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Papers by LUIS MIGUEL VALVAS LINARES

The Journal of Immunology

Osteosarcoma (OS) and Ewing tumor (ET) together account for the majority of musculoskeletal sarco... more Osteosarcoma (OS) and Ewing tumor (ET) together account for the majority of musculoskeletal sarcomas diagnosed in patients of all ages and nearly 90% of those occurring in children and adolescents. Natural IgM antibodies to tumor antigen have been reported in patients with early-stage cancer, and a panel of serum antibodies can detect cancer many years prior to imaging detection. Circulating immune complexes formed by tumor antigens and immunoglobulin M (IgM) represent a novel class of biomarkers with diagnostic value for early cancer detection. In the present study, we investigated the presence of ANG-IgM, VEGF-IgM, bFGF-IgM, PDGF-IgM in the sera of children with bone tumors. The study included 174 pediatric patients with newly diagnosed bone tumors. Express ELISA techniques have been developed to quantify immune complexes in INR. Serum samples from all patients were analyzed for the presence of biomarker-IgM immune complexes. We compared the serum level of angiogenic factors and i...

Proceedings of the Ninth International Conference on Enterprise Information Systems, 2007

The rendering process allows the developer to obtain a raster 2D image from the definition of a 3... more The rendering process allows the developer to obtain a raster 2D image from the definition of a 3D scene. This process is computationally intensive if the source scene has a certain complexity or high-quality images are required. Therefore, a lot of time is spent and many computational resources are needed. In this paper, a novel approach called QUEKARO (standing for a QUalitative Expert Knowledge Approach to Rendering Optimization) is presented for adjusting some relevant parameters involved in the rendering process by using expert systems. This way, the developer can obtain optimized results which reduce the time spent in the rendering process and, in most cases, do not affect the final quality of the raster 2D image. These results will be exposed on the result section, in which different optimizations will be studied. As we discuss on the final section of this paper, the use of expert systems in the rendering process involves a novel approach which reduces drastically the resources used and provides us with a high-scalable system. Using these arguments, we will justify the inclusion of expert systems in this area and will study future works.

Proceedings of the International Conference on Agents and Artificial Intelligence, 2009

Nowadays, the design and development of intelligent surveillance systems is a hot research topic ... more Nowadays, the design and development of intelligent surveillance systems is a hot research topic thanks to the recent advances in related fields such as computer perception, artificial intelligence, and distributed devices infrastructures. These systems are gradually going from the classic CCTV passive surveillance systems towards systems which are capable of offering automatic interpretation of the events occurred in a monitored environment and decision support information based on the data obtained from a number of heterogeneous perception devices. In this work, we introduce the formal definition of an intermediate layer in the architecture of an intelligent surveillance system, of which purpose is to provide the components responsible for performing the reasoning processes with the data from the environment they need. Such data is provided by means of environment views, which are data objects that contain not only data from different sensors, but also associated semantics which depends on the particular context in which the analysis of the normality of a concept is performed.

Proceedings of the 11th International Conference on Enterprise Information, 2009

Recently, there is a growing interest in the development and deployment of intelligent surveillan... more Recently, there is a growing interest in the development and deployment of intelligent surveillance systems capable of finding out and analyzing simple and complex events that take place on scenes monitored by cameras. Within this context, the use of expert knowledge may offer a realistic solution when dealing with the design of a surveillance system. In this paper, we briefly describe the architecture of an intelligent surveillance system based on normality components and expert knowledge. These components specify how a certain object must ideally behave according to one concept. A specific normality component which analyzes the trajectories followed by objects is studied in depth in order to analyze behaviors in an outdoor environment. The analysis of trajectories in the surveillance context is an interesting issue because any moving object has always a goal in an environment, and it usually goes towards one destination to achieve it.

AIP Conference Proceedings, 2004

In this work we study the strange quark matter in an extented version of the Chromodielectric Mod... more In this work we study the strange quark matter in an extented version of the Chromodielectric Model (CDM) with a BCS quark pairing implemented, and analyze the superconducting color flavor locked (CFL) phase. We compare the equation of state and the stability of the strange quark matter from QCD in the CFL phase with the superconducting version of the CDM. In the CDM there is a confining potential which originates a dynamical bag constant in the sense that its value depends on the density. Our results indicate that the inclusion in the energy density of the pairing quark interaction allows for an absolutely stable quark matter state even for large potential energies, preventing the metastability of quark matter found in the CDM at high densities.

Una Perspectiva De La Inteligencia Artificial En Su 50 Aniversario Campus Multidisciplinar En Percepcion E Inteligencia Cmpi 2006 Albacete Espana 10 14 De Julio Del 2006 Actas Vol 2 2006 Isbn 84 689 9562 2 Pags 763 768, 2006

Scientia agropecuaria, 2011

Resumen El objetivo de la presente revisión científica fue sistematizar información bibliográfica... more Resumen El objetivo de la presente revisión científica fue sistematizar información bibliográfica actualizada, concerniente a los aspectos genéticos, morfológicos, zootécnicos y potencial carnicero de los cerdos criollos de Latinoamérica encontró una población de 73 millones de cerdos criollos en Latinoamérica, la mayoría de ellos criados bajo sistemas de producción extensivos, semiextensivos y agro pastoriles. Dado su origen europeo, la adaptación a los diferentes ecosistemas del continente y la introducción de razas ha devenido en una gran diversidad de cerdos criollos, lo que ha dado origen al aumento de variabilidad genética de los cerdos criollos latinos beneficiando su rusticidad, que involucra una mayor eficiencia del sistema inmunológico. De la misma manera, su calidad de omnívoro le permitió una buena adaptación a regímenes alimentarios variados. Los cerdos criollos manifiestan un comportamiento reproductivo aceptable, tomando como referencia los indicadores de producción intensiva, precocidad sexual y alta viabilidad de los lechones al destete; sin embargo, su crecimiento es lento y su periodo de lactancia es largo. Con respecto a la calidad de sus cortes cárnicos, tomando en cuenta criterios subjetivos como la terneza y el valor nutricional, el cerdo criollo tiene mayor valor económico aventajando a los cