Khaled El-Asmar - Academia.edu (original) (raw)

Papers by Khaled El-Asmar

Research paper thumbnail of The Effectiveness of Combined Balloon and Bougie Dilatation Technique in Children with Impassable Esophageal Stricture

Journal of Laparoendoscopic & Advanced Surgical Techniques

Research paper thumbnail of Iatrogenic esophageal perforation caused by endoscopic dilatation of caustic stricture: Current management and possibility of esophageal salvage

Journal of Pediatric Surgery

Research paper thumbnail of Accuracy of contrast swallow study in assessment of caustic esophageal stricture length in children: agreement study

Journal of Pediatric Surgery

Research paper thumbnail of Surgical management of congenital chylous ascites

Annals of Pediatric Surgery

Research paper thumbnail of Correction of anterior hypospadias without urethroplasty

Annals of Pediatric Surgery

Research paper thumbnail of Foreign body ingestion in children

Annals of Pediatric Surgery

Research paper thumbnail of Retrograde Endoscopic Dilatation for Difficult Caustic Esophageal Strictures: Feasibility and Effectiveness

Journal of Pediatric Surgery

Research paper thumbnail of Surgical management of corrosive-induced gastric injury in children: 10 years' experience

Journal of Pediatric Surgery

Research paper thumbnail of Closed Gastroschisis

Journal of neonatal surgery

Closed gastroschisis is a rare entity usually associated with intestinal atresia and short bowel ... more Closed gastroschisis is a rare entity usually associated with intestinal atresia and short bowel syndrome. We report two cases of closed gastroschisis presenting with neonatal intestinal obstruction and para-umbilical evisceration without an abdominal defect.

Research paper thumbnail of Colonic Atresia: Association with Other Anomalies

Journal of Neonatal Surgery, 2016

Background: Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may... more Background: Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may be isolated, it is more commonly reported in literature in association with other congenital anomalies.Materials and Methods: This study is a review of prospectively collected data of all the patients with colonic atresia presented to our center (Ain Shams University) during 2008 to 2016.Results: Twelve patients were enrolled in this study. The atresia was of type I in one case, type II in four cases, type IIIa in six cases, type IV in one case. These cases accounted for 4.9 % of intestinal atresias managed in our center during the same period. Five cases were isolated CA, while the other seven cases had associated abdominal congenital anomalies (exomphalos, Hirschsprung’s disease, imperforate anus, closing gastroschisis, colonic duplication, and multiple small bowel atresia in two cases). The management in ten cases was by staged procedure with creation of a temporary stoma initially, ...

Research paper thumbnail of One-stage transanal Swenson procedure for rectosigmoid Hirschsprung’s disease in infants and children

Annals of Pediatric Surgery, 2016

Research paper thumbnail of Topical Mitomycin C application for esophageal stricture: Safe, precise, and novel endoscopic technique

Journal of Pediatric Surgery, 2013

The first line of management of benign esophageal stricture is endoscopic dilatation; however, mu... more The first line of management of benign esophageal stricture is endoscopic dilatation; however, multiple sessions are usually indicated especially in resistant cases. Topical Mitomycin C (MCC) application is a new adjuvant treatment in the management of esophageal stricture with promising results in different case series. Several techniques have been reported for application; nevertheless, the ideal technique has not been described yet. In this series we have devised a new technique using both the flexible and the rigid endoscope and a specially designed Nelaton catheter. This technique was applied in 38 sessions for 16 caustic esophageal strictures with technical success in all cases. No procedure-related complications were observed in this series. This novel technique is feasible and effective and can be considered as standard for topical MMC application on esophageal stricture.

Research paper thumbnail of The radiological assessment of colonic replacement of the esophagus in children: A review of 43 cases

European journal of radiology, Jan 25, 2015

To define the characteristic radiological features following colonic replacement of the esophagus... more To define the characteristic radiological features following colonic replacement of the esophagus in children. The upper gastro-intestinal contrast studies of 43 patients who underwent colonic replacement of the esophagus at our pediatric surgery unit were available for analysis. UGI contrast studies were performed routinely in the post-surgical period in 17 cases (first asymptomatic group), while the rest of contrast studies (26) belonged to a second group of out-patients complaining of dysphagia (18) or dyspepsia (8) following colonic replacement of the esophagus. Based on our observations, we proposed a grading system to describe the degree of colonic redundancy in the thorax. Redundancy of the colonic conduit in the thoracic cavity was a common radiological finding (62.8%). The redundancy was mild (grade 1) in 18 patients, moderate (grade 2) in eight, and severe (grade 3) in only one patient. In 88.9%, the redundancy was in the right hemi-thorax. Patients presenting with postope...

Research paper thumbnail of Surgical aspects of inflammatory bowel diseases in pediatric and adolescent age groups

International Journal of Colorectal Disease, 2015

Inflammatory bowel disease (IBD) is increasingly encountered in children. Early disease is associ... more Inflammatory bowel disease (IBD) is increasingly encountered in children. Early disease is associated with higher complication rate with increased incidence of surgical intervention. From January 2010 to June 2015, 25 patients in the pediatric and adolescent age groups with IBD underwent surgical intervention in our center. They were classified into two groups. Group I included 15 patients with ulcerative colitis where 5 cases had left colon disease underwent left colectomy, while 10 cases had pancolonic disease underwent total colectomy and anal mucosectomy with ileo-anal or ileal pouch-anal anastomosis with covering ileostomy. Group II included 10 cases with Crohn's disease where the indications for surgery were intestinal obstruction in seven cases, fulminant perianal infection with septic shock in one, perianal fistula and ulcers in one, and growth failure due to resistant intestinal fistula in one. Group I included eight males and seven females; mean age at surgery was 10.6 years. There were postoperative complications in seven cases in the form of pelvic abscess and wound infection in one, wound infection in two, and recurrent pouchitis in four cases. Group II contained eight males and two females; mean age at surgery was 6.6 years. Two cases had recurrent symptoms after stricturoplasty. The mean length of time from diagnosis to surgery was 2.4 years (ranging from 6 to 36 months). A multidisciplinary team is mandatory for proper management of IBD cases. The risk of the disease and the expected surgical complications determine the timing of surgical interference.

Research paper thumbnail of The radiological assessment of colonic replacement of the esophagus in children: A review of 43 cases

European Journal of Radiology, 2015

To define the characteristic radiological features following colonic replacement of the esophagus... more To define the characteristic radiological features following colonic replacement of the esophagus in children. The upper gastro-intestinal contrast studies of 43 patients who underwent colonic replacement of the esophagus at our pediatric surgery unit were available for analysis. UGI contrast studies were performed routinely in the post-surgical period in 17 cases (first asymptomatic group), while the rest of contrast studies (26) belonged to a second group of out-patients complaining of dysphagia (18) or dyspepsia (8) following colonic replacement of the esophagus. Based on our observations, we proposed a grading system to describe the degree of colonic redundancy in the thorax. Redundancy of the colonic conduit in the thoracic cavity was a common radiological finding (62.8%). The redundancy was mild (grade 1) in 18 patients, moderate (grade 2) in eight, and severe (grade 3) in only one patient. In 88.9%, the redundancy was in the right hemi-thorax. Patients presenting with postoperative dysphagia had a stricture at the site of the esophago-colic anastomosis in the neck, which should be differentiated from other sites of anatomical narrowing at the inlet and outlet of the thoracic cavity. Gastro-colic reflux was common among patients who underwent colonic replacement of the esophagus without an anti-reflux procedure. Colonic replacement of the esophagus in children results in considerable anatomical alterations. Knowledge about the normal post-surgical changes and imaging features of the commonly encountered complications can increase the diagnostic confidence among radiologists and clinicians when dealing with these cases.

Research paper thumbnail of Using the renal pelvis flap to replace the whole hypoplastic ureter

Annals of Pediatric Surgery, 2014

ABSTRACT Background Hypoplastic ureter is a rare condition usually associated with hypoplastic ki... more ABSTRACT Background Hypoplastic ureter is a rare condition usually associated with hypoplastic kidney, and it ends with nephrectomy in most of the cases. Many techniques have been described as ureteric substitutes in the literature. Here, we describe a new technique using the renal pelvis flap to replace the whole hypoplastic ureter in two cases. Objective The aim of this study was to describe a new surgical technique in the management of ureteric hypoplasia. Patients and methods Of the two boys diagnosed antenatally, unilateral hydronephrosis was detected in one boy and a huge renal cyst was present in the other, with evidence of postnatal progressive obstruction necessitating surgical intervention. On exploration, hypoplastic ureter throughout its entire length was an accidental intraoperative finding. The renal pelvis flap was taken and tubularized to replace the entire ureter, and reimplanted into the urinary bladder. This technique was the primary procedure in one case, whereas it was the secondary procedure in the other case after failure of initial trial of pyeloplasty. Results The postoperative period was uneventful with adequate drainage of the renal pelvis in the short-term follow-up (6 and 3 months consecutively). Conclusion The renal pelvis flap is a new feasible alternative procedure for ureteric replacement in a hypoplastic ureter when there is preserved renal parenchyma.

Research paper thumbnail of Can the modified Tan–Bianchi circumumbilical approach be used for treating older children?

Annals of Pediatric Surgery, 2011

ABSTRACT Background and aim: Since Tan and Bianchi reported umbilical incision as an access for p... more ABSTRACT Background and aim: Since Tan and Bianchi reported umbilical incision as an access for pyloromyotomy in infantile hypertrophic pyloric stenosis, many pediatric surgeons have used this approach for a number of other procedures. Most of these studies focused on the usefulness of such an approach in neonates. This study aims at assessing the usefulness of the circumumbilical approach for exploring the abdominal cavity of infants and older children for treating a variety of surgical intra-abdominal diseases to achieve minimally invasive surgery with excellent cosmetic results. Patients and methods: All patients who underwent a circumumbilical skin incision for an exploratory laparotomy during the period June 2009 to October 2010 were reviewed. Age, operative procedure, conversions to standard laparotomy, complications, and follow-up data were recorded. Results: A total of 27 infants and children with ages ranging from 3 months to 8 years underwent circumumbilical incision for abdominal exploration. The indications were as follows: nonrotational malrotation of the midgut (n=2), intussusception (n=13), complicated V–P shunts (n=4), acute abdomen that proved to be due to Meckel's diverticulitis (n=2), gastrotomy for removal of an impacted foreign body from the stomach (n=1), pyloroplasty for caustic injury of the pylorus (n=1), lymphatic mesenteric cyst (n=1), and complicated appendicitis (n=3). Conversion to a standard midline incision was necessary in one case. The complications encountered included wound infection (n=5), burst abdomen (n=1), and incisional hernia (n=2). Subsequent follow-up revealed that all incisions had healed and the scars were almost imperceptible as affirmed by parental satisfaction during outpatient clinic consultation. Conclusion: The circumumbilical approach appears to be safe, flexible, and easily reproducible, providing adequate exposure for some abdominal surgeries even in older infants and children as it has been tried successfully in neonates. The low-complication rate and pleasing aesthetic outcome are well-appreciated by parents and operators alike.

Research paper thumbnail of Mitomycin C application in resistant caustic esophageal stricture

Annals of Pediatric Surgery, 2011

Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for An... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Annals of Pediatric Surgery. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...

Research paper thumbnail of Gastrografin in the management of adhesive small bowel obstruction in children

Annals of Pediatric Surgery, 2011

Research paper thumbnail of Topical mitomycin C can effectively alleviate dysphagia in children with long-segment caustic esophageal strictures

Diseases of the Esophagus, 2014

Caustic ingestion in children and the resulting long esophageal strictures are usually difficult ... more Caustic ingestion in children and the resulting long esophageal strictures are usually difficult to be managed, and eventually, esophageal replacement was required for cases refractory to frequent dilatation sessions. Topical mitomycin C (MMC) application has been used recently to improve the results of endoscopic dilatation for short esophageal strictures. The study aims to assess the role of MMC application in management of long-segment caustic esophageal strictures. From January 2009 to June December 2013, patients presented with long caustic esophageal stricture (>3 cm in length) were included in this study and subjected to topical MMC application after endoscopic esophageal dilatation on multiple sessions. Regular follow-up and re-evaluation were done. A dysphagia score was used for close follow-up clinically; verification was done radiologically and endoscopically. During the specified follow-up period, 21 patients with long caustic esophageal stricture were subjected to topical MMC application sessions. Clinical, radiological, and endoscopic resolution of strictures occurred in 18 patients (85.7% cure rate). Number of dilatation sessions to achieve resolution of dysphagia was (n = 14.3 ± 5.7) with application of mitomycin two to six times. There was no recurrence in short- and mid-term follow-up. No complications were encountered related to topical MMC application. MMC is a promising agent in management of long-segment caustic esophageal strictures. Long-term follow-up is needed to prove its efficacy and to evaluate potential long-term side-effects of MMC application.

