Khagani Isgandarov - Academia.edu (original) (raw)

Papers by Khagani Isgandarov

Türk kardiyoloji derneği arşivi, Jun 1, 2018

Türk kardiyoloji derneği arşivi, 2017

Türk kardiyoloji derneği arşivi, 2018

Heart and Vessels

Presence of right heart failure (RHF) is associated with a worse prognosis in patients with left ... more Presence of right heart failure (RHF) is associated with a worse prognosis in patients with left ventricular failure (LVF). While the cause of RHF secondary to LVF is multifactorial, an increased right ventricular (RV) afterload is believed as the major cause of RHF. However, data are scarce on the adaptive responses of the RV in patients with LVF. Our aim was to understand the relationship of right ventricular hypertrophy (RVH) with RHF and RV systolic and diastolic properties in patients with LVF. 55 patients with a left ventricular ejection fraction of 40% or less were included in the present study. A comprehensive two-dimensional transthoracic echocardiographic examination was done to all participants. 12 patients (21.8%) had RHF, and patients with RHF had a significantly lower right ventricular free wall thickness (RVFWT) as compared to patients without RHF (5.3 ± 1.7 mm vs. 6.6 ± 0.9 mm, p = 0.02) and the difference remained statistically significant after adjusting for confounders (Δx̅:1.34 mm, p = 0.002). RVFWT had a statistically significant correlation with tricuspid annular plane systolic excursion (r = 0.479, p < 0.001) and tricuspid annular lateral systolic velocity (r = 0.360, p = 0.007), but not with the indices of the RV diastolic function. None of the patients with concentric RVH had RHF, while 22.2% of patients with eccentric RVH and 66.7% of patients without RVH had RHF (p < 0.01 as compared to patients with concentric RVH). In patients with left ventricular systolic dysfunction, absence of RVH was associated with worse RV systolic performance and a significantly higher incidence of RHF.

Türk kardiyoloji derneği arşivi, Jun 1, 2021

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2022

Percutaneous transluminal angioplasty has gained increasing popularity in the treatment of periph... more Percutaneous transluminal angioplasty has gained increasing popularity in the treatment of peripheral artery disease. However, the increase in the frequency of this procedure also increases the risk of complications. Percutaneous transluminal angioplasty has serious and general complications in terms of device and technique at puncture and dilatation sites. In this case, we describe the easy and practical management of deflating an undeflated ballon in the right superficial femoral artery.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, Jun 1, 2018

Hypertrophic obstructive cardiomyopathy is an inheritable cardiac disease that typically manifest... more Hypertrophic obstructive cardiomyopathy is an inheritable cardiac disease that typically manifests with an increased left ventricular outflow tract gradient. In most cases, basal septal hypertrophy and systolic anterior motion of the anterior mitral valve leaflet are the key components of the left ventricular outflow tract obstruction. The goal of septal reduction therapy, a widely accepted treatment modality, is to remove this obstruction. Although myectomy is a wellestablished and effective surgical technique for septal reduction therapy, transcoronary alcohol septal ablation is an alternative therapy for patients who decline to have surgery or who are not suited to a surgical intervention. A new septal reduction method has also been described in the literature. This case report describes the successful treatment of hypertrophic obstructive cardiomyopathy in a 57-year-old female using the new septal reduction technique.

