. All of them were diagnosed with either primary or secondary cancer. Histology and use of radioactive molecules confirmed the presence and type of cancer in the patients. Among them those who were diagnosed with coexistence of diabetes or hypertension were more affected with cancer. We also observed that cancer risk was associated with smoking and nutritional status in Bangladeshi patients. These findings indicate that these are correlated with cancers in the Bangladeshi adults. More study will be required to repeat the findings and establish the trend regarding correlation found.

Research paper thumbnail of Maternal Socio-demographic factors and anthropometric characteristics related to infant birth weight

Research paper thumbnail of Effect of early diagnosis, response to conventional therapies and possibility of recurrence of disease in different cancer patients in Bangladeshi adults

Recurrence is a great problem in cancer treatment. A proportion of cancer patients develop recurr... more Recurrence is a great problem in cancer treatment. A proportion of cancer patients develop recurrence, even after curative resection. In the present study, data of a total 315 cancer patients, age between 22 to 60 years were analyzed, among them 130 patients were male and 185 were female. Patients were diagnosed with primary stage of cancer (72%) and secondary stage of cancer (28%). They were treated with either chemo-therapy or radiation therapy or surgery. We found that most patients show good response and improved clinical features on surgical removal than other treatment. Cancer may recur after conventional therapies and this recurrence may be prevented through early diagnosis and treatment, proper knowledge, life style change.://www.innspub.net 59 Rahman et al.

Research paper thumbnail of Sensitivity and specificity of direct and concentrated smear microscopy using culture and PCR based on IS6110 analysis for the detection of acid-fast Bacilli in suspected and having pulmonary tuberculosis

Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated... more Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated by PCR analysis and culture methods to determine a rapid and cheap detection of pulmonary tuberculosis. In this study 305 patients were selected and 915 specimens were collected from suspected and hospital admitted patients. Patients were taken from Dhaka Central Jail Hospital and National TB Hospital, Dhaka, Bangladesh. All samples were smeared and Ziehl-Neelsen method and Lowenstein-Jensen (L-J) method were applied. PCR analysis and culture method was used to confirm the detection. Isolated DNA was used in PCR analysis. In this detection study PCR based IS6110 analysis was developed to identify the pulmonary tuberculosis rapidly and cheaply. A total of 915 samples were prepared for analysis and found 70.47% and 82.85% sensitivity in direct and concentrated smears respectively. Both type of smears (direct and concentrated) showed 100% sensitivity and specificity in culture and PCR IS61...

Research paper thumbnail of Sex, Conception Interval, Gestational Age, Apgar Score, and Anthropometric Surrogates in relation to Birth Weight of Bangladeshi Newborns: A Cross-Sectional Study

ISRN Public Health, 2013

In developing countries, where about 75% of births occur at home or in the community, logistic pr... more In developing countries, where about 75% of births occur at home or in the community, logistic problems prevent the weighing of every newborn child. Baby born with a weight less than 2,500 g is considered low birth weight, since below this value birth-specific infant mortality begins to rise rapidly. In Bangladesh, the prevalence of low birth weight is unacceptably high. Infant's sex differences, birth to conception interval, gestational age, and Apgar score are associated with infant birth weight. To screen low-birth-weight babies, simple anthropometric parameters can be used in rural areas where 80–90% of deliveries take place. A sample of 343 newborn singletons, 186 male and 157 female babies, were studied in Southwest region of Bangladesh to examine the birth weight status of newborns and to identify the relationship between birth weight and other anthropometric parameters of newborns. The mean birth weight was 2754.81±465.57 g, and 28.6% were low-birth-weight (<2,500 g) ...

Research paper thumbnail of Evaluation of Real Time PCR for the diagnosis of Extrapulmonary Tuberculosis and comparison with AFB Microscopy among Bangladeshi population

International Journal of Natural Sciences, 2012

Tuberculosis is a global public health issue and a disease burden in Africa and Asia. Bangladesh ... more Tuberculosis is a global public health issue and a disease burden in Africa and Asia. Bangladesh is one of the high burden countries in Southeast Asian region. Mycobacterium tuberculosis the causative agent of tuberculosis, is a devastating bacterium because it spreads person to person, acquired multiple antibiotic resistance and most importantly has the limitation in rapid diagnosis, specially in case of extrapulmonary infection. Here we showed Real-Time PCR assay with the primers targeting IS6110 is a better method than conventional AFB microscopy for the diagnosis of extrapulmonary tuberculosis. For the comparative study 99 extrapulmonary specimens from 9 different parts of the body were collected from suspected patients. Among those only 10 samples were positive, where 50% them were scanty positive in AFB microscopy, on the other hand 33 samples were positive in Real–Time PCR assay. All samples positive in AFB microscopy were also positive in Real-Time PCR assay with an addition...