Research paper thumbnail of The Effectiveness of Combined Balloon and Bougie Dilatation Technique in Children with Impassable Esophageal Stricture

Journal of Laparoendoscopic & Advanced Surgical Techniques

Research paper thumbnail of Iatrogenic esophageal perforation caused by endoscopic dilatation of caustic stricture: Current management and possibility of esophageal salvage

Journal of Pediatric Surgery

Research paper thumbnail of Accuracy of contrast swallow study in assessment of caustic esophageal stricture length in children: agreement study

Journal of Pediatric Surgery

Research paper thumbnail of Surgical management of congenital chylous ascites

Annals of Pediatric Surgery

Research paper thumbnail of Correction of anterior hypospadias without urethroplasty

Annals of Pediatric Surgery

Research paper thumbnail of Foreign body ingestion in children

Annals of Pediatric Surgery

Research paper thumbnail of Retrograde Endoscopic Dilatation for Difficult Caustic Esophageal Strictures: Feasibility and Effectiveness

Journal of Pediatric Surgery

Research paper thumbnail of Surgical management of corrosive-induced gastric injury in children: 10 years' experience

Journal of Pediatric Surgery

Research paper thumbnail of Closed Gastroschisis

Journal of neonatal surgery

Closed gastroschisis is a rare entity usually associated with intestinal atresia and short bowel ... more Closed gastroschisis is a rare entity usually associated with intestinal atresia and short bowel syndrome. We report two cases of closed gastroschisis presenting with neonatal intestinal obstruction and para-umbilical evisceration without an abdominal defect.

Research paper thumbnail of Colonic Atresia: Association with Other Anomalies

Journal of Neonatal Surgery, 2016

Background: Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may... more Background: Colonic atresia (CA) is a rare form of congenital intestinal atresia. Although CA may be isolated, it is more commonly reported in literature in association with other congenital anomalies.Materials and Methods: This study is a review of prospectively collected data of all the patients with colonic atresia presented to our center (Ain Shams University) during 2008 to 2016.Results: Twelve patients were enrolled in this study. The atresia was of type I in one case, type II in four cases, type IIIa in six cases, type IV in one case. These cases accounted for 4.9 % of intestinal atresias managed in our center during the same period. Five cases were isolated CA, while the other seven cases had associated abdominal congenital anomalies (exomphalos, Hirschsprung’s disease, imperforate anus, closing gastroschisis, colonic duplication, and multiple small bowel atresia in two cases). The management in ten cases was by staged procedure with creation of a temporary stoma initially, ...

Research paper thumbnail of One-stage transanal Swenson procedure for rectosigmoid Hirschsprung’s disease in infants and children

Annals of Pediatric Surgery, 2016

Research paper thumbnail of Topical Mitomycin C application for esophageal stricture: Safe, precise, and novel endoscopic technique

Journal of Pediatric Surgery, 2013

The first line of management of benign esophageal stricture is endoscopic dilatation; however, mu... more The first line of management of benign esophageal stricture is endoscopic dilatation; however, multiple sessions are usually indicated especially in resistant cases. Topical Mitomycin C (MCC) application is a new adjuvant treatment in the management of esophageal stricture with promising results in different case series. Several techniques have been reported for application; nevertheless, the ideal technique has not been described yet. In this series we have devised a new technique using both the flexible and the rigid endoscope and a specially designed Nelaton catheter. This technique was applied in 38 sessions for 16 caustic esophageal strictures with technical success in all cases. No procedure-related complications were observed in this series. This novel technique is feasible and effective and can be considered as standard for topical MMC application on esophageal stricture.

Research paper thumbnail of The radiological assessment of colonic replacement of the esophagus in children: A review of 43 cases

European journal of radiology, Jan 25, 2015

To define the characteristic radiological features following colonic replacement of the esophagus... more To define the characteristic radiological features following colonic replacement of the esophagus in children. The upper gastro-intestinal contrast studies of 43 patients who underwent colonic replacement of the esophagus at our pediatric surgery unit were available for analysis. UGI contrast studies were performed routinely in the post-surgical period in 17 cases (first asymptomatic group), while the rest of contrast studies (26) belonged to a second group of out-patients complaining of dysphagia (18) or dyspepsia (8) following colonic replacement of the esophagus. Based on our observations, we proposed a grading system to describe the degree of colonic redundancy in the thorax. Redundancy of the colonic conduit in the thoracic cavity was a common radiological finding (62.8%). The redundancy was mild (grade 1) in 18 patients, moderate (grade 2) in eight, and severe (grade 3) in only one patient. In 88.9%, the redundancy was in the right hemi-thorax. Patients presenting with postope...

Research paper thumbnail of Surgical aspects of inflammatory bowel diseases in pediatric and adolescent age groups

International Journal of Colorectal Disease, 2015

Inflammatory bowel disease (IBD) is increasingly encountered in children. Early disease is associ... more Inflammatory bowel disease (IBD) is increasingly encountered in children. Early disease is associated with higher complication rate with increased incidence of surgical intervention. From January 2010 to June 2015, 25 patients in the pediatric and adolescent age groups with IBD underwent surgical intervention in our center. They were classified into two groups. Group I included 15 patients with ulcerative colitis where 5 cases had left colon disease underwent left colectomy, while 10 cases had pancolonic disease underwent total colectomy and anal mucosectomy with ileo-anal or ileal pouch-anal anastomosis with covering ileostomy. Group II included 10 cases with Crohn's disease where the indications for surgery were intestinal obstruction in seven cases, fulminant perianal infection with septic shock in one, perianal fistula and ulcers in one, and growth failure due to resistant intestinal fistula in one. Group I included eight males and seven females; mean age at surgery was 10.6 years. There were postoperative complications in seven cases in the form of pelvic abscess and wound infection in one, wound infection in two, and recurrent pouchitis in four cases. Group II contained eight males and two females; mean age at surgery was 6.6 years. Two cases had recurrent symptoms after stricturoplasty. The mean length of time from diagnosis to surgery was 2.4 years (ranging from 6 to 36 months). A multidisciplinary team is mandatory for proper management of IBD cases. The risk of the disease and the expected surgical complications determine the timing of surgical interference.

Research paper thumbnail of The radiological assessment of colonic replacement of the esophagus in children: A review of 43 cases

European Journal of Radiology, 2015

To define the characteristic radiological features following colonic replacement of the esophagus... more To define the characteristic radiological features following colonic replacement of the esophagus in children. The upper gastro-intestinal contrast studies of 43 patients who underwent colonic replacement of the esophagus at our pediatric surgery unit were available for analysis. UGI contrast studies were performed routinely in the post-surgical period in 17 cases (first asymptomatic group), while the rest of contrast studies (26) belonged to a second group of out-patients complaining of dysphagia (18) or dyspepsia (8) following colonic replacement of the esophagus. Based on our observations, we proposed a grading system to describe the degree of colonic redundancy in the thorax. Redundancy of the colonic conduit in the thoracic cavity was a common radiological finding (62.8%). The redundancy was mild (grade 1) in 18 patients, moderate (grade 2) in eight, and severe (grade 3) in only one patient. In 88.9%, the redundancy was in the right hemi-thorax. Patients presenting with postoperative dysphagia had a stricture at the site of the esophago-colic anastomosis in the neck, which should be differentiated from other sites of anatomical narrowing at the inlet and outlet of the thoracic cavity. Gastro-colic reflux was common among patients who underwent colonic replacement of the esophagus without an anti-reflux procedure. Colonic replacement of the esophagus in children results in considerable anatomical alterations. Knowledge about the normal post-surgical changes and imaging features of the commonly encountered complications can increase the diagnostic confidence among radiologists and clinicians when dealing with these cases.

Research paper thumbnail of Using the renal pelvis flap to replace the whole hypoplastic ureter

Annals of Pediatric Surgery, 2014

ABSTRACT Background Hypoplastic ureter is a rare condition usually associated with hypoplastic ki... more ABSTRACT Background Hypoplastic ureter is a rare condition usually associated with hypoplastic kidney, and it ends with nephrectomy in most of the cases. Many techniques have been described as ureteric substitutes in the literature. Here, we describe a new technique using the renal pelvis flap to replace the whole hypoplastic ureter in two cases. Objective The aim of this study was to describe a new surgical technique in the management of ureteric hypoplasia. Patients and methods Of the two boys diagnosed antenatally, unilateral hydronephrosis was detected in one boy and a huge renal cyst was present in the other, with evidence of postnatal progressive obstruction necessitating surgical intervention. On exploration, hypoplastic ureter throughout its entire length was an accidental intraoperative finding. The renal pelvis flap was taken and tubularized to replace the entire ureter, and reimplanted into the urinary bladder. This technique was the primary procedure in one case, whereas it was the secondary procedure in the other case after failure of initial trial of pyeloplasty. Results The postoperative period was uneventful with adequate drainage of the renal pelvis in the short-term follow-up (6 and 3 months consecutively). Conclusion The renal pelvis flap is a new feasible alternative procedure for ureteric replacement in a hypoplastic ureter when there is preserved renal parenchyma.

