Kiran Patil - Academia.edu (original) (raw)
Papers by Kiran Patil
The Journal of the Acoustical Society of America, 2016
Journal of orthopaedic case reports
Osteoblastoma is a rare (incidence <1%) benign locally aggressive osteoblastic lesion of bone ... more Osteoblastoma is a rare (incidence <1%) benign locally aggressive osteoblastic lesion of bone with rare malignant transformation. Benign osteoblastoma is the term used by Jaffe to denote an uncommon neoplasm of bone characterized by vascular osteoid and bone forming matrix rich in osteoblasts. Here we report a case of osteoblastoma of talus in eighteen year old male patient from Bijapur with complaints of pain and difficulty in walking for one year. Relevant investigations and radiographs were taken. It was treated with wide excision and bone grafting from ipsilateral ilium and talo-navicular fusion with cannulated cancellous screw fixation. Histopathology of the biopsy confirmed the diagnosis. Patient was immobilized with below knee plaster cast for six weeks later with gradual mobilization. Guarded weight bear was allowed after three months. Patient achieved satisfactory range of movements and full weight bear mobilization after six months. Symptoms relieved with no evidence of...
Nucleic acids research, Jan 4, 2016
RNA duplex regions are often involved in tertiary interactions and protein binding and thus there... more RNA duplex regions are often involved in tertiary interactions and protein binding and thus there is great potential in developing ligands that sequence-specifically bind to RNA duplexes. We have developed a convenient synthesis method for a modified peptide nucleic acid (PNA) monomer with a guanidine-modified 5-methyl cytosine base. We demonstrated by gel electrophoresis, fluorescence and thermal melting experiments that short PNAs incorporating the modified residue show high binding affinity and sequence specificity in the recognition of an RNA duplex containing an internal inverted Watson-Crick C-G base pair. Remarkably, the relatively short PNAs show no appreciable binding to DNA duplexes or single-stranded RNAs. The attached guanidine group stabilizes the base triple through hydrogen bonding with the G base in a C-G pair. Selective binding towards an RNA duplex over a single-stranded RNA can be rationalized by the fact that alkylation of the amine of a 5-methyl C base blocks th...
Reactive Distillation (RD) is a combination of reaction and distillation in a single vessel owing... more Reactive Distillation (RD) is a combination of reaction and distillation in a single vessel owing to which it enjoys a number of specific advantages over conventional sequential approach of reaction followed by distillation. Improved selectivity, increased conversion, better heat control, effective utilization of reaction heat, scope for difficult separations and the avoidance of azeotropes are the few of the advantages offered by RD. This paper describes an investigation into modelling and simulation work of the heterogeneous esterification of acetic acid with Isoamyl alcohol, catalyzed by an acidic cationexchange resin. The simulations are based on the equilibrium-stage (EQ model) approach and, for comparison; a Non-equilibrium model (NEQ model) is also used. This paper addresses the development of a satisfactory steady state model for RD, which requires attention considering the fundamental behavior of the system, including the reaction and phase behavior, together with the principles behind the equilibrium stage model for distillation operations. The full RD column model is presented and then applied to simulation of Isoamyl acetate column where experimental data is available.
Scientific Reports, 2016
The diversity of industrially important molecules for which microbial production routes have been... more The diversity of industrially important molecules for which microbial production routes have been experimentally demonstrated is rapidly increasing. The development of economically viable producer cells is, however, lagging behind, as it requires substantial engineering of the host metabolism. A chassis strain suitable for production of a range of molecules is therefore highly sought after but remains elusive. Here, we propose a genome-scale metabolic modeling approach to design chassis strains of Saccharomyces cerevisiae - a widely used microbial cell factory. For a group of 29 products covering a broad range of biochemistry and applications, we identified modular metabolic engineering strategies for re-routing carbon flux towards the desired product. We find distinct product families with shared targets forming the basis for the corresponding chassis cells. The design strategies include overexpression targets that group products by similarity in precursor and cofactor requirements, as well as gene deletion strategies for growth-product coupling that lead to non-intuitive product groups. Our results reveal the extent and the nature of flux re-routing necessary for producing a diverse range of products in a widely used cell factory and provide blueprints for constructing pre-optimized chassis strains.