Research paper thumbnail of Int. J. Biosci

Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated... more Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated by PCR analysis and culture methods to determine a rapid and cheap detection of pulmonary tuberculosis. In this study 305 patients were selected and 915 specimens were collected from suspected and hospital admitted patients. Patients were taken from Dhaka Central Jail Hospital and National TB Hospital, Dhaka, Bangladesh. All samples were smeared and Ziehl-Neelsen method and Lowenstein-Jensen (L-J) method were applied. PCR analysis and culture method was used to confirm the detection. Isolated DNA was used in PCR analysis. In this detection study PCR based IS6110 analysis was developed to identify the pulmonary tuberculosis rapidly and cheaply. A total of 915 samples were prepared for analysis and found 70.47% and 82.85% sensitivity in direct and concentrated smears respectively. Both type of smears (direct and concentrated) showed 100% sensitivity and specificity in culture and PCR IS61...

Research paper thumbnail of In silico ADME/T and 3D QSAR analysis of KDR inhibitors

Journal of Applied Pharmaceutical Science, 2017

Research paper thumbnail of 58 Rahman et al

Effect of early diagnosis, response to conventional therapies and possibility of recurrence of di... more Effect of early diagnosis, response to conventional therapies and possibility of recurrence of disease in different cancer patients in Bangladeshi adults

Research paper thumbnail of Maternal obstetric and morbidity factors in relation to infant birth weight

Low birth weight is an important factor that affects infant's morbidity and mortality. It is asso... more Low birth weight is an important factor that affects infant's morbidity and mortality. It is associated with infant's physiology, psychology, behavior and learning process during childhood. It is also determinant factors for future chronic health problems. The objective of this study was to investigate the association of maternal obstetric and morbidity factors with infant birth weight. In this study, a total of 343 newborns and their mothers were enrolled. The mean birth weight was 2755 ± 466 g. We found that multi-para had highest incidence of low birth weight (35.7%) and incidence of low birth weight was found higher among mothers who had started antenatal check up at 3rd trimester. Highest incidence of low birth weight (100%) was found among mothers having systolic blood pressure up to 99.9 mm Hg and lowest (16.2%) among mothers having systolic blood pressure ≥140 mm Hg. Incidence of low birth weight was 32.5% among mothers who had urinary tract infection and 24.9% who were normal. Incidence of low birth weight was highest (35.5%) when haemoglobin level was <9 g/dl and lowest (13.2%) when the level was ≥ 11. In conclusion this study we found that maternal obstetric and morbidity factors influences birth weight of newborns.

Research paper thumbnail of 76 Monirujjaman et al. Correlation between different cancers with age, sex, physiological, clinical and nutritional status in Bangladeshi adults International Journal of Biosciences (IJB)

Cancer is one of the leading causes of death all over the world including Bangladesh. Cancer inci... more Cancer is one of the leading causes of death all over the world including Bangladesh. Cancer incidence is dependent on different factors like age, sex, physiology, many other diseases and nutritional status. In this study, total 105 cancer patients aged between 20 and 79 were diagnosed; among them 41 patients were male and 64 were female. All of them were diagnosed with either primary or secondary cancer. Histology and use of radioactive molecules confirmed the presence and type of cancer in the patients. Among them those who were diagnosed with coexistence of diabetes or hypertension were more affected with cancer. We also observed that cancer risk was associated with smoking and nutritional status in Bangladeshi patients. These findings indicate that these are correlated with cancers in the Bangladeshi adults. More study will be required to repeat the findings and establish the trend regarding correlation found.

Research paper thumbnail of Maternal Socio-demographic factors and anthropometric characteristics related to infant birth weight

Research paper thumbnail of Effect of early diagnosis, response to conventional therapies and possibility of recurrence of disease in different cancer patients in Bangladeshi adults

Recurrence is a great problem in cancer treatment. A proportion of cancer patients develop recurr... more Recurrence is a great problem in cancer treatment. A proportion of cancer patients develop recurrence, even after curative resection. In the present study, data of a total 315 cancer patients, age between 22 to 60 years were analyzed, among them 130 patients were male and 185 were female. Patients were diagnosed with primary stage of cancer (72%) and secondary stage of cancer (28%). They were treated with either chemo-therapy or radiation therapy or surgery. We found that most patients show good response and improved clinical features on surgical removal than other treatment. Cancer may recur after conventional therapies and this recurrence may be prevented through early diagnosis and treatment, proper knowledge, life style change.://www.innspub.net 59 Rahman et al.

