Khalid Malik - Academia.edu (original) (raw)

Papers by Khalid Malik

Respiratory Medicine Case Reports, 2021

IgG4-related lung disease is an extremely rare and novel entity which is still poorly understood.... more IgG4-related lung disease is an extremely rare and novel entity which is still poorly understood. We reviewed the 16 patients diagnosed with IgG4-related disease from October 2014 through December 2019 at our institution. The three cases that showed pulmonary involvement are included in this series. Of these, two patients had cavitary lung disease and developed aspergilloma and chronic cavitating aspergillosis after a prolonged course of steroid therapy, and one had isolated pulmonary nodule and ground glass opacity. We reviewed the updated literature and briefly described disease epidemiology, clinical characteristics, diagnostic approaches, and management strategies for IgG4-related lung disease.

Critical Care Nursing Quarterly, 2021

Chronic obstructive pulmonary disease or COPD is characterized by airflow obstruction, causing re... more Chronic obstructive pulmonary disease or COPD is characterized by airflow obstruction, causing respiratory symptoms. There are treatments available for COPD; however, COPD has significant extrapulmonary effects, including well-recognized ones as cardiovascular disease and often underdiagnosed ones as osteoporosis. It is imperative to be aware of these comorbidities to optimize COPD patient care.

2018 IEEE International Conference on Smart Energy Grid Engineering (SEGE), 2018

The connectivity of power domains is a key factor for realizing a smart grid. Different power dom... more The connectivity of power domains is a key factor for realizing a smart grid. Different power domains in smart grid (SG) involves various types of applications and devices each of which comes with its own requirements. In addition, different communication protocols and data models have been already proposed to address those requirements. Due to the differences in communication technologies, interoperability challenges have been raised in SG. Interoperability issues not only deteriorate the connectivity of different domains, but also compromise the potentials of data sharing in SG. The Data Distribution Service (DDS) has emerged as a possible solution since it supports different features such as transport configuration and dynamic discovery mechanism. In this paper, we describe how DDS can be used to address both data interoperability and protocol interoperability in SG. We first describe interoperability issues in SG and then describe the use of a unified data model with DDS and configuring DDS for TCP/IP and UDP/IP. We also implement the configurations and present the results of the implementations for comparative analysis.

Bone & Joint Open, 2021

Aims The primary objective was to determine the incidence of COVID-19 infection and 30-day mortal... more Aims The primary objective was to determine the incidence of COVID-19 infection and 30-day mortality in patients undergoing foot and ankle surgery during the global pandemic. Secondary objectives were to determine if there was a change in infection and complication profile with changes introduced in practice. Methods This UK-based multicentre retrospective national audit studied foot and ankle patients who underwent surgery between 13 January and 31 July 2020, examining time periods pre-UK national lockdown, during lockdown (23 March to 11 May 2020), and post-lockdown. All adult patients undergoing foot and ankle surgery in an operating theatre during the study period were included. A total of 43 centres in England, Scotland, Wales, and Northern Ireland participated. Variables recorded included demographic data, surgical data, comorbidity data, COVID-19 and mortality rates, complications, and infection rates. Results A total of 6,644 patients were included. Of the operated patients,...

Case Reports in Pulmonology, 2017

Choriocarcinoma is part of the spectrum of gestational trophoblastic disease that occurs in women... more Choriocarcinoma is part of the spectrum of gestational trophoblastic disease that occurs in women of reproductive age. Although the most common metastatic site of choriocarcinoma is the lung, primary pulmonary choriocarcinoma is rare. To diagnose primary pulmonary choriocarcinoma, the patient should have no previous gynecologic malignancy, have elevated human chorionic gonadotropin, and have pathological confirmation of the disease excluding gonadal primary site of the tumor. Due to the paucity of data, there are no guidelines for treatment. Prognosis of this malignancy is extremely poor. We report a rare case of metastatic primary lung choriocarcinoma in a 69-year-old postmenopausal woman who was treated with combination of surgery, chemotherapy, and radiation. The patient had a good outcome and is doing well after 1-year follow-up.

Emergency Medicine News, 2019

Emergency Medicine News, 2018

Postgraduate Medicine, 2002

To avoid confusion and to improve communication, it is helpful to describe the level of conscious... more To avoid confusion and to improve communication, it is helpful to describe the level of consciousness with terms such as "alert," "drowsy," "stuporous," or "comatose" and to avoid words like "lethargic" or "obtunded," which lack precise meanings. Because other conditions ...

Journal of Ultrasound in Medicine, 2009

Objective. Nerve stimulator-assisted localization of the femoral nerve is well described; however... more Objective. Nerve stimulator-assisted localization of the femoral nerve is well described; however, direct ultrasound imaging of the femoral nerve branches may be challenging. The purpose of this study was to correlate the evoked motor responses obtained by femoral nerve stimulation and the topographic orientation of the femoral nerve branches during ultrasound examinations of the infrainguinal region. Methods. Eighty-two patients undergoing total knee replacement were enrolled in this study. A 25-mm, 5-to 10-MHz broadband linear array transducer was used to identify the femoral nerve at the inguinal crease. The medial and lateral aspects of the femoral nerve were stimulated under ultrasound imaging. Twenty cadavers were dissected to support our clinical findings. Results. A quadriceps contraction was elicited in 1.2% and 96% of the patients when stimulating the medial and lateral aspects of the femoral nerve, respectively. In contrast, a sartorius muscle contraction was elicited in 94% and 0% when stimulating the medial and lateral aspects of the femoral nerve. Our findings during anatomic dissection revealed that the femoral nerve branch to the quadriceps muscle, when compared with the branch to the sartorius muscle, originated laterally in 95% and medially in 5% of the specimens. Conclusions. When using out-of-plane ultrasound imaging at the inguinal crease, directing the stimulating needle to the lateral half of the femoral nerve may be associated with a higher probability of encountering the motor branch to the quadriceps muscle.

Human Development Report, 2013

Environmental Management and Health, 2002

... sans interruption. Plus d&amp;amp;amp;amp;amp;#x27;un million de titres à notre catal... more ... sans interruption. Plus d&amp;amp;amp;amp;amp;#x27;un million de titres à notre catalogue ! »Afficher votre panier«. WebAnalytics solution by WebAnalytics - AT Internet. Notice. Imprimer la notice.Capacity for Development : New Solutions to Old Problems. ...

Annals of Saudi medicine

Mutations in several genes are known to cause steroid-resistant nephrotic syndome (SRNS), most co... more Mutations in several genes are known to cause steroid-resistant nephrotic syndome (SRNS), most commonly in NPHS1, NPHS2, and WT1. Our aims were to determine the frequency of mutations in these genes in children with SRNS, the response of patients with SRNS to various immunosuppressants, and the disease outcome, and to review the predictive value of genetic testing and renal biopsy result. A retrospective review was performed of the medical records for all children with SRNS who were treated and followed-up in the Pediatric Nephrology Unit of King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia from 2002-2012. We retrospectively reviewed the medical records of children above 1 year of age, who presented with SRNS to KAUH, Jeddah, Saudi Arabia, in the 10-year interval from 2002-2012 and for whom the results of genetic testing for NPHS1, NPHS2, and WT1 were available. We compared the clinical phenotype, including response to treatment and renal outcome to genotype data. We i...

Essentials of Pain Medicine, 2011

F1000 - Post-publication peer review of the biomedical literature, 2010

Pain Practice, 2011

Scalene muscle injections are used to confirm the diagnosis of neurogenic thoracic outlet syndrom... more Scalene muscle injections are used to confirm the diagnosis of neurogenic thoracic outlet syndrome and predict the response of patients to surgery. We performed a retrospective study to determine if relief of pain was related to brachial plexus blockade in these patients. Methods: We reviewed the charts of 12 patients who had anterior and middle scalene muscle injections, for neurogenic thoracic outlet syndrome, between April 2009 and September 2010. The injections were performed under ultrasound guidance wherein 2 to 5 mL of 0.25% bupivacaine was injected into the belly of the anterior and scalene muscles. The following were noted: (1) sites of preprocedure pain; (2) volume injected into each of the anterior and middle scalene muscles; (3) presence of numbness after injection; and (4) presence and duration of pain relief. Results: All 12 patients had relief of their pain. Six of the twelve patients developed numbness, which ranged from blockade of the C4-5, C6-7, and C4-T1 dermatomes. In the patients who developed numbness, there was no relationship between the duration of numbness and the duration of pain relief or the location of numbness and the location of pain relief. Conclusions: The relief from scalene muscle injections in patients with neurogenic thoracic outlet syndrome is not related to blockade of the brachial plexus. n

American family physician, Jan 15, 2008

Fatigue, a common presenting symptom in primary care, negatively impacts work performance, family... more Fatigue, a common presenting symptom in primary care, negatively impacts work performance, family life, and social relationships. The differential diagnosis of fatigue includes lifestyle issues, physical conditions, mental disorders, and treatment side effects. Fatigue can be classified as secondary to other medical conditions, physiologic, or chronic. The history and physical examination should focus on identifying common secondary causes (e.g., medications, anemia, pregnancy) and life-threatening problems, such as cancer. Results of laboratory studies affect management in only 5 percent of patients, and if initial results are normal, repeat testing is generally not indicated. Treatment of all types of fatigue should include a structured plan for regular physical activity that consists of stretching and aerobic exercise, such as walking. Caffeine and modafinil may be useful for episodic situations requiring alertness. Short naps are proven performance enhancers. Selective serotonin...

Pain Practice, 2012

Our study surveyed physician members of 3 American pain societies to determine prescription patte... more Our study surveyed physician members of 3 American pain societies to determine prescription patterns and whether these practices reflect current expert opinion. We sent 3 mailings to 2938 physicians from January 2010 to January 2011. The questionnaire contained 49 questions on topics related to opioids, antidepressants, anticonvulsants, and preferences for the different pain syndromes. A total of 474 physicians responded, representing a 16% return. Seventy-two percent ask patients to sign an opioid agreement, 59% order random urine drug testing, 13% wait until the dose of methadone is between 100 and 150 mg before converting the drug to another opioid, and 85% do not think there is a maximum dose of opioids with respect to driving. Most responders prescribe codeine to Caucasians and Asians. While 42% stated that the maximum daily dose of acetaminophen is 3000 mg, 75% would decrease the dose in patients who are moderate or heavy drinkers. Fifty-four percent do not order an ECG at all when prescribing tricyclic antidepressants. The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments. However, we identified gaps in knowledge, including the prescription of codeine in certain populations and the use of electrocardiogram in patients on antidepressants. Further education of physicians who treat chronic pain pharmacologically is warranted.

Practical Management of Pain, 2014

Pharmacotherapy, 2003

A 46-year-old morbidly obese man was admitted to the medical intensive care unit with respiratory... more A 46-year-old morbidly obese man was admitted to the medical intensive care unit with respiratory failure. He required pressure-control ventilation and high levels of sedation with continuous-infusion lorazepam. He developed Stenotrophomonas maltophilia pneumonia; treatment included scheduled intravenous trimethoprim-sulfamethoxazole. Each of these drugs contain several hundred milligrams/milliliter of propylene glycol. On day 17 of his hospital course, 3 days after starting the trimethoprim-sulfamethoxazole, the patient developed acute renal failure consistent with acute tubular necrosis. Propylene glycol toxicity was suspected; therefore, all drugs containing propylene glycol were discontinued, and laboratory data were collected. A marked osmol gap, metabolic acidosis, and renal toxicity were attributed to both continuous and large intermittent doses of intravenous propylene glycol. Particular attention should be paid to the total amount of propylene glycol provided to patients from administered drugs. Patients in the intensive care setting who require high doses of intravenous lorazepam for sedation, as well as antimicrobial therapy with trimethoprim-sulfamethoxazole for treatment of either Stenotrophomonas maltophilia or Pneumocystis carinii pneumonia, may be at increased risk for propylene glycol toxicity and should be monitored closely.