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2017

DergiPark (Istanbul University), Feb 17, 2023

Introduction: One of the pharmacological treatment options for improving the symptoms of peripher... more Introduction: One of the pharmacological treatment options for improving the symptoms of peripheral artery disease (PAD) and increasing the quality of life is cilostazol. Cilostazol is a pharmacological agent that shows vasodilator activity mainly by reducing cAMP degradation through specific cellular phosphodiesterase 3A enzyme inhibition. The effect of cilostazol on electrocardiographic parameters is not clear. In this study, we aimed to examine the effect of cilostazol on electrocardiographic parameters in PAD patients. Patients and Methods: The study included a total of 32 patients diagnosed with intermittent claudication and peripheral artery disease (PAD), who were selected for medical treatment based on peripheral artery imaging. The subjects were started on 100 mg of cilostazol twice a day. The electrocardiographic measurements of the subjects before the cilostazol treatment and three months after the initiation of cilostazol were compared. Results: After a period of three months, statistically significant prolongation was observed in the ventricular repolarization parameters QTd, QTc, and Tpe of the subjects compared to their premedication values (p= 0.01, for all). Conclusion: It is known that patients with peripheral artery disease (PAD) are at an increased risk of major adverse cardiovascular events (MACE), including sudden cardiac death (SCD). In this context, close monitoring of electrocardiography markers for ventricular repolarization heterogeneity, such as QTd, QTc, and Tpe, is necessary when initiating cilostazol therapy in patients with peripheral artery disease (PAD). These markers may be closely associated with major adverse cardiovascular events (MACE), including sudden cardiac death (SCD), and therefore require careful monitoring in PAD patients receiving cilostazol treatment.

Research Square (Research Square), Sep 6, 2022

Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid... more Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid aortic valve (BAV) disease is scarce. Also, the impact of afterload and the involved mechanisms are unclear. In this work, we study the relationship between LV function assessed with myocardial work index (MWI) and arterial stiffness in a cohort of normo-functioning BAV patients. Methods In this study, we included a total of 38 consecutive patients with isolated BAV and 44 age-and gendermatched control subjects with tricuspid aortic valve (TAV). All participants underwent transthoracic echocardiography (TTE) to assess conventional parameters, global longitudinal strain (GLS), and MW by non-invasive left ventricular pressure-strain loop (LV-PSL) method. The aortic pulse wave velocity(PWV) was used to determine arterial stiffnessand wave re ection was evaluated by applanation tonometry. Results The mean aortic PWV was signi cantly higher in BAV patients (6.4 ± 0.80, 7.02 ± .1.2, p = 0.01, respectively). The statistical difference was not signi cant for the parameters linked to LV-MW, such as global work index (GWI) and global constructive work (GCW) between the BAV and control groups (1969

Arquivos Brasileiros De Cardiologia, Jun 23, 2022

Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é im... more Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é importante para se alcançar concentrações de LDL-C recomendadas por diretrizes e para reduzir resultados cardiovasculares adversos em pacientes diabéticos. A equação de Friedewald comumente usada (LDL-Cf) produz resultados imprecisos em pacientes diabéticos devido a dislipidemia diabética associada. Recentemente, duas novas equações-Martin/Hopkins (LDL-CMH) e Sampson (LDL-Cs)-foram desenvolvidas para melhorar a precisão da estimativa de LDL-C, mas os dados são insuficientes para sugerir a superioridade de uma equação sobre a outra. Objetivos: O presente estudo comparou a precisão e a utilidade clínica das novas equações de Martin/Hopkins e Sampson em pacientes diabéticos. Método: Foram incluídos no estudo quatrocentos e dois (402) pacientes com diabetes. O risco cardiovascular dos pacientes e as metas de LDL-C foram calculadas por diretrizes europeias. As concentrações de LDL-Cmh, LDL-Cs, e LDL-Cf calculadas foram comparadas à concentração de LDL-C direto (LDL-Cd) para testar a concordância entre essas equações e LDL-Cd. Um P valor <0,05 foi aceito como estatisticamente significativo. Resultados: A LDL-CMH e a LDL-Cs tiveram concordância melhor com o LDL-Cd em comparação com a LDL-Cf, mas não houve diferenças estatísticas entre as novas equações para concordância com o LDL-Cd (Alfa de Cronbach de 0,955 para ambos, p=1). Da mesma forma, a LDL-CMH e a LDL-Cs tinham um grau semelhante de concordância com o LDL-Cd para determinar se o paciente estava dentro da meta de LDL-C (96,3% para LDL-Cmh e 96,0% para LDL-Cs), que eram ligeiramente melhores que a LDL-Cf (94,6%). Em pacientes com uma concentração de triglicérides >400 mg/dl, a concordância com o LDL-Cd foi ruim, independentemente do método usado. Conclusão: As equações de Martin/Hopkins e Sampson mostram uma precisão similar para o cálculo de concentrações de LDL-C nos pacientes com diabetes, e ambas as equações são ligeiramente melhores que a equação de Friedewald.

