Kisan Jadhav - Academia.edu (original) (raw)

Papers by Kisan Jadhav

Archives of Applied Science Research, 2012

Clopidogrel bisulfate belongs to the class of P2Y12 ADP platelet receptors inhibitor. The aim of ... more Clopidogrel bisulfate belongs to the class of P2Y12 ADP platelet receptors inhibitor. The aim of this study was to develop simple, sensitive, cost effective, accurate, precise and rapid ultraviolet (UV) Spectrophotometric method for the estimation of Clopidogrel bisulfate in pure form and its formulations. For the estimation of Clopidogrel bisulfate, solvent system employed was triple distilled water pH 1 instead of Acetonitrile and wavelength of detection was 222 nm. The developed method was used to estimate the total drug content in commercially available tablet formulations of Clopidogrel bisulfate.

Research Journal of Pharmacy and Technology, 2010

Der Pharmacia Lettre, 2012

Ursodeoxycholic acid (UDCA) belongs to Biopharmaceutical Classification System (BCS) class II and... more Ursodeoxycholic acid (UDCA) belongs to Biopharmaceutical Classification System (BCS) class II and hence exhibits low aqueous solubility and high permeability. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The purpose of the present study is to design an immediate release tablet containing ursodeoxycholic acid by wet granulation technique with help of diluents, superdisintegrants and surfactant. Tablets are analysed for weight variation, thickness, hardness, friability, disintegration time and to c

Der Pharmacia Lettre, 2010

Poor aqueous solubility is a major issue in the pharmaceutical industries for dosage form develop... more Poor aqueous solubility is a major issue in the pharmaceutical industries for dosage form development. A limiting factor for in vivo performance of these drugs after oral administration is their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal tract. Particle engineering techniques are tools to modify the physicochemical, micromeritics and biopharmaceutical properties of the poorly soluble drug and hence solubility. In the present review different approaches of particle engineering technology like mechanical techniques, evaporative precipitation into aqueous solution, controlled precipitation, supercritical fluid technologies, freezing techniques, sonication technology etc. which improve the aqueous solubility of drugs are discussed.

Expert Opinion on Drug Delivery, Dec 4, 2013

Recently, Nanotechnology is receiving considerable acknowledgment due to its potential to combine... more Recently, Nanotechnology is receiving considerable acknowledgment due to its potential to combine features that are difficult to achieve by making use of a drug alone. Cyclodextrin-based nanosponges are yet another contemporary approach for highlighting the advancements which could be brought about in a drug delivery system. Statistical analyses have shown that around 40% of currently marketed drugs and about 90% of drugs in their developmental phase encounter solubility-related problems. Cyclodextrin-based nanosponges have the capacity to emerge as a productive approach over conventional cyclodextrins by overcoming the disadvantages associated with the latter. This review is intended to give an insight regarding cyclodextrin-based nanosponges such as their physical and chemical properties. In addition, methods of preparation and characterization are discussed along with biocompatibility, and how these nanomeric elements can be exploited in developing effective drug formulations. This emerging technology of cyclodextrin-based nanosponges is expected to provide technical solutions to the formulation arena and to come up with some successful products in the pharmaceutical market. It also has an exciting future in the field of therapeutics wherein it can cater site-directed drug delivery and hence it possesses vibrant opportunities.

World Journal of Pharmaceutical and life sciences, Apr 8, 2005

Among all the drug delivery route, oral route is most preferred route mainly because of ease of a... more Among all the drug delivery route, oral route is most preferred route mainly because of ease of administration. Bioavailability of many drugs is affected by short gastric residence of drugs, to overcome this limitation various approaches have been proposed to increase gastric residence of drug in upper GI tract includes floating drug delivery, swelling and expanding system, Mucoadhesive system, high density system, modified shape system, magnetic system. Current review focuses on technological developments in floating drug delivery and comprehensive evaluation of floating drug delivery system.

Research Journal of Pharmacy and Technology, May 28, 2012

The dissolution of a hydrophilic polymer in water can be prevented by adding cross-links via eith... more The dissolution of a hydrophilic polymer in water can be prevented by adding cross-links via either a physical or a chemical process. A cross-linked hydrosol is called a hydrogel and swells in the surrounding liquid to a certain swelling ratio, depending on the number of cross-links, i.e., the cross-linking density. These hydrogels have many advantageous features including, stimuli responsive, good diffusion properties, low toxicity and good compatibility, Because of their chemical structures are similar to those of the bioactive Glycosoaminoglycan (GAG) molecules present in the extra-cellular matrix. Hydrogel preparation by freeze-thaw method involves physical cross-linking due to crystallite formation. This method does not require the presence of a cross-linking agent such physically cross-linked materials also exhibit higher mechanical strength than chemical or irradiative techniques. In Physical hydrogels, mechanical load can be distributed along the crystallites of the three dimensional structures. Extent crosslinking hydrogel analyzed by FTIR and DSC. The molecular transport phenomenon, as studied by the dynamic swelling experiments.

Journal of Drug Delivery Science and Technology, Jun 1, 2021

ABSTRACT The objectives of current work were to develop chitosan microparticles loaded controlled... more ABSTRACT The objectives of current work were to develop chitosan microparticles loaded controlled release floating gas generating minitablets of captopril. Chitosan microparticles were developed using ionic gelation method by dropping sodium tripolyphosphate solution into chitosan solution under stirring. Primary formulation variables were screened by applying Plackett Burman design and levels of most significant risk factors were optimized using 32 factorial design. Primary formulation variables were chitosan concentration (X1), sodium tripolyphosphate concentration (X2) and speed of stirring. Optimized batch of microparticle has particle size of 346.9 nm, zeta potential of 9.16 and drug release of 96% in simulated gastric fluid at the end of 8 hr. Further microparticle loaded minitablets were developed and optimized. Microparticle loaded minitablets are characterized for parameters like dissolution, floating lag time, total floating time etc. Stability study of the optimized batch was carried out at 40 ᵒC/75% RH for 6 months and at 30 ᵒC/5% RH for 1 year. In vivo behaviour of optimized tablets was studied in rabbits with the help of X-ray studies. Optimised formulations were retained and floating in the gastric region for more than 24hrs. Bioavailability study confirms prolonged drug release.

Current Drug Therapy, Nov 1, 2010

Materials Letters, Oct 1, 2005

A simple and inexpensive spray pyrolysis method was used for the preparation of lanthanum oxide t... more A simple and inexpensive spray pyrolysis method was used for the preparation of lanthanum oxide thin films. The films were prepared by spraying 0.1 M lanthanum chloride solution onto the conducting and non conducting glass substrates. The substrate temperature was varied from 523 to 723 K and structural, optical and electrical properties of the films were studied. A photoelectrochemical (PEC) cell was formed using La 2 O 3 films as a photoelectrode.

Current Drug Therapy, May 1, 2016

Current Nanoscience, May 1, 2009

... Polyion complex micelles [64] (also termed ''block ionomer complexes'') a... more ... Polyion complex micelles [64] (also termed ''block ionomer complexes'') are novel nanosystems for incorporation of charged molecules. ... Page 9. Nanotechnology in Therapeutics – Current Technologies Current Nanoscience, 2009, Vol. 5, No. 2 149 ...

Expert Opinion on Drug Delivery, Aug 16, 2012

Aptamers hold great promise as molecular tool in biomedical applications due to the therapeutic u... more Aptamers hold great promise as molecular tool in biomedical applications due to the therapeutic utility exhibited by their target specificity and sensitivity. Although current development of aptamer is hindered by its probable in vivo degradation, inefficient immobilization on probe surface, and generation of low detection signal, bioconjugation with nanomaterials can feasibly solve these problems. Nanostructures such as dendrimers, with multivalency and nonimmunogenicity, bioconjugated with aptamers have opened newer vistas for better pharmaceutical applications of aptamers. This review covers brief overview of aptamers and dendrimers, with specific focus on recent progresses of aptamer-dendrimer (Apt-D) bioconjugate in areas of targeted drug delivery, diagnosis, and molecular imaging along with the discussion on the currently available conjugates, using their in vitro and in vivo results. The novel Apt-D bioconjugates have led to advances in targeting cancer cell, have amplified biosensing, and offered in vivo cell imaging. Because of the unique properties and applications, Apt-D bioconjugate propose an exciting future. However, further research in synthesis of new target-specific aptamers and their conjugation with dendrimers is required to establish full potential of Apt-D bioconjugate.