ABSTRACT ABSTRACT This paper addresses an industrially important problem of recovery of acetic ac... more ABSTRACT ABSTRACT This paper addresses an industrially important problem of recovery of acetic acid from a waste water streams via reactive distillation. The separation (or recovery) of organic residues from aqueous waste streams released from chemical and petrochemical industries is critical and indispensable from the points of view of pollution control and recovery of useful materials. The disposal of waste waters containing most widely-used industrial organic acids such as acetic acid, formic acid and propionic acid has been recognized as a significant expense to the industry and environment. In this paper, existing methods of physical separation of acetic acid from waste water is presented. Available conventional techniques including fractional distillation, liquid extraction, adsorption, precipitation, ion exchange, etc. have been briefly reviewed emphasizing the major drawbacks of these methods. A new method – reactive distillation - for recovering acetic acids from dilute aqueous solutions is described and compared with the other conventional techniques. Reactive distillation is an efficient, economical, and environmental friendly method for separation of acetic acids from waste water streams
World Journal of Medical and Surgical Case Reports, Jan 5, 2014
Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining i... more Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining industry for the conversion of heavy gas oil to gasoline and diesel. Furthermore, valuable gases such as ethylene, propylene and isobutylene are produced. This work describes development of a mathematical model that can simulate the behavior of the FCC unit, which consists of feed and preheat system, riser, stripper, reactor, regenerator, and the main fractionator. The model describes the seven main sections of the entire FCC unit: (1) the feed and preheating system, (2) riser, (3) stripper, (4) reactor, (5) regenerator, and main fractionator. This model is able to predict and describe the compositions of the final production rate, and the distribution of the main components in the final product. This allows the estimation of economic factors, related to the operation of the FCCU. For the present study, a refinery process is simulated in Aspen Hysys v7.3 environment. Simulation Basic Manager, a fluid package is selected along with the components which are to be in the input stream. In the process, Peng-Robinson was selected as the fluid package as it is able to handle hypothetical components (pseudo-components). In this work, a basic refinery process is designed and the vacuum gas oil from the vacuum distillation column is used as feed in the FCC unit.
International Journal of Nursing Education, 2016
Journal of Water Pollution Purification Research, Jun 6, 2014
Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining i... more Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining industry for the conversion of heavy gasoil to gasoline and diesel. Furthermore, valuable gases such as ethylene, propylene and isobutylene are produced. The performance of the FCC units plays a major role on the overall economics of refinery plants. Any improvement in operation or control of FCC units will result in dramatic economic benefits. This work describes development of a mathematical model that can simulate the behavior of the FCC unit, which consists of feed and preheat system, riser, stripper, reactor, regenerator, catalyst circulation lines, and the main fractionator. The model describes the seven main sections of the entire FCC unit: (1) the feed and preheating system, (2) riser, (3) stripper, (4) reactor, and (5) main fractionator. The process is simulated in Aspen Hysys v7.3 environment. In this work, a basic refinery process is designed and the vacuum gas oil from the vacuum distillation column is used as feed in the FCC unit. The data used are the typical data of refinery, in which few changes were made in order to achieve proper simulation. A parametric sensitivity study is also carried out to give a view of the effect of these parameters on the production of Gasoline, Light cycle oil, Heavy cycle oil and the total conversion in the FCC unit.
Indian Journal of Chemistry Section a, May 12, 2013
The user has requested enhancement of the downloaded file.
The Journal of the Acoustical Society of America, 2016
Journal of orthopaedic case reports
Osteoblastoma is a rare (incidence <1%) benign locally aggressive osteoblastic lesion of bone ... more Osteoblastoma is a rare (incidence <1%) benign locally aggressive osteoblastic lesion of bone with rare malignant transformation. Benign osteoblastoma is the term used by Jaffe to denote an uncommon neoplasm of bone characterized by vascular osteoid and bone forming matrix rich in osteoblasts. Here we report a case of osteoblastoma of talus in eighteen year old male patient from Bijapur with complaints of pain and difficulty in walking for one year. Relevant investigations and radiographs were taken. It was treated with wide excision and bone grafting from ipsilateral ilium and talo-navicular fusion with cannulated cancellous screw fixation. Histopathology of the biopsy confirmed the diagnosis. Patient was immobilized with below knee plaster cast for six weeks later with gradual mobilization. Guarded weight bear was allowed after three months. Patient achieved satisfactory range of movements and full weight bear mobilization after six months. Symptoms relieved with no evidence of...
Nucleic acids research, Jan 4, 2016
RNA duplex regions are often involved in tertiary interactions and protein binding and thus there... more RNA duplex regions are often involved in tertiary interactions and protein binding and thus there is great potential in developing ligands that sequence-specifically bind to RNA duplexes. We have developed a convenient synthesis method for a modified peptide nucleic acid (PNA) monomer with a guanidine-modified 5-methyl cytosine base. We demonstrated by gel electrophoresis, fluorescence and thermal melting experiments that short PNAs incorporating the modified residue show high binding affinity and sequence specificity in the recognition of an RNA duplex containing an internal inverted Watson-Crick C-G base pair. Remarkably, the relatively short PNAs show no appreciable binding to DNA duplexes or single-stranded RNAs. The attached guanidine group stabilizes the base triple through hydrogen bonding with the G base in a C-G pair. Selective binding towards an RNA duplex over a single-stranded RNA can be rationalized by the fact that alkylation of the amine of a 5-methyl C base blocks th...
