Keyvan Pakshir - Academia.edu (original) (raw)

Papers by Keyvan Pakshir

Research paper thumbnail of Subcutaneous Mycoses in Fars Province (1381-1384)

Research paper thumbnail of Real time PCR study of cathelicidin gene expression in murine macrophages pretreated with different types of interferons and treated with Candida albicans and lipopolysaccharide

Research in Pharmaceutical Sciences, Aug 30, 2012

Research paper thumbnail of Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran

Mycopathologia, Sep 14, 2015

Research paper thumbnail of The concentration of aflatoxin M<sub>1</sub>in the mothers′ milk in Khorrambid City, Fars, Iran

Advanced Biomedical Research, 2014

Research paper thumbnail of Accompanying a semi‐nested <scp>PCR</scp> assay to support histopathology findings of fungal keratitis in formalin‐fixed paraffin‐embedded corneal samples

Journal of Clinical Laboratory Analysis, Nov 13, 2022

Research paper thumbnail of Evaluating the typing power of six isoenzymatic systems for differentiation of clinical and standard isolates of Candida species

Advanced Biomedical Research, 2023

Research paper thumbnail of Chemical composition and antimicrobial activities of the essential oils from three ecotypes of Zataria multiflora

Pharmacognosy Magazine, 2011

Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (... more Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated.

Research paper thumbnail of Chemical composition and antimicrobial activities of the essential oil from Myrtus communis leaves

Journal of Essential Oil Bearing Plants, Feb 1, 2013

Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Inc... more Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Increasing resistance to antibiotics makes the treatment of these infections more difficult. Novel antimicrobial compounds derived from natural sources may be useful for addressing antiobiotic resistance. The objective of this study is to determine the chemical composition and antimicrobial activities of essential oils from Myrtus communis L. (Myrtaceae) leaves against pathogens causing nosocomial infections. The chemical composition of essential oil from M. communis leaves was analysed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the essential oil against bacteria and fungi was evaluated by broth micro-dilution as per the Clinical and Laboratory Standards Institute (CLSI) methods. GC-MS analysis revealed that the major constituents of the essential oil were α-pinene (39.2 %), 1,8-cineole (22.0 %), and linalool (18.4 %). The essential oil exhibited antimicrobial activity against all Gram positive and Gram nega- tive bacteria with MICs in the range of 0.5-32 µL/mL and 8-64 µL/mL, respectively. MICs for the tested clinical and standard fungi were in the range of 0.03-16 µL/mL. The essential oil exhibited strong antibacte- rial and antifungal activities against all the causative agents of nosocomial infections examined, particularly against strains with antibiotic resistance. The essential oil from M. communis leaves is a potential source of novel antimicrobial agents for the treatment of nosocomial infections.

Research paper thumbnail of Molecular identification of Malassezia species isolated from neonates hospitalized in Neonatal intensive care units and their mothers

Current medical mycology, Nov 23, 2021

Research paper thumbnail of In Vivo Antifungal Activity and Computational Studies of Some Azole Derivatives against Candida Albicans

Journal of Chemistry, Jan 12, 2023

Research paper thumbnail of Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents

Research paper thumbnail of Chemical Composition and Antimicrobial Activities of Essential Oils from <i>Nepeta cataria</i> L. against Common Causes of Food-Borne Infections

ISRN Pharmaceutics (Print), Jun 17, 2012

Research paper thumbnail of Burden of musculoskeletal disorders in Iran during 1990–2017: estimates from the Global Burden of Disease Study 2017

Archives of Osteoporosis, 2020

Research paper thumbnail of Interactions between immune response to fungal infection and microRNAs: The pioneer tuners

Mycoses, 2019

SummaryDue to their physiological and biological characteristics, numerous fungi are potentially ... more SummaryDue to their physiological and biological characteristics, numerous fungi are potentially emerging pathogens. Active dynamicity of fungal pathogens causes life‐threatening infections annually impose high costs to the health systems. Although immune responses play crucial roles in controlling the fate of fungal infections, immunocompromised patients are at high risk with high mortality. Tuning the immune response against fungal infections might be an effective strategy for controlling and reducing the pathological damages. MicroRNAs (miRNAs) are known as the master regulators of immune response. These single‐stranded tuners (18‐23 bp non‐coding RNAs) are endogenously expressed by all metazoan eukaryotes and have emerged as the master gene expression controllers of at least 30% human genes. In this review article, following the review of biology and physiology (biogenesis and mechanism of actions) of miRNAs and immune response against fungal infections, the interactions between...

