Kuo-sheng Cheng - Academia.edu (original) (raw)

Papers by Kuo-sheng Cheng

Journal of Medical and Biological Engineering, Jul 31, 2023

Purpose Identifying the effective treatments for diseases has been a critical issue in daily clin... more Purpose Identifying the effective treatments for diseases has been a critical issue in daily clinical practice, especially for Alzheimer's dementia (AD). Abundant evidence showed that non-invasive brain stimulation (NIBS) has the potential to slow or reverse cognitive function decline. Among them, the transcranial Direct Current Stimulation (tDCS) would be relatively safe for patients with AD. The purpose of this study was to review the relevant articles to explore the mechanism and effect of tDCS and other NIBS in AD treatment. Methods All the reported works were retrieved from two databases (i.e., PubMed and Google Scholar) by using the keywords "NIBS" and "AD". The mechanisms and effects of different NIBS applied in AD, including transcranial ultrasound stimulation (TUS), transcranial near-infrared (tNIR) light therapy, transcranial magnetic stimulation (TMS), and transcranial electric stimulation (TES) were reviewed. Results The positive effects of TUS and tNIR on AD were supported by a few small samples and uncontrolled pilot studies. tDCS and repetitive TMS have been often used in an attempt to improve the cognition in people with brain disorders. Both the tDCS and TMS have benefits in AD by introducing long-term potentiation like change in synaptic strength. The reports showed that tDCS could be more safe, convenient, affordable, and well-tolerated method among all applications for AD treatment. Conclusion In this review, it was shown that all the NIBS have positive effects on AD treatment. But, however, tDCS showed the great potential in improving the cognition of AD.

PLOS ONE, Oct 13, 2016

Minimal axial diameter (MIAD) in magnetic resonance imaging (MRI) was recognized as the most usef... more Minimal axial diameter (MIAD) in magnetic resonance imaging (MRI) was recognized as the most useful parameter in diagnosing lateral retropharyngeal lymph (LRPL) nodes in nasopharyngeal carcinoma (NPC). This study aims to explore the additional nodal parameters in MRI and positron emission tomography-computed tomography for increasing the prediction accuracy.

Biomedical Engineering Online, Mar 19, 2013

Background: Electrical biopsy illustrates a tissue's electrical properties by electrical impedanc... more Background: Electrical biopsy illustrates a tissue's electrical properties by electrical impedance spectroscopy. However, electrical biopsy parameters are different from conventional morphological-based examinations. The correlation between electrical biopsy and the morphological observation has not been checked. Considering the tissue responses to injury, extracellular resistance should be most sensitive with the accumulation of fluid in tissue, and it is expected to increase the ratio of optical low staining area on histological images. In this study, we calculated the ratio of optical low staining area of sampled histological images and compared with the results of electrical biopsy to verify the hypothesis of that the extracellular resistance of electrical biopsy most highly correlates with the ratio of optical low staining area on histological images. Methods: The irradiated intestinal tissues of rats after different latent period were used for study. The sampled tissues were measured by electrical impedance spectroscopy for electrical biopsy and the microscopic images were acquired. The sampled histological images were transformed into the Hue-Saturation-Density (HSD) colour model to decouple the stain density. The ratio of optical low staining area on histological images was computed to quantify the morphological changes. The results were related to the parameters from electrical biopsy according to three element circuit model by Spearman's rank correlation test. Results: The ratio of optical low staining area varied as well as the tissue's electrical parameters. The extracellular resistance (R e) and intracellular resistance (R i) by electrical biopsy tended to increase with the ratio of low staining area decreasing. The membrane capacitance (C m) by electrical biopsy tended to increase with the ratio of optical low staining area increasing. The extracellular resistance (R e) of electrical biopsy was the parameter most highly correlated with the ratio of optical low staining area with a correlation coefficient of −0.757 (p < 0.001). Conclusions: The results of this report confirm the hypothesis and support the idea that electrical biopsy results reflect the changes in tissues seen in conventional histological findings in a sense of conventional histological knowledge, and this approach may have a great potential for augmenting the pathological diagnosis of tissues.

