Tara Kingston - Academia.edu (original) (raw)

Papers by Tara Kingston

Journal of the National Comprehensive Cancer Network : JNCCN, 2020

BACKGROUND The NCCN Guidelines for Survivorship recommend dedicated sleep assessment. Reported in... more BACKGROUND The NCCN Guidelines for Survivorship recommend dedicated sleep assessment. Reported insomnia prevalence in the general Irish population is 6% to 15%. Reported insomnia prevalence internationally among new/recently diagnosed patients with cancer varies from 30.9% to 54.3%. Insomnia prevalence has not been previously quantified in an Irish oncology cohort. METHODS A 40-item questionnaire was prospectively administered to ambulatory patients with cancer aged ≥18 years. Prespecified criteria to define insomnia syndrome combined those of the International Classification of Sleep Disorders, version 1, and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The Hospital Anxiety and Depression Scale-Depression/Anxiety (HADS-D/A) was used to screen for potential confounding variables. RESULTS The response rate to the questionnaire was 87% (294/337). The predominant respondent age group was 55 to 64 years (26%; 77/294), 70.7% were female (208/294), a...

... MD theses. Title. A Six Year Follow-up of the Cavan/Monaghan First Episode Psychosis Study. A... more ... MD theses. Title. A Six Year Follow-up of the Cavan/Monaghan First Episode Psychosis Study. Author. ... Systematic comparisons are made with SA, BD and MDDP. Additionally, the study illuminates rarely considered aspects of SF, DD, BrPsy, PNOS, SIP, SIM, PGMC and MGMC. ...

European Neuropsychopharmacology

Psychological Medicine

Background Research on psychotic illness is loosening emphasis on diagnostic stringency in favour... more Background Research on psychotic illness is loosening emphasis on diagnostic stringency in favour of including a more dimensionally based conceptualization of psychopathology and pathobiology. However, to clarify these notions requires investigation of the full scope of psychotic diagnoses. Methods The Cavan–Monaghan First Episode Psychosis Study ascertained cases of first episode psychosis across all 12 DSM-IV psychotic diagnoses via all routes to care: public, private or forensic; home-based, outpatient or inpatient. There was no arbitrary upper age cut-off and minimal impact of factors associated with variations in social milieu, ethnicity or urbanicity. Cases were evaluated epidemiologically and assessed for psychopathology, neuropsychology, neurology, antecedent factors, insight and quality of life. Results Among 432 cases, the annual incidence of any DSM-IV psychotic diagnosis was 34.1/100 000 of population and encompassed functional psychotic diagnoses, substance-induced psyc...

CNS Neuroscience & Therapeutics

Objective: While long-term outcome following a first psychotic episode is well studied in schizop... more Objective: While long-term outcome following a first psychotic episode is well studied in schizophrenia (SZ), schizoaffective disorder (SA), and bipolar disorder (BD), major depressive disorder with psychotic features (MDDP) has received less investigation. This study compares MDDP with SZ, SA, and BD at 6-year follow-up. Methods: At 6 years after a first psychotic episode, follow-up data on psychopathology, functioning, quality of life, and service engagement were obtained for 27 cases of MDDP in comparison to 60 SZ, 27 SA, and 35 BD. Results: Positive psychotic symptoms were less prominent in MDDP and BD than in SZ and SA. Negative symptoms, impaired functioning, and reduction in objectively determined quality of life were less prominent in MDDP and BD, intermediate in SA and most prominent in SZ. However, subjectively determined quality of life was indistinguishable across diagnoses. Service engagement was highest for MDDP, intermediate for SA and BD, and lowest for SZ. Conclusions: At 6-year follow-up, these diagnoses are characterized by quantitative rather than qualitative differences in psychopathology, functionality, quality of life, and service engagement, with considerable overlap between them. These findings suggest that MDDP should join SZ, SA, and BD in a milieu of psychosis that transcends arbitrary boundaries.

Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it ... more Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in persistent fatigue in those recovered from acute infection. We examined the prevalence of fatigue in individuals recovered from the acute phase of COVID-19 illness using the Chalder Fatigue Score (CFQ-11). We further examined potential predictors of fatigue following COVID-19 infection, evaluating indicators of COVID-19 severity, markers of peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported persistent fatigue (52.3%; 45/128) at 10 weeks (median) after initial COVID-19 symptoms. There was no association between COVID-19 severity (need for inpatient admission, supplemental oxygen or critical care) and fatigue following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation and cell turnover (leukocyte, neutrophil or ...

Handbook of Schizophrenia Spectrum Disorders, Volume II, 2011

Abstract Schizophrenia spectrum disorders, however broadly defined, still fail to capture large... more Abstract Schizophrenia spectrum disorders, however broadly defined, still fail to capture large tranches of psychotic illness whose epidemiological, psychopatho-logical and pathobiological characteristics are likely important for holistic under-standing of psychosis. We outline ...

Schizophrenia Research, 2012

Advances in Schizophrenia Research 2009, 2009

Among numerous impediments to further advancement between the fifth and sixth symposia on Search ... more Among numerous impediments to further advancement between the fifth and sixth symposia on Search for the Causes of Schizophrenia, several uncertainties endure: (i) What are the boundaries of psychotic illness? (ii) Where do we position what we currently conceptualise and ...