Kardiologia Polska, Dec 15, 2017

Background and aim: The objective of this study was to assess the potential role of mitral regurg... more Background and aim: The objective of this study was to assess the potential role of mitral regurgitation (MR) in the release of copeptin in heart failure patients with reduced ejection fraction (HFrEF). Methods: The study included 63 patients of whom 33 had functional mild MR (Group 1) and 30 had functional severe MR (Group 2). The functional class of both groups was New York Heart Association (NYHA) Class III. Blood samples for the determination of plasma copeptin and B-type natriuretic peptide (BNP) levels were obtained on the same day with the echocardiographic examination. Standard echocardiographic studies were performed. Results: Copeptin and BNP levels showed a substantial agreement in the whole study group (Kappa level: 0.607, p < 0.0001). Also, copeptin and BNP showed a strong correlation and were both increased and significantly higher in Group 2 than in Group 1 (p < 0.001 and p < 0.05, respectively). Left ventricular global longitudinal strain and left ventricular ejection fraction values were similar in both groups. The study population were divided into two subgroups on the basis of copeptin median level (6.4 ng/mL), and the prevalence of severe MR was significantly higher in the above-median-copeptin subgroup. A linear regression analysis showed that the presence of severe MR was the only independent predictor of high circulating plasma copeptin level (OR 7.5, 95% CI 2.8-12.1; p = 0.002). Conclusions: Severe MR is an independent predictor of elevated plasma copeptin level in HFREF irrespective of systolic function.

Endocrinology Research and Practice

Arquivos Brasileiros de Cardiologia

Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é im... more Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é importante para se alcançar concentrações de LDL-C recomendadas por diretrizes e para reduzir resultados cardiovasculares adversos em pacientes diabéticos. A equação de Friedewald comumente usada (LDL-Cf) produz resultados imprecisos em pacientes diabéticos devido a dislipidemia diabética associada. Recentemente, duas novas equações-Martin/Hopkins (LDL-CMH) e Sampson (LDL-Cs)-foram desenvolvidas para melhorar a precisão da estimativa de LDL-C, mas os dados são insuficientes para sugerir a superioridade de uma equação sobre a outra. Objetivos: O presente estudo comparou a precisão e a utilidade clínica das novas equações de Martin/Hopkins e Sampson em pacientes diabéticos. Método: Foram incluídos no estudo quatrocentos e dois (402) pacientes com diabetes. O risco cardiovascular dos pacientes e as metas de LDL-C foram calculadas por diretrizes europeias. As concentrações de LDL-Cmh, LDL-Cs, e LDL-Cf calculadas foram comparadas à concentração de LDL-C direto (LDL-Cd) para testar a concordância entre essas equações e LDL-Cd. Um P valor <0,05 foi aceito como estatisticamente significativo. Resultados: A LDL-CMH e a LDL-Cs tiveram concordância melhor com o LDL-Cd em comparação com a LDL-Cf, mas não houve diferenças estatísticas entre as novas equações para concordância com o LDL-Cd (Alfa de Cronbach de 0,955 para ambos, p=1). Da mesma forma, a LDL-CMH e a LDL-Cs tinham um grau semelhante de concordância com o LDL-Cd para determinar se o paciente estava dentro da meta de LDL-C (96,3% para LDL-Cmh e 96,0% para LDL-Cs), que eram ligeiramente melhores que a LDL-Cf (94,6%). Em pacientes com uma concentração de triglicérides >400 mg/dl, a concordância com o LDL-Cd foi ruim, independentemente do método usado. Conclusão: As equações de Martin/Hopkins e Sampson mostram uma precisão similar para o cálculo de concentrações de LDL-C nos pacientes com diabetes, e ambas as equações são ligeiramente melhores que a equação de Friedewald.

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology

In recent years, percutaneous transluminal angioplasty has become the preferred revascularization... more In recent years, percutaneous transluminal angioplasty has become the preferred revascularization option for chronic limb-threatening ischemia (CLTI) and infrapopliteal (IP) arterial disease. CLTI and IP disease require complex and lengthy procedures that necessitate multiple balloon inflations and frequent contrast injections. It will lead to severe discomfort if periprocedural pain control is inadequate. Conventional methods such as local anesthesia and systemic opioids are usually inadequate to provide pain control for complex IP arterial disease interventions. Ultrasound-guided peripheral nerve blockade (PNB) has been recently employed in peripheral procedures, with several small studies reporting favorable results in patients who underwent not complex interventions. In the present series, we report our experience of 4 patients who underwent PNB to relieve pain during endovascular treatment of complex IP disease, and in whom we have observed excellent periprocedural pain control that led to satisfactory postprocedural outcomes. Özet-Son yıllarda, perkütan translüminal anjiyoplasti, ekstremiteleri tehdit eden kronik iskemi (CLTI) ve infra-popliteal (İP) arter hastalığı için tercih edilen revaskülarizasyon seçeneği haline gelmiştir. CLTİ ve İP arter hastalığı; mükerrer balon dilatasyonu ve sık kontrast enjeksiyonunu gerektiren karmaşık ve uzun prosedürler gerektirir. Periprosedürel ağrı kontrolünün yetersiz kalması ciddi rahatsızlıklara yol açacaktır. Lokal anestezi ve sistemik opioidler gibi geleneksel yöntemler, kompleks İP girişimler sırasında ağrı kontrolünü sağlamak için genellikle yetersizdir. Ultrason rehberliğinde periferik sinir blokajı (PNB), son zamanlarda periferik prosedürlerde kullanılmıştır ve birkaç küçük çalışma, kompleks olmayan girişim yapılan hastalarda olumlu sonuçlar bildirmiştir. Bu seride, kompleks İP hastalığı olan dört hastada endovasküler tedavi sırasında ağrıyı azaltmak için PNB uygulanan, işlem sonrası tatmin edici sonuçlara yol açan ve mükemmel periprosedürel ağrı kontrolünü gözlemlediğimiz deneyimimizi bildirdik. RT, Walker JD, et al. Guidelines for performing ultrasound guided vascular cannulation: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists.

The Anatolian Journal of Cardiology, 2020

Kardiologia polska, Jan 17, 2017

The objective of this study was to assess the potential role of mitral regurgitation (MR) in the ... more The objective of this study was to assess the potential role of mitral regurgitation (MR) in the release of copeptin in HF patients with reduced ejection fraction (HFREF). The study included 63 patients of whom 33 had functional mild MR (Group 1) and 30 had functional severe MR (Group 2).The functional classes of the groups were both NYHA Class III. Blood samples for the determination of plasma copeptin and B-type natriuretic peptide (BNP) levels were obtained at the same day with the echocardiographic examination. Standard echocardiographic studies were performed. Copeptin and BNP levels showed a substantial agreement in whole study group (Kappa level: 0.607, p < 0.0001). Also, copeptin and BNP showed a strong correlation and were both increased and significantly higher in Group 2 than Group 1 (p< 0.001 and p< 0.05, respectively ). Left ventricular global longitudinal strain and LVEF values were similar in both groups. The study population were divided into two subgroups o...

Objective Data related to the existence of left ventricular (LV) abnormalities in normo-functiona... more Objective Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid aortic valve (BAV) disease is scarce. Also, the impact of afterload and the involved mechanisms are unclear. In this work, we study the relationship between LV function assessed with myocardial work index (MWI) and arterial stiffness in a cohort of normo-functioning BAV patients. Methods In this study, we included a total of 38 consecutive patients with isolated BAV and 44 age- and gender-matched control subjects with tricuspid aortic valve (TAV). All participants underwent transthoracic echocardiography (TTE) to assess conventional parameters, global longitudinal strain (GLS), and MW by non-invasive left ventricular pressure–strain loop (LV-PSL) method. The aortic pulse wave velocity(PWV) was used to determine arterial stiffnessand wave reflection was evaluated by applanation tonometry. Results The mean aortic PWV was significantly higher in BAV patients (6.4 ± 0.80, 7.02 ± ....

Türk kardiyoloji derneği arşivi, Jun 1, 2018

Türk kardiyoloji derneği arşivi, 2017

Türk kardiyoloji derneği arşivi, 2018

Heart and Vessels

Presence of right heart failure (RHF) is associated with a worse prognosis in patients with left ... more Presence of right heart failure (RHF) is associated with a worse prognosis in patients with left ventricular failure (LVF). While the cause of RHF secondary to LVF is multifactorial, an increased right ventricular (RV) afterload is believed as the major cause of RHF. However, data are scarce on the adaptive responses of the RV in patients with LVF. Our aim was to understand the relationship of right ventricular hypertrophy (RVH) with RHF and RV systolic and diastolic properties in patients with LVF. 55 patients with a left ventricular ejection fraction of 40% or less were included in the present study. A comprehensive two-dimensional transthoracic echocardiographic examination was done to all participants. 12 patients (21.8%) had RHF, and patients with RHF had a significantly lower right ventricular free wall thickness (RVFWT) as compared to patients without RHF (5.3 ± 1.7 mm vs. 6.6 ± 0.9 mm, p = 0.02) and the difference remained statistically significant after adjusting for confounders (Δx̅:1.34 mm, p = 0.002). RVFWT had a statistically significant correlation with tricuspid annular plane systolic excursion (r = 0.479, p < 0.001) and tricuspid annular lateral systolic velocity (r = 0.360, p = 0.007), but not with the indices of the RV diastolic function. None of the patients with concentric RVH had RHF, while 22.2% of patients with eccentric RVH and 66.7% of patients without RVH had RHF (p < 0.01 as compared to patients with concentric RVH). In patients with left ventricular systolic dysfunction, absence of RVH was associated with worse RV systolic performance and a significantly higher incidence of RHF.

Türk kardiyoloji derneği arşivi, Jun 1, 2021

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2022

Percutaneous transluminal angioplasty has gained increasing popularity in the treatment of periph... more Percutaneous transluminal angioplasty has gained increasing popularity in the treatment of peripheral artery disease. However, the increase in the frequency of this procedure also increases the risk of complications. Percutaneous transluminal angioplasty has serious and general complications in terms of device and technique at puncture and dilatation sites. In this case, we describe the easy and practical management of deflating an undeflated ballon in the right superficial femoral artery.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, Jun 1, 2018

Hypertrophic obstructive cardiomyopathy is an inheritable cardiac disease that typically manifest... more Hypertrophic obstructive cardiomyopathy is an inheritable cardiac disease that typically manifests with an increased left ventricular outflow tract gradient. In most cases, basal septal hypertrophy and systolic anterior motion of the anterior mitral valve leaflet are the key components of the left ventricular outflow tract obstruction. The goal of septal reduction therapy, a widely accepted treatment modality, is to remove this obstruction. Although myectomy is a wellestablished and effective surgical technique for septal reduction therapy, transcoronary alcohol septal ablation is an alternative therapy for patients who decline to have surgery or who are not suited to a surgical intervention. A new septal reduction method has also been described in the literature. This case report describes the successful treatment of hypertrophic obstructive cardiomyopathy in a 57-year-old female using the new septal reduction technique.

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2017

DergiPark (Istanbul University), Feb 17, 2023

Introduction: One of the pharmacological treatment options for improving the symptoms of peripher... more Introduction: One of the pharmacological treatment options for improving the symptoms of peripheral artery disease (PAD) and increasing the quality of life is cilostazol. Cilostazol is a pharmacological agent that shows vasodilator activity mainly by reducing cAMP degradation through specific cellular phosphodiesterase 3A enzyme inhibition. The effect of cilostazol on electrocardiographic parameters is not clear. In this study, we aimed to examine the effect of cilostazol on electrocardiographic parameters in PAD patients. Patients and Methods: The study included a total of 32 patients diagnosed with intermittent claudication and peripheral artery disease (PAD), who were selected for medical treatment based on peripheral artery imaging. The subjects were started on 100 mg of cilostazol twice a day. The electrocardiographic measurements of the subjects before the cilostazol treatment and three months after the initiation of cilostazol were compared. Results: After a period of three months, statistically significant prolongation was observed in the ventricular repolarization parameters QTd, QTc, and Tpe of the subjects compared to their premedication values (p= 0.01, for all). Conclusion: It is known that patients with peripheral artery disease (PAD) are at an increased risk of major adverse cardiovascular events (MACE), including sudden cardiac death (SCD). In this context, close monitoring of electrocardiography markers for ventricular repolarization heterogeneity, such as QTd, QTc, and Tpe, is necessary when initiating cilostazol therapy in patients with peripheral artery disease (PAD). These markers may be closely associated with major adverse cardiovascular events (MACE), including sudden cardiac death (SCD), and therefore require careful monitoring in PAD patients receiving cilostazol treatment.

