Kuniaki Otsuka - Profile on Academia.edu (original) (raw)

Papers by Kuniaki Otsuka

Biomedicine & Pharmacotherapy, 2005

Daily data on solar magnetism, available from May 1975 to April 2002, were analyzed by linearnonl... more Daily data on solar magnetism, available from May 1975 to April 2002, were analyzed by linearnonlinear rhythmometry, with particular focus on the near-transyear, slightly longer than the calendar year. The time structure of solar magnetism is compared to that of solar activity, gauged by Wolf numbers. An about 27-day component corresponding to the solar rotation period, is common to both variables but differs in harmonic content. About 10-year component characterizes solar activity but not solar magnetism. A near-transyear with a period of about 1.05 years is detected in solar magnetism. In solar activity, a near-transyear is also found but its period of about 1.10 years is longer than that characterizing solar magnetism, and it may be paired with an about 0.9-year component to correspond to an about 10-year modulation in amplitude or phase of an about-yearly component.

The Open nutraceuticals journal, Mar 22, 2012

Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African ... more Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African Americans compared to people of European origin [1]. Data on ABP and heart rate (HR) on American Indians and Asian Indians could have made this study even more interesting [2]. Details on diet and lifestyle factors also appear to be important for mapping circadian changes in blood pressure (BP) in populations studied by the BIOCOS group [3]. Circadian changes in BP are synchronized by the daily routine via plasma concentrations of neurotransmitters, released by the pineal, pituitary and adrenal cortices, coordinated by clock genes situated in the brain's suprachiasmatic nucleus [2], and at the cellular level [4, 5].

Biomedicine & Pharmacotherapy, Nov 1, 2000

This self-study in a clinically healthy man explores by rhythmometry any circadian aspects of pos... more This self-study in a clinically healthy man explores by rhythmometry any circadian aspects of positive and negative affect in relation to blood pressure (BP) and heart rate (HR), monitored over several months for 24 hours per day.

Springer eBooks, 2016

Intervention aimed at preventing stroke induced an improvement of the cognitive function in an el... more Intervention aimed at preventing stroke induced an improvement of the cognitive function in an elderly community-dwelling population, especially in people suffering from hypertension, tachycardia, or decreased heart rate variability. People with a disordered coordination of cardiovascular function were more sensitive to such an intervention, suggesting that the cardiovascular function was a major factor affecting cognitive function. The comprehensive geriatric assessment involved measurement of arterial stiffness; blood pressure variability as shown in orthostatic hypotension, quality of sleep, and heart rate variability, useful for "prehabilitation" in elderly community-dwelling people.

From Self-Surveillance in Schools and Monitoring in the Experimental Laboratory to Vascular Variability Disorders

Chronobiologic analyses of weeklong around-the-clock records of simultaneously monitored blood pressure and activity

Masaryk University, 2020

Harm vs. Benefit from Losartan with Hydrochlorothiazide Atdifferent Circadian Times in Mesor-Hypertension or Chat

HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYP... more HARM VS. BENEFIT FROM LOSARTAN WITH HYDROCHLOROTHIAZIDE AT DIFFERENT CIRCADIAN TIMES IN MESOR-HYPERTENSION OR CHAT

The cosmos with aeolian cycles, tipping the scale between death and survival: An indispensable control

Should 7-day/24-hour chronobiologically interpreted bloodpressure monitoring replace single measurements before cataractsurgery?

Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single meas... more Should 7-day/24-hour chronobiologically interpreted blood pressure monitoring replace single measurements before cataract surgery?

Chronomic Community Screening: Depressive Mood, Heart Rate Variability, and Cardiovascular Outcomes in a Community

Humans have developed “clock” genes of the circadian, and probably many other components in the s... more Humans have developed “clock” genes of the circadian, and probably many other components in the spectral element of chronomes, beyond about-yearly (circannual) and about-weekly (circaseptan) features, as a product of adaptation to, or rather integration with, cycles in the cosmos. While life originally integrated itself into the cycles of an anthropogenically unpolluted environment, the environmental cycles are now being changed in keeping with the schedules of societal life as in the case of global temperature. Hence, a variety of cognitive, neurobehavioral and neuropsychological as well as cardiovascular functions will need to be investigated to more precisely map their chronomes in space and time, in order to understand chronoastrobiology, based on both the system times and time horizons yielded by chronomes.