Research paper thumbnail of Can the modified Tan–Bianchi circumumbilical approach be used for treating older children?

Annals of Pediatric Surgery, 2011

ABSTRACT Background and aim: Since Tan and Bianchi reported umbilical incision as an access for p... more ABSTRACT Background and aim: Since Tan and Bianchi reported umbilical incision as an access for pyloromyotomy in infantile hypertrophic pyloric stenosis, many pediatric surgeons have used this approach for a number of other procedures. Most of these studies focused on the usefulness of such an approach in neonates. This study aims at assessing the usefulness of the circumumbilical approach for exploring the abdominal cavity of infants and older children for treating a variety of surgical intra-abdominal diseases to achieve minimally invasive surgery with excellent cosmetic results. Patients and methods: All patients who underwent a circumumbilical skin incision for an exploratory laparotomy during the period June 2009 to October 2010 were reviewed. Age, operative procedure, conversions to standard laparotomy, complications, and follow-up data were recorded. Results: A total of 27 infants and children with ages ranging from 3 months to 8 years underwent circumumbilical incision for abdominal exploration. The indications were as follows: nonrotational malrotation of the midgut (n=2), intussusception (n=13), complicated V–P shunts (n=4), acute abdomen that proved to be due to Meckel's diverticulitis (n=2), gastrotomy for removal of an impacted foreign body from the stomach (n=1), pyloroplasty for caustic injury of the pylorus (n=1), lymphatic mesenteric cyst (n=1), and complicated appendicitis (n=3). Conversion to a standard midline incision was necessary in one case. The complications encountered included wound infection (n=5), burst abdomen (n=1), and incisional hernia (n=2). Subsequent follow-up revealed that all incisions had healed and the scars were almost imperceptible as affirmed by parental satisfaction during outpatient clinic consultation. Conclusion: The circumumbilical approach appears to be safe, flexible, and easily reproducible, providing adequate exposure for some abdominal surgeries even in older infants and children as it has been tried successfully in neonates. The low-complication rate and pleasing aesthetic outcome are well-appreciated by parents and operators alike.

Research paper thumbnail of Mitomycin C application in resistant caustic esophageal stricture

Annals of Pediatric Surgery, 2011

Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for An... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Annals of Pediatric Surgery. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...

Research paper thumbnail of Gastrografin in the management of adhesive small bowel obstruction in children

Annals of Pediatric Surgery, 2011

Research paper thumbnail of Topical mitomycin C can effectively alleviate dysphagia in children with long-segment caustic esophageal strictures

Diseases of the Esophagus, 2014

Caustic ingestion in children and the resulting long esophageal strictures are usually difficult ... more Caustic ingestion in children and the resulting long esophageal strictures are usually difficult to be managed, and eventually, esophageal replacement was required for cases refractory to frequent dilatation sessions. Topical mitomycin C (MMC) application has been used recently to improve the results of endoscopic dilatation for short esophageal strictures. The study aims to assess the role of MMC application in management of long-segment caustic esophageal strictures. From January 2009 to June December 2013, patients presented with long caustic esophageal stricture (>3 cm in length) were included in this study and subjected to topical MMC application after endoscopic esophageal dilatation on multiple sessions. Regular follow-up and re-evaluation were done. A dysphagia score was used for close follow-up clinically; verification was done radiologically and endoscopically. During the specified follow-up period, 21 patients with long caustic esophageal stricture were subjected to topical MMC application sessions. Clinical, radiological, and endoscopic resolution of strictures occurred in 18 patients (85.7% cure rate). Number of dilatation sessions to achieve resolution of dysphagia was (n = 14.3 ± 5.7) with application of mitomycin two to six times. There was no recurrence in short- and mid-term follow-up. No complications were encountered related to topical MMC application. MMC is a promising agent in management of long-segment caustic esophageal strictures. Long-term follow-up is needed to prove its efficacy and to evaluate potential long-term side-effects of MMC application.