Research Square (Research Square), Sep 6, 2022

Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid... more Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid aortic valve (BAV) disease is scarce. Also, the impact of afterload and the involved mechanisms are unclear. In this work, we study the relationship between LV function assessed with myocardial work index (MWI) and arterial stiffness in a cohort of normo-functioning BAV patients. Methods In this study, we included a total of 38 consecutive patients with isolated BAV and 44 age-and gendermatched control subjects with tricuspid aortic valve (TAV). All participants underwent transthoracic echocardiography (TTE) to assess conventional parameters, global longitudinal strain (GLS), and MW by non-invasive left ventricular pressure-strain loop (LV-PSL) method. The aortic pulse wave velocity(PWV) was used to determine arterial stiffnessand wave re ection was evaluated by applanation tonometry. Results The mean aortic PWV was signi cantly higher in BAV patients (6.4 ± 0.80, 7.02 ± .1.2, p = 0.01, respectively). The statistical difference was not signi cant for the parameters linked to LV-MW, such as global work index (GWI) and global constructive work (GCW) between the BAV and control groups (1969

Arquivos Brasileiros De Cardiologia, Jun 23, 2022

Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é im... more Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é importante para se alcançar concentrações de LDL-C recomendadas por diretrizes e para reduzir resultados cardiovasculares adversos em pacientes diabéticos. A equação de Friedewald comumente usada (LDL-Cf) produz resultados imprecisos em pacientes diabéticos devido a dislipidemia diabética associada. Recentemente, duas novas equações-Martin/Hopkins (LDL-CMH) e Sampson (LDL-Cs)-foram desenvolvidas para melhorar a precisão da estimativa de LDL-C, mas os dados são insuficientes para sugerir a superioridade de uma equação sobre a outra. Objetivos: O presente estudo comparou a precisão e a utilidade clínica das novas equações de Martin/Hopkins e Sampson em pacientes diabéticos. Método: Foram incluídos no estudo quatrocentos e dois (402) pacientes com diabetes. O risco cardiovascular dos pacientes e as metas de LDL-C foram calculadas por diretrizes europeias. As concentrações de LDL-Cmh, LDL-Cs, e LDL-Cf calculadas foram comparadas à concentração de LDL-C direto (LDL-Cd) para testar a concordância entre essas equações e LDL-Cd. Um P valor <0,05 foi aceito como estatisticamente significativo. Resultados: A LDL-CMH e a LDL-Cs tiveram concordância melhor com o LDL-Cd em comparação com a LDL-Cf, mas não houve diferenças estatísticas entre as novas equações para concordância com o LDL-Cd (Alfa de Cronbach de 0,955 para ambos, p=1). Da mesma forma, a LDL-CMH e a LDL-Cs tinham um grau semelhante de concordância com o LDL-Cd para determinar se o paciente estava dentro da meta de LDL-C (96,3% para LDL-Cmh e 96,0% para LDL-Cs), que eram ligeiramente melhores que a LDL-Cf (94,6%). Em pacientes com uma concentração de triglicérides >400 mg/dl, a concordância com o LDL-Cd foi ruim, independentemente do método usado. Conclusão: As equações de Martin/Hopkins e Sampson mostram uma precisão similar para o cálculo de concentrações de LDL-C nos pacientes com diabetes, e ambas as equações são ligeiramente melhores que a equação de Friedewald.

