Ki Hong - Academia.edu (original) (raw)

Papers by Ki Hong

Open Access Journal of Clinical Surgery, 2021

JCSM Clinical Reports, 2021

Korea is an ‘aged’ society on its way to becoming a ‘super aged’ society. As the population ages,... more Korea is an ‘aged’ society on its way to becoming a ‘super aged’ society. As the population ages, new medical diseases become more prevalent. One such problem is sarcopenia. Sarcopenia, by definition, is skeletal muscle loss. Furthermore, additional studies have also pointed out smooth muscle loss. In this study, we focused on the correlation between thyroid hormones and sarcopenia with a biochemical viewpoint through creatine kinase.

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In this study, the plausible grid size was estimated to increase for efficiency of reservoir mana... more In this study, the plausible grid size was estimated to increase for efficiency of reservoir management using 3 dimensional water quality model. To validate utilization of a real time water quality management tool, ELCOM-CAEDYM model was applied to Soyang reservoir in korea. 100m grid size can represent the real topography and take out exact analysis results. grid can be easily used to analysis because of data capacity. Consequently, the grid size of 200m or 300m was recommended to establish 3D model considering the required simulation time and the irrelevance between horizontal grid size and vertical distribution for temperature and turbidity analysis.

International Journal of Highway Engineering, 2017

PURPOSES : A composite pavement utilizes both an asphalt surface and a concrete base. Typically, ... more PURPOSES : A composite pavement utilizes both an asphalt surface and a concrete base. Typically, a concrete base layer provides structural capacity, while an asphalt surface layer provides smoothness and riding quality. This pavement type can be used in conjunction with rollercompacted concrete (RCC) pavement as a base layer due to its fast construction, economic efficiency, and structural performance. However, the service life and functionality of composite pavement may be reduced due to interfacial bond failure. Therefore, adequate interfacial bonding between the asphalt surface and the concrete base is essential to achieving monolithic behavior. The purpose of this study is to investigate the bond characteristics at the interface between asphalt (HMA; hot-mixed asphalt) and the RCC base. METHODS : This study was performed to determine the optimal type and application rate of tack coat material for RCC-base composite pavement. In addition, the core size effect, temperature condition, and bonding failure shape were analyzed to investigate the bonding characteristics at the interface between the RCC base and HMA surface. To evaluate the bond strength, a pull-off test was performed using different diameters of specimens such as 50 mm and 100 mm. Tack coat materials such as RSC-4 and BD-Coat were applied in amounts of 0.3, 0.5, 0.7, 0.9, and 1.1 /m 2 to determine the optimal application rate. In order to evaluate the bond strength characteristics with temperature changes, a pull-off test was carried out at-15, 0, 20, and 40. In addition, the bond failure shapes were analyzed using an image analysis program after the pull-off tests were completed. RESULTS : The test results indicated that the optimal application rate of RSC-4 and BD-Coat were 0.8 /m 2 , 0.9 /m 2 , respectively. The core size effect was determined to be negligible because the bond strengths were similar in specimens with diameters of 50 mm and 100 mm. The bond strengths of RSC-4 and BD-Coat were found to decrease significantly when the temperature increased. As a result of the bonding failure shape in low-temperature conditions such as-15, 0, and 20 , it was found that most of the debonding occurred at the interface between the tack coat and RCC surface. On the other hand, the interface between the HMA and tack coat was weaker than that between the tack coat and RCC at a high temperature of 40. CONCLUSIONS : This study suggested an optimal application rate of tack coat materials to apply to RCC-base composite pavement. The bond strengths at high temperatures were significantly lower than the required bond (tensile) strength of 0.4 MPa. It was known that the temperature was a critical factor affecting the bond strength at the interface of the RCC-base composite pavement.

Journal of Inflammation Research, 2020

Purpose: Vitamins exert its effect through different isoforms. The isoform conversion phases invo... more Purpose: Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, α-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES). Materials and Methods: This study was based on data acquired from the 7th edition (2016-2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum α-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics. Results: There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between α-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched. Conclusion: There was a negative correlation between serum retinol and hs-CRP and positive correlation between α-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.

Biology, 2020

Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease, with few bi... more Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease, with few biomarkers and treatment options currently available. Non-alcoholic steatohepatitis (NASH), a progressive disease of NAFLD, may lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Epigenetic modification can contribute to the progression of NAFLD causing non-alcoholic steatohepatitis (NASH), in which the exact role of epigenetics remains poorly understood. To identify potential therapeutics for NASH, we tested small-molecule inhibitors of the epigenetic target histone methyltransferase EZH2, Tazemetostat (EPZ-6438), and UNC1999 in STAM NASH mice. The results demonstrate that treatment with EZH2 inhibitors decreased serum TNF-alpha in NASH. In this study, we investigated that inhibition of EZH2 reduced mRNA expression of inflammatory cytokines and fibrosis markers in NASH mice. In conclusion, these results suggest that EZH2 may present a promising therapeutic target in the treatment ...

Molecules, 2019

Hypervalent iodine reagents are of considerable relevance in organic chemistry as they can provid... more Hypervalent iodine reagents are of considerable relevance in organic chemistry as they can provide a complementary reaction strategy to the use of traditional transition metal chemistry. Over the past two decades, there have been an increasing number of applications including stoichiometric oxidation and catalytic asymmetric variations. This review outlines the main advances in the past 10 years in regard to alkene heterofunctionalization chemistry using achiral and chiral hypervalent iodine reagents and catalysts.

Advanced Synthesis & Catalysis, 2017

A metal-free oxidative difunctionalization of Nallylamides and N-allylthioamides has been develop... more A metal-free oxidative difunctionalization of Nallylamides and N-allylthioamides has been developed. This system features the use of a hypervalent iodine oxidant with electron-deficient amines to access 5-aminooxazoline and thiazoline scaffolds under mild conditions. Notably, various electron-deficient amines were systematically evaluated and we verified the reaction profile was originated from an attached (benzene)sulfonyl group.

Climate, 2017

Climate change can have serious impacts on human health, resulting in increased healthcare utiliz... more Climate change can have serious impacts on human health, resulting in increased healthcare utilization. Many studies on the relationship between mortality and temperature exist, but few studies focus on heat related outbreaks. Our objective was to verify the relationship between ambient temperature and heat related illnesses during the summer months. This study analyzed the National Health Insurance Service (NHIS) database. Patients with an ICD-10 code T67 (Effects of Heat and Light) presenting between May and September were included. Generalized additive models (GAM) were used to determine the association between ambient temperature and heat related illnesses including differences by region and patient age. A total of 335,759 patients with heat related illnesses were identified from 2002 to 2013. The number of heat related illnesses increased from 14,994 in 2002 to 29,332 in 2013. For every 1 • C increase in the daily temperature above 29.5 • C, the number of patients with heat related illnesses also increased (RR 1.060; 95% CI, 1.059 to 1.061). In addition, a higher association between temperature and outbreaks of heat related to elderly patients (RR 1.084; 95% CI, 1.081 to 1.086) and rural patients (RR 1.229; 95% CI, 1.208 to 1.251) was identified. The association between the daily maximum temperature and outbreaks of heat related illness is identified. The number of patients with heat related illnesses increased over the years and was especially noted in elderly and rural patients.

BackgroundThe World Health Organization currently recommends artesunate-amodiaquine (AS-AQ) as a ... more BackgroundThe World Health Organization currently recommends artesunate-amodiaquine (AS-AQ) as a first-line treatment for uncomplicated falciparum malaria. The clinical efficacy of AS-AQ is very high but its effectiveness in the field varies considerably. This study aimed at comparing the efficacy, effectiveness and safety of AS-AQ fixed dose combination (FDC) and non-fixed formulation (non-FDC) in controlled and real-life settings using a pharmacological model of antimalarial treatment.MethodsThe effectiveness and safety of different drug formulations in different treatment scenarios were investigated using a pharmacological model of AS-AQ treatment. The model simulated multiple treatment scenarios to assess the effects of age-or weight-based dosing bands in three geographically distinct patient populations, and poor patient adherence.ResultsThe model output was consistent with clinical trials in terms of cure rates, recrudescence rates and the pattern of AQ overdosing with age- an...

Molecules (Basel, Switzerland), Jan 14, 2018

Although mollugin, the main ingredient of the oriental medicinal herb has considerable anti-infla... more Although mollugin, the main ingredient of the oriental medicinal herb has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollugin derivatives have been synthesized and evaluated for their ability to inhibit U937 monocyte cell adhesion to HT-29 colonic epithelial cells in TNF-α- or IL-6-induced models of colon inflammation. The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound ) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-α- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that is a potential anti-inflammatory agent.

Beilstein journal of organic chemistry, 2018

Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing b... more Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups. In this regard, we have developed a Ritter-type alkene functionalization utilizing a PhI(OAc) ((diacetoxyiodo)benzene, PIDA)/Lewis acid combination in order to access isoxazoline and pyrazoline cores. Based on allyl ketone oximes and allyl ketone tosylhydrazones, we have developed an alkene oxyamidation and amido-amidation protocol en route to accessing both isoxazoline and pyrazoline cores. Additionally, acetonitrile serves as both the solvent and an amine source in the presence of this PIDA/Lewis acid combination. This operationally straightforward and metal-free protocol provides an easy access to isoxazoline and pyrazoline derivatives.

Journal of Korea Spatial Information Society, 2014

The fact that the limits of information recency, diversity, and usability are mainly caused by th... more The fact that the limits of information recency, diversity, and usability are mainly caused by the supply oriented geospatial data and service development is commonly recognized. It is recently tried to overcome the limits by facilitating user experience and VGI(Volunteered Geographic Information) in several geospatial web services. This study suggests 10C framework of geospatial web service for VGI through review and examination of previous research. Based on the 10C framework, the value chain system of 23 use cases relevant to the geospatial web service involving the creation of user's VGI is investigated. The result of the value chain analysis is applied to examine and formulate the strategies to generate value addition from public spatial information with respect to creation, aggregation, delivery, and consumption process of VGI.

RSC Advances, 2016

The fabrication of a micropatterned QD composite with superior PL properties in that the presence... more The fabrication of a micropatterned QD composite with superior PL properties in that the presence of a positive charge on the QDs enhances the dispersion interaction between the QDs, and the allylic group enables the QDs to form strong chemical binding to the polymer matrix.

BMC infectious diseases, Jun 7, 2017

With the emergence of macrolide resistance, concerns about the efficacy of macrolides for the tre... more With the emergence of macrolide resistance, concerns about the efficacy of macrolides for the treatment of Mycoplasma pneumoniae (MP) pneumonia in children have been raised. This study aimed to determine the effect of macrolide resistance on the outcome of children who were hospitalized with MP pneumonia. Between 2010 and 2015, we performed culture of MP from nasopharyngeal samples obtained from children who were hospitalized with pneumonia at five hospitals in Korea. Macrolide resistance was determined by the analysis of 23S rRNA gene transition and the minimal inhibitory concentrations of four macrolides. Medical records were reviewed to analyze the clinical response to treatment with macrolides. MP was detected in 116 (4.8%) of the 2436 children with pneumonia. MP pneumonia was prevalent in 2011 and 2015. Of the 116 patients with MP pneumonia, 82 (70.7%) were macrolide-resistant. There were no differences in the age distribution, total duration of fever, and chest x-ray patterns ...

Journal of food science, 2016

No prior research has investigated whether the cold plasma treatment (CPT) resulted in the format... more No prior research has investigated whether the cold plasma treatment (CPT) resulted in the formation of toxic compounds. Therefore, this study carried out the experiment to check the safety of edible films treated with cold plasma by examining their acute and subacute oral toxicity in a rat model. Single-dose acute (5000 mg/kg body weight) and 14-d subacute (1000 mg/kg body weight/day) oral toxicity of cold plasma-treated edible films was assessed for male and female Sprague-Dawley (SD) rats. Rats administered 5000 mg/kg of edible film did not show the signs of acute toxicity or death after 14 d of observation. Similarly, no signs of acute toxicity or death were recorded during 14 d in rats administered 1000 mg/kg/day of edible film treated with cold plasma. Although changes in the levels of several blood components (hematocrit, hemoglobin, bilirubin, creatinine, and aspartate aminotransferase) of samples were observed, the changes compared to the control were considered to be toxic...

Nutrition Research and Practice, 2016

BACKDROUND/OBJECTIVE: Constipation is a condition that can result from intestinal deformation. Be... more BACKDROUND/OBJECTIVE: Constipation is a condition that can result from intestinal deformation. Because humans have an upright posture, the effects of gravity can cause this shape deformation. Oligosaccharides are common prebiotics and their effects on bowel health are well known. However, studies of the physiological functionality of a product that contains both lactulose and galactooligosaccharides are insufficient. We investigated the constipation reduction effect of a dual-type oligosaccharide, Dual-Oligo, in loperamide-treated rats. MATERIALS/METHODS: Dual-Oligo consists of galactooligosaccharides (15.80%) and lactulose (51.67%). Animals were randomly divided into four groups, the normal group (normal), control group (control), low concentration of Dual-Oligo (LDO) group, and high concentration of Dual-Oligo (HDO) group. After 7 days of oral administration, fecal pellet amount, fecal weight, water content of fecal were measured. Blood chemistry, short-chain fatty acid (SCFA), gastrointestinal transit ratio and length and intestinal mucosa were analyzed. RESULTS: Dual-Oligo increased the fecal weight, and water content of feces in rats with loperamide-induced constipation. Gastrointestinal transit ratio and length and area of intestinal mucosa significantly increased after treatment with Dual-Oligo in loperamide-induced rats. A high concentration of Dual-Oligo tended to produce more acetic acid than that observed for the control group, and Dual-Oligo affected the production of total SCFA. Bifidobacteria concentration of cecal contents in the high-concentration oligosaccharide (HDO) and low-concentration oligosaccharide (LDO) groups was similar to the result of the normal group. CONCLUSIONS: These results showed that Dual-Oligo is a functional material that is derived from a natural food product and is effective in ameliorating constipation.

Preventive nutrition and food science, 2016

Omega-3 rich fish oils are extremely labile, thus requiring control of oxidation and off flavor d... more Omega-3 rich fish oils are extremely labile, thus requiring control of oxidation and off flavor development. A recently proposed emulsification method, layer-by-layer (LbL) deposition, was found to be a plausible method to enhance the characteristics of bioactive ingredients, especially lipids. The present work was designed to test the possibility of enhancing the uptake and utilization of omega-3 fatty acids present in fish oil. The bioavailability of nano-emulsified fish oil was monitored in terms of intestinal absorption as well as skin permeability by using the everted intestinal sac model and Franz cell model. The skin permeability and intestinal absorption characteristics was significantly improved by LbL emulsification with lecithin/chitosan/low methoxypectin. Multilayer encapsulation along with nano-emulsification can be a useful method to deliver biologically active lipids and related components, such as fish oil. The protective effect of this tool from lipid oxidation stil...

Food Technology and Biotechnology, 2016

Galactooligosaccharides (GOS) are an important class of dietary prebiotics that exert benefi cial... more Galactooligosaccharides (GOS) are an important class of dietary prebiotics that exert benefi cial eff ects on intestinal microbiota and gut barrier function. In this study, high-purity GOS (HP-GOS) were investigated in vitro and in vivo and confi rmed as prebiotic ingredients in rat diet. HP-GOS were successfully produced using a two-step process, enzymatic hydrolysis and fermentation by yeast. They were found to serve as a good substrate and carbon source for supporting the growth of probiotic bacteria more eff ectively than other commercial GOS. Following administration of 1 % (by mass) of HP-GOS to rats, the growth of Bifi dobacterium bifi dum and B. longum in the gut increased most rapidly up to 12 h, and thereaft er the increase was slow. Therefore, 1 % HP-GOS was found to be acceptable for the growth of probiotic bacteria. Groups of animals that were orally administered HP-GOS and bifi dobacteria during the study, and the group administered HP-GOS during the 2nd (days 13-15) and 4th (days 28-30) period of the study had signifi cantly (p<0.05) higher numbers of bifi dobacteria in faeces than groups receiving a single dose of bifi dobacteria. HP-GOS aff ected the expression of genes encoding glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). There was a signifi cant upregulation of GLP-1 and PYY mRNA with HP-GOS and bifi dobacteria intake. We propose that the prebiotic properties of HP-GOS are potentially valuable for the production of functional foods for human consumption.