Kisou Kubota - Academia.edu (original) (raw)

Papers by Kisou Kubota

Japanese Journal of Pharmacology

Proceedings of the Japan Academy

Spectrochimica Acta Part A: Molecular Spectroscopy

Journal of Neurophysiology

We measured regional cerebral blood flow (rCBF) using positron emission tomography (PET) to deter... more We measured regional cerebral blood flow (rCBF) using positron emission tomography (PET) to determine which brain regions are involved in the assessment of facial emotion. We asked right-handed normal subjects to assess the signalers’ emotional state based on facial gestures and to assess the facial attractiveness, as well as to discriminate the background color of the facial stimuli, and compared the activity produced by each condition. The right inferior frontal cortex showed significant activation during the assessment of facial emotion in comparison with the other two tests. The activated area was located within a triangular area of the inferior frontal cortex in the right cerebral hemisphere. These results, together with those of previous imaging and clinical studies, suggest that the right inferior frontal cortex processes emotional communicative signals that could be visual or auditory and that there is a hemispheric asymmetry in the inferior frontal cortex in relation to the...

Neuroscience Research Supplements

Biochem Biophys Res Commun, 1982

Neuroscience Research Supplements, 1990

Neuroscience Research Supplements, 1991

Neuroscience Research the Official Journal of the Japan Neuroscience Society, Jul 1, 2004

We studied the effect of habitual jogging on the performance of a frontal lobe functioning test. ... more We studied the effect of habitual jogging on the performance of a frontal lobe functioning test. Fourteen subjects were divided into a jogging trained group (TG) or a jogging untrained group (NG). The TG jogged for 12 weeks, for 30 min, 2.6 times per week, while the NG did not. We administered a prefrontal branching task (BR) combining a Spatial Delayed-Response Test (DR) and a Go/No-Go Test (GNG). Each test alone and a Simple Reaction Time Test (SR) were given as controls. All tests were given three times at 6 week intervals over 12 weeks in both groups. In the TG, the tests were given two times after termination of the jogging. The maximal oxygen uptake (VO2max) was measured in the TG during the 12 weeks. After 12 weeks, the correct performance rates in the BR task were more improved in the TG than in the NG. The control and reaction time tests were unchanged in both groups. The improved performance in the BR task in the TG decreased after stopping the jogging. The VO2max increased significantly during the 12 weeks of jogging in the TG. Thus, the habitual jogging improved performance in a prefrontal BR.

Neuroscience Research, Sep 30, 1997

Single-neuron activity in the premo tor cortex of monkeys was examined while they performed a vis... more Single-neuron activity in the premo tor cortex of monkeys was examined while they performed a visually guided reaching task with their eyes fixated. We recorded a total of 177 visually responsive neurons that showed significantly enhanced activity after a presentation of visuospatial cue ('visual response'). Of these neurons, 57% (n = 101) also showed significantly enhanced activity after an onset of the go-signal and before movement (,movement-associated response'). These were designated as 'visuomovement neurons'. The visual response latencies of 81% of the visuomovement neurons were between 60 and 160 ms (median = 100 ms) and the response durations were less than 240 ms in 80% of the neurons. The preferred direction of the visual response (PDV) was toward the contralateral side in 57% and the ipsilateral side in 20% of the neurons. The preferred direction of the movement-associated response (PDM) was toward the contralateral side in 50% of the neurons. In most of the neurons (74/101, 73%), the PDV and the PDM corresponded to approximately the same direction. These results suggest that premotor visuomovement neurons playa role in receiving visuospatial information for visually guided reaching, and commanding reaching movements.

Arch Toxicol, 1983

Effects of a single intraperitoneal (i.p.) injection of cadmium (Cd) on the primary humoral antib... more Effects of a single intraperitoneal (i.p.) injection of cadmium (Cd) on the primary humoral antibody responses against sheep red blood cells (SRBC) in mice were studied by assaying splenic plaque forming cells (PFC). PFC responses in mice were suppressed when exposed to Cd 2 days after immunization, and inconsistently stimulated when exposed before immunization. Dose-response relationships were observed in the suppressive effect of Cd exposure 2 days after immunization, but not consistently in the stimulative effect of Cd exposure before immunization. Thymus weights and cell numbers decreased markedly 4 days after Cd exposure with or without the antigenic stimulus. Splenic weights increased 2 days after Cd exposure, while the number of spleen cells was dramatically decreased 1 days after Cd exposure and still remained below normal 2 days after exposure.

Clin Neurophysiol, 2006

Whether event-related desynchronization (ERD) of alpha oscillatory activity changes depending on ... more Whether event-related desynchronization (ERD) of alpha oscillatory activity changes depending on fine difference in stimuli were examined on human scalp EEG using alphabetic character discrimination task. Methods: EEGs were recorded from 7 healthy men. Subjects had no learning experience of Russian language. EEGs were analyzed using event-related power analysis with 250 ms time window. Target stimuli (S2) for character discrimination were presented 2 s after warning stimuli (S1). Cue stimuli for motor reaction (S3) were presented 2 s after S2. Subjects were instructed to push a button when presented character of S2 matched with that of S1. Characters as stimuli, three English characters (A, E, N) and three Russian characters (Ä , Ç , È) were employed, and were presented in order of pseudo-random. Results: (1) Alpha-band ERD between S1 and S2 was greater than that between S2-S3 in both 'Go' and 'NoGo' condition. (2) In 'NoGo' condition, alpha-band ERD after S2 in 'Russian' condition was significantly greater than that in 'English' condition. Discussion: In 'Russian' condition, alpha-band ERD still be continued after S2, although no cognitive motor processing was required at that stage in 'NoGo' condition. With respect to the subjects, Russian alphabetic characters were not familiar at all, while English alphabetic characters were quite common. Discrepancy in alpha-band ERD between 'Russian' and 'English' condition likely reflects difference in 'Sub-second temporal attention' between those two conditions.

Neuroscience Research Supplements, 1987

An attempt was made to clarify the laminar distributions of neurons activated during a symmetrica... more An attempt was made to clarify the laminar distributions of neurons activated during a symmetrically reinforced, visually guided GO/NO-GO task with visual cues for which Brodmann's area 8 (Walker, 1940) is considered an essential region (cf. Petrides, 1986). We systematically recorded single unit activities in area 8 in 200 microns steps from the surface to the bottom of the cortex, using a glass-coated microelectrode that contained a carbon fiber. The GO/NO-GO task consisted of four periods in sequence: an intertrial interval (ITI; waiting period, warning period (which started with a warning cue), GO/NO-GO period (which started with a GO/NO-GO cue), and reward period. Activities of GO cue-coupled neurons, intermediate neurons and movement-coupled neurons in GO trials were recorded in layers II-VI, layers II-VI and layers III-VI of the area 8, respectively. Activities of NO-GO cu-coupled and NO-GO response-related neurons in NO-GO trials were recorded in layers II-VI and layers III-VI, respectively. It was considered that task-related visual information may be fed to layer III and IV, as a GO/NO-GO cue coupled activity, and then flow upward and/or downward to layers III-VI where movement-coupled activities are recorded. NO-GO response-related activity appears to suppress GO activity in layers III-VI. It was noted that the laminar distribution of NO-GO response-related neurons was similar to that of movement-coupled neurons in GO trials, and that the shape of spikes of NO-GO response-related neurons in our study resembled that of spikes of putative GABAergic neurons in a previous study. These results suggest that NO-GO response-related neurons are involved in response inhibition through GABAergic mechanisms.