Keita Ando - Academia.edu (original) (raw)

Papers by Keita Ando

Research paper thumbnail of Dynamic stressing measurement of viscous liquids using microfluidic chips

2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS), 2013

This paper demonstrates the dynamic stressing of viscous liquids in microfluidic channels. An inf... more This paper demonstrates the dynamic stressing of viscous liquids in microfluidic channels. An infrared laser pulse is focused within the testing liquid in a microfluidic channel and a spherical shock wave near an air-liquid interface is created. The shock is reflected as a tension wave by the free surface due to the acoustic impedance mismatch. The displacement of the free surface within hundred nanoseconds is captured by a developed double-exposure optical system. The tensile strength can be estimated by extrapolating a series of shock pressure approximation at several different distances between the bubble and the free surface to the measurement accuracy. This study has a great potential in the optical breakdown of biomaterials.

Research paper thumbnail of 2009 Improvement of acoustic theory of ultrasonic waves in dilute bubbly liquids

Abstract: The theory of the acoustics of dilute bubbly liquids is reviewed, and the dispersion re... more Abstract: The theory of the acoustics of dilute bubbly liquids is reviewed, and the dispersion relation is modified by including the effect of liquid compressibility on the natural frequency of the bubbles. The modified theory is shown to more accurately predict the trend in measured attenuation of ultrasonic waves. The model limitations associated with such high-frequency waves are discussed.

Research paper thumbnail of Experimental Study of Free-Surface Deformation and Cavitation Bubble Dynamics in a Megasonic Cleaning Bath

Volume 5: Multiphase Flow, 2019

Underwater ultrasound causes various physical phenomena in megasonic cleaning baths, e.g. cavitat... more Underwater ultrasound causes various physical phenomena in megasonic cleaning baths, e.g. cavitation inception, bubble translation and free-surface deformation (FSD) due to acoustic radiation pressure. Because FSD is especially noticeable in the case of high frequency ultrasound due to its high directivity, it is essential to investigate the interaction between FSD and bubble translation in megasonic cleaning bath. In our present experiments, we construct a typical setup for megasonic cleaning and irradiate water with 1 MHz ultrasound vertically upwards. We visualize FSD and bubbles and analyze the height of FSD and the translational velocity in frequency space. The bubbles translate in both short and long time scales caused by bubble-bubble interaction and periodic FSD, respectively, and the latter has periodicity. The most dominant frequency component in FSD shows good agreement with that in the translational velocity of the bubbles and does not depend on whether cavitation occurs...

Research paper thumbnail of Quantitative Analysis of Acoustic Pressure for Sonophoresis and Its Effect on Transdermal Penetration

Ultrasound in Medicine & Biology, 2022

Research paper thumbnail of Bubble cloud nucleation induced by the interaction between multiple laser-induced shocks and bubbles

Bulletin of the American Physical Society, 2013

Research paper thumbnail of Chemically controlled megasonic cleaning of patterned structures using solutions with dissolved gas and surfactant

Ultrasonics Sonochemistry, 2021

Graphical abstract

Research paper thumbnail of Numerical simulation of shock propagation in a polydisperse bubbly liquid

International Journal of Multiphase Flow, 2011

Research paper thumbnail of Shock Propagation in Polydisperse Bubbly Liquids

Bubble Dynamics and Shock Waves, 2013

Research paper thumbnail of Statistical equilibrium of bubble oscillations in dilute bubbly flows

Research paper thumbnail of Fast on-demand droplet fusion using transient cavitation bubbles

Research paper thumbnail of Shock propagation through a bubbly liquid in a deformable tube

Journal of Fluid Mechanics, 2011

Shock propagation through a bubbly liquid contained in a deformable tube is considered. Quasi-one... more Shock propagation through a bubbly liquid contained in a deformable tube is considered. Quasi-one-dimensional mixture-averaged flow equations that include fluid–structure interaction are formulated. The steady shock relations are derived and the nonlinear effect due to the gas-phase compressibility is examined. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material and pressure on the tube wall are measured. The experimental data indicate that the linear theory is incapable of properly predicting the propagation speeds of finite-amplitude waves in a mixture-filled tube; the shock theory is found to more accurately estimate the measured wave speeds.

Research paper thumbnail of Improvement of acoustic theory of ultrasonic waves in dilute bubbly liquids

The Journal of the Acoustical Society of America, 2009

Research paper thumbnail of Video: Drop fragmentation on impact

70th Annual Meeting of the APS Division of Fluid Dynamics - Gallery of Fluid Motion

Research paper thumbnail of Acoustic streaming induced by MHz-frequency ultrasound extends the volume limit of cell suspension culture

The Journal of the Acoustical Society of America

Large-scale cell suspension culture technology opens up opportunities for numerous medical and bi... more Large-scale cell suspension culture technology opens up opportunities for numerous medical and bioengineering applications. For these purposes, scale-up of the culture system is paramount. For initial small-scale culture, a simple static suspension culture (SSC) is generally employed. However, cell sedimentation due to the lack of agitation limits the culture volume feasible for SSC. Thus, when scaling up, cell suspensions must be manually transferred from the culture flask to another vessel suitable for agitation, which increases the risk of contamination and human error. Ideally, the number of culture transfer steps should be kept to a minimum. The present study describes the fabrication of an ultrasonic suspension culture system that stirs cell suspensions with the use of acoustic streaming generated by ultrasound irradiation at a MHz frequency. This system was applied to 100-mL suspension cultures of Chinese hamster ovary cells-a volume tenfold larger than that generally used. The cell proliferation rate in this system was 1.88/day when applying an input voltage of 40 V to the ultrasonic transducer, while that of the SSC was 1.14/day. Hence, the proposed method can extend the volume limit of static cell suspension cultures, thereby reducing the number of cell culture transfer steps.

Research paper thumbnail of Numerical Analysis of High Speed Droplet Impact

When a droplet impacts a solid surface at high speed, the contact periphery expands very quickly ... more When a droplet impacts a solid surface at high speed, the contact periphery expands very quickly and liquid compressibility plays an important role in the initial dynamics and the formation of lateral jets. The high speed impact results in high pressures that can account for the surface erosion. In this study, we numerically investigated a high speed droplet impacts on a solid wall. The multicomponent Euler equations with the stiffened equation of state are computed using a FV-WENO scheme with an HLLC Riemann solver (Johnsen & Colonius 2006) that accurately captures shocks and interfaces. In order to compare the available theories and experiments, 1D, 2D and axisymmetric solutions are obtained. The generated pressures, shock speeds, and the lateral jetting generation are investigated. In addition, the effect of target compliance is evaluated.

Research paper thumbnail of Effects of bubble size distributions on acoustics of dilute bubbly liquids

Research paper thumbnail of Particle Removal in Ultrasonic Water Flow Cleaning Role of Cavitation Bubbles as Cleaning Agents

Solid State Phenomena

Visualization experiments are performed to examine the role of acoustic cavitation bubbles that a... more Visualization experiments are performed to examine the role of acoustic cavitation bubbles that appear in 0.43-MHz ultrasonic water flow spreading over glass surfaces in the context of physical cleaning. The cleaning performance is evaluated using glass samples on which small silica particles are spin-coated. The visualization suggests that acoustic cavitation bubbles play a major role in particle removal as in the case of conventional cleaning with ultrasonic cleaning baths.

Research paper thumbnail of S01 超音波照射下の粘弾性体における球形気泡の力学に関する理論および実験(特別講演)

Research paper thumbnail of Shock Theory of a Bubbly Liquid in a Deformable Tube

Shock propagation through a bubbly liquid filled in a deformable cylindrical tube is considered. ... more Shock propagation through a bubbly liquid filled in a deformable cylindrical tube is considered. Quasi-one-dimensional bubbly flow equations that include fluid-structure interaction are formulated, and the steady shock relations are derived. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material are measured. The experimental data indicate that the linear theory cannot properly predict the propagation speeds of shock waves in mixture-filled tubes; the shock theory is found to more accurately estimate the measured wave speeds.

Research paper thumbnail of Shock Propagation in Polydisperse Bubbly Flows

The effect of distributed bubble size on shock propagation in homogeneous bubbly liquids is compu... more The effect of distributed bubble size on shock propagation in homogeneous bubbly liquids is computed using a continuum two-phase model. An ensemble-averaging technique is employed to derive the statistically averaged equations and a finite-volume method is used to solve the model equations. The bubble dynamics are incorporated using a Rayleigh-Plesset-type equation which includes the effects of heat transfer, liquid viscosity and compressibility. For the case of monodisperse bubbles, it is known that relaxation oscillations occur behind the shock due to the bubble dynamics. The present computations for the case of polydisperse bubbles show that bubble size distributions lead to additional damping of the shock dynamics. If the distribution is sufficiently broad, the statistical effect dominates over the physical damping associated with the single bubble dynamics. This smooths out the oscillatory shock structure.

Research paper thumbnail of Dynamic stressing measurement of viscous liquids using microfluidic chips

2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS), 2013

This paper demonstrates the dynamic stressing of viscous liquids in microfluidic channels. An inf... more This paper demonstrates the dynamic stressing of viscous liquids in microfluidic channels. An infrared laser pulse is focused within the testing liquid in a microfluidic channel and a spherical shock wave near an air-liquid interface is created. The shock is reflected as a tension wave by the free surface due to the acoustic impedance mismatch. The displacement of the free surface within hundred nanoseconds is captured by a developed double-exposure optical system. The tensile strength can be estimated by extrapolating a series of shock pressure approximation at several different distances between the bubble and the free surface to the measurement accuracy. This study has a great potential in the optical breakdown of biomaterials.

Research paper thumbnail of 2009 Improvement of acoustic theory of ultrasonic waves in dilute bubbly liquids

Abstract: The theory of the acoustics of dilute bubbly liquids is reviewed, and the dispersion re... more Abstract: The theory of the acoustics of dilute bubbly liquids is reviewed, and the dispersion relation is modified by including the effect of liquid compressibility on the natural frequency of the bubbles. The modified theory is shown to more accurately predict the trend in measured attenuation of ultrasonic waves. The model limitations associated with such high-frequency waves are discussed.

Research paper thumbnail of Experimental Study of Free-Surface Deformation and Cavitation Bubble Dynamics in a Megasonic Cleaning Bath

Volume 5: Multiphase Flow, 2019

Underwater ultrasound causes various physical phenomena in megasonic cleaning baths, e.g. cavitat... more Underwater ultrasound causes various physical phenomena in megasonic cleaning baths, e.g. cavitation inception, bubble translation and free-surface deformation (FSD) due to acoustic radiation pressure. Because FSD is especially noticeable in the case of high frequency ultrasound due to its high directivity, it is essential to investigate the interaction between FSD and bubble translation in megasonic cleaning bath. In our present experiments, we construct a typical setup for megasonic cleaning and irradiate water with 1 MHz ultrasound vertically upwards. We visualize FSD and bubbles and analyze the height of FSD and the translational velocity in frequency space. The bubbles translate in both short and long time scales caused by bubble-bubble interaction and periodic FSD, respectively, and the latter has periodicity. The most dominant frequency component in FSD shows good agreement with that in the translational velocity of the bubbles and does not depend on whether cavitation occurs...

Research paper thumbnail of Quantitative Analysis of Acoustic Pressure for Sonophoresis and Its Effect on Transdermal Penetration

Ultrasound in Medicine & Biology, 2022

Research paper thumbnail of Bubble cloud nucleation induced by the interaction between multiple laser-induced shocks and bubbles

Bulletin of the American Physical Society, 2013

Research paper thumbnail of Chemically controlled megasonic cleaning of patterned structures using solutions with dissolved gas and surfactant

Ultrasonics Sonochemistry, 2021

Graphical abstract

Research paper thumbnail of Numerical simulation of shock propagation in a polydisperse bubbly liquid

International Journal of Multiphase Flow, 2011

Research paper thumbnail of Shock Propagation in Polydisperse Bubbly Liquids

Bubble Dynamics and Shock Waves, 2013

Research paper thumbnail of Statistical equilibrium of bubble oscillations in dilute bubbly flows

Research paper thumbnail of Fast on-demand droplet fusion using transient cavitation bubbles

Research paper thumbnail of Shock propagation through a bubbly liquid in a deformable tube

Journal of Fluid Mechanics, 2011

Shock propagation through a bubbly liquid contained in a deformable tube is considered. Quasi-one... more Shock propagation through a bubbly liquid contained in a deformable tube is considered. Quasi-one-dimensional mixture-averaged flow equations that include fluid–structure interaction are formulated. The steady shock relations are derived and the nonlinear effect due to the gas-phase compressibility is examined. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material and pressure on the tube wall are measured. The experimental data indicate that the linear theory is incapable of properly predicting the propagation speeds of finite-amplitude waves in a mixture-filled tube; the shock theory is found to more accurately estimate the measured wave speeds.

Research paper thumbnail of Improvement of acoustic theory of ultrasonic waves in dilute bubbly liquids

The Journal of the Acoustical Society of America, 2009

Research paper thumbnail of Video: Drop fragmentation on impact

70th Annual Meeting of the APS Division of Fluid Dynamics - Gallery of Fluid Motion

Research paper thumbnail of Acoustic streaming induced by MHz-frequency ultrasound extends the volume limit of cell suspension culture

The Journal of the Acoustical Society of America

Large-scale cell suspension culture technology opens up opportunities for numerous medical and bi... more Large-scale cell suspension culture technology opens up opportunities for numerous medical and bioengineering applications. For these purposes, scale-up of the culture system is paramount. For initial small-scale culture, a simple static suspension culture (SSC) is generally employed. However, cell sedimentation due to the lack of agitation limits the culture volume feasible for SSC. Thus, when scaling up, cell suspensions must be manually transferred from the culture flask to another vessel suitable for agitation, which increases the risk of contamination and human error. Ideally, the number of culture transfer steps should be kept to a minimum. The present study describes the fabrication of an ultrasonic suspension culture system that stirs cell suspensions with the use of acoustic streaming generated by ultrasound irradiation at a MHz frequency. This system was applied to 100-mL suspension cultures of Chinese hamster ovary cells-a volume tenfold larger than that generally used. The cell proliferation rate in this system was 1.88/day when applying an input voltage of 40 V to the ultrasonic transducer, while that of the SSC was 1.14/day. Hence, the proposed method can extend the volume limit of static cell suspension cultures, thereby reducing the number of cell culture transfer steps.

Research paper thumbnail of Numerical Analysis of High Speed Droplet Impact

When a droplet impacts a solid surface at high speed, the contact periphery expands very quickly ... more When a droplet impacts a solid surface at high speed, the contact periphery expands very quickly and liquid compressibility plays an important role in the initial dynamics and the formation of lateral jets. The high speed impact results in high pressures that can account for the surface erosion. In this study, we numerically investigated a high speed droplet impacts on a solid wall. The multicomponent Euler equations with the stiffened equation of state are computed using a FV-WENO scheme with an HLLC Riemann solver (Johnsen & Colonius 2006) that accurately captures shocks and interfaces. In order to compare the available theories and experiments, 1D, 2D and axisymmetric solutions are obtained. The generated pressures, shock speeds, and the lateral jetting generation are investigated. In addition, the effect of target compliance is evaluated.

Research paper thumbnail of Effects of bubble size distributions on acoustics of dilute bubbly liquids

Research paper thumbnail of Particle Removal in Ultrasonic Water Flow Cleaning Role of Cavitation Bubbles as Cleaning Agents

Solid State Phenomena

Visualization experiments are performed to examine the role of acoustic cavitation bubbles that a... more Visualization experiments are performed to examine the role of acoustic cavitation bubbles that appear in 0.43-MHz ultrasonic water flow spreading over glass surfaces in the context of physical cleaning. The cleaning performance is evaluated using glass samples on which small silica particles are spin-coated. The visualization suggests that acoustic cavitation bubbles play a major role in particle removal as in the case of conventional cleaning with ultrasonic cleaning baths.

Research paper thumbnail of S01 超音波照射下の粘弾性体における球形気泡の力学に関する理論および実験(特別講演)

Research paper thumbnail of Shock Theory of a Bubbly Liquid in a Deformable Tube

Shock propagation through a bubbly liquid filled in a deformable cylindrical tube is considered. ... more Shock propagation through a bubbly liquid filled in a deformable cylindrical tube is considered. Quasi-one-dimensional bubbly flow equations that include fluid-structure interaction are formulated, and the steady shock relations are derived. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material are measured. The experimental data indicate that the linear theory cannot properly predict the propagation speeds of shock waves in mixture-filled tubes; the shock theory is found to more accurately estimate the measured wave speeds.

Research paper thumbnail of Shock Propagation in Polydisperse Bubbly Flows

The effect of distributed bubble size on shock propagation in homogeneous bubbly liquids is compu... more The effect of distributed bubble size on shock propagation in homogeneous bubbly liquids is computed using a continuum two-phase model. An ensemble-averaging technique is employed to derive the statistically averaged equations and a finite-volume method is used to solve the model equations. The bubble dynamics are incorporated using a Rayleigh-Plesset-type equation which includes the effects of heat transfer, liquid viscosity and compressibility. For the case of monodisperse bubbles, it is known that relaxation oscillations occur behind the shock due to the bubble dynamics. The present computations for the case of polydisperse bubbles show that bubble size distributions lead to additional damping of the shock dynamics. If the distribution is sufficiently broad, the statistical effect dominates over the physical damping associated with the single bubble dynamics. This smooths out the oscillatory shock structure.