Research paper thumbnail of Sensitivity and specificity of direct and concentrated smear microscopy using culture and PCR based on IS6110 analysis for the detection of acid-fast Bacilli in suspected and having pulmonary tuberculosis

Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated... more Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated by PCR analysis and culture methods to determine a rapid and cheap detection of pulmonary tuberculosis. In this study 305 patients were selected and 915 specimens were collected from suspected and hospital admitted patients. Patients were taken from Dhaka Central Jail Hospital and National TB Hospital, Dhaka, Bangladesh. All samples were smeared and Ziehl-Neelsen method and Lowenstein-Jensen (L-J) method were applied. PCR analysis and culture method was used to confirm the detection. Isolated DNA was used in PCR analysis. In this detection study PCR based IS6110 analysis was developed to identify the pulmonary tuberculosis rapidly and cheaply. A total of 915 samples were prepared for analysis and found 70.47% and 82.85% sensitivity in direct and concentrated smears respectively. Both type of smears (direct and concentrated) showed 100% sensitivity and specificity in culture and PCR IS61...

Research paper thumbnail of Sex, Conception Interval, Gestational Age, Apgar Score, and Anthropometric Surrogates in relation to Birth Weight of Bangladeshi Newborns: A Cross-Sectional Study

ISRN Public Health, 2013

In developing countries, where about 75% of births occur at home or in the community, logistic pr... more In developing countries, where about 75% of births occur at home or in the community, logistic problems prevent the weighing of every newborn child. Baby born with a weight less than 2,500 g is considered low birth weight, since below this value birth-specific infant mortality begins to rise rapidly. In Bangladesh, the prevalence of low birth weight is unacceptably high. Infant's sex differences, birth to conception interval, gestational age, and Apgar score are associated with infant birth weight. To screen low-birth-weight babies, simple anthropometric parameters can be used in rural areas where 80–90% of deliveries take place. A sample of 343 newborn singletons, 186 male and 157 female babies, were studied in Southwest region of Bangladesh to examine the birth weight status of newborns and to identify the relationship between birth weight and other anthropometric parameters of newborns. The mean birth weight was 2754.81±465.57 g, and 28.6% were low-birth-weight (<2,500 g) ...

Research paper thumbnail of Evaluation of Real Time PCR for the diagnosis of Extrapulmonary Tuberculosis and comparison with AFB Microscopy among Bangladeshi population

International Journal of Natural Sciences, 2012

Tuberculosis is a global public health issue and a disease burden in Africa and Asia. Bangladesh ... more Tuberculosis is a global public health issue and a disease burden in Africa and Asia. Bangladesh is one of the high burden countries in Southeast Asian region. Mycobacterium tuberculosis the causative agent of tuberculosis, is a devastating bacterium because it spreads person to person, acquired multiple antibiotic resistance and most importantly has the limitation in rapid diagnosis, specially in case of extrapulmonary infection. Here we showed Real-Time PCR assay with the primers targeting IS6110 is a better method than conventional AFB microscopy for the diagnosis of extrapulmonary tuberculosis. For the comparative study 99 extrapulmonary specimens from 9 different parts of the body were collected from suspected patients. Among those only 10 samples were positive, where 50% them were scanty positive in AFB microscopy, on the other hand 33 samples were positive in Real–Time PCR assay. All samples positive in AFB microscopy were also positive in Real-Time PCR assay with an addition...

Research paper thumbnail of Int. J. Biosci

Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated... more Sensitivity and specificity of direct and concentrated AFB smear microscopy has been investigated by PCR analysis and culture methods to determine a rapid and cheap detection of pulmonary tuberculosis. In this study 305 patients were selected and 915 specimens were collected from suspected and hospital admitted patients. Patients were taken from Dhaka Central Jail Hospital and National TB Hospital, Dhaka, Bangladesh. All samples were smeared and Ziehl-Neelsen method and Lowenstein-Jensen (L-J) method were applied. PCR analysis and culture method was used to confirm the detection. Isolated DNA was used in PCR analysis. In this detection study PCR based IS6110 analysis was developed to identify the pulmonary tuberculosis rapidly and cheaply. A total of 915 samples were prepared for analysis and found 70.47% and 82.85% sensitivity in direct and concentrated smears respectively. Both type of smears (direct and concentrated) showed 100% sensitivity and specificity in culture and PCR IS61...

Research paper thumbnail of In silico ADME/T and 3D QSAR analysis of KDR inhibitors

Journal of Applied Pharmaceutical Science, 2017