Journal of Alzheimer's Disease, Feb 8, 2022

Background: The earlier detection of dementia is needed as cases increase yearly in the aging pop... more Background: The earlier detection of dementia is needed as cases increase yearly in the aging populations of Taiwan and the world. In recent years, the global internet usage rate has gradually increased among older people. To expand dementia screening and provide timely medical intervention, a simple self-administrated assessment tool to assist in easily screening for dementia is needed. Objective: The two-part goal of this pilot study was, first, to develop a Game-Based Cognitive Assessment (GBCA) tool, and then, to evaluate its validity at early screening for patients with cognitive impairment. Method: The researchers recruited 67 patients with neurocognitive disorders (NCDs) and 57 healthy controls (HCs). Each participant underwent the GBCA and other clinical cognitive assessments (CDR, CASI, and MMSE), and filled out a questionnaire evaluating their experience of using the GBCA. Statistical analyses were used to measure the validity of the GBCA at screening for degenerative dementia. Results: The average GBCA scores of the HC and NCD groups were 87 (SD = 7.9) and 52 (SD = 21.7), respectively. The GBCA correlated well with the CASI (r2 = 0.90, p < 0.001) and with the MMSE (r2 = 0.92, p < 0.001), indicating concurrent validity. The GBCA cut-off of 75/76 corresponded to measurements of sensitivity, specificity, and area under curve of 85.1%, 91.5%, and 0.978, respectively. The positive predictive value was 91.9%, and the negative predictive value was 84.4%. The results of the user-experience questionnaire for the HC and NCD groups were good and acceptable, respectively. Conclusion: The GBCA is an effective and acceptable tool for screening for degenerative dementia.

Depression is a common and serious mental disorder. About 1.9 million people in Taiwan are identi... more Depression is a common and serious mental disorder. About 1.9 million people in Taiwan are identified as having depression. There is a trend of increase of the prevalence of depression, three times more depressed persons within the past six years. A few patients with depression were in treatment. Therefore, an available algorithm will be build to measure the neurophysiology of depression. In this study, the physiological signals from depressed patients will be compared with those from normal people. This experiment use different pictures expresses happiness, sadness fear, and disgust to cause the emotion of subjects. The physiological signals of the patient is measured at the same time. The preliminary results show that the galvanic skin response, heart rate variability, and blood volume pulse of patients with depression is lower than the normal people does. More subjects will be evaluated in the project for investing the clinical significance.

International Journal of Radiation Oncology Biology Physics, Nov 1, 2012

Electrical impedance tomography is a technique for reconstructing the spatial distribution of the... more Electrical impedance tomography is a technique for reconstructing the spatial distribution of the parameters characterizing the electrical properties of tissues within a body. These parameters, conductivity and relative permittivity, cannot be obtained by other imaging modalities. In this paper, the simulated annealing, the genetic algorithms, and the Newton-Raphson method are developed for electrical impedance image reconstruction. From the results, both the simulated annealing and genetic algorithm based methods are demonstrated to be feasible for producing the dynamic image of resistivity distribution. In order to reduce the number of degree of freedom in these two methods, a guided technique based upon the voltage measurements is also designed. In addition, a modified Newton-Raphson method is also proposed for improving the image contrast. Three electrode models for describing the effect of electrode are also investigated. Afterwards, A simple gap electrode model for its best performance is also included in the FEM forward solver.

Genetic algorithm is one of the major tools for solving the optimization problem. Its global conv... more Genetic algorithm is one of the major tools for solving the optimization problem. Its global convergence and searching strategy significantly affect the performance. In This work, a novel genetic algorithm is proposed to include the diversity strategy and reviving strategy. From the experimental results of solving two typical test functions, the performance of the proposed algorithm is better than that of the traditional genetic algorithm.

The purpose of this study is to characterize the cognitive functions of schizophrenic patients us... more The purpose of this study is to characterize the cognitive functions of schizophrenic patients using different auditory and visual event-related potentials (ERPs) based on Wisconsin card sorting test (WCST). From the experimental results, it is indicated that there is a slowness of automatic cognitive processing and controlled cognitive processing during WCST in comparison with ERPs for schizophrenic patients.

IFMBE proceedings, May 30, 2018

The AV access is usually evaluated by feeling thrill and pulsation through palpation, listening f... more The AV access is usually evaluated by feeling thrill and pulsation through palpation, listening for the bruit by using a stethoscope, Doppler ultrasound imaging, or angiography, etc. However, these techniques require specific equipment and operator. Phonoangiography is a noninvasive tool for identifying vascular diameter change. In this study, a mock model has been set up to simplify the simulation of blood flow condition. Phonographic signal is recorded by electronic stethoscope and further signal processed. The relationship of phonographic signals and stenotic lesions is studied. Early detection of hemodialysis access problems such as stenosis and thrombosis is very important issue. The purpose of this study is to develop a phonographic system to evaluate arteriovenous shunt (AVS) stenosis of hemodialysis patients. The degree of stenosis (DOS) is used as an index to classify the AV access condition, and is determined by the narrowing percentage of normal vessels. In this mock model, the DOS is set to be varied from 0, 50, 70, 80, 85, 90, 92.5 to 95%. The empirical mode decomposition (EMD) method is applied to analyze the relationship between DOS and spectrogram. Verification is based on Doppler ultrasound which is the golden standard in clinical application. From the experimental results, the proposed method is demonstrated to be feasible for charactering the staging of DOS conditions. There is a great correlation between the phonoangiography and the severity of DOS in AV access. This noninvasive method may be useful and potential for early detection in home-care use.

Page 1. 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Soci... more Page 1. 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Amsterdam 1996 3.4.1: Electrical Impedance Tomograpy-Reconstruction Algorithms CAL IMPEDANCE IMAGE RECONSTRUCTION USING THE GENETIC ALGORITHM ...

... of temperature changes of skin, and demonstrated to be a novel method for detecting the patho... more ... of temperature changes of skin, and demonstrated to be a novel method for detecting the pathological blood circulation area. ... [18] RC Conzalez and RE Woods, Digital Image Processing, Cambridge, MA ... [19] ID Swain and LJ Grant, “Methods of measuring skin blood flow”, Phys. ...

IEICE Transactions on Information and Systems, Dec 1, 2005

Pattern extraction is an indispensable step in bare printed circuit board (PCB) inspection and pl... more Pattern extraction is an indispensable step in bare printed circuit board (PCB) inspection and plays an important role in automatic inspection system design. A good approach for pattern definition and extraction will make the following PCB diagnosis easy and efficient. The window-based technique has great potential in PCB patterns extraction due to its simplicity. The conventional window-based pattern extraction methods, such as Small Seeds Window Extraction method (SSWE) and Large Seeds Window Extraction method (LSWE), have the problems of losing some useful copper traces and splitting slanted-lines into too many small similar windows. These methods introduce the difficulty and computation intensive in automatic inspection. In this paper, a novel method called Contour Based Window Extraction (CBWE) algorithm is proposed for improvement. In comparison with both SSWE and LSWE methods, the CBWE algorithm has several advantages in application. Firstly, all traces can be segmented and enclosed by a valid window. Secondly, the type of the entire horizontal or vertical line of copper trace is preserved. Thirdly, the number of the valid windows is less than that extracted by SSWE and LSWE. From the experimental results, the proposed CBWE algorithm is demonstrated to be very effective in basic pattern extraction from bare PCB image analysis.

IEEE Journal on Emerging and Selected Topics in Circuits and Systems, Dec 1, 2019

Portal area segmentation is an important step in the quantitative histological analysis process f... more Portal area segmentation is an important step in the quantitative histological analysis process for hepatitis grading. However, portal areas often appear of different sizes and appearances due to the variations of surrounding components such as the ductule, bile duct, artery, and portal vein. The slim fibrosis expanding from the portal area further increases challenges of the portal area segmentation. A Multi-scale Receptive Field Convolutional Neural Network (MRF-CNN) for the segmentation of the liver portal areas in hematoxylin and eosin (H&E) stained whole slide images (WSIs) is proposed in this paper. The MRF-CNN adopts the atrous spatial pyramid pooling (ASPP) with multiple atrous rates and symmetric encoder-decoder with feature concatenation architecture. The atrous rates in ASPP are devised of receptive fields to extract features of meaningful tissue components in parallel in portal areas. Along with the MRF-CNN, a small object sensitive loss function is also proposed to have the network focus on small portal areas and slim fibrosis. The results show that the proposed model achieves Intersection over Union (IOU) of 0.87 and sensitivity of 0.92. Compared to recent segmentation researches such as Fully Convolutional Network (FCN), U-Net and SegNet, the proposed network achieves an overall the best IOU and sensitivity performance. Experimental results also show that the designed ASPP block benefits in feature extraction, and the ability of identifying small objects in proposed small object sensitive loss has a significant improvement of the segmentation result comparing to the original cross entropy loss.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, Nov 30, 2022

Objective: Moderate and severe behavioral and psychological symptoms of dementia (BPSD) often nee... more Objective: Moderate and severe behavioral and psychological symptoms of dementia (BPSD) often need medical treatment to improve symptoms. Agomelatine is a selective melatonergic (MT1/MT2) agonist that has normalizing effects on disturbed circadian rhythms and disrupted sleep−wake cycles. Its activity of 5HT-2C receptor antagonism is associated with lessening depression and anxiety and increasing slow-wave sleep. Based on past clinical records and current findings it suggests that agomelatine can improve BPSD for patients. This retrospective cohort study was designed to compare the BPSD before and after using agomelatine. Methods: Records of dementia cases who had ever received agomelatine treatment for BPSD in a general hospital setting during the past 2.5 years were identified and reviewed. Scores from before and after 3 months of treatment with agomelatine were collected for Neuropsychiatric Inventory (NPI), Brief Psychiatric Rating Scale (BPRS), and Clinical Global Impression (CGI) to compare and analyze the difference of psychological and behavioral symptoms pre-and post-agomelatine used. Results: Records of 144 cases of dementia with BPSD who had ever used agomelatine from January 2015 to June 2017 were collected. All of the 112 cases had BPRS and CGI scores, of which 75 cases had additional NPI scores. Among these 112 cases, the BPRS and CGI scores were significantly improved in all types of dementia. NPI scores indicated that the use of agomelatine alleviated obvious symptoms and decreased overall distress, especially in the depression/poor mood, anxiety, and sleep/night behavior. Conclusion: It is consistent with an effective result of agomelatine in improving BPSD.