Kemal Demirkırkan - Academia.edu (original) (raw)

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Papers by Kemal Demirkırkan

DergiPark (Istanbul University), Aug 1, 2003

Multiple system atrophy is a progressive neurodegenerative disease occurring sporadically and cha... more Multiple system atrophy is a progressive neurodegenerative disease occurring sporadically and characterized extrapyramidal, cerebellar, and autonomic symptoms in any combination. In this case report, a 78 years old male patient admitted to neurology department with many serious complaints was discussed in the light of relevant literature. His complaints include bradykinesia, hypomimia and impaired memory appeared first, 4 years ago and dysartria and ataxia having developed since then.

Kocatepe tıp dergisi, Aug 1, 2002

Tohoku Journal of Experimental Medicine, 2006

DergiPark (Istanbul University), Apr 1, 2004

Bilimsel Zemin: Kronik gerilim tipi basagrisi tedavisinde kullanilan Trisiklik antidepresanlarin ... more Bilimsel Zemin: Kronik gerilim tipi basagrisi tedavisinde kullanilan Trisiklik antidepresanlarin istenme— yen yan etkileri, bu ilaclarin kullanimlarini sinirlamaktadir. Selektif serotonin-noradrenalin geri alim inhibitoru olan Venlafaksin degisik tipteki kronik agrilarda kullanilan ve yan etkileri gorece daha az olan bir ilactir. Amac: Bu calismada kronik gerilim tipi basagrilarinin prosaktik tedavisinde Venlafaksin ve Amitriptilin’in et— kinlikleri karsilastirilmistir. Gerec ve Yontem: Prospektif olarak yapilan bu calismaya 41 hasta alindi. 20 hasta Amitriptilin, 21 hasta Venlafaksin kullandi. Hamilton Depresyon skalasiyla depresyon tanisi dislanan hastalarin tedavi oncesi aylik agri sikligi, agri suresi ve agri siddeti kaydedildi. Hastalar 3 ay boyunca ayda bir kez kontrole cagrilarak tedavi sirasindaki degisimler ve yan etkiler belirlendi. Bulgular: Calisma tamamlandiginda Amitriptilin grubunda ortalama ilac dozu 25751847 mg/gun, Venlafaksin grubunda 101.62i33.9 mg/gun olarak sap...

Ataksi Telenjiektazi nadir gorulen, otozomal resesif gecisli norodejeneratif bir hastaliktir. Kli... more Ataksi Telenjiektazi nadir gorulen, otozomal resesif gecisli norodejeneratif bir hastaliktir. Klinik olarak erken cocukluk doneminde baslayan progresif serebellar ataksi, okulokutanoz telenjiektaziler, degisen oranda hucresel ve humoral immun yetmezlikler ve buna bagli olarak artmis kanser riski goze carpmaktadir. Olgumuz 14 yasinda kadin. Alti yasina kadar normal buyume gelisme sureci yasamis. Alti yasindan itibaren baslayan ve yavas ilerleyen dengesiz yurume, peltek konusma ve okul basarisinda dusme yakinmalari ile klinigimize basvurdu. Her iki sklerada telenjiektaziler dikkati cekiyordu. Bu makalede , ataksi telenjiektazi tanisini koydugumuz bir olgu nedeniyle , ilgili literatur gozden gecirilerek hastaligin klinik ve patalojik ozellikleri sunulmustur

Neuroscience Letters, 2006

Decreased cerebral flow velocities in Parkinsonian patients were reported previously. Because of ... more Decreased cerebral flow velocities in Parkinsonian patients were reported previously. Because of the limited data on vascular changes in Parkinson disease (PD), which may have a vascular etiology, we aimed to disclose any possible cerebral hemodynamic alteration in Parkinsonian patients. We prospectively evaluated 28 non-demented, idiopathic parkinsonian patients and 19 age and sex matched controls with Doppler sonography. Flow volumes, peak systolic flow velocities, and cross-sectional areas of vertebral and internal carotid arteries (ICA) were measured and compared between patients and controls. Correlation of patient age and disease duration with Doppler parameters was observed; and each Doppler parameter of patients within each Hoehn-Yahr scale was compared. There was no significant difference of measured parameters between groups. No correlation was found between disease duration and age with flow volume, cross-sectional area or peak systolic velocity. Hoehn-Yahr scale was not found having significant relation with Doppler parameters. Values of vertebral, internal carotid and cerebral blood flow volumes (CBF), peak systolic velocities, and cross-sectional areas were not significantly different between Parkinsonian patients and age and sex matched controls. Although regional blood flow decreases may be seen as reported previously, Parkinson disease is not associated with a flow volume or velocity alteration of extracranial cerebral arteries.

Kocatepe Tıp Dergisi, Apr 1, 2003

Background : Migraine is one of the most common causes of primary headaches. In our study, we aim... more Background : Migraine is one of the most common causes of primary headaches. In our study, we aimed to investigate the relation of migraine with thyroid dysfunction by determining the blood levels of free T3, free T4 and TSH in the patients with migraine. Methods: This study was performed to 234 out-patients diagnosed as migraine. Age, gender, family history, history of thyroid disease, nausea, vomiting, motion sickness, photophobia, phonophobia; type, duration, frequency and intensity of the migraine and relation of these parameters with thyroid function tests were assessed; and compared with the control group. Forty eight healthy people who applied to Family Medicine policlinic with similar age and gender were included to the control group. Results: In study group there were 17 migraineurs with aura (7.3%), four basilar-type migraine (1.7%) and one retinal migraine (0.4%). The mean migraine duration in study group was 9.8±8.2 years. Also the frequency of the migraine was 43.2±2.6 ...