Research paper thumbnail of Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations

Research paper thumbnail of Molecular epidemiology of environmental Cryptococcus species isolates based on amplified fragment length polymorphism

Journal de Mycologie Médicale, 2018

Research paper thumbnail of Determination of antifungal susceptibility patterns among the clinical isolates of Candida species

Journal of global infectious diseases, 2011

Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to ... more Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to potentially life-threatening fungemia. The emergence of resistance to antifungal drugs has been increased in the past two decades.

Research paper thumbnail of Morphogenesis and Pathogenesis Regulation of Candida Albicans by Probiotic Bacterium – Pediococcus Acidilactici

Journal of microbiology, biotechnology and food sciences, 2020

The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells,... more The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells, forming biofilm and invasion. Therefore, the effect of Pediococcus acidilactici on morphogenesis and pathogenesis of C. albicans were examined. Inhibitory activity of P. acidilactici on Candida species growth was investigated and inhibition of C. albicans biofilm formation was measured by XTT method. Also, expression of seven genes as: Agglutinin-like protein 1 (ALS1,3), hyphal cell-wall protein (HWP1), secreted aspartyl proteinase (SAP4,6), Enhanced filamentous growth 1 (EFG1) and Enhanced activated protein 1 (EAP1) were studied by RT-PCR with different concentrations of P. acidilactici. The experimental activity of this probiotic bacterium was evaluated in an animal model by culture and histopathological methods. P. acidilactici inhibited the growth of Candida species at concentrations of 8-512 µg/mL (approximately 8 × 106 to 5 × 108 CFU/ml). This probiotic bacterium inhibited the ge...

Research paper thumbnail of Evaluation of exoenzyme activities, biofilm formation, and co-hemolytic effect in clinical isolates of Candida parapsilosis species complex

Journal of Global Infectious Diseases, 2018

Research paper thumbnail of Design and Synthesis of Imidazole and Benzimidazole Derivatives as Antifungal Agents

Anti-Infective Agents in Medicinal Chemistry, Jul 1, 2008

Research paper thumbnail of Subcutaneous Mycoses in Fars Province (1381-1384)

Research paper thumbnail of Real time PCR study of cathelicidin gene expression in murine macrophages pretreated with different types of interferons and treated with Candida albicans and lipopolysaccharide

Research in Pharmaceutical Sciences, Aug 30, 2012

Research paper thumbnail of Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran

Mycopathologia, Sep 14, 2015

Research paper thumbnail of The concentration of aflatoxin M<sub>1</sub>in the mothers′ milk in Khorrambid City, Fars, Iran

Advanced Biomedical Research, 2014

Research paper thumbnail of Accompanying a semi‐nested <scp>PCR</scp> assay to support histopathology findings of fungal keratitis in formalin‐fixed paraffin‐embedded corneal samples

Journal of Clinical Laboratory Analysis, Nov 13, 2022

Research paper thumbnail of Evaluating the typing power of six isoenzymatic systems for differentiation of clinical and standard isolates of Candida species

Advanced Biomedical Research, 2023

Research paper thumbnail of Chemical composition and antimicrobial activities of the essential oils from three ecotypes of Zataria multiflora

Pharmacognosy Magazine, 2011

Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (... more Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated.

Research paper thumbnail of Chemical composition and antimicrobial activities of the essential oil from Myrtus communis leaves

Journal of Essential Oil Bearing Plants, Feb 1, 2013

Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Inc... more Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Increasing resistance to antibiotics makes the treatment of these infections more difficult. Novel antimicrobial compounds derived from natural sources may be useful for addressing antiobiotic resistance. The objective of this study is to determine the chemical composition and antimicrobial activities of essential oils from Myrtus communis L. (Myrtaceae) leaves against pathogens causing nosocomial infections. The chemical composition of essential oil from M. communis leaves was analysed by gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the essential oil against bacteria and fungi was evaluated by broth micro-dilution as per the Clinical and Laboratory Standards Institute (CLSI) methods. GC-MS analysis revealed that the major constituents of the essential oil were α-pinene (39.2 %), 1,8-cineole (22.0 %), and linalool (18.4 %). The essential oil exhibited antimicrobial activity against all Gram positive and Gram nega- tive bacteria with MICs in the range of 0.5-32 µL/mL and 8-64 µL/mL, respectively. MICs for the tested clinical and standard fungi were in the range of 0.03-16 µL/mL. The essential oil exhibited strong antibacte- rial and antifungal activities against all the causative agents of nosocomial infections examined, particularly against strains with antibiotic resistance. The essential oil from M. communis leaves is a potential source of novel antimicrobial agents for the treatment of nosocomial infections.