Research Journal of Pharmacy and Technology, 2019

Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short b... more Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.

Research Journal of Pharmacy and Technology, Jun 28, 2010

The objective of the present study was to develop controlled release tablet of water soluble drug... more The objective of the present study was to develop controlled release tablet of water soluble drug (X) which can release the drug up to time of 12 hrs in predetermined rate. The drug release for extended duration, particularly for highly water soluble drug using a hydrophilic matrix system is restricted because of the rapid diffusion of the dissolved drug though the hydrophilic network. For such drug with high water solubility hydrophobic polymers are suitable, along with a hydrophilic matrix for developing sustained release dosage forms. Therefore in this study both the hydrophilic and hydrophobic polymer was used as matrix material to obtain a desirable drug release, patient compliance and cost– effectiveness. Hence in the present study work an attempt has been made to develop controlled release matrix tablet using hydrophobic and hydrophilic polymers. Matrix materials such as (HPMC) hydroxyl propyl methyl cellulose, hydroxyl propyl cellulose (HPC) and ethyl cellulose (EC), Na CMC, hydrogenated castor oil are tried. The in vitro drug release study and optimization studies revealed that low concentration of HPMC and high concentration of Ethyl Cellulose was able to control the simultaneous release of water soluble drug for 12 hours. Optimization was done using 32factorial design. The in vitro release data followed higuchi equation or matrix model, respectively. In conclusion, the in vitro release profile and the mathematical models indicate that release of drug can be effectively controlled from a single tablet using HPMC and EC matrix system.

Springer eBooks, 2015

Transdermal delivery of drugs has always been a challenge, as stratum corneum (SC, the outermost ... more Transdermal delivery of drugs has always been a challenge, as stratum corneum (SC, the outermost layer of skin) is not easy to traverse. SC consists of keratinized, flattened remnants of once actively dividing epidermal cells, and its main function is to prevent entry of exogenous substances into the systemic circulation via the skin. Therefore, one option to overcome this problem is to design drugs that have the inherent ability to squeeze through the SC of the skin and reach the target site (systemic circulation) without adversely affecting the skin membrane. In practice, it is not easy to design a drug/prodrug that would have desired characteristics to pass through the skin barrier. The other relatively simpler option includes the use of carrier systems that can help in delivering the drug entity from the SC to the systemic circulation without causing irreversible alterations to the barrier function of the skin. Different types of delivery systems such as microemulsions, liposomes, nanoparticles, patches, and gels have been explored as effective transdermal delivery systems. All of these drug delivery systems are covered in great detail in various chapters of this book. This chapter will cover the preparation, properties, percutaneous enhancement ability, and application of a unique type of micellar gels, i.e., lecithin organogels (LOs).

Current Drug Therapy, Dec 1, 2012

ABSTRACT Amorphous materials have always been an essential part of pharmaceutical research They a... more ABSTRACT Amorphous materials have always been an essential part of pharmaceutical research They are important because of their characteristic solubility characteristics, common occurrence, and physicochemical instability relative to corresponding crystals. Some pharmaceutical agents have a tendency to exist as amorphous solids, while others require prevention of their crystallization to remain in the amorphous state in order to achieve desire characteristics. Amorphous solids can be stabilized by some common pharmaceutical processes like solid dispersion technique, solvent evaporation, milling, lipid dispersion. This article reviews the methodologies and approaches for stabilization of amorphous form.

Current Drug Therapy, May 1, 2010