DergiPark (Istanbul University), Aug 1, 2003

Multiple system atrophy is a progressive neurodegenerative disease occurring sporadically and cha... more Multiple system atrophy is a progressive neurodegenerative disease occurring sporadically and characterized extrapyramidal, cerebellar, and autonomic symptoms in any combination. In this case report, a 78 years old male patient admitted to neurology department with many serious complaints was discussed in the light of relevant literature. His complaints include bradykinesia, hypomimia and impaired memory appeared first, 4 years ago and dysartria and ataxia having developed since then.

Kocatepe tıp dergisi, Aug 1, 2002

Tohoku Journal of Experimental Medicine, 2006

DergiPark (Istanbul University), Apr 1, 2004

Bilimsel Zemin: Kronik gerilim tipi basagrisi tedavisinde kullanilan Trisiklik antidepresanlarin ... more Bilimsel Zemin: Kronik gerilim tipi basagrisi tedavisinde kullanilan Trisiklik antidepresanlarin istenme— yen yan etkileri, bu ilaclarin kullanimlarini sinirlamaktadir. Selektif serotonin-noradrenalin geri alim inhibitoru olan Venlafaksin degisik tipteki kronik agrilarda kullanilan ve yan etkileri gorece daha az olan bir ilactir. Amac: Bu calismada kronik gerilim tipi basagrilarinin prosaktik tedavisinde Venlafaksin ve Amitriptilin’in et— kinlikleri karsilastirilmistir. Gerec ve Yontem: Prospektif olarak yapilan bu calismaya 41 hasta alindi. 20 hasta Amitriptilin, 21 hasta Venlafaksin kullandi. Hamilton Depresyon skalasiyla depresyon tanisi dislanan hastalarin tedavi oncesi aylik agri sikligi, agri suresi ve agri siddeti kaydedildi. Hastalar 3 ay boyunca ayda bir kez kontrole cagrilarak tedavi sirasindaki degisimler ve yan etkiler belirlendi. Bulgular: Calisma tamamlandiginda Amitriptilin grubunda ortalama ilac dozu 25751847 mg/gun, Venlafaksin grubunda 101.62i33.9 mg/gun olarak sap...

Ataksi Telenjiektazi nadir gorulen, otozomal resesif gecisli norodejeneratif bir hastaliktir. Kli... more Ataksi Telenjiektazi nadir gorulen, otozomal resesif gecisli norodejeneratif bir hastaliktir. Klinik olarak erken cocukluk doneminde baslayan progresif serebellar ataksi, okulokutanoz telenjiektaziler, degisen oranda hucresel ve humoral immun yetmezlikler ve buna bagli olarak artmis kanser riski goze carpmaktadir. Olgumuz 14 yasinda kadin. Alti yasina kadar normal buyume gelisme sureci yasamis. Alti yasindan itibaren baslayan ve yavas ilerleyen dengesiz yurume, peltek konusma ve okul basarisinda dusme yakinmalari ile klinigimize basvurdu. Her iki sklerada telenjiektaziler dikkati cekiyordu. Bu makalede , ataksi telenjiektazi tanisini koydugumuz bir olgu nedeniyle , ilgili literatur gozden gecirilerek hastaligin klinik ve patalojik ozellikleri sunulmustur

Neuroscience Letters, 2006

Decreased cerebral flow velocities in Parkinsonian patients were reported previously. Because of ... more Decreased cerebral flow velocities in Parkinsonian patients were reported previously. Because of the limited data on vascular changes in Parkinson disease (PD), which may have a vascular etiology, we aimed to disclose any possible cerebral hemodynamic alteration in Parkinsonian patients. We prospectively evaluated 28 non-demented, idiopathic parkinsonian patients and 19 age and sex matched controls with Doppler sonography. Flow volumes, peak systolic flow velocities, and cross-sectional areas of vertebral and internal carotid arteries (ICA) were measured and compared between patients and controls. Correlation of patient age and disease duration with Doppler parameters was observed; and each Doppler parameter of patients within each Hoehn-Yahr scale was compared. There was no significant difference of measured parameters between groups. No correlation was found between disease duration and age with flow volume, cross-sectional area or peak systolic velocity. Hoehn-Yahr scale was not found having significant relation with Doppler parameters. Values of vertebral, internal carotid and cerebral blood flow volumes (CBF), peak systolic velocities, and cross-sectional areas were not significantly different between Parkinsonian patients and age and sex matched controls. Although regional blood flow decreases may be seen as reported previously, Parkinson disease is not associated with a flow volume or velocity alteration of extracranial cerebral arteries.

Kocatepe Tıp Dergisi, Apr 1, 2003

Background : Migraine is one of the most common causes of primary headaches. In our study, we aim... more Background : Migraine is one of the most common causes of primary headaches. In our study, we aimed to investigate the relation of migraine with thyroid dysfunction by determining the blood levels of free T3, free T4 and TSH in the patients with migraine. Methods: This study was performed to 234 out-patients diagnosed as migraine. Age, gender, family history, history of thyroid disease, nausea, vomiting, motion sickness, photophobia, phonophobia; type, duration, frequency and intensity of the migraine and relation of these parameters with thyroid function tests were assessed; and compared with the control group. Forty eight healthy people who applied to Family Medicine policlinic with similar age and gender were included to the control group. Results: In study group there were 17 migraineurs with aura (7.3%), four basilar-type migraine (1.7%) and one retinal migraine (0.4%). The mean migraine duration in study group was 9.8±8.2 years. Also the frequency of the migraine was 43.2±2.6 ...