Keyvan Pakshir - Academia.edu (original) (raw)
Papers by Keyvan Pakshir
Research in Pharmaceutical Sciences, Aug 30, 2012
Mycopathologia, Sep 14, 2015
Advanced Biomedical Research, 2014
Journal of Clinical Laboratory Analysis, Nov 13, 2022
Advanced Biomedical Research, 2023
Pharmacognosy Magazine, 2011
Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (... more Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated.
Journal of Essential Oil Bearing Plants, Feb 1, 2013
Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Inc... more Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Increasing resistance to antibiotics makes the treatment of these infections more difficult. Novel antimicrobial compounds derived from natural sources may be useful for addressing antiobiotic resistance. The objective of this study is to determine the chemical composition and antimicrobial activities of essential oils from Myrtus communis L. (Myrtaceae) leaves against pathogens causing nosocomial infections. The chemical composition of essential oil from M. communis leaves was analysed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the essential oil against bacteria and fungi was evaluated by broth micro-dilution as per the Clinical and Laboratory Standards Institute (CLSI) methods. GC-MS analysis revealed that the major constituents of the essential oil were α-pinene (39.2 %), 1,8-cineole (22.0 %), and linalool (18.4 %). The essential oil exhibited antimicrobial activity against all Gram positive and Gram nega- tive bacteria with MICs in the range of 0.5-32 µL/mL and 8-64 µL/mL, respectively. MICs for the tested clinical and standard fungi were in the range of 0.03-16 µL/mL. The essential oil exhibited strong antibacte- rial and antifungal activities against all the causative agents of nosocomial infections examined, particularly against strains with antibiotic resistance. The essential oil from M. communis leaves is a potential source of novel antimicrobial agents for the treatment of nosocomial infections.
Current medical mycology, Nov 23, 2021
Journal of Chemistry, Jan 12, 2023
ISRN Pharmaceutics (Print), Jun 17, 2012
Archives of Osteoporosis, 2020
Mycoses, 2019
SummaryDue to their physiological and biological characteristics, numerous fungi are potentially ... more SummaryDue to their physiological and biological characteristics, numerous fungi are potentially emerging pathogens. Active dynamicity of fungal pathogens causes life‐threatening infections annually impose high costs to the health systems. Although immune responses play crucial roles in controlling the fate of fungal infections, immunocompromised patients are at high risk with high mortality. Tuning the immune response against fungal infections might be an effective strategy for controlling and reducing the pathological damages. MicroRNAs (miRNAs) are known as the master regulators of immune response. These single‐stranded tuners (18‐23 bp non‐coding RNAs) are endogenously expressed by all metazoan eukaryotes and have emerged as the master gene expression controllers of at least 30% human genes. In this review article, following the review of biology and physiology (biogenesis and mechanism of actions) of miRNAs and immune response against fungal infections, the interactions between...
Journal de Mycologie Médicale, 2018
Journal of global infectious diseases, 2011
Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to ... more Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to potentially life-threatening fungemia. The emergence of resistance to antifungal drugs has been increased in the past two decades.
Journal of microbiology, biotechnology and food sciences, 2020
The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells,... more The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells, forming biofilm and invasion. Therefore, the effect of Pediococcus acidilactici on morphogenesis and pathogenesis of C. albicans were examined. Inhibitory activity of P. acidilactici on Candida species growth was investigated and inhibition of C. albicans biofilm formation was measured by XTT method. Also, expression of seven genes as: Agglutinin-like protein 1 (ALS1,3), hyphal cell-wall protein (HWP1), secreted aspartyl proteinase (SAP4,6), Enhanced filamentous growth 1 (EFG1) and Enhanced activated protein 1 (EAP1) were studied by RT-PCR with different concentrations of P. acidilactici. The experimental activity of this probiotic bacterium was evaluated in an animal model by culture and histopathological methods. P. acidilactici inhibited the growth of Candida species at concentrations of 8-512 µg/mL (approximately 8 × 106 to 5 × 108 CFU/ml). This probiotic bacterium inhibited the ge...
Journal of Global Infectious Diseases, 2018
Anti-Infective Agents in Medicinal Chemistry, Jul 1, 2008
Research in Pharmaceutical Sciences, Aug 30, 2012
Mycopathologia, Sep 14, 2015
Advanced Biomedical Research, 2014
Journal of Clinical Laboratory Analysis, Nov 13, 2022
Advanced Biomedical Research, 2023
Pharmacognosy Magazine, 2011
Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (... more Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated.
Journal of Essential Oil Bearing Plants, Feb 1, 2013
Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Inc... more Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Increasing resistance to antibiotics makes the treatment of these infections more difficult. Novel antimicrobial compounds derived from natural sources may be useful for addressing antiobiotic resistance. The objective of this study is to determine the chemical composition and antimicrobial activities of essential oils from Myrtus communis L. (Myrtaceae) leaves against pathogens causing nosocomial infections. The chemical composition of essential oil from M. communis leaves was analysed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the essential oil against bacteria and fungi was evaluated by broth micro-dilution as per the Clinical and Laboratory Standards Institute (CLSI) methods. GC-MS analysis revealed that the major constituents of the essential oil were α-pinene (39.2 %), 1,8-cineole (22.0 %), and linalool (18.4 %). The essential oil exhibited antimicrobial activity against all Gram positive and Gram nega- tive bacteria with MICs in the range of 0.5-32 µL/mL and 8-64 µL/mL, respectively. MICs for the tested clinical and standard fungi were in the range of 0.03-16 µL/mL. The essential oil exhibited strong antibacte- rial and antifungal activities against all the causative agents of nosocomial infections examined, particularly against strains with antibiotic resistance. The essential oil from M. communis leaves is a potential source of novel antimicrobial agents for the treatment of nosocomial infections.
Current medical mycology, Nov 23, 2021
Journal of Chemistry, Jan 12, 2023
ISRN Pharmaceutics (Print), Jun 17, 2012
Archives of Osteoporosis, 2020
Mycoses, 2019
SummaryDue to their physiological and biological characteristics, numerous fungi are potentially ... more SummaryDue to their physiological and biological characteristics, numerous fungi are potentially emerging pathogens. Active dynamicity of fungal pathogens causes life‐threatening infections annually impose high costs to the health systems. Although immune responses play crucial roles in controlling the fate of fungal infections, immunocompromised patients are at high risk with high mortality. Tuning the immune response against fungal infections might be an effective strategy for controlling and reducing the pathological damages. MicroRNAs (miRNAs) are known as the master regulators of immune response. These single‐stranded tuners (18‐23 bp non‐coding RNAs) are endogenously expressed by all metazoan eukaryotes and have emerged as the master gene expression controllers of at least 30% human genes. In this review article, following the review of biology and physiology (biogenesis and mechanism of actions) of miRNAs and immune response against fungal infections, the interactions between...
Journal de Mycologie Médicale, 2018
Journal of global infectious diseases, 2011
Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to ... more Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to potentially life-threatening fungemia. The emergence of resistance to antifungal drugs has been increased in the past two decades.
Journal of microbiology, biotechnology and food sciences, 2020
The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells,... more The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells, forming biofilm and invasion. Therefore, the effect of Pediococcus acidilactici on morphogenesis and pathogenesis of C. albicans were examined. Inhibitory activity of P. acidilactici on Candida species growth was investigated and inhibition of C. albicans biofilm formation was measured by XTT method. Also, expression of seven genes as: Agglutinin-like protein 1 (ALS1,3), hyphal cell-wall protein (HWP1), secreted aspartyl proteinase (SAP4,6), Enhanced filamentous growth 1 (EFG1) and Enhanced activated protein 1 (EAP1) were studied by RT-PCR with different concentrations of P. acidilactici. The experimental activity of this probiotic bacterium was evaluated in an animal model by culture and histopathological methods. P. acidilactici inhibited the growth of Candida species at concentrations of 8-512 µg/mL (approximately 8 × 106 to 5 × 108 CFU/ml). This probiotic bacterium inhibited the ge...
Journal of Global Infectious Diseases, 2018
Anti-Infective Agents in Medicinal Chemistry, Jul 1, 2008