Kardiologia Polska, Dec 15, 2017

Background and aim: The objective of this study was to assess the potential role of mitral regurg... more Background and aim: The objective of this study was to assess the potential role of mitral regurgitation (MR) in the release of copeptin in heart failure patients with reduced ejection fraction (HFrEF). Methods: The study included 63 patients of whom 33 had functional mild MR (Group 1) and 30 had functional severe MR (Group 2). The functional class of both groups was New York Heart Association (NYHA) Class III. Blood samples for the determination of plasma copeptin and B-type natriuretic peptide (BNP) levels were obtained on the same day with the echocardiographic examination. Standard echocardiographic studies were performed. Results: Copeptin and BNP levels showed a substantial agreement in the whole study group (Kappa level: 0.607, p < 0.0001). Also, copeptin and BNP showed a strong correlation and were both increased and significantly higher in Group 2 than in Group 1 (p < 0.001 and p < 0.05, respectively). Left ventricular global longitudinal strain and left ventricular ejection fraction values were similar in both groups. The study population were divided into two subgroups on the basis of copeptin median level (6.4 ng/mL), and the prevalence of severe MR was significantly higher in the above-median-copeptin subgroup. A linear regression analysis showed that the presence of severe MR was the only independent predictor of high circulating plasma copeptin level (OR 7.5, 95% CI 2.8-12.1; p = 0.002). Conclusions: Severe MR is an independent predictor of elevated plasma copeptin level in HFREF irrespective of systolic function.

Endocrinology Research and Practice

Arquivos Brasileiros de Cardiologia

Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é im... more Fundamentos: A determinação precisa do colesterol de lipoproteína de baixa densidade (LDL-C) é importante para se alcançar concentrações de LDL-C recomendadas por diretrizes e para reduzir resultados cardiovasculares adversos em pacientes diabéticos. A equação de Friedewald comumente usada (LDL-Cf) produz resultados imprecisos em pacientes diabéticos devido a dislipidemia diabética associada. Recentemente, duas novas equações-Martin/Hopkins (LDL-CMH) e Sampson (LDL-Cs)-foram desenvolvidas para melhorar a precisão da estimativa de LDL-C, mas os dados são insuficientes para sugerir a superioridade de uma equação sobre a outra. Objetivos: O presente estudo comparou a precisão e a utilidade clínica das novas equações de Martin/Hopkins e Sampson em pacientes diabéticos. Método: Foram incluídos no estudo quatrocentos e dois (402) pacientes com diabetes. O risco cardiovascular dos pacientes e as metas de LDL-C foram calculadas por diretrizes europeias. As concentrações de LDL-Cmh, LDL-Cs, e LDL-Cf calculadas foram comparadas à concentração de LDL-C direto (LDL-Cd) para testar a concordância entre essas equações e LDL-Cd. Um P valor <0,05 foi aceito como estatisticamente significativo. Resultados: A LDL-CMH e a LDL-Cs tiveram concordância melhor com o LDL-Cd em comparação com a LDL-Cf, mas não houve diferenças estatísticas entre as novas equações para concordância com o LDL-Cd (Alfa de Cronbach de 0,955 para ambos, p=1). Da mesma forma, a LDL-CMH e a LDL-Cs tinham um grau semelhante de concordância com o LDL-Cd para determinar se o paciente estava dentro da meta de LDL-C (96,3% para LDL-Cmh e 96,0% para LDL-Cs), que eram ligeiramente melhores que a LDL-Cf (94,6%). Em pacientes com uma concentração de triglicérides >400 mg/dl, a concordância com o LDL-Cd foi ruim, independentemente do método usado. Conclusão: As equações de Martin/Hopkins e Sampson mostram uma precisão similar para o cálculo de concentrações de LDL-C nos pacientes com diabetes, e ambas as equações são ligeiramente melhores que a equação de Friedewald.

