Ladan Rashidi - Academia.edu (original) (raw)

Papers by Ladan Rashidi

Industrial Crops and Products, Oct 1, 2023

Background: Treatment of the ischemic stroke has remained a major healthcare challenge. The pheno... more Background: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, sesamol, has shown promising antioxidant and neuroprotective effects, however, fast clearance may negatively affect its efficiency. This, prompted us to incorporate sesamol into the nanostructured lipid carriers (S-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. Methods: S-NLCs formulations were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of the optimal formulation in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard. Two-or three-way ANOVA, Mann-Whitney U test, and Student's t-test were used for data analysis. Results: Formation of S-NLCs which exhibited a controlled release profile, was confirmed by scanning electron microscope and differential scanning calorimetry. 1-and 8-h OGD followed by 24 h re-oxygenation significantly reduced PC12 cell viability, increased lactate dehydrogenase activity and the number of condensed nuclei, and induced oxidative stress as revealed by increased malondialdehyde level and decreased glutathione content and superoxide dismutase and catalase activities. Sesamol (80 and 100 μM) reduced the cytotoxicity, oxidative stress, and cellular damage only after 1-h OGD, while, S-NLCs (containing 80 and 100 μM of sesamol) were effective at both time points. Intravenous injections of S-NLCs (20 and 25 mg/kg) into rats markedly attenuated I/R-induced neurobehavioural deficits, cellular damage, and oxidative stress, while, free sesamol failed. Pre-treatment with PI3K inhibitor, LY294002, abolished the protective effects against OGD or I/R. Conclusions: S-NLCs improve the pharmacological profile of sesamol and provide longer lasting protective effects for this phenolic phytochemical. This nanoformulation by activating PI3K pathway may serve as a promising candidate for neuroprotection against the cerebral stroke or other neurodegenerative disorders.

Journal of Food Measurement and Characterization, Mar 22, 2023

Social Science Research Network, 2022

Iranian Journal of Nutrition Sciences and Food Technology, Jan 10, 2016

Background and Objectives: Monoacylglycerols can be used as organogelator in production of oleoge... more Background and Objectives: Monoacylglycerols can be used as organogelator in production of oleogels. In this study, the effect of monoacylglycerols addition on the physicochemical properties of sunflower oil was evaluated. Materials & Methods: Three oleogel samples were made by adding 0.5, 3.0 or 5.0% distillated monoacylglycerols into the sunflower oil. Fatty acid composition, iodine value, oxidative stability, melting point, solid fat content, crystallization kinetics and rheological properties of the samples were evaluated. Changes in the samples' peroxide value and free fatty acid content during storage at 60 °C were also investigated in a 31-day time course (with 3-day intervals). Results: Compared to the pure sunflower oil, the oleogel samples made using monoacylglycerols had higher saturated fatty acid content, melting point, solid fat content, storage and loss modules, and lower iodine value and induction period of crystallization. Though monoacylglycerols had not any effect on the induction period of oxidation, the oleogels containing 5% monoacylglycerols had higher peroxide value and free fatty acid content after 14 days of storage at 60°C. Conclusions: Totally, by the addition of monoacylglycerols into the sunflower oil, its properties shifted from oil to a fat. This was accompanied with a little increase in saturated fatty acid content and a decrease in oxidative stability.

Small Ruminant Research, Aug 1, 2017

Highlights  Pomegranate seed oil (PSO) and linseed oil (LSO) in lactating goat's diet.  PSO and... more Highlights  Pomegranate seed oil (PSO) and linseed oil (LSO) in lactating goat's diet.  PSO and LSO inclusion in diet did not affect goat's dairy performance.  PSO increased total antioxidant capacity (TAC), but LSO decreased TAC of milk.  Dietary PSO increased total polyphenols and decreased somatic cell count in milk.

Iranian Journal of Nutrition Sciences and Food Technology, Sep 15, 2017

Journal of Porous Materials, Mar 25, 2022

The aim of this study was to encapsulate 2-tert-butylhydroquinone (TBHQ), as a common synthetic a... more The aim of this study was to encapsulate 2-tert-butylhydroquinone (TBHQ), as a common synthetic antioxidant in food industries, by mesoporous silica nanoparticles (MSNs) and their amine-functionalized nanoparticles (AP-MSNs). Release profiles of TBHQ from nanocarriers in the simulated body, gastric, and gastrointestinal fluids were investigated. In addition, the cytotoxicity effects of free-TBHQ, TBHQ-loaded MSNs (MSNs/TBHQ), and TBHQ-loaded AP-MSNs (AP-MSNs/TBHQ) were studied using MTT assay. Results showed that the AP-MSNs has a little effect on TBHQ loading percentage (2% increased), whereas it has a considerable effect on the TBHQ release pattern. Cell viability studies indicated that viability in treated cells by nanoparticles or free-TBHQ was in a time- and dose-dependent manner. For MSNs/TBHQ and AP-MSNs/TBHQ, a lower cytotoxicity was detected at different concentrations. Sustained release of TBHQ from nanocarriers with increase of its antioxidant activity was observed. The cellular uptake of MSNs/TBHQ and AP-MSNs/TBHQ by MCF-7 and HPHMF cells was confirmed by TEM images.