Incidence pattern and treatment of a clinical entity - Overswinging or circadian hyperamplitudetension (CHAT)

Circadian stage-dependent infradian-modulated changes in amental function during aging

C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-de... more C:\ger\Papers\MEFA2008\Submit\Brno1MTE.doc Monday, September 15, 2008 14:26:56 Circadian stage-dependent infradian-modulated changes in a mental function during aging Franz Halberg, Germaine Cornelissen, Robert B. Sothern, Kuniaki Otsuka, Miguel Revilla 1 Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA 2 Tokyo Women's Medical University, Medical Center East, Tokyo, Japan 3 University of Valladolid, Valladolid, Spain

Chronobiologically-interpreted ABPM reveals another vascular variability anomaly (VVA): Excessive pulse pressure product (PPP) updated conference report

To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systoli... more To assess the risk associated with an Excessive Pulse Pressure Product (EPPP, where PPP = systolic blood pressure x heart rate / 100), PPP was determined from Chronobiologically and chronomically interpreted aroundthe-clock Ambulatory Blood Pressure Monitoring (CABPM) and related to outcomes in three different investigations, carried out in the Czech Republic, Japan, and Taiwan. In these three outcome studies, values of PPP above 100 were associated with a statistically significant increase in cardiovascular disease risk. As such, EPPP in a 7-day or longer around-the-clock record qualifies as a new Vascular Variability Anomaly (VVA), or, if it persists in a series of 7-day records, a Vascular Variability Disorder (VVD). Being the product of blood pressure and heart rate, EPPP is not independent from MESOR-hypertension. The extent to which EPPP may contribute additive cardiovascular disease risk to other VVDs will require larger outcome studies capable of separating the risk associat...

1-day versus 7-day CHAT: indicators of physiological versus putatively pathological blood pressure dynamics

To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities ... more To document further beyond earlier studies the need for a minimal 7-day record, if abnormalities indicating a risc of stroke and other severe illness greater than that of hypertension are to be picked up and reliably diagnosed in order to be treated if they are consistent upon further monitoring.

Mathematical model of cardiovascular disease risk based on Vascular Variability Disorders

Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventio... more Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the circadian characteristics of the BP waveform adjusted for gender and age enable a better estimation of cardiovascular morbidity and mortality risk. Apart from increased 24-hour mean values of BP (MESOR, short for Midline Estimating Statistic of Rhythm), an attribute of MESOR-hypertension (MH), altered patterns of variability in BP and heart rate (HR) are markers of cardiovascular disease risk. Screening for these Vascular Variability Disorders (VVDs) yields a refined diagnosis and prognosis regarding the risk of cardiovascular morbidity and mortality. It also serves as a guide for timed treatment (chronotherapy) when warranted. This chronobiologic approach based on ambulatory BP monitoring remains applicable to ...

Ambulatory blood pressure monitoring for clinical applications and basic science

Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated ... more Monitoring for spans longer then 24 hours, prefably for 7 days at the outset, has been advocated to obtain more reliable estimates of the circadian characteristics of blood pressure and heart rate. Herein, using data from a chronotherapy tria, we adress the desirability of complementing the global analysis of the entire record by the computation of daily sphygmochrons to gain a better assessment of the day-to-day variability in the circadian patterns of these variables.

Time-specified norms reveal full systolic but incompletediastolic early MESOR-hypertension, MH

Time-specified norms reveal full systolic but incomplete diastolic early MESOR-hypertension, MH

Brain-heart interactions and circadian rhythms in chronic heart failure (Homage to Dr. Franz Halberg on the 2nd anniversary of his death on 9th June 2013)

Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring. Abstract

Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate a... more Effect of alcohol intake and treatment with calcium antagonist on blood pressure and heart rate assessed by ambulatory monitoring.