Research paper thumbnail of Molecular identification of Malassezia species isolated from neonates hospitalized in Neonatal intensive care units and their mothers

Current medical mycology, Nov 23, 2021

Research paper thumbnail of In Vivo Antifungal Activity and Computational Studies of Some Azole Derivatives against Candida Albicans

Journal of Chemistry, Jan 12, 2023

Research paper thumbnail of Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents

Research paper thumbnail of Chemical Composition and Antimicrobial Activities of Essential Oils from <i>Nepeta cataria</i> L. against Common Causes of Food-Borne Infections

ISRN Pharmaceutics (Print), Jun 17, 2012

Research paper thumbnail of Burden of musculoskeletal disorders in Iran during 1990–2017: estimates from the Global Burden of Disease Study 2017

Archives of Osteoporosis, 2020

Research paper thumbnail of Interactions between immune response to fungal infection and microRNAs: The pioneer tuners

Mycoses, 2019

SummaryDue to their physiological and biological characteristics, numerous fungi are potentially ... more SummaryDue to their physiological and biological characteristics, numerous fungi are potentially emerging pathogens. Active dynamicity of fungal pathogens causes life‐threatening infections annually impose high costs to the health systems. Although immune responses play crucial roles in controlling the fate of fungal infections, immunocompromised patients are at high risk with high mortality. Tuning the immune response against fungal infections might be an effective strategy for controlling and reducing the pathological damages. MicroRNAs (miRNAs) are known as the master regulators of immune response. These single‐stranded tuners (18‐23 bp non‐coding RNAs) are endogenously expressed by all metazoan eukaryotes and have emerged as the master gene expression controllers of at least 30% human genes. In this review article, following the review of biology and physiology (biogenesis and mechanism of actions) of miRNAs and immune response against fungal infections, the interactions between...

Research paper thumbnail of Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations

Research paper thumbnail of Molecular epidemiology of environmental Cryptococcus species isolates based on amplified fragment length polymorphism

Journal de Mycologie Médicale, 2018

Research paper thumbnail of Determination of antifungal susceptibility patterns among the clinical isolates of Candida species

Journal of global infectious diseases, 2011

Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to ... more Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to potentially life-threatening fungemia. The emergence of resistance to antifungal drugs has been increased in the past two decades.

Research paper thumbnail of Morphogenesis and Pathogenesis Regulation of Candida Albicans by Probiotic Bacterium – Pediococcus Acidilactici

Journal of microbiology, biotechnology and food sciences, 2020

The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells,... more The transition of Candida albicans from yeast to hyphae cause the attachment to epithelial cells, forming biofilm and invasion. Therefore, the effect of Pediococcus acidilactici on morphogenesis and pathogenesis of C. albicans were examined. Inhibitory activity of P. acidilactici on Candida species growth was investigated and inhibition of C. albicans biofilm formation was measured by XTT method. Also, expression of seven genes as: Agglutinin-like protein 1 (ALS1,3), hyphal cell-wall protein (HWP1), secreted aspartyl proteinase (SAP4,6), Enhanced filamentous growth 1 (EFG1) and Enhanced activated protein 1 (EAP1) were studied by RT-PCR with different concentrations of P. acidilactici. The experimental activity of this probiotic bacterium was evaluated in an animal model by culture and histopathological methods. P. acidilactici inhibited the growth of Candida species at concentrations of 8-512 µg/mL (approximately 8 × 106 to 5 × 108 CFU/ml). This probiotic bacterium inhibited the ge...

Research paper thumbnail of Evaluation of exoenzyme activities, biofilm formation, and co-hemolytic effect in clinical isolates of Candida parapsilosis species complex

Journal of Global Infectious Diseases, 2018

Research paper thumbnail of Design and Synthesis of Imidazole and Benzimidazole Derivatives as Antifungal Agents

Anti-Infective Agents in Medicinal Chemistry, Jul 1, 2008