Food Analytical Methods, Sep 17, 2021

Herein, the current investigation presents the study of two novel methods namely saponification l... more Herein, the current investigation presents the study of two novel methods namely saponification liquid–liquid extraction coupled TLC (Sp-LLE-TLC) and direct liquid–liquid microextraction (LLME). These two methods were developed for enhanced determination of vitamin D3 in the fortified sunflower oil prior HPLC–UV analysis. By employing the proposed methods, linear dynamic range of 0.1–10 µg m/L with high determination coefficient of R2 > 0.94 was achieved in this work. Moreover, the obtained limit of detection and recovery values were found to be in reasonable range of 0.03–0.1 µg m/L and 71.7–101.44% (RSDs, 1.2–6.1%), respectively. Finally, by comparing two methods, the LLME was found to be green (organic solvent 500 µL), fast, and economic method for determination of vitamin D3 in the fortified sunflower oil as compared to Sp-LLE-TLC. Thus, the current work proposed a facile, economic, and green method for fast estimation of vitamin D3 in the fortified sunflower oil.

Meat Science, Jul 1, 2019

Twenty-four Mahabadi goat kids (5-6 months of age) were used to evaluate the effects of feeding o... more Twenty-four Mahabadi goat kids (5-6 months of age) were used to evaluate the effects of feeding olive leaves (OL) on performance, carcass traits and antioxidant status. The kids received three dietary treatments for 84 d with three levels of OL: 0 (control), 7.5 (OL7.5) and 15 (OL15) % (DM basis). Supplementation with OL had no effects on kid performance (P> 0.05). Total antioxidant capacity (TAC) was increased and malondialdehyde (MDA) concentration was decreased in plasma blood (P< 0.01) and Longissimus lumborum (LL) muscle (days 1, 4, 7 and 10) of kids (P< 0.01) with increasing level of OL in diet. The activity of glutathione peroxidase (GSH-Px) in LL muscle was increased (P< 0.05) in OL15 fed kids compared with control group. Also, glucose content of serum was decreased by adding OL to kid diets (P< 0.01). Finally, inclusion of OL to kid diets resulted in similar growth performance compared to alfalfa feeding, and improved the antioxidative potential of LL muscle.

World Mycotoxin Journal, Jul 1, 2020

The effect of heating (roasting and microwave radiation heating) along with a traditional pistach... more The effect of heating (roasting and microwave radiation heating) along with a traditional pistachio flavouring mixture (containing verjuice, thyme extract, and sodium chloride) was investigated on reducing aflatoxins (AFs) and ochratoxin A (OTA) in pistachios. The naturally and artificially contaminated samples were soaked in the flavouring mixture (for 5, 10 and 24 h) and then subjected to roasting (at 120 and 150 °C for 50 min) and heating by microwave radiation (6 and 10 min). The residual mycotoxins were determined by high-performance liquid chromatography. The results showed that all treatments were able to reduce mycotoxin content (aflatoxin B 1 , B 2 , G 1 , G 2 and OTA) significantly (P<0.05), up to 85.7±2.5% (during roasting) and up to 72.5±2.6% (during heating by microwave radiation). The highest reduction of AFs and OTA (ranging from 51.7±2.3 to 85.7±2.5%) was found when the contaminated (naturally and artificially) samples were soaked in the traditional mixture for 24 h and roasted at 150 °C. It could be concluded that the traditional flavouring method in combination with the roasting process or heating by microwave radiation could be applied as a useful and safe method for mycotoxin degradation in pistachio. Although, complete elimination of mycotoxins was not achieved, the method reduced mycotoxins more than 60% without adverse effect on the taste and appearance of pistachios.

Livestock Science, Nov 1, 2016

The objective of this experiment was to investigate the effects of dietary pomegranate seed oil a... more The objective of this experiment was to investigate the effects of dietary pomegranate seed oil and linseed oil on lactational performance, ruminal fermentation parameters, nutrients digestibility and milk fatty acid (FA) content, particularly conjugated linoleic acid (CLA), conjugated linolenic acid (CLnA) and vaccenic acid (VA) of dairy goats. Twenty-four Mahabadi goats in mid lactation were assigned to three dietary treatments: 1-control diet, basal diet without added oil (CON), 2-diet supplemented with 25 g/kg pomegranate seed oil (PSO), and 3diet supplemented with 25 g/kg linseed oil (LSO), on a dry matter (DM) basis. Feed intake, milk yield and 4% fat-corrected milk yield were similar for goats fed different diets. Milk fat concentration (P < 0.01) and fat/ protein ratio (P < 0.0001) of goats fed PSO and LSO diets increased, while milk protein, lactose and solid not fat concentrations were not affected by diets (P > 0.05). Addition of vegetable oils to diet had no effect on apparent digestibility of nutrients and ruminal fermentation parameters (P > 0.05). The proportions of VA (P < 0.001) and C18:1 (trans-9+trans-10, P < 0.01) acids were increased in milk fat from goats fed PSO and LSO diets compared with goats fed CON diet. The concentration of cis-9, trans-11 CLA (rumenic acid) increased with oil supplements (P < 0.0001) and was greatest for goats fed PSO diet. Compared with CON and LSO diets, feeding PSO diet increased cis-9, trans-11, cis-13 C18:3 CLnA (punicic acid) in milk fat (P < 0.0001). The concentrations of monounsaturated fatty acids (MUFA; P < 0.05), polyunsaturated fatty acids (PUFA; P < 0.0001) and n-3PUFA (P < 0.0001) increased and n-6/n-3 PUFA ratio (P < 0.0001) decreased with oil supplemented diets. In conclusion, feeding PSO and LSO to dairy goats was a useful way to increase milk fat, CLA, and VA content of milk and to reduce the n-6/n-3 PUFA ratio without negative effects on intake, milk yield, and nutrients digestibility.

Food Science and Nutrition, Jun 16, 2023

This study investigated the physicochemical properties and polyphenol composition of extra virgin... more This study investigated the physicochemical properties and polyphenol composition of extra virgin olive oils (EVOOs) extracted from three olive cultivars. The investigated cultivars were Arbequina, Koroneiki, and Manzanilla, grown in Olive Research Station in Rudbar county, Gilan province, Iran, at three ripening stages. Several parameters were analyzed, including peroxide and acidity values, unsaponifiable matter, oxidative stability, total aliphatic alcohols, fatty acids (FAs), sterols, and triacylglycerol composition. The results showed that as maturity increased, parameters such as oil content, acidity value, and iodine value, rise, while parameters including peroxide value, oxidative stability, aliphatic alcohols, and unsaponifiable matter decreased (p < .05). The saponification value was slightly reduced in the developing ripening process (p > .05). The MUFA/PUFA ratio and total sterol content declined during the olive ripening stages (p < .05). The triterpenes decreased in Arbequina and Koroneiki cultivars but increased in Manzanilla cultivar during the maturity stages. According to the data, oleuropein decreased while oleuropein aglycone, oxidized aldehyde, and hydroxylic form of oleuropein increased for all EVOOs during maturation. Apigenin, quercetin, ligstroside aglycone, aldehyde and hydroxylic form, ferulic acid, caffeic acid, and catechin decreased during the ripening of fruits (p < .05). The main triglycerides were triolein (OOO), palmitodiolein (POO), dioleolinolein (OOL), and palmitooleolinolein (PLO) in all EVOOs. In addition, the olive cultivar and harvesting date influence the physicochemical properties and polyphenol composition of EVOOs extracted from olive varieties grown in one region. In conclusion, the results can present helpful information to determine the optimum maturity stage for the investigated olive cultivars.

Biodesulfurization (BDS) offers the potential for an effective method for lowering the sulfur con... more Biodesulfurization (BDS) offers the potential for an effective method for lowering the sulfur content of petroleum products because insufficiently desulfurized distillates of petroleum products is a significant source of environmental pollution. This review describes the development of BDS; and compares destructive and non-destructive pathways as well as aerobic and anaerobic BDS. The process variables affecting growth and activity of microorganisms of BDS are described. Also genetic modifications and bioreactor designs, which lead to an increased BDS efficiency and commercial aspects, are discussed. Finally, the critical factor for industrial application of BDS as an efficient process is an adequate bioreactor design. The application of mixtures of biocatalysts is necessary for an efficient desulfurization of crude oil containing a wide range of sulfur compounds.

International Journal of Biological Macromolecules

Journal of Food Measurement and Characterization

Biodegradable Polymer-Based Food Packaging, 2022

Food Science & Nutrition

In this study, physicochemical and quality properties, fatty acid composition, and triglyceride c... more In this study, physicochemical and quality properties, fatty acid composition, and triglyceride composition of Iranian Kurdish butter oil (IKBO) obtained from yogurt drink (doogh) butter were investigated. Local doogh butter, prepared from cow's (CIKBO) and ewe's milk (EIKBO), was utilized as the raw material for this purpose. The free fatty acids (FFA) and peroxide values of IKBOs of the cow (CIKBO) and ewe (EIKBO) were obtained at 0.41 ± 0.01 and 0.39 ± 0.01 (g Oleic acid 100/g oil), and 1.32 ± 0.00 and 1.35 ± 0.00 (meq O2 kg/oil), respectively. The amounts of saturated fatty acids (SFAs): 70.27 ± 0.62 and 72.13 ± 0.84 (g/100 g), monounsaturated fatty acids (MUFAs): 19.37 ± 0.74 and 20.56 ± 0.97 (g/100 g), and polyunsaturated fatty acids (PUFAs): 1.22 ± 0.12 and 2.75 ± 0.38 (g/100 g) were obtained in CIKBO and EIKBO, respectively. The significant majority of the fatty acids (FAs) in the examined CIKBO and EIKBO were myristic (CIKBO: 13.76 ± 0.02 (g/100 g) and EIKBO: 14.83 ...