Reactive Distillation (RD) is a combination of reaction and distillation in a single vessel owing... more Reactive Distillation (RD) is a combination of reaction and distillation in a single vessel owing to which it enjoys a number of specific advantages over conventional sequential approach of reaction followed by distillation. Improved selectivity, increased conversion, better heat control, effective utilization of reaction heat, scope for difficult separations and the avoidance of azeotropes are the few of the advantages offered by RD. This paper describes an investigation into modelling and simulation work of the heterogeneous esterification of acetic acid with Isoamyl alcohol, catalyzed by an acidic cationexchange resin. The simulations are based on the equilibrium-stage (EQ model) approach and, for comparison; a Non-equilibrium model (NEQ model) is also used. This paper addresses the development of a satisfactory steady state model for RD, which requires attention considering the fundamental behavior of the system, including the reaction and phase behavior, together with the principles behind the equilibrium stage model for distillation operations. The full RD column model is presented and then applied to simulation of Isoamyl acetate column where experimental data is available.
Scientific Reports, 2016
The diversity of industrially important molecules for which microbial production routes have been... more The diversity of industrially important molecules for which microbial production routes have been experimentally demonstrated is rapidly increasing. The development of economically viable producer cells is, however, lagging behind, as it requires substantial engineering of the host metabolism. A chassis strain suitable for production of a range of molecules is therefore highly sought after but remains elusive. Here, we propose a genome-scale metabolic modeling approach to design chassis strains of Saccharomyces cerevisiae - a widely used microbial cell factory. For a group of 29 products covering a broad range of biochemistry and applications, we identified modular metabolic engineering strategies for re-routing carbon flux towards the desired product. We find distinct product families with shared targets forming the basis for the corresponding chassis cells. The design strategies include overexpression targets that group products by similarity in precursor and cofactor requirements, as well as gene deletion strategies for growth-product coupling that lead to non-intuitive product groups. Our results reveal the extent and the nature of flux re-routing necessary for producing a diverse range of products in a widely used cell factory and provide blueprints for constructing pre-optimized chassis strains.
ABSTRACT ABSTRACT This paper addresses an industrially important problem of recovery of acetic ac... more ABSTRACT ABSTRACT This paper addresses an industrially important problem of recovery of acetic acid from a waste water streams via reactive distillation. The separation (or recovery) of organic residues from aqueous waste streams released from chemical and petrochemical industries is critical and indispensable from the points of view of pollution control and recovery of useful materials. The disposal of waste waters containing most widely-used industrial organic acids such as acetic acid, formic acid and propionic acid has been recognized as a significant expense to the industry and environment. In this paper, existing methods of physical separation of acetic acid from waste water is presented. Available conventional techniques including fractional distillation, liquid extraction, adsorption, precipitation, ion exchange, etc. have been briefly reviewed emphasizing the major drawbacks of these methods. A new method – reactive distillation - for recovering acetic acids from dilute aqueous solutions is described and compared with the other conventional techniques. Reactive distillation is an efficient, economical, and environmental friendly method for separation of acetic acids from waste water streams
World Journal of Medical and Surgical Case Reports, Jan 5, 2014
Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining i... more Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining industry for the conversion of heavy gas oil to gasoline and diesel. Furthermore, valuable gases such as ethylene, propylene and isobutylene are produced. This work describes development of a mathematical model that can simulate the behavior of the FCC unit, which consists of feed and preheat system, riser, stripper, reactor, regenerator, and the main fractionator. The model describes the seven main sections of the entire FCC unit: (1) the feed and preheating system, (2) riser, (3) stripper, (4) reactor, (5) regenerator, and main fractionator. This model is able to predict and describe the compositions of the final production rate, and the distribution of the main components in the final product. This allows the estimation of economic factors, related to the operation of the FCCU. For the present study, a refinery process is simulated in Aspen Hysys v7.3 environment. Simulation Basic Manager, a fluid package is selected along with the components which are to be in the input stream. In the process, Peng-Robinson was selected as the fluid package as it is able to handle hypothetical components (pseudo-components). In this work, a basic refinery process is designed and the vacuum gas oil from the vacuum distillation column is used as feed in the FCC unit.
International Journal of Nursing Education, 2016
Journal of Water Pollution Purification Research, Jun 6, 2014
Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining i... more Fluid catalytic cracking (FCC) is one of the most important processes in the petroleum refining industry for the conversion of heavy gasoil to gasoline and diesel. Furthermore, valuable gases such as ethylene, propylene and isobutylene are produced. The performance of the FCC units plays a major role on the overall economics of refinery plants. Any improvement in operation or control of FCC units will result in dramatic economic benefits. This work describes development of a mathematical model that can simulate the behavior of the FCC unit, which consists of feed and preheat system, riser, stripper, reactor, regenerator, catalyst circulation lines, and the main fractionator. The model describes the seven main sections of the entire FCC unit: (1) the feed and preheating system, (2) riser, (3) stripper, (4) reactor, and (5) main fractionator. The process is simulated in Aspen Hysys v7.3 environment. In this work, a basic refinery process is designed and the vacuum gas oil from the vacuum distillation column is used as feed in the FCC unit. The data used are the typical data of refinery, in which few changes were made in order to achieve proper simulation. A parametric sensitivity study is also carried out to give a view of the effect of these parameters on the production of Gasoline, Light cycle oil, Heavy cycle oil and the total conversion in the FCC unit.
Indian Journal of Chemistry Section a, May 12, 2013
The user has requested enhancement of the downloaded file.