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology

In recent years, percutaneous transluminal angioplasty has become the preferred revascularization... more In recent years, percutaneous transluminal angioplasty has become the preferred revascularization option for chronic limb-threatening ischemia (CLTI) and infrapopliteal (IP) arterial disease. CLTI and IP disease require complex and lengthy procedures that necessitate multiple balloon inflations and frequent contrast injections. It will lead to severe discomfort if periprocedural pain control is inadequate. Conventional methods such as local anesthesia and systemic opioids are usually inadequate to provide pain control for complex IP arterial disease interventions. Ultrasound-guided peripheral nerve blockade (PNB) has been recently employed in peripheral procedures, with several small studies reporting favorable results in patients who underwent not complex interventions. In the present series, we report our experience of 4 patients who underwent PNB to relieve pain during endovascular treatment of complex IP disease, and in whom we have observed excellent periprocedural pain control that led to satisfactory postprocedural outcomes. Özet-Son yıllarda, perkütan translüminal anjiyoplasti, ekstremiteleri tehdit eden kronik iskemi (CLTI) ve infra-popliteal (İP) arter hastalığı için tercih edilen revaskülarizasyon seçeneği haline gelmiştir. CLTİ ve İP arter hastalığı; mükerrer balon dilatasyonu ve sık kontrast enjeksiyonunu gerektiren karmaşık ve uzun prosedürler gerektirir. Periprosedürel ağrı kontrolünün yetersiz kalması ciddi rahatsızlıklara yol açacaktır. Lokal anestezi ve sistemik opioidler gibi geleneksel yöntemler, kompleks İP girişimler sırasında ağrı kontrolünü sağlamak için genellikle yetersizdir. Ultrason rehberliğinde periferik sinir blokajı (PNB), son zamanlarda periferik prosedürlerde kullanılmıştır ve birkaç küçük çalışma, kompleks olmayan girişim yapılan hastalarda olumlu sonuçlar bildirmiştir. Bu seride, kompleks İP hastalığı olan dört hastada endovasküler tedavi sırasında ağrıyı azaltmak için PNB uygulanan, işlem sonrası tatmin edici sonuçlara yol açan ve mükemmel periprosedürel ağrı kontrolünü gözlemlediğimiz deneyimimizi bildirdik. RT, Walker JD, et al. Guidelines for performing ultrasound guided vascular cannulation: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists.

The Anatolian Journal of Cardiology, 2020

Kardiologia polska, Jan 17, 2017

The objective of this study was to assess the potential role of mitral regurgitation (MR) in the ... more The objective of this study was to assess the potential role of mitral regurgitation (MR) in the release of copeptin in HF patients with reduced ejection fraction (HFREF). The study included 63 patients of whom 33 had functional mild MR (Group 1) and 30 had functional severe MR (Group 2).The functional classes of the groups were both NYHA Class III. Blood samples for the determination of plasma copeptin and B-type natriuretic peptide (BNP) levels were obtained at the same day with the echocardiographic examination. Standard echocardiographic studies were performed. Copeptin and BNP levels showed a substantial agreement in whole study group (Kappa level: 0.607, p < 0.0001). Also, copeptin and BNP showed a strong correlation and were both increased and significantly higher in Group 2 than Group 1 (p< 0.001 and p< 0.05, respectively ). Left ventricular global longitudinal strain and LVEF values were similar in both groups. The study population were divided into two subgroups o...

Objective Data related to the existence of left ventricular (LV) abnormalities in normo-functiona... more Objective Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid aortic valve (BAV) disease is scarce. Also, the impact of afterload and the involved mechanisms are unclear. In this work, we study the relationship between LV function assessed with myocardial work index (MWI) and arterial stiffness in a cohort of normo-functioning BAV patients. Methods In this study, we included a total of 38 consecutive patients with isolated BAV and 44 age- and gender-matched control subjects with tricuspid aortic valve (TAV). All participants underwent transthoracic echocardiography (TTE) to assess conventional parameters, global longitudinal strain (GLS), and MW by non-invasive left ventricular pressure–strain loop (LV-PSL) method. The aortic pulse wave velocity(PWV) was used to determine arterial stiffnessand wave reflection was evaluated by applanation tonometry. Results The mean aortic PWV was significantly higher in BAV patients (6.4 ± 0.80, 7.02 ± ....