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Papers by Kevin Ken

Research paper thumbnail of Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13

Genetic Epidemiology, 2003

Twelve teams of investigators constituted a group which analyzed phenotypes related to metabolic ... more Twelve teams of investigators constituted a group which analyzed phenotypes related to metabolic syndrome, making use of the available longitudinal measurements from the family component of the Framingham Heart Study or the simulated data, as distributed by Genetic Analysis Workshop 13 (GAW13). Body mass index, obesity, lipid abnormalities, glucose, or combinations of these traits were analyzed by this group. A wide variety of approaches were taken to construct phenotypes from the longitudinal measurements, including considering single or multiple cross-sectional time points, single ages, minimum values, maximum values, means, other lifetime values, ever/never dichotomy, or age at onset of some threshold value. Approaches also differed in the family structures utilized (sib pairs to full extended pedigrees), the genetic data considered (two-point or multipoint), and the statistics calculated (model-free and parametric), and led to a diverse set of analyses being performed. Inferences were made about heritability, and attempts were made to map underlying genes. Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses. Genet Epidemiol 25 (Suppl. 1):S78–S89, 2003. Published 2003 Wiley-Liss, Inc.

Research paper thumbnail of The Role of Allergy and Smoking in Chronic Rhinosinusitis and Polyposis

Laryngoscope, 2008

Objectives/Hypothesis: The article considers the interrelatedness of allergic rhinitis and chroni... more Objectives/Hypothesis: The article considers the interrelatedness of allergic rhinitis and chronic rhinosinusitis (CRS). The negative impact of perennial allergy and tobacco use on polyposis in sinus surgery patients is explored.Study Design: A retrospective chart review, performed by the first author over a 6-year period, of patients who underwent functional endoscopic sinus surgery for CRS.Methods: The subjects' allergy status and smoking history are scrutinized by summary statistics and a multiple linear logistic model for predicting the presence of polyps.Results: High prevalence of perennial allergic rhinitis (PAR) is seen in the subject population (56.4%). Both PAR and tobacco use are associated with nasal polyposis (P = .0073 and P = .0114, respectively).Conclusions: The close association of PAR and CRS suggests a possible causal link. Management of allergic rhinitis and tobacco cessation may provide greater control of chronic hyperplastic rhinosinusitis.

Research paper thumbnail of The Role of Sequential and Concurrent Sexual Relationships in the Risk of Sexually Transmitted Diseases Among Adolescents

To explore whether patterns of sexual relationships, such as sequential (nonoverlapping in time) ... more To explore whether patterns of sexual relationships, such as sequential (nonoverlapping in time) or concurrent (overlapping in time), are more important indicators of sexually transmitted disease (STD) risk among adolescents than number of sexual partners.

Research paper thumbnail of A PROBLEM IN ASCERTAINMENT

Communications in Statistics-theory and Methods, 2001

Page 1. A PROBLEM IN ASCERTAINMENT Kevin J. Keen and Robert C. Elston Department of Epidemiology ... more Page 1. A PROBLEM IN ASCERTAINMENT Kevin J. Keen and Robert C. Elston Department of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, Ohio 44109-1998 ABSTRACT ...

Research paper thumbnail of Mobile agents on mobile robotic platforms: a survey

ACM Southeast Regional Conference, 2008

In this paper several papers that have been written on mobile agents and robots are surveyed with... more In this paper several papers that have been written on mobile agents and robots are surveyed with a view toward determining the state of the art of software mobile agents running on robotic platforms.

Research paper thumbnail of Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13

Genetic Epidemiology, 2003

Twelve teams of investigators constituted a group which analyzed phenotypes related to metabolic ... more Twelve teams of investigators constituted a group which analyzed phenotypes related to metabolic syndrome, making use of the available longitudinal measurements from the family component of the Framingham Heart Study or the simulated data, as distributed by Genetic Analysis Workshop 13 (GAW13). Body mass index, obesity, lipid abnormalities, glucose, or combinations of these traits were analyzed by this group. A wide variety of approaches were taken to construct phenotypes from the longitudinal measurements, including considering single or multiple cross-sectional time points, single ages, minimum values, maximum values, means, other lifetime values, ever/never dichotomy, or age at onset of some threshold value. Approaches also differed in the family structures utilized (sib pairs to full extended pedigrees), the genetic data considered (two-point or multipoint), and the statistics calculated (model-free and parametric), and led to a diverse set of analyses being performed. Inferences were made about heritability, and attempts were made to map underlying genes. Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses. Genet Epidemiol 25 (Suppl. 1):S78–S89, 2003. Published 2003 Wiley-Liss, Inc.

Research paper thumbnail of The Role of Allergy and Smoking in Chronic Rhinosinusitis and Polyposis

Laryngoscope, 2008

Objectives/Hypothesis: The article considers the interrelatedness of allergic rhinitis and chroni... more Objectives/Hypothesis: The article considers the interrelatedness of allergic rhinitis and chronic rhinosinusitis (CRS). The negative impact of perennial allergy and tobacco use on polyposis in sinus surgery patients is explored.Study Design: A retrospective chart review, performed by the first author over a 6-year period, of patients who underwent functional endoscopic sinus surgery for CRS.Methods: The subjects' allergy status and smoking history are scrutinized by summary statistics and a multiple linear logistic model for predicting the presence of polyps.Results: High prevalence of perennial allergic rhinitis (PAR) is seen in the subject population (56.4%). Both PAR and tobacco use are associated with nasal polyposis (P = .0073 and P = .0114, respectively).Conclusions: The close association of PAR and CRS suggests a possible causal link. Management of allergic rhinitis and tobacco cessation may provide greater control of chronic hyperplastic rhinosinusitis.

Research paper thumbnail of The Role of Sequential and Concurrent Sexual Relationships in the Risk of Sexually Transmitted Diseases Among Adolescents

To explore whether patterns of sexual relationships, such as sequential (nonoverlapping in time) ... more To explore whether patterns of sexual relationships, such as sequential (nonoverlapping in time) or concurrent (overlapping in time), are more important indicators of sexually transmitted disease (STD) risk among adolescents than number of sexual partners.

Research paper thumbnail of A PROBLEM IN ASCERTAINMENT

Communications in Statistics-theory and Methods, 2001

Page 1. A PROBLEM IN ASCERTAINMENT Kevin J. Keen and Robert C. Elston Department of Epidemiology ... more Page 1. A PROBLEM IN ASCERTAINMENT Kevin J. Keen and Robert C. Elston Department of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, Ohio 44109-1998 ABSTRACT ...

Research paper thumbnail of Mobile agents on mobile robotic platforms: a survey

ACM Southeast Regional Conference, 2008

In this paper several papers that have been written on mobile agents and robots are surveyed with... more In this paper several papers that have been written on mobile agents and robots are surveyed with a view toward determining the state of the art of software mobile agents running on robotic platforms.