Schizophrenia Bulletin, 2013

While recent research on psychotic illness has focussed on the nosological, clinical, and biologi... more While recent research on psychotic illness has focussed on the nosological, clinical, and biological relationships between schizophrenia and bipolar disorder, little attention has been directed to the most common other psychotic diagnosis, major depressive disorder with psychotic features (MDDP). As this diagnostic category captures the confluence between dimensions of psychotic and affective psychopathology, it is of unappreciated heuristic potential to inform on the nature of psychotic illness. Therefore, the epidemiology and clinical characteristics of MDDP were compared with those of schizophrenia and bipolar disorder within the Cavan-Monaghan First Episode Psychosis Study (n = 370). Epidemiologically, the first psychotic episode of MDDP (n = 77) was uniformly distributed across the adult life span, while schizophrenia (n = 73) and bipolar disorder (n = 73) were primarily disorders of young adulthood; the incidence of MDDP, like bipolar disorder, did not differ between the sexes, while the incidence of schizophrenia was more common in males than in females. Clinically, MDDP was characterized by negative symptoms, executive dysfunction, neurological soft signs (NSS), premorbid intellectual function, premorbid adjustment, and quality of life similar to those for schizophrenia, while bipolar disorder was characterized by less prominent negative symptoms, executive dysfunction and NSS, and better quality of life. These findings suggest that what we currently categorize as MDDP may be more closely aligned with other psychotic diagnoses than has been considered previously. They indicate that differences in how psychosis is manifested vis-à-vis depression and mania may be quantitative rather than qualitative and occur within a dimensional space, rather than validating categorical distinctions.

Psychological Medicine, 2013

The boundaries of psychotic illness and the extent to which operational diagnostic categories are... more The boundaries of psychotic illness and the extent to which operational diagnostic categories are distinct in the long term remain poorly understood. Clarification of these issues requires prospective evaluation of diagnostic trajectory, interplay and convergence/divergence across psychotic illness, without a priori diagnostic or other restrictions. The Cavan-Monaghan First Episode Psychosis Study (CAMFEPS), conducted using methods to attain the closest approximation to epidemiological completeness, incepts all 12 DSM-IV psychotic diagnoses. In this study we applied methodologies to achieve diagnostic reassessments on follow-up, at a mean of 6.4 years after first presentation, for 196 (97%) of the first 202 cases, with quantification of prospective and retrospective consistency. Over 6 years, the 12 initial psychotic diagnoses were characterized by numerous transitions but only limited convergence towards a smaller number of more stable diagnostic nodes. In particular, for initial brief psychotic disorder (BrP), in 85% of cases this was the harbinger of long-term evolution to serious psychotic illness of diagnostic diversity; for initial major depressive disorder with psychotic features (MDDP), in 18% of cases this was associated with mortality of diverse causality; and for initial psychotic disorder not otherwise specified (PNOS), 31% of cases continued to defy DSM-IV criteria. CAMFEPS methodology revealed, on an individual case basis, a diversity of stabilities in, and transitions between, all 12 DSM-IV psychotic diagnoses over 6 years; thus, psychotic illness showed longitudinal disrespect to current nosology and may be better accommodated by a dimensional model. In particular, a first episode of BrP or MDDP may benefit from more vigorous, sustained interventions.

Aquaculture Research, 2001

Individual growth rates, feeding rates (%BWd ±1 ) and food conversions for cuttle®sh (S. of®cinal... more Individual growth rates, feeding rates (%BWd ±1 ) and food conversions for cuttle®sh (S. of®cinalis) hatchlings and juveniles were determined during this study. A¯ow-through system was used. Water temperature reached 30°C during the hottest part of the day, gradually decreasing to 25°C during the night; salinity varied between 37 T 3 ppt and lights were kept on for 14 h day ±1 . Hatchlings were placed in separate compartments with a water volume of 1.2 L. Juvenile cuttle®sh (from 0.5 to 25 g) were placed in bigger baskets, with a water volume of 5.2 L. Water¯ow was 120 L h ±1 . The biggest cuttle®sh used in these experiments (> 25 g) were gathered in groups of ®ve and placed in circular tanks (water volume of 250±300 L). Thus, results obtained in this case are means and not individual data. During the ®rst 10, 20, 30 and 40 days, mean growth rates (of all individuals sampled by age group) decreased consistently (11.8 T 4.1, 9.8 T 1.8, 8.1 T 2.2 and 7.3 T 0.7%BW ±1 respectively); in similar fashion, mean feeding rates decreased with age group (33.7 T 13.5, 22.0 T 7.9, 17.3 T 3.9 and 16.7%BWd ±1 respectively). Mean food conversions varied between 3.6 and 2.5 between the age groups. When grouping results by weight class, similar patterns occur, as growth and feeding rates decrease consistently as cuttle®sh grow bigger. Highest mean growth and feeding rates are obtained by hatchlings (< 0.1 g) with 12.4 T 4.5 and 35.3 T 15.1%BWd ±1 , respec-tively, while the lowest growth and feeding rates were recorded for the largest animals, between 15 and 25 g (3.4 T 1.1 and 10.8 T 4.1%BWd ±1 respectively). For these weight classes, mean food conversions varied between 2.7 T 0.9 and 3.8 T 2.8.

Psychology and Psychotherapy: Theory, Research and Practice, 2007

Objectives. Mindfulness-based cognitive therapy (MBCT) is a new group-based intervention for prev... more Objectives. Mindfulness-based cognitive therapy (MBCT) is a new group-based intervention for prevention of relapse in recurrent depression which has not been scientifically evaluated regarding its clinical effectiveness for ameliorating residual depressive symptoms following a depressive episode. The aim of this study was to assess the efficacy of MBCT in reducing residual depressive symptoms in psychiatric outpatients with recurrent depression, and to particularly explore the effects of mindfulness techniques on rumination.