Kimberly Lane - Academia.edu (original) (raw)

Papers by Kimberly Lane

Journal of Clinical Oncology

TPS11634 Background: Modern treatment for breast cancer (BC) has led to improved survival; howeve... more TPS11634 Background: Modern treatment for breast cancer (BC) has led to improved survival; however, this improvement can be offset by an increase in cancer therapy-related morbidity and mortality. Over one-third of early stage BC patients treated with cancer therapy experience CV injury, left ventricular (LV) dysfunction, exercise intolerance, or fatigue. CV disease is a leading cause of mortality in BC survivors. There is limited information on the time course and long-term CV health of BC survivors. UPBEAT, a multicenter study, will prospectively evaluate CV risk factors and outcomes in early stage BC patients,treated with modern cancer therapies. This will facilitate evaluation of primary CV prevention strategies in this patient population. Methods: This is a prospective cohort study of 840 patients with early stage (I-III) BC treated with chemotherapy +/- radiation and 160 controls. Baseline and serial longitudinal measures will examine the influence of cancer treatment on CV fu...

Preventing Chronic Disease

Chronic diseases, including heart disease, stroke, cancer, diabetes, and obesity, are the leading... more Chronic diseases, including heart disease, stroke, cancer, diabetes, and obesity, are the leading causes of death in the United States and account for most of the nation's health care costs (1). Heart disease is the leading cause of death among men and women in the United States, accounting for 1 of every 4 deaths (1). Approximately 140,000 Americans die each year from stroke, and it is a leading cause of long-term disability (2,3). It is estimated that more than 9% of the US population has diabetes, which is the leading cause of kidney failure, lower-limb amputations other than those caused by injury, and new cases of blindness among adults (4). Additionally, more than one-third of US adults have obesity, which is associated with several chronic conditions (5,6). Chronic diseases are common and costly, but many are preventable. Although it is important to address the underlying risk factors for chronic diseases at the individual level, it is also critical to implement population-based interventions, including healthpromoting policies and environments that affect where we work, live, play, and receive health care. This requires a multifaceted approach and the collective efforts of federal, state, local, private, and community-based organizations along with national partners. The Centers for Disease Control and Prevention's (CDC's) mission is to prevent or control all diseases that affect Americans (7). CDC puts science into action by tracking diseases and determining their causes and by identifying the most effective ways to prevent and control them (7). This work entails tackling the major health problems that cause death and disability for Americans and promoting healthy and safe behaviors, communities, and environments (7).

... 丐 Fig. 15 Starting from the left: Dr. James Ragusa, Consultant; from TARDEC Ed Recke,Steven S... more ... 丐 Fig. 15 Starting from the left: Dr. James Ragusa, Consultant; from TARDEC Ed Recke,Steven Schehr, Dr. Grace Bochenek, Dr. Thomas Meitzler, and Ron Phelps, NASA-KSC in front ofpad A. Page 17. Methodology Preliminary ...

Journal of Cardiovascular Magnetic Resonance

Background Previously, we have shown that increased visceral adiposity was an independent predict... more Background Previously, we have shown that increased visceral adiposity was an independent predictor of thoracic aortic wall thickness in elderly individuals at risk for future cardiovascular (CV) events. In this study, we sought to assess the influence of obesity on rest and stress induced changes in aortic stiffness in older individuals with hypertension, diabetes or coronary artery disease at risk for future CV events.

The fusion of visual and infrared sensor images of potential driving hazards in static infrared a... more The fusion of visual and infrared sensor images of potential driving hazards in static infrared and visual scenes is computed using the Fuzzy Logic Approach (FLA). The FLA is presented as a new method for combining images from different sensors for achieving an image that displays more information than either image separately. Both Mamdani and ANFIS methods are used. The fused sensor images are compared to metrics to measure the increased perception of a driving hazard in the sensor-fused image. The metrics are correlated to experimental ranking of the image quality. The image rankings are obtained by presenting imagery in the TARDEC Visual Perception Lab (VPL) to subjects. Probability of detection of a driving hazard is computed using data obtained in observer tests.

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PLoS pathogens, May 1, 2016

Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic... more Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in the development of a vaccine or other clinical interventions. Here, we utilize deep sequencing data and apply a genetic distance-based method to investigate whether the mode of sexual transmission shapes the nascent founder viral genome. Analysis of 74 acute and early HIV-1 infected subjects revealed that 83% of men who have sex with men (MSM) exhibit a single founder virus, levels similar to those previously observed in heterosexual (HSX) transmission. In a metadata analysis of a total of 354 subjects, including HSX, MSM and injecting drug users (IDU), we also observed no significant differences in the frequency of single founder virus infections between HSX and MSM transmissions. Howev...

Amia Annual Symposium Proceedings Amia Symposium Amia Symposium, Feb 1, 2008

The Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) centers at the HMO Resea... more The Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) centers at the HMO Research Network Center for Education and Research on Therapeutics (HMORN CERT) and the University of Pennsylvania are developing a design for a scalable distributed research network (DRN) to support a wide array of purposes related to therapeutics, including comparative effectiveness, safety, and utilization, as well as quality of care research. The project will implement a system prototype, conduct a proof of principle research project on hypertension therapy, and make recommendations for future expansion of the network.

ABSTRACT A method is described for using the photosimulation laboratory environment to evaluate t... more ABSTRACT A method is described for using the photosimulation laboratory environment to evaluate the effectiveness of camouflage for military vehicles. There are distinct advantages to acquiring images at the field site and then bringing them back for observer testing in a ...