Kuniaki Otsuka - Academia.edu (original) (raw)

Papers by Kuniaki Otsuka

Research paper thumbnail of The Evolution of Biochemical Storm of Circadian Rhythm and Circadian Dysfunction in Relation to Vascular Disease and Diabetes

Research paper thumbnail of Correction: Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study

NPJ microgravity, Sep 29, 2016

In this Article, data within Table 1 and a sentence within the Methods inadvertently included inf... more In this Article, data within Table 1 and a sentence within the Methods inadvertently included information that breached subject confidentiality. This information has been removed from Table 1 and Methods in the online versions of the paper.

Research paper thumbnail of Coronary Risk Factors and Ambulatory Blood Pressure and Heart Rate in Asian Indians

The Open nutraceuticals journal, Mar 22, 2012

Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African ... more Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African Americans compared to people of European origin [1]. Data on ABP and heart rate (HR) on American Indians and Asian Indians could have made this study even more interesting [2]. Details on diet and lifestyle factors also appear to be important for mapping circadian changes in blood pressure (BP) in populations studied by the BIOCOS group [3]. Circadian changes in BP are synchronized by the daily routine via plasma concentrations of neurotransmitters, released by the pineal, pituitary and adrenal cortices, coordinated by clock genes situated in the brain's suprachiasmatic nucleus [2], and at the cellular level [4, 5].

Research paper thumbnail of Circadian and infradian rhythms in mood

Biomedicine & Pharmacotherapy, Nov 1, 2000

Research paper thumbnail of Chronomics and Continuous Ambulatory Blood Pressure Monitoring

Research paper thumbnail of From Self-Surveillance in Schools and Monitoring in the Experimental Laboratory to Vascular Variability Disorders

Research paper thumbnail of Chronobiologic analyses of weeklong around-the-clock records of simultaneously monitored blood pressure and activity

Research paper thumbnail of Harm vs. Benefit from Losartan with Hydrochlorothiazide Atdifferent Circadian Times in Mesor-Hypertension or Chat

HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYP... more HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYPERTENSION OR CHAT

Research paper thumbnail of The cosmos with aeolian cycles, tipping the scale between death and survival: An indispensable control

Research paper thumbnail of Should 7-day/24-hour chronobiologically interpreted bloodpressure monitoring replace single measurements before cataractsurgery?

Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single meas... more Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single measurements before cataract surgery?

Research paper thumbnail of Chronomic Community Screening: Depressive Mood, Heart Rate Variability, and Cardiovascular Outcomes in a Community

Humans have developed “clock” genes of the circadian, and probably many other components in the s... more Humans have developed “clock” genes of the circadian, and probably many other components in the spectral element of chronomes, beyond about-yearly (circannual) and about-weekly (circaseptan) features, as a product of adaptation to, or rather integration with, cycles in the cosmos. While life originally integrated itself into the cycles of an anthropogenically unpolluted environment, the environmental cycles are now being changed in keeping with the schedules of societal life as in the case of global temperature. Hence, a variety of cognitive, neurobehavioral and neuropsychological as well as cardiovascular functions will need to be investigated to more precisely map their chronomes in space and time, in order to understand chronoastrobiology, based on both the system times and time horizons yielded by chronomes.

Research paper thumbnail of Incidence pattern and treatment of a clinical entity - Overswinging or circadian hyperamplitudetension (CHAT)

Research paper thumbnail of Circadian stage-dependent infradian-modulated changes in amental function during aging

C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-de... more C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-dependent infradian-modulated changes in a mental function during aging Franz Halberg, Germaine Cornelissen, Robert B. Sothern, Kuniaki Otsuka, Miguel Revilla 1 Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA 2 Tokyo Women's Medical University, Medical Center East, Tokyo, Japan 3 University of Valladolid, Valladolid, Spain

Research paper thumbnail of Chronobiologically-interpreted ABPM reveals another vascular variability anomaly (VVA): Excessive pulse pressure product (PPP) updated conference report

