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Papers by Kian Khodadad

Inflammatory Myofibroblastic Tumor of the Lung: Case Series

Background: Inflammatory myofibroblastic tumor is a rare occurrence in general practice. Its biol... more Background: Inflammatory myofibroblastic tumor is a rare occurrence in general practice. Its biologic nature, natural history and response to different treatment modalities are obscure. Materials and Methods: We retrospectively reviewed clinical and pathological features of 5 patients with inflammatory myofibroblastic tumor of the lung observed between 1999 and 2006. Results: Under-study patients were 3 women and 2 men with a median age of 32.6 years. All patients were symptomatic. Computed tomography (CT) scan demonstrated a mass in all cases. Four patients underwent surgery (tumor resection in 1, lobectomy in 1, bilobectomy in 1 and lobectomy with mediastinal mass debulking also in 1). Complete resection was achieved in 2 patients who are currently alive with no evidence of disease. One died due to progressive disease. Another is alive with disease after incomplete resection, and one refused any kind of surgery. There was no operative mortality. All patients were under follow-up (...

Indian journal of cancer

We present a 30-year-old man admitted with generalized cutaneous lesions, fever and cough. Examin... more We present a 30-year-old man admitted with generalized cutaneous lesions, fever and cough. Examination of skin biopsies of a papular lesion revealed dense neutrophilic infiltration of the upper dermis, so these lesions were diagnosed as neutrophilic dermatosis. Peripheral blood examination and bone marrow findings confirmed the diagnosis of myelodysplastic syndrome with excess blasts. The cutaneous lesions improved after administration of corticosteroid and follow-up bone marrow examination revealed a normocellular marrow. One year later he referred with acute myelogenous leukemia (AML-M0). Unfortunately, he did not respond to treatment and died a few months later due to disease progression.

Iranian Red Crescent Medical Journal, 2014

Clinical lung cancer, 2012

The melanoma-associated antigen (MAGE) genes families are found in different cancers, including n... more The melanoma-associated antigen (MAGE) genes families are found in different cancers, including non-small-cell lung cancers. These genes are silent in normal tissues, except for the testis. The goal of this study was to investigate the differentially expressed profile of the different MAGE genes subclass in non-small-cell lung cancer (NSCLC) tumoral tissue.

Inflammatory Myofibroblastic Tumor of the Lung: Case Series

Tanaffos, 2009

Tanaffos (2009) 8(1), 68-74 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Di... more Tanaffos (2009) 8(1), 68-74 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ... Kian Khodadad 1, Neda Hashemi 1, Shirin Karimi 2,3, Mehrdad Arab 4 1 Thoracic Oncology Department, 2 Department of Pathology, 3 Mycobacteriology ...

Analysis of Cisplatin-Induced Ototoxicity Risk Factors in Iranian Patients with Solid Tumors: a Cohort, Prospective and Single Institute Study

Asian Pacific journal of cancer prevention : APJCP, Mar 1, 2017

Background: Cisplatin has been associated with irreversible hearing damage. Up to now, there is n... more Background: Cisplatin has been associated with irreversible hearing damage. Up to now, there is no therapeutic intervention showing benefit in preventing Cisplatin-induced ototoxicity. The aim of this study was to determine risk factors contributing to hearing impairment after cisplatin administration in Iranian patients. Methods: Hearing thresholds of 124 patients before and after cisplatin administration were assessed with reference to pure-tone audiometry averages at several frequencies from 2006 to 2010. Mean values were calculated at each tested frequency in each ear at baseline and subsequent follow-up audiometry. Hearing impairment was assessed with the Münster score. Results: The mean age at diagnosis and the median cumulative Cisplatin dose were 47.3 years and 453.8 milligrams, respectively. Bilateral hearing loss, mostly of grade 1, and tinnitus were detected in 26% and 3.2% of patients. Logistic regression analysis showed that a high cumulative dose of cisplatin was the m...

International Journal of Epidemiology, Jul 6, 2010

Background Lung cancer remains the leading cause of cancer death in the world. In Iran, lung canc... more Background Lung cancer remains the leading cause of cancer death in the world. In Iran, lung cancer is one of the five leading tumours and its incidence has been increasing steadily in both men and women. There is a paucity of data from Iran on risk factors for lung cancer. We evaluated environmental risk factors for lung cancer in a case-control study in five hospitals of Tehran. Between October 2002 and October 2005, 242 (178 male, 64 female) patients with histologically confirmed lung cancer and two controls for each patient (242 hospital controls and 242 visiting healthy controls) matched for age, sex and place of residence were interviewed using a structured questionnaire on potential risk factors for lung cancer, including environmental and occupational exposures. Associations between risk factors and lung cancer were assessed using conditional logistic regression. Smokers were 66.5% of all cases (85.4% of men and 14.1% of women) and smoking was the strongest correlate of lung cancer in multivariate analysis [odds ratio (OR) 5.4, 95% confidence interval (CI) 3.2-8.9]. Occupational exposures to inorganic dusts (OR 4.2, 95% CI 2.8-6.7), chemical compounds (OR ¼ 3.4, 95% CI 2.1-5.6) and heavy metals (OR 3.0, 95% CI 1.3-7.0) were also independent risk factors for lung cancer. Conclusions In our study, smoking was the principal risk factor for lung cancer. However, preventable exposures in the environment, including occupational settings, should not be ignored.

Iranian Journal of Pharmaceutical Research Ijpr, Feb 12, 2011

Ginger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiem... more Ginger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. For evaluating the effect of zingiber officinalis on nausea and vomiting (N and V) in patients receiving cisplatin based regimens, a randomized double-blind placebocontrolled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherapeutic agents. The patients were randomly assigned to receive ginger capsules (rhizome of zingiber officinalis) or placebo in their first cycle of the study. All patients received standard antiemetics for chemotherapy induced nausea and vomiting (CINV). The patients were crossed-over to receive ginger or placebo in their next cycle of chemotherapy. Among 36 eligible patients who received both cycles of treatment, there were no difference in prevalence, severity, and duration of both acute and delayed N and V. Addition of ginger to the standard antiemetic regimen has shown no advantage in reducing acute and delayed N and V in patients with cisplatin-based regimen in this study.

A Clinicopathologic Study of Lung Cancer Cases in Iran

Tanaffos (2009) 8(3), 28-36 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Di... more Tanaffos (2009) 8(3), 28-36 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ... Mostafa Hosseini 1, Seyed Ahmad Seyed Alinaghi 2, Parisa Adimi Naghan 3,4, Shirin Karimi 5,6, Moslem Bahadori 5, Kian Khodadad 4,7, Forozan Mohammadi ...

Relationship between angiogenic squamous dysplasia and bronchogenic carcinoma in patients undergoing white light bronchoscopy

Canadian Respiratory Journal Journal of the Canadian Thoracic Society, May 1, 2012

OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (A... more OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy.METHODS: Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied.RESULTS: ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimens, and to metaplasia in one case in the control group.CONCLUSION: ASD is a unique morphological entity that should be considered by pathologists even on bronchoscopic biopsies from patients who undergo white light bronchoscopy. The presence of ASD may represent a risk biomarker of bronchogenic carcinoma in screening programs and in chemoprevention of lung cancer.

Bilateral Lymphoblastic Lymphoma of Breast Mimicking Inflammatory Breast Cancer: A Case Report and Review of Literature

Tanaffos, 2015

We report a 45 year-old woman who had bilateral breast masses with extradural involvement. Pathol... more We report a 45 year-old woman who had bilateral breast masses with extradural involvement. Pathologic report revealed malignant high-grade lymphoblastic lymphoma. Systemic chemotherapy was performed but 3 months later, lesions indicating relapse in bone and breast re-appeared. She received salvage chemotherapy, but 4 months after that she was expired.

Background: Primary mediastinal large B cell lymphoma (PMBL) is an aggressive non-Hodgkin's l... more Background: Primary mediastinal large B cell lymphoma (PMBL) is an aggressive non-Hodgkin's lymphoma (NHL) and has distinct clinico-pathologic as well as molecular characteristics. Mutation of P53 has been reported in PMBL in 13-16% of cases in the previous studies. The role of Retinoblastoma (Rb) gene, another tumor suppressor gene, in this type of lymphoma genesis has not been established yet. Previous studies showed the absence of bcl-2 gene expression in PMBL. Materials and Methods: To determine the pathogenic roles of these two tumor suppressor genes and bcl-2, an anti - apoptotic factor, we analyzed formalin fixed paraffin embedded blocks of ten cases of PMBL by Immunohistochemical staining (IHC). Results: Six cases were P53 positive, and 8 cases were strongly positive for Rb. There were also strong cytoplasmic positivity for bcl-2 antibody in 6 cases. Two P53 positive cases were negative for bcl-2, and nuclear staining for P53 and positive reaction for bcl-2 were detected...

Infantile Histiocytosis X: Case Report

Tanaffos

Langerhans cell histiocytosis (LCH) is a disease of unknown etiology that presents in three forms... more Langerhans cell histiocytosis (LCH) is a disease of unknown etiology that presents in three forms: Letterer-Siwe disease, Hand-Schuller-Christian disease, and Eosinophilic Granuloma. It is a multifocal disease that usually affects several organs and unifocal forms are rare. Pulmonary involvement occurs in approximately 40% of cases and almost always in young adults. Lungs are rarely affected in infant patients. This report presents a 15-month-old male infant that was admitted for cyanosis and respiratory distress. Diagnostic work up revealed a primary pulmonary histiocytosis and the treatment made a significant improvement of signs and symptoms by the time of discharge.

Role of CYP1A1 MspI polymorphism in CYP1A1 gene with susceptibility to lung cancer in Iranian patients

BACKGROUND: Lung cancer has remained the most prevalent malignancy worldwide. It is the fifth lea... more BACKGROUND: Lung cancer has remained the most prevalent malignancy worldwide. It is the fifth leading cause of cancer death in Iran. Nevertheless, during last few years a gradual permanent increase in its incidence has been reported. Although the crucial role of tobacco smoke in lung cancer initiation has long been established, it is tempting to hypothesize that genetic polymorphisms may contribute to lung cancer predisposition. CYP1A1 gene encodes the main enzyme responsible for metabolic activation of several to- bacco carcinogens. CYP1A1 MspI (6235T→C) polymorphism is the most studied variation within the CYP1A1, impacts on the basal levels of metabolism and is believed to be associated with elevated lung cancer risk, mainly in Asian population. METHODS: We investigated the frequency of this genetic variation in Iranian lung cancer patients through a cross-sectional study. 65 lung cancer cases and 80 healthy controls were recruited. RESULTS: The present findings confirmed the low...

Gastroenterology and hepatology from bed to bench, 2013

In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and... more In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and the correlation between its variant alleles with colorectal cancer in patients and control groups. Human cells are routinely exposed to mutagenic and carcinogenic aromatic amines via smoking, pollution areas and other sources. These chemicals can form DNA adducts in vivo and thus lead to DNA damage. Amongst the known genetic polymorphisms of the DNA-repair genes the xeroderma pigmentosum group D (XPD, also known as ERCC2) has been the most extensively studied most commonly. This study has examined the relationship between the XPD Lys 751 Gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. Genomic DNA from peripheral whole blood was extracted using Miller method to determine the genotype of subjects with RFLP-PCR analysis. This study shows cancer patients have more of the heterozygous genotype (XPD Lys 751 Gln) compared to control group. Howev...

Clinicopathologic and survival characteristics of childhood and adolescent non Hodgkin's lymphoma in Yazd, Iran

Asian Pacific journal of cancer prevention : APJCP, 2014

Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of thi... more Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of this study was to assess the epidemiological and histomorphological features and survival of affected patients in our center. The clinicopathologic features and outcome of 44 children and adolescents with non Hodgkin lymphoma diagnosed during 2004-2012, were investigated retrospectively. The influence of potential prognostic parameters in overall survival was investigated by log-rank test and Cox regression analysis. The mean age at presentation was 13.8 ± 6.16 years with a male predilection (M: F=3:1). Malignant lymphoma, not otherwise specified, diffuse large cell lymphoma and Burkitt lymphoma were the three most common histological types observed. The tumors were 36.4% intermediate grade, 27.3% high grade and 34.1% belonged to the malignant lymphoma not otherwise specified group. Immunohistochemistry findings were available in 39 cases. Out of these cases 33 (84.6%) had B cell lineage, 4...

Relationship between angiogenic squamous dysplasia and bronchogenic carcinoma in patients undergoing white light bronchoscopy

Canadian respiratory journal : journal of the Canadian Thoracic Society

To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its... more To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy. Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied. ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimen...

Journal of the National Comprehensive Cancer Network : JNCCN, 2010

Colorectal cancer is less common in the Middle East and South Asia than in western countries, wit... more Colorectal cancer is less common in the Middle East and South Asia than in western countries, with the rectum the most common primary site, unlike in the United States. A project was planned to address various local issues regarding the management of common cancers, including colorectal cancer, and to adapt the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) to the Middle East and North Africa (MENA) region. A survey of oncologists in this geographic area showed that the management practices and issues regarding colorectal cancer are similar to those presented in the NCCN Colorectal Cancer Guidelines. However, 2 major differences exist: most oncologists in the MENA region prefer chest radiograph over CT in pretreatment workup, and almost 50% of them prefer to use cetuximab in the first-line treatment of patients with the wild-type KRAS gene. The committee, comprising 9 oncologists from different countries, proposed 4 modifications to the 2009 version of the NCCN Colo...

P-510 Cisplatin in combination with 5-fluorouracil and epirubicin in advanced non-small cell lung carcinoma (NSCLC)

Lung Cancer, 2005

BMC Cancer, 2014

Background: Despite many prospective and retrospective studies about the association of dietary h... more Background: Despite many prospective and retrospective studies about the association of dietary habit and lung cancer, the topic still remains controversial. So, this study aims to investigate the association of lung cancer with dietary factors. Method: In this study 242 lung cancer patients and their 484 matched controls on age, sex, and place of residence were enrolled between October 2002 to 2005. Trained physicians interviewed all participants with standardized questionnaires. The middle and upper third consumer groups were compared to the lower third according to the distribution in controls unless the linear trend was significant across exposure groups.

Inflammatory Myofibroblastic Tumor of the Lung: Case Series

Background: Inflammatory myofibroblastic tumor is a rare occurrence in general practice. Its biol... more Background: Inflammatory myofibroblastic tumor is a rare occurrence in general practice. Its biologic nature, natural history and response to different treatment modalities are obscure. Materials and Methods: We retrospectively reviewed clinical and pathological features of 5 patients with inflammatory myofibroblastic tumor of the lung observed between 1999 and 2006. Results: Under-study patients were 3 women and 2 men with a median age of 32.6 years. All patients were symptomatic. Computed tomography (CT) scan demonstrated a mass in all cases. Four patients underwent surgery (tumor resection in 1, lobectomy in 1, bilobectomy in 1 and lobectomy with mediastinal mass debulking also in 1). Complete resection was achieved in 2 patients who are currently alive with no evidence of disease. One died due to progressive disease. Another is alive with disease after incomplete resection, and one refused any kind of surgery. There was no operative mortality. All patients were under follow-up (...

Indian journal of cancer

We present a 30-year-old man admitted with generalized cutaneous lesions, fever and cough. Examin... more We present a 30-year-old man admitted with generalized cutaneous lesions, fever and cough. Examination of skin biopsies of a papular lesion revealed dense neutrophilic infiltration of the upper dermis, so these lesions were diagnosed as neutrophilic dermatosis. Peripheral blood examination and bone marrow findings confirmed the diagnosis of myelodysplastic syndrome with excess blasts. The cutaneous lesions improved after administration of corticosteroid and follow-up bone marrow examination revealed a normocellular marrow. One year later he referred with acute myelogenous leukemia (AML-M0). Unfortunately, he did not respond to treatment and died a few months later due to disease progression.

Iranian Red Crescent Medical Journal, 2014

Clinical lung cancer, 2012

The melanoma-associated antigen (MAGE) genes families are found in different cancers, including n... more The melanoma-associated antigen (MAGE) genes families are found in different cancers, including non-small-cell lung cancers. These genes are silent in normal tissues, except for the testis. The goal of this study was to investigate the differentially expressed profile of the different MAGE genes subclass in non-small-cell lung cancer (NSCLC) tumoral tissue.

Inflammatory Myofibroblastic Tumor of the Lung: Case Series

Tanaffos, 2009

Tanaffos (2009) 8(1), 68-74 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Di... more Tanaffos (2009) 8(1), 68-74 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ... Kian Khodadad 1, Neda Hashemi 1, Shirin Karimi 2,3, Mehrdad Arab 4 1 Thoracic Oncology Department, 2 Department of Pathology, 3 Mycobacteriology ...

Analysis of Cisplatin-Induced Ototoxicity Risk Factors in Iranian Patients with Solid Tumors: a Cohort, Prospective and Single Institute Study

Asian Pacific journal of cancer prevention : APJCP, Mar 1, 2017

Background: Cisplatin has been associated with irreversible hearing damage. Up to now, there is n... more Background: Cisplatin has been associated with irreversible hearing damage. Up to now, there is no therapeutic intervention showing benefit in preventing Cisplatin-induced ototoxicity. The aim of this study was to determine risk factors contributing to hearing impairment after cisplatin administration in Iranian patients. Methods: Hearing thresholds of 124 patients before and after cisplatin administration were assessed with reference to pure-tone audiometry averages at several frequencies from 2006 to 2010. Mean values were calculated at each tested frequency in each ear at baseline and subsequent follow-up audiometry. Hearing impairment was assessed with the Münster score. Results: The mean age at diagnosis and the median cumulative Cisplatin dose were 47.3 years and 453.8 milligrams, respectively. Bilateral hearing loss, mostly of grade 1, and tinnitus were detected in 26% and 3.2% of patients. Logistic regression analysis showed that a high cumulative dose of cisplatin was the m...

International Journal of Epidemiology, Jul 6, 2010

Background Lung cancer remains the leading cause of cancer death in the world. In Iran, lung canc... more Background Lung cancer remains the leading cause of cancer death in the world. In Iran, lung cancer is one of the five leading tumours and its incidence has been increasing steadily in both men and women. There is a paucity of data from Iran on risk factors for lung cancer. We evaluated environmental risk factors for lung cancer in a case-control study in five hospitals of Tehran. Between October 2002 and October 2005, 242 (178 male, 64 female) patients with histologically confirmed lung cancer and two controls for each patient (242 hospital controls and 242 visiting healthy controls) matched for age, sex and place of residence were interviewed using a structured questionnaire on potential risk factors for lung cancer, including environmental and occupational exposures. Associations between risk factors and lung cancer were assessed using conditional logistic regression. Smokers were 66.5% of all cases (85.4% of men and 14.1% of women) and smoking was the strongest correlate of lung cancer in multivariate analysis [odds ratio (OR) 5.4, 95% confidence interval (CI) 3.2-8.9]. Occupational exposures to inorganic dusts (OR 4.2, 95% CI 2.8-6.7), chemical compounds (OR ¼ 3.4, 95% CI 2.1-5.6) and heavy metals (OR 3.0, 95% CI 1.3-7.0) were also independent risk factors for lung cancer. Conclusions In our study, smoking was the principal risk factor for lung cancer. However, preventable exposures in the environment, including occupational settings, should not be ignored.

Iranian Journal of Pharmaceutical Research Ijpr, Feb 12, 2011

Ginger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiem... more Ginger, the rhizome of Zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. For evaluating the effect of zingiber officinalis on nausea and vomiting (N and V) in patients receiving cisplatin based regimens, a randomized double-blind placebocontrolled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherapeutic agents. The patients were randomly assigned to receive ginger capsules (rhizome of zingiber officinalis) or placebo in their first cycle of the study. All patients received standard antiemetics for chemotherapy induced nausea and vomiting (CINV). The patients were crossed-over to receive ginger or placebo in their next cycle of chemotherapy. Among 36 eligible patients who received both cycles of treatment, there were no difference in prevalence, severity, and duration of both acute and delayed N and V. Addition of ginger to the standard antiemetic regimen has shown no advantage in reducing acute and delayed N and V in patients with cisplatin-based regimen in this study.

A Clinicopathologic Study of Lung Cancer Cases in Iran

Tanaffos (2009) 8(3), 28-36 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Di... more Tanaffos (2009) 8(3), 28-36 ©2009 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ... Mostafa Hosseini 1, Seyed Ahmad Seyed Alinaghi 2, Parisa Adimi Naghan 3,4, Shirin Karimi 5,6, Moslem Bahadori 5, Kian Khodadad 4,7, Forozan Mohammadi ...

Relationship between angiogenic squamous dysplasia and bronchogenic carcinoma in patients undergoing white light bronchoscopy

Canadian Respiratory Journal Journal of the Canadian Thoracic Society, May 1, 2012

OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (A... more OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy.METHODS: Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied.RESULTS: ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimens, and to metaplasia in one case in the control group.CONCLUSION: ASD is a unique morphological entity that should be considered by pathologists even on bronchoscopic biopsies from patients who undergo white light bronchoscopy. The presence of ASD may represent a risk biomarker of bronchogenic carcinoma in screening programs and in chemoprevention of lung cancer.

Bilateral Lymphoblastic Lymphoma of Breast Mimicking Inflammatory Breast Cancer: A Case Report and Review of Literature

Tanaffos, 2015

We report a 45 year-old woman who had bilateral breast masses with extradural involvement. Pathol... more We report a 45 year-old woman who had bilateral breast masses with extradural involvement. Pathologic report revealed malignant high-grade lymphoblastic lymphoma. Systemic chemotherapy was performed but 3 months later, lesions indicating relapse in bone and breast re-appeared. She received salvage chemotherapy, but 4 months after that she was expired.

Background: Primary mediastinal large B cell lymphoma (PMBL) is an aggressive non-Hodgkin's l... more Background: Primary mediastinal large B cell lymphoma (PMBL) is an aggressive non-Hodgkin's lymphoma (NHL) and has distinct clinico-pathologic as well as molecular characteristics. Mutation of P53 has been reported in PMBL in 13-16% of cases in the previous studies. The role of Retinoblastoma (Rb) gene, another tumor suppressor gene, in this type of lymphoma genesis has not been established yet. Previous studies showed the absence of bcl-2 gene expression in PMBL. Materials and Methods: To determine the pathogenic roles of these two tumor suppressor genes and bcl-2, an anti - apoptotic factor, we analyzed formalin fixed paraffin embedded blocks of ten cases of PMBL by Immunohistochemical staining (IHC). Results: Six cases were P53 positive, and 8 cases were strongly positive for Rb. There were also strong cytoplasmic positivity for bcl-2 antibody in 6 cases. Two P53 positive cases were negative for bcl-2, and nuclear staining for P53 and positive reaction for bcl-2 were detected...

Infantile Histiocytosis X: Case Report

Tanaffos

Langerhans cell histiocytosis (LCH) is a disease of unknown etiology that presents in three forms... more Langerhans cell histiocytosis (LCH) is a disease of unknown etiology that presents in three forms: Letterer-Siwe disease, Hand-Schuller-Christian disease, and Eosinophilic Granuloma. It is a multifocal disease that usually affects several organs and unifocal forms are rare. Pulmonary involvement occurs in approximately 40% of cases and almost always in young adults. Lungs are rarely affected in infant patients. This report presents a 15-month-old male infant that was admitted for cyanosis and respiratory distress. Diagnostic work up revealed a primary pulmonary histiocytosis and the treatment made a significant improvement of signs and symptoms by the time of discharge.

Role of CYP1A1 MspI polymorphism in CYP1A1 gene with susceptibility to lung cancer in Iranian patients

BACKGROUND: Lung cancer has remained the most prevalent malignancy worldwide. It is the fifth lea... more BACKGROUND: Lung cancer has remained the most prevalent malignancy worldwide. It is the fifth leading cause of cancer death in Iran. Nevertheless, during last few years a gradual permanent increase in its incidence has been reported. Although the crucial role of tobacco smoke in lung cancer initiation has long been established, it is tempting to hypothesize that genetic polymorphisms may contribute to lung cancer predisposition. CYP1A1 gene encodes the main enzyme responsible for metabolic activation of several to- bacco carcinogens. CYP1A1 MspI (6235T→C) polymorphism is the most studied variation within the CYP1A1, impacts on the basal levels of metabolism and is believed to be associated with elevated lung cancer risk, mainly in Asian population. METHODS: We investigated the frequency of this genetic variation in Iranian lung cancer patients through a cross-sectional study. 65 lung cancer cases and 80 healthy controls were recruited. RESULTS: The present findings confirmed the low...

Gastroenterology and hepatology from bed to bench, 2013

In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and... more In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and the correlation between its variant alleles with colorectal cancer in patients and control groups. Human cells are routinely exposed to mutagenic and carcinogenic aromatic amines via smoking, pollution areas and other sources. These chemicals can form DNA adducts in vivo and thus lead to DNA damage. Amongst the known genetic polymorphisms of the DNA-repair genes the xeroderma pigmentosum group D (XPD, also known as ERCC2) has been the most extensively studied most commonly. This study has examined the relationship between the XPD Lys 751 Gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. Genomic DNA from peripheral whole blood was extracted using Miller method to determine the genotype of subjects with RFLP-PCR analysis. This study shows cancer patients have more of the heterozygous genotype (XPD Lys 751 Gln) compared to control group. Howev...

Clinicopathologic and survival characteristics of childhood and adolescent non Hodgkin's lymphoma in Yazd, Iran

Asian Pacific journal of cancer prevention : APJCP, 2014

Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of thi... more Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of this study was to assess the epidemiological and histomorphological features and survival of affected patients in our center. The clinicopathologic features and outcome of 44 children and adolescents with non Hodgkin lymphoma diagnosed during 2004-2012, were investigated retrospectively. The influence of potential prognostic parameters in overall survival was investigated by log-rank test and Cox regression analysis. The mean age at presentation was 13.8 ± 6.16 years with a male predilection (M: F=3:1). Malignant lymphoma, not otherwise specified, diffuse large cell lymphoma and Burkitt lymphoma were the three most common histological types observed. The tumors were 36.4% intermediate grade, 27.3% high grade and 34.1% belonged to the malignant lymphoma not otherwise specified group. Immunohistochemistry findings were available in 39 cases. Out of these cases 33 (84.6%) had B cell lineage, 4...

Relationship between angiogenic squamous dysplasia and bronchogenic carcinoma in patients undergoing white light bronchoscopy

Canadian respiratory journal : journal of the Canadian Thoracic Society

To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its... more To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy. Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied. ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimen...

Journal of the National Comprehensive Cancer Network : JNCCN, 2010

Colorectal cancer is less common in the Middle East and South Asia than in western countries, wit... more Colorectal cancer is less common in the Middle East and South Asia than in western countries, with the rectum the most common primary site, unlike in the United States. A project was planned to address various local issues regarding the management of common cancers, including colorectal cancer, and to adapt the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) to the Middle East and North Africa (MENA) region. A survey of oncologists in this geographic area showed that the management practices and issues regarding colorectal cancer are similar to those presented in the NCCN Colorectal Cancer Guidelines. However, 2 major differences exist: most oncologists in the MENA region prefer chest radiograph over CT in pretreatment workup, and almost 50% of them prefer to use cetuximab in the first-line treatment of patients with the wild-type KRAS gene. The committee, comprising 9 oncologists from different countries, proposed 4 modifications to the 2009 version of the NCCN Colo...

P-510 Cisplatin in combination with 5-fluorouracil and epirubicin in advanced non-small cell lung carcinoma (NSCLC)

Lung Cancer, 2005

BMC Cancer, 2014

Background: Despite many prospective and retrospective studies about the association of dietary h... more Background: Despite many prospective and retrospective studies about the association of dietary habit and lung cancer, the topic still remains controversial. So, this study aims to investigate the association of lung cancer with dietary factors. Method: In this study 242 lung cancer patients and their 484 matched controls on age, sex, and place of residence were enrolled between October 2002 to 2005. Trained physicians interviewed all participants with standardized questionnaires. The middle and upper third consumer groups were compared to the lower third according to the distribution in controls unless the linear trend was significant across exposure groups.