Khursheed Khan - Academia.edu (original) (raw)

Papers by Khursheed Khan

Irradiation Technology: Processing of Fruits and Vegetables

Technological Interventions in the Processing of Fruits and Vegetables

Fluorescein sodium fluorescence: role in stereotactic brain biopsy

British Journal of Neurosurgery, 2021

BACKGROUND Stereotactic brain biopsy for eloquent area brain tumours is associated with complicat... more BACKGROUND Stereotactic brain biopsy for eloquent area brain tumours is associated with complications like hemorrhage due to multiple sampling and increased operative time due to dependence on neuropathologist for frozen section assessment. In order to curb these limitations, we investigated the use of Fluorescein sodium fluorescence in confirming pathological tissue samples in stereotactic brain biopsy of gadolinium-enhancing tumours. METHODS This prospective observational study included 23 consecutive patients who underwent stereotactic biopsy of gadolinium-contrast-enhancing brain lesions with intravenous fluorescein sodium administration. 93 specimens were obtained and examined for the presence of fluorescence using a microscope with fluorescence visualisation capability. Later the nature of the samples was confirmed on histopathology. The sensitivity and specificity of flourescein sodium fluorescence were calculated based on histopathological confirmation. RESULTS 58 (62.3%) fluorescent and 35 (37.6%) nonfluorescent samples were obtained. All fluorescent specimens contained diagnostic tissue appropriate for tumor grading. Of 35 nonfluorescent specimens, 12 (34.3%) did not contain tumor, 11 (31.4%) contained minor hypercellularity or gliosis, and 12 (34.3%) contained tumor with a high proportion of necrosis. The sensitivity and specificity for fluorescein fluorescence were 83% and 100%, respectively. CONCLUSIONS Fluorescein fluorescence is a handy tool to detect the pathological tissue in stereotactic brain biopsy and may improve its diagnostic accuracy and expedite the procedure.

Bioavailable constituents/metabolites of pomegranate (L) preferentially inhibit COX2 activity and IL-1beta-induced PGEproduction in human chondrocytes -3

Ribed in Materials and Methods. Data were derived from two independent experiments, each run in d... more Ribed in Materials and Methods. Data were derived from two independent experiments, each run in duplicate. Values shown are Mean ± SE and differ without a common letter (< 0.005).<b>Copyright information:</b>Taken from "Bioavailable constituents/metabolites of pomegranate (L) preferentially inhibit COX2 activity and IL-1beta-induced PGEproduction in human chondrocytes "http://www.journal-inflammation.com/content/5/1/9Journal of Inflammation (London, England) 2008;5():9-9.Published online 13 Jun 2008PMCID:PMC2438359.

Bioavailable constituents/metabolites of pomegranate (L) preferentially inhibit COX2 activity and IL-1beta-induced PGEproduction in human chondrocytes -2

for 24 hrs. At the end of incubation, 100 μl of the medium was removed for measuring nitrite prod... more for 24 hrs. At the end of incubation, 100 μl of the medium was removed for measuring nitrite production by Griess reaction. Control values were obtained in the absence of plasma or IL-1β. Data were derived from two independent experiments, each run in triplicate, and expressed as Mean ± SE. Values without a common letter differ (< 0.05 a vs b; < 0.005, a vs c; b vs c).<b>Copyright information:</b>Taken from "Bioavailable constituents/metabolites of pomegranate (L) preferentially inhibit COX2 activity and IL-1beta-induced PGEproduction in human chondrocytes "http://www.journal-inflammation.com/content/5/1/9Journal of Inflammation (London, England) 2008;5():9-9.Published online 13 Jun 2008PMCID:PMC2438359.

Role of Canning Technology in Preservation of Fruits and Vegetables

Technological Interventions in the Processing of Fruits and Vegetables, 2018

International Journal of Ayurvedic Medicine, 2021

Tinospora cordifolia (TC) a traditional plant used in Indian Ayurvedic medicine widely. Different... more Tinospora cordifolia (TC) a traditional plant used in Indian Ayurvedic medicine widely. Different parts of this plant such as stem, roots, leaves are used for treatment and control of various health issues as well as an ingredient in functional foods. It possesses many health promoting and protecting properties. The present article is a critical review providing a comprehensive discussion on therapeutic application and functional significance of TC. The aim of this review is to develop a clear understanding of these issues. Specifically coverage in this review are published information in the areas of Diabetic retinopathy, Free radical scavenging, Anti-Diabetic, Cognition enhancing, Anti-inflammatory, Anti-allergic, Immunomodulatory and Anti-cancer, Management of Hay Fever, Antioxidant, Hypoglycaemic and Hypolipidaemic, Osteoblasts formation, Immunomodulatory, Immunostimulatory, Protection from Skeletal Muscle Atrophy, Gastroprotective, Antiosteoporotic etc. Uses of TC as plant di...

Expert Opinion: Use of sodium glucose co-transporter type-2 inhibitors in South Asian population -The Pakistan perspective

JPMA. The Journal of the Pakistan Medical Association, 2019

Sodium-glucose co-transporter type 2 inhibitors (SGLT 2- i)are increasingly being used in the man... more Sodium-glucose co-transporter type 2 inhibitors (SGLT 2- i)are increasingly being used in the management of type 2 diabetes mellitus (T2DM). With the novel insulinindependent glycosuric action, these agents help to attain glycaemic goals by lowering HbA1c and fasting blood glucose. In addition, these agents improve metabolic control in diabetes and ameliorate comorbidities like obesity and hyper tension. Beneficial effec ts on cardiovascular outcomes have been a key attraction for physicians. These agents are used alone or in combination with oral antidiabetic agents and insulin to attain glycaemic and metabolic targets. A major disadvantagewith these agents is the increased risk for genital andurinary infections. When used in appropriate settings, there is no additional increased risk of hypoglycaemia or volume depletion with these agents. Available evidence suggests good efficacy and safety of these agents in diabetes management. The easy and convenient oncedaily dosing should be ...

Evaluation of idiopathic dilated cardiomyopathy with cardiac magnetic resonance imaging

Heart India, 2021

Purpose: The present study was aimed to assess the prevalence, location, and patterns of late gad... more Purpose: The present study was aimed to assess the prevalence, location, and patterns of late gadolinium enhancement (LGE) in idiopathic dilated cardiomyopathy (DCM) on cardiac magnetic resonance (CMR) imaging and to correlate the left ventricular (LV) functions obtained by cine CMR with the values obtained by echocardiography. Methods: This was a prospective single-center study covering a 2-year study period. The authors studied the prevalence, location, and patterns of LGE in idiopathic DCM on CMR and correlated the ventricular functions obtained by CMR with those obtained by echocardiography. Results: LGE was seen in 18/40 (45%) and was absent in 22/40 (55%) of patients. With regard to location, septal enhancement was the most common, seen in 8 (20%) followed by free-wall enhancement in 4 (10%) and a concomitant septal and free-wall enhancement in 6 (15%). In terms of pattern, midwall enhancement was observed in 10 (25%), subepicardial in 2 (5%), subendocardial in 4 (10%), and fo...

Upper Extremity Dysfunction after Trans-Radial Interventions- Experience from a Tertiary Care Center of North India

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020

Introduction: Coronary artery disease treatment by percutaneous intervention has revolutionised t... more Introduction: Coronary artery disease treatment by percutaneous intervention has revolutionised the management of this disease and the choice and safety of vascular access site has significantly contributed to the outcome of the overall procedure. Aim: To assess upper extremity dysfunction in patients undergoing Transradial Coronary Angiography (CAG) and Percutaneous Coronary Interventions (PCI). Materials and Methods: This study involved patients planned for transradial coronary intervention. Patients were assessed for development of upper extremity dysfunction and other local complications post procedure at 24 hours, 2 weeks, 1 month and 6 months. Data analysis was done using SPSS Version 21. Results: A total of 165 patients were enrolled in the study. There were 123 (74.5%) males. Total 156 patients (94.5%) had stable angina as underlying diagnosis, 4 (2.4%) had unstable angina, 2 (1.2%) had Non ST Elevation Myocardial Infarction (NSTEMI), 1 (0.6%) had ST Elevation Myocardial Inf...

Indian Journal of Neurotrauma, 2019

Aims Evaluation of clinical profile, mode of injury, and clinical outcome in patients of traumati... more Aims Evaluation of clinical profile, mode of injury, and clinical outcome in patients of traumatic atlantoaxial dislocation (AAD) who underwent posterior C1 and C2 screw and rod fixation by using Harms and Goel technique. Materials and Methods It is a retrospective study involving all traumatic AAD patients of all age groups admitted at Department of Neurosurgery, RMLIMS, Lucknow, during the last two years. Inclusion criteria was all cases having traumatic AAD with or without C2 fracture and underwent posterior C1 and C2 screw and rod fixation by Harms and Goel technique. Clinical profile, age, sex, mode of injury, types of injury (detected in MRI and CT of cranio-vertebral junction), preoperative and postoperative (after one month of surgery) neurological status were evaluated and outcome analyzed. Results Over all, out of 14 patients, 12 (85.7%) patients improved in the form of either reduced spasticity, improved sensation, increased power of one or more limbs, or bladder and bowe...

Journal of Inflammation, 2008

Several recent studies have documented that supplementation with pomegranate fruit extract inhibi... more Several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo. However, the molecular basis of the observed effects has not been fully revealed. Although previous studies have documented the inhibition of nitric oxide and cyclooxygenase (COX) activity in vitro by plant and fruit extracts added directly into the culture medium but whether concentrations of bioactive compounds sufficient enough to exert such inhibitory effects in vivo can be achieved through oral consumption has not been reported. In the present study we determined the effect of rabbit plasma obtained after ingestion of a polyphenol rich extract of pomegranate fruit (PFE) on COX enzyme activity ex vivo and the IL-1β-induced production of NO and PGE2 in chondrocytes in vitro. Plasma samples collected before and 2 hr after supplementation with PFE were tested. Plasma samples collected after oral ingestion of PFE were found to inhibit the IL-1β-induced P...

Journal of the College …, 2009

Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts o... more Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland. It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine ...

Studies of the Dermatophytic Infection of Man in West Pakistan

STUDIES OF THE DERMATOPHYTIC INFECTION OF MAN IN WEST PAKISTAN. Khan,Khursheed Ali (1996) STUDIES... more STUDIES OF THE DERMATOPHYTIC INFECTION OF MAN IN WEST PAKISTAN. Khan,Khursheed Ali (1996) STUDIES OF THE DERMATOPHYTIC INFECTION OF MAN IN WEST PAKISTAN. ... ID Code: 1292. Deposited By: Mr. Muhammad Asif. Deposited On: 27 Jan 2007. ...

Mannich Reaction Product of Quinolin-8-ol (Oxine) and its Antibacterial Activity

Australian Journal of Chemistry, 1997

Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and m-nitrobenzaldehyde afforded 7-(α-hydr... more Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and m-nitrobenzaldehyde afforded 7-(α-hydroxy- m-nitrobenzyl)quinolin-8-ol (2), which is an unusual Mannich reaction product. The structure of (2) was determined by spectroscopic and single-crystal X-ray diffraction studies. Preliminary antimicrobial screening showed that (1) and (2) have activity against a large number of Gram-positive and Gram-negative bacteria.

Primary percutaneous coronary intervention without cardiac surgery on-site: Coming to a hospital near you?

American Heart Journal, 2008

Asian Fisheries Science, Oct 27, 2007

Electrophoresis in native 7.5% polyacrylamide gel made in Tris-HCl and run in Tris-borate reveale... more Electrophoresis in native 7.5% polyacrylamide gel made in Tris-HCl and run in Tris-borate revealed three parvalbumin phenotypes in soluble proteins of white skeletal muscle of spotted snakehead Channa punctata. Parvalbumins (PV) were initially recognized because of fast electrophoretic migration at alkaline pH (that indicates acidic nature), exceptional thermostability, relatively high concentration and acetone fractionation. Though constituted by isoforms PVIII, PVI or PVII, acetone purified each of the three phenotypes stacked as single bands of identical M r of ~11 kD following SDS-PAGE. Phenotype-specific but soluble aggregates were formed by incubating muscle extracts at 70°C. These results demonstrate that modified PAGE protocols can reveal polymorphism, which may be obscure under alternative systems. Further, heat-stable soluble muscle proteins, specifically the isoparvalbumins may be good candidates for such screening.

Polyacrylamide gel electrophoresis (PAGE) revealed that almost all of serum proteins of spotted s... more Polyacrylamide gel electrophoresis (PAGE) revealed that almost all of serum proteins of spotted snakehead Channa punctata precipitate at 75% ammonium sulphate (AS) saturation. AS fractions of 65% predominantly contained γ-globulins, traces of haptoglobin and β-globulin. Two of β-globulins, haptoglobins and transferrins were identifiable due to specific staining. Fraction of 45% AS saturation had only globulins, while fraction of 25% contained almost pure albumin-like protein. Albumin-like protein showed cross reactivity against rabbit anti-HSA antiserum. For albumin-like protein of Channa punctata, a molecular weight of 70 kD was determined by SDS-PAGE, which was similar to the value reported for HSA. Since serum albumin is not ubiquitously distributed in class Pisces, its occurrence in C. punctata, which is a fish of evolutionarily remote origin is significant.

La Presse Médicale, 2006

Sinonasal mucosal malignant melanoma Introduction > Mucosal melanomas are rare tumors, and primar... more Sinonasal mucosal malignant melanoma Introduction > Mucosal melanomas are rare tumors, and primary sinonasal malignant melanomas uncommon tumors that are frequently misclassified. Differential diagnosis should rule out other sinonasal malignancies, including carcinoma, lymphoma, sarcoma, and olfactory neuroblastoma. Case > We report two new cases of sinonasal melanoma. One involved a 68-year-old man being followed for chronic sinusitis, despite antibiotics; he presented a tumor of the right nasal cavity. The second case was that of a 77-year-old woman, referred for painful gingival swelling shown to involve osteolytic growth in the left maxillary sinus. In both cases, pathologic examination of the biopsy samples concluded that these were sinonasal malignant melanomas. Discussion > Histologically, the diagnosis is very difficult because of the polymorphic features of this tumor, and immunohistochemical studies are very important. The relative inaccessibility of the mucosa to self-examination often delays diagnosis and leads to late detection and poor prognosis.