To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systoli... more To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systolic blood pressure x heart rate / 100), PPP was determined from Chronobiologically and chronomically interpreted aroundthe-clock Ambulatory Blood Pressure Monitoring (CABPM) and related to outcomes in three different investigations, carried out in the Czech Republic, Japan, and Taiwan. In these three outcome studies, values of PPP above 100 were associated with a statistically significant increase in cardiovascular disease risk. As such, EPPP in a 7-day or longer around-the-clock record qualifies as a new Vascular Variability Anomaly (VVA), or, if it persists in a series of 7-day records, a Vascular Variability Disorder (VVD). Being the product of blood pressure and heart rate, EPPP is not independent from MESOR-hypertension. The extent to which EPPP may contribute additive cardiovascular disease risk to other VVDs will require larger outcome studies capable of separating the risk associat...

Research paper thumbnail of 1-day versus 7-day CHAT: indicators of physiological versus putatively pathological blood pressure dynamics

To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities ... more To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities indicating a risc of stroke and other severe illness greater than that of hypertension are to be picked up and reliably diagnosed in order to be treated if they are consistent upon further monitoring.

Research paper thumbnail of Mathematical model of cardiovascular disease risk based on Vascular Variability Disorders

Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventio... more Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to ...

Research paper thumbnail of Ambulatory blood pressure monitoring for clinical applications and basic science

Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated ... more Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated to obtain more reliable estimates of the circadian characteristics of blood pressure and heart rate. Herein, using data from a chronotherapy tria, we adress the desirability of complementing the global analysis of the entire record by the computation of daily sphygmochrons to gain a better assessment of the day-to-day variability in the circadian patterns of these variables.

Research paper thumbnail of Time-specified norms reveal full systolic but incompletediastolic early MESOR-hypertension, MH

Time-specified norms reveal full systolic but incomplete diastolic early MESOR-hypertension, MH

Research paper thumbnail of Brain-heart interactions and circadian rhythms in chronic heart failure (Homage to Dr. Franz Halberg on the 2nd anniversary of his death on 9th June 2013)

Research paper thumbnail of Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring. Abstract

Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate a... more Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring.

Research paper thumbnail of The Evolution of Biochemical Storm of Circadian Rhythm and Circadian Dysfunction in Relation to Vascular Disease and Diabetes

Research paper thumbnail of Correction: Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study

NPJ microgravity, Sep 29, 2016

In this Article, data within Table 1 and a sentence within the Methods inadvertently included inf... more In this Article, data within Table 1 and a sentence within the Methods inadvertently included information that breached subject confidentiality. This information has been removed from Table 1 and Methods in the online versions of the paper.

Research paper thumbnail of Coronary Risk Factors and Ambulatory Blood Pressure and Heart Rate in Asian Indians

The Open nutraceuticals journal, Mar 22, 2012

Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African ... more Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African Americans compared to people of European origin [1]. Data on ABP and heart rate (HR) on American Indians and Asian Indians could have made this study even more interesting [2]. Details on diet and lifestyle factors also appear to be important for mapping circadian changes in blood pressure (BP) in populations studied by the BIOCOS group [3]. Circadian changes in BP are synchronized by the daily routine via plasma concentrations of neurotransmitters, released by the pineal, pituitary and adrenal cortices, coordinated by clock genes situated in the brain's suprachiasmatic nucleus [2], and at the cellular level [4, 5].

Research paper thumbnail of Circadian and infradian rhythms in mood

Biomedicine & Pharmacotherapy, Nov 1, 2000

Research paper thumbnail of Chronomics and Continuous Ambulatory Blood Pressure Monitoring

Research paper thumbnail of From Self-Surveillance in Schools and Monitoring in the Experimental Laboratory to Vascular Variability Disorders

Research paper thumbnail of Chronobiologic analyses of weeklong around-the-clock records of simultaneously monitored blood pressure and activity

Research paper thumbnail of Harm vs. Benefit from Losartan with Hydrochlorothiazide Atdifferent Circadian Times in Mesor-Hypertension or Chat

HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYP... more HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYPERTENSION OR CHAT

Research paper thumbnail of The cosmos with aeolian cycles, tipping the scale between death and survival: An indispensable control

Research paper thumbnail of Should 7-day/24-hour chronobiologically interpreted bloodpressure monitoring replace single measurements before cataractsurgery?

Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single meas... more Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single measurements before cataract surgery?

Research paper thumbnail of Chronomic Community Screening: Depressive Mood, Heart Rate Variability, and Cardiovascular Outcomes in a Community

Humans have developed “clock” genes of the circadian, and probably many other components in the s... more Humans have developed “clock” genes of the circadian, and probably many other components in the spectral element of chronomes, beyond about-yearly (circannual) and about-weekly (circaseptan) features, as a product of adaptation to, or rather integration with, cycles in the cosmos. While life originally integrated itself into the cycles of an anthropogenically unpolluted environment, the environmental cycles are now being changed in keeping with the schedules of societal life as in the case of global temperature. Hence, a variety of cognitive, neurobehavioral and neuropsychological as well as cardiovascular functions will need to be investigated to more precisely map their chronomes in space and time, in order to understand chronoastrobiology, based on both the system times and time horizons yielded by chronomes.

Research paper thumbnail of Incidence pattern and treatment of a clinical entity - Overswinging or circadian hyperamplitudetension (CHAT)

Research paper thumbnail of Circadian stage-dependent infradian-modulated changes in amental function during aging

C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-de... more C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-dependent infradian-modulated changes in a mental function during aging Franz Halberg, Germaine Cornelissen, Robert B. Sothern, Kuniaki Otsuka, Miguel Revilla 1 Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA 2 Tokyo Women's Medical University, Medical Center East, Tokyo, Japan 3 University of Valladolid, Valladolid, Spain

Research paper thumbnail of Chronobiologically-interpreted ABPM reveals another vascular variability anomaly (VVA): Excessive pulse pressure product (PPP) updated conference report

To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systoli... more To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systolic blood pressure x heart rate / 100), PPP was determined from Chronobiologically and chronomically interpreted aroundthe-clock Ambulatory Blood Pressure Monitoring (CABPM) and related to outcomes in three different investigations, carried out in the Czech Republic, Japan, and Taiwan. In these three outcome studies, values of PPP above 100 were associated with a statistically significant increase in cardiovascular disease risk. As such, EPPP in a 7-day or longer around-the-clock record qualifies as a new Vascular Variability Anomaly (VVA), or, if it persists in a series of 7-day records, a Vascular Variability Disorder (VVD). Being the product of blood pressure and heart rate, EPPP is not independent from MESOR-hypertension. The extent to which EPPP may contribute additive cardiovascular disease risk to other VVDs will require larger outcome studies capable of separating the risk associat...

Research paper thumbnail of 1-day versus 7-day CHAT: indicators of physiological versus putatively pathological blood pressure dynamics

To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities ... more To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities indicating a risc of stroke and other severe illness greater than that of hypertension are to be picked up and reliably diagnosed in order to be treated if they are consistent upon further monitoring.

Research paper thumbnail of Mathematical model of cardiovascular disease risk based on Vascular Variability Disorders

Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventio... more Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to ...

Research paper thumbnail of Ambulatory blood pressure monitoring for clinical applications and basic science

Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated ... more Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated to obtain more reliable estimates of the circadian characteristics of blood pressure and heart rate. Herein, using data from a chronotherapy tria, we adress the desirability of complementing the global analysis of the entire record by the computation of daily sphygmochrons to gain a better assessment of the day-to-day variability in the circadian patterns of these variables.

Research paper thumbnail of Time-specified norms reveal full systolic but incompletediastolic early MESOR-hypertension, MH

Time-specified norms reveal full systolic but incomplete diastolic early MESOR-hypertension, MH

Research paper thumbnail of Brain-heart interactions and circadian rhythms in chronic heart failure (Homage to Dr. Franz Halberg on the 2nd anniversary of his death on 9th June 2013)

Research paper thumbnail of Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring. Abstract

Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate a... more Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring.