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Papers by Kimberly Jackson

Research paper thumbnail of Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and Th cells

Circulation …, 2005

Immune cell infiltration, vascular smooth muscle cell (VSMC) proliferation, and apoptosis are pat... more Immune cell infiltration, vascular smooth muscle cell (VSMC) proliferation, and apoptosis are pathological hallmarks of atherosclerosis. The multifocal, chronic, and inflammatory nature of this disease of the cardiovascular system complicates targeted cellular therapy and emphasizes the need to understand the role and interaction of immune cells with VSMCs. We characterized the immune cell subsets present in human atherosclerotic tissue derived from atherosclerotic abdominal aortic aneurysm (AAA) and expanded them to study their interaction with autologous plaque-derived VSMCs in vitro. We show here that apart from T lymphocytes, plaque infiltrates consist of lots of NK cells and significant proportions of NKT cells that express T cell receptor (TCR) ␣␤, CD4, and the NK markers CD56 and CD161. The infiltrates are predominantly IFN-␥-producing Type 1 lymphoid cells. When cocultured, the T and NKT cells adhere to VSMCs. CD4 ϩ T cells enhance VSMC proliferation. VSMCs in turn enhance CD4 ϩ CD161 ϩ NKT but not CD4 ϩ or CD8 ϩ T cell proliferation. CD4 ϩ CD161 ϩ NKT cells inhibit VSMC proliferation by inducing apoptosis. Our results suggest that the interactions of Type 1 CD4 ϩ T and CD4 ϩ CD161 ϩ NKT cells with VSMCs may regulate VSMC proliferation and death respectively in atherosclerosis and the balance of these interactions could determine plaque stability.

Research paper thumbnail of Transthoracic Real‐Time Three‐Dimensional Echocardiography Using the Rotational Scanning Approach for Data Acquisition

…, 1994

Three-dimensional reconstruction is widely used in the field of radiology by means of CT and MRI.... more Three-dimensional reconstruction is widely used in the field of radiology by means of CT and MRI. From the tomographic slices three-dimensional reconstruction is done either men-tally in the brain of the physician or via hard-ware and software using a dedicated three-di- ...

Research paper thumbnail of Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel

Anaesthesia, 2007

A 47-year-old woman presented for mastectomy and immediate latissimus dorsi flap reconstruction h... more A 47-year-old woman presented for mastectomy and immediate latissimus dorsi flap reconstruction having been diagnosed with carcinoma of the breast 6 months previously. In the preceding months she had received neo-adjuvant chemotherapy with epirubicin, paclitaxel (Taxol Ò) and cyclophosphamide. This had been apparently uncomplicated and she had maintained a remarkably high level of physical activity. She was found to be bradycardic at pre-operative assessment but had no cardiac symptoms. Second degree Mobitz type II atrioventricular block was diagnosed on electrocardiogram, and temporary transvenous ventricular pacing instituted in the peri-operative period. We discuss how evidence-based guidelines would not have been helpful in this case, and how chemotherapy can exhibit substantial cardiotoxicity that may develop over many years. We suggest that patients who have received chemotherapy at any time should have a pre-operative electrocardiogram even if they are asymptomatic.

Research paper thumbnail of Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and Th cells

Circulation …, 2005

Immune cell infiltration, vascular smooth muscle cell (VSMC) proliferation, and apoptosis are pat... more Immune cell infiltration, vascular smooth muscle cell (VSMC) proliferation, and apoptosis are pathological hallmarks of atherosclerosis. The multifocal, chronic, and inflammatory nature of this disease of the cardiovascular system complicates targeted cellular therapy and emphasizes the need to understand the role and interaction of immune cells with VSMCs. We characterized the immune cell subsets present in human atherosclerotic tissue derived from atherosclerotic abdominal aortic aneurysm (AAA) and expanded them to study their interaction with autologous plaque-derived VSMCs in vitro. We show here that apart from T lymphocytes, plaque infiltrates consist of lots of NK cells and significant proportions of NKT cells that express T cell receptor (TCR) ␣␤, CD4, and the NK markers CD56 and CD161. The infiltrates are predominantly IFN-␥-producing Type 1 lymphoid cells. When cocultured, the T and NKT cells adhere to VSMCs. CD4 ϩ T cells enhance VSMC proliferation. VSMCs in turn enhance CD4 ϩ CD161 ϩ NKT but not CD4 ϩ or CD8 ϩ T cell proliferation. CD4 ϩ CD161 ϩ NKT cells inhibit VSMC proliferation by inducing apoptosis. Our results suggest that the interactions of Type 1 CD4 ϩ T and CD4 ϩ CD161 ϩ NKT cells with VSMCs may regulate VSMC proliferation and death respectively in atherosclerosis and the balance of these interactions could determine plaque stability.

Research paper thumbnail of Transthoracic Real‐Time Three‐Dimensional Echocardiography Using the Rotational Scanning Approach for Data Acquisition

…, 1994

Three-dimensional reconstruction is widely used in the field of radiology by means of CT and MRI.... more Three-dimensional reconstruction is widely used in the field of radiology by means of CT and MRI. From the tomographic slices three-dimensional reconstruction is done either men-tally in the brain of the physician or via hard-ware and software using a dedicated three-di- ...

Research paper thumbnail of Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel

Anaesthesia, 2007

A 47-year-old woman presented for mastectomy and immediate latissimus dorsi flap reconstruction h... more A 47-year-old woman presented for mastectomy and immediate latissimus dorsi flap reconstruction having been diagnosed with carcinoma of the breast 6 months previously. In the preceding months she had received neo-adjuvant chemotherapy with epirubicin, paclitaxel (Taxol Ò) and cyclophosphamide. This had been apparently uncomplicated and she had maintained a remarkably high level of physical activity. She was found to be bradycardic at pre-operative assessment but had no cardiac symptoms. Second degree Mobitz type II atrioventricular block was diagnosed on electrocardiogram, and temporary transvenous ventricular pacing instituted in the peri-operative period. We discuss how evidence-based guidelines would not have been helpful in this case, and how chemotherapy can exhibit substantial cardiotoxicity that may develop over many years. We suggest that patients who have received chemotherapy at any time should have a pre-operative electrocardiogram even if they are asymptomatic.

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