Kevin Viel - Academia.edu (original) (raw)

Papers by Kevin Viel

Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quanti- tative trait ... more Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quanti- tative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population vari- ability observed for this trait. Because less than 2.5% of the structural FVIII gene (F8) has been examined previously,

Thrombosis Research, 1997

Heparin is an effective agent in the treatment of unstable angina and myocardialinfarction. The c... more Heparin is an effective agent in the treatment of unstable angina and myocardialinfarction. The clinicalutility of heparin is limited by bleeding complications.This studywas performedto determinewhether static delivery of heparin could effectivelyinhibitfirther plateletdeposition. Thrombogenic grail segmentswere incorporatedinto chronic arteriovenousshunts in pigs. Autologous plateletswere labeledwith 11IIndium. Platelet deposition was quantitatedwith gamma camera imaging. The grafts were exposed to blood flow for 15 min in order to induce platelet deposition on the thrombogenic surface. Heparin was deliveredlocally either by direct exposure or with a double balloon catheter. Afler a 15 minute exposure period, the heparin solutionwas removedand subsequentplateletdepositionwas monitoredfor 90 minutes. Heparin,administeredwith the doublebaJlooncatheter in doses as low as 12.5U, effectivelyinhibitedfix-therplateletdeposition. An intravenous injectionof 100 U of heparin,the highestdose use for local delive~, did not perturb bleeding time or the activated partial thromboplastin time. In conclusion,platelet depositioncan be inhibitedwith static local delivery of heparinat dosesthat are not associatedwith systemicbleeding. @1997Elsevier Science L%d

New England Journal of Medicine, 2009

Background-Black patients with hemophilia A (factor VIII deficiency) are twice as likely as white... more Background-Black patients with hemophilia A (factor VIII deficiency) are twice as likely as white patients to produce inhibitors against factor VIII proteins given as replacement therapy. There are six wild-type factor VIII proteins, designated H1 through H6, but only two (H1 and H2) match the recombinant factor VIII products used clinically. H1 and H2 are found in all racial groups and are the only factor VIII proteins found in the white population to date. H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients.

Journal of Thrombosis and Haemostasis, 2012

To cite this article: Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard... more To cite this article: Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE. Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective. J Thromb Haemost 2012; 10: 1961-5.

Journal of Public Health Management and Practice, 2003

The public health burden of arthritis and related conditions is incompletely described by commonl... more The public health burden of arthritis and related conditions is incompletely described by commonly used public health surveillance systems. We examined the potential of administrative data as a supplement. The administrative data sources we used underestimated the prevalence of arthritis and overestimated service utilization for persons with arthritis when data from only one year were used. The use of five year&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s data doubled the prevalence estimate and reduced the service utilization estimate by half. The demographics of the population covered by administrative data also influence the prevalence estimate. Administrative data may usefully supplement routine public health surveillance systems but must be used with caution.

BMC Genetics, 2005

The information content of a continuous variable exceeds that of its categorical counterpart. The... more The information content of a continuous variable exceeds that of its categorical counterpart. The parameterization of a model may diminish the benefit of using a continuous variable. We explored the use of continuous versus discrete environment in variance components based analyses examining gene × environment interaction in the electrophysiological phenotypes from the Collaborative Study on the Genetics of Alcoholism.

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2008

The use of alcohol and tobacco is highly prevalent. Studying the rate of consumption in a non-sel... more The use of alcohol and tobacco is highly prevalent. Studying the rate of consumption in a non-selected population could contribute to the elucidation of pathways involved in addiction or to the development of prevention programs. The San Antonio Family Heart Study has approximately 1,400 members with longitudinal data and did not select the proband with regard to exposure status. The goal of this study was to perform genome-wide linkage analysis of the rate of alcohol and cigarette consumption in a ''normal'' population. We used SOLAR to perform variance-components based analysis of the transformed maximal rate of consumption. Despite estimated heritabilities of 0.52 (P < 0.001) for cigarette and 0.39 (P < 0.001) for alcohol consumption, univariate linkage analyses produced only suggestive LOD scores, however the second suggestive linkage peak for the alcohol phenotype was present at 148 cM on chromosome 10, in the exact vicinity of the peak for the cigarette phenotype. In a bivariate analyses, the environmental correlation between alcohol and cigarette consumption was not significantly different from zero (r e ¼ À0.15, P ¼ 0.18) and the overall genetic correlation was not different from zero (r g ¼ 0.16, P ¼ 0.34). The results from the bivariate linkage analysis found a maximum LOD score of 3.82 (genome-wide P ¼ 0.0054) at 151 cM on chromosome 10, at the location of the overlapping peaks from the univariate analyses. ß

The American Journal of Cardiology, 2009

Several definitions have been used to assess rates of contrast-induced nephropathy (CIN) in patie... more Several definitions have been used to assess rates of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI). Whether the definition influences observed rates of CIN is unclear. The Oxilan Registry was the first-ever prospective analysis of the efficacy and safety of ioxilan (low-osmolar and low-viscosity contrast medium), including rates of CIN assessed by multiple definitions, in PCI. From July 2006 to June 2007, consecutive patients undergoing PCI using ioxilan were enrolled. Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) were assessed at baseline and 3 to 5 days after PCI. CIN was defined as SCr increase >0.5 mg/dl, eGFR decrease >25%, SCr increase >25%, or the composite. Of 400 patients (age 62 ؎ 11 years), 19% were women, 37% were diabetic, 22% were anemic, and 8% had a history of congestive heart failure. Baseline SCr was 1.12 ؎ 0.3 mg/dl and 24% had an eGFR <60 ml/min. CIN rates were 3.3% (SCr increase >0.5 mg/dl), 7.6% (eGFR decrease >25%), 10.2% (SCr increase >25%), and 10.5% (composite). Hospitalization was prolonged in 3.4% of patients with CIN and none required dialysis. There were no deaths or severe allergic reactions. Non-ST-elevation myocardial infarction and repeat revascularization each occurred in 0.8%. In conclusion, in this unselected population undergoing PCI, CIN ranged in frequency from 3.3% to 10.5% depending on the definition used and was not associated with in-hospital mortality or substantial morbidity, such as dialysis. The wide variation in CIN and its lack of association with adverse outcomes underscore the need for a standardized, clinically relevant definition.

American Heart Journal, 1995

Thrombogenicity of a fibronectin-coated, experimental polytetrafluoroethylene graft. Surgery 1987... more Thrombogenicity of a fibronectin-coated, experimental polytetrafluoroethylene graft. Surgery 1987;101:439-44. 17. Ellis SG, Roubin GS, King SBI, Douglas JSJ, Weintraub WS, Thomas RG, Cox WR. Angiographic and clinical predictors of acute closure after native vessel coronary angiop!asty. Circulation 1988;77:372-9. 18, Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ. HMEC-I: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992;99:683-90.