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Kitti Thiankhaw

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Papers by Kitti Thiankhaw

Research paper thumbnail of Factors Associated with Unfavorable Functional Outcomes After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

International Journal of General Medicine, 2022

Research paper thumbnail of The effects of hyperbaric oxygen therapy on the brain with middle cerebral artery occlusion

Journal of Cellular Physiology, 2020

Middle cerebral artery occlusion (MCAO) causes focal cerebral hypoperfusion, resulting in cerebra... more Middle cerebral artery occlusion (MCAO) causes focal cerebral hypoperfusion, resulting in cerebral ischemia or ischemic stroke. The main therapeutic approach is to restore an adequate blood flow to the brain via the process of reperfusion. However, rapid reperfusion can itself aggravate brain damage; this adverse effect is known as ischemic/reperfusion (I/R) injury. The pathological conditions that occur after cerebral ischemia and cerebral I/R are microvascular injury, blood–brain barrier dysfunction, post‐ischemic inflammation, increased oxidative stress/reactive oxygen species, and a reduction in neuronal survival, leading to brain infarction. Animal and clinical studies on hyperbaric oxygen therapy (HBOT) have recently been carried out, and there is evidence of positive effects on neurological outcomes after cerebral ischemia. However, some evidence has shown that HBOT may not affect the functional recovery after ischemic injury. This review describes the current evidence, both in vivo and clinical data, regarding the potential benefits of HBOT after MCAO and cerebral I/R injury. The contrary data are also discussed to verify the effectiveness of HBOT in stroke outcomes.

Research paper thumbnail of Implications of the Presence of Hyperdense Middle Cerebral Artery Sign in Determining the Subtypes of Stroke Etiology

Stroke research and treatment, 2021

Background Identifying stroke subtypes is crucial in choosing appropriate treatment, predicting o... more Background Identifying stroke subtypes is crucial in choosing appropriate treatment, predicting outcomes, and managing recurrent stroke prevention. Objectives To study the association of hyperdense middle cerebral artery sign (HMCAS) on noncontrast computed tomography (NCCT) brain and subtypes of stroke etiology. Methods This is a retrospective hypothesis testing study. Patients aged 18 or over who had middle cerebral artery occlusion symptoms with HMCAS with verification on brain NCCT and received intravenous thrombolysis between January 2016 and June 2019 were enrolled. The demographic data, clinical outcomes, stroke subtypes, and characteristics of HMCAS were collected from medical records. Results Ninety-nine out of 299 enrolled patients presented with HMCAS. The most common stroke subtype was cardioembolism (59%). Of the baseline characteristics, hypertension was more common in cases of large-artery atherosclerosis (LAA) (86.4%), and atrial fibrillation (AF) was the highest in ...

Research paper thumbnail of Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition

Biochimica et Biophysica Acta (BBA) - General Subjects

Research paper thumbnail of Conglomerate ring and tract-like enhancement lesions: Neuroimaging in Listeria monocytogenes brain abscess

Research paper thumbnail of PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes

Research paper thumbnail of Internal carotid artery and bilateral vertebral arteries dissections associated with amphetamine abuse: Case report

Annals of Medicine and Surgery

Research paper thumbnail of Factors Associated with Unfavorable Functional Outcomes After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

International Journal of General Medicine, 2022

Research paper thumbnail of The effects of hyperbaric oxygen therapy on the brain with middle cerebral artery occlusion

Journal of Cellular Physiology, 2020

Middle cerebral artery occlusion (MCAO) causes focal cerebral hypoperfusion, resulting in cerebra... more Middle cerebral artery occlusion (MCAO) causes focal cerebral hypoperfusion, resulting in cerebral ischemia or ischemic stroke. The main therapeutic approach is to restore an adequate blood flow to the brain via the process of reperfusion. However, rapid reperfusion can itself aggravate brain damage; this adverse effect is known as ischemic/reperfusion (I/R) injury. The pathological conditions that occur after cerebral ischemia and cerebral I/R are microvascular injury, blood–brain barrier dysfunction, post‐ischemic inflammation, increased oxidative stress/reactive oxygen species, and a reduction in neuronal survival, leading to brain infarction. Animal and clinical studies on hyperbaric oxygen therapy (HBOT) have recently been carried out, and there is evidence of positive effects on neurological outcomes after cerebral ischemia. However, some evidence has shown that HBOT may not affect the functional recovery after ischemic injury. This review describes the current evidence, both in vivo and clinical data, regarding the potential benefits of HBOT after MCAO and cerebral I/R injury. The contrary data are also discussed to verify the effectiveness of HBOT in stroke outcomes.

Research paper thumbnail of Implications of the Presence of Hyperdense Middle Cerebral Artery Sign in Determining the Subtypes of Stroke Etiology

Stroke research and treatment, 2021

Background Identifying stroke subtypes is crucial in choosing appropriate treatment, predicting o... more Background Identifying stroke subtypes is crucial in choosing appropriate treatment, predicting outcomes, and managing recurrent stroke prevention. Objectives To study the association of hyperdense middle cerebral artery sign (HMCAS) on noncontrast computed tomography (NCCT) brain and subtypes of stroke etiology. Methods This is a retrospective hypothesis testing study. Patients aged 18 or over who had middle cerebral artery occlusion symptoms with HMCAS with verification on brain NCCT and received intravenous thrombolysis between January 2016 and June 2019 were enrolled. The demographic data, clinical outcomes, stroke subtypes, and characteristics of HMCAS were collected from medical records. Results Ninety-nine out of 299 enrolled patients presented with HMCAS. The most common stroke subtype was cardioembolism (59%). Of the baseline characteristics, hypertension was more common in cases of large-artery atherosclerosis (LAA) (86.4%), and atrial fibrillation (AF) was the highest in ...

Research paper thumbnail of Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition

Biochimica et Biophysica Acta (BBA) - General Subjects

Research paper thumbnail of Conglomerate ring and tract-like enhancement lesions: Neuroimaging in Listeria monocytogenes brain abscess

Research paper thumbnail of PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes

Research paper thumbnail of Internal carotid artery and bilateral vertebral arteries dissections associated with amphetamine abuse: Case report

Annals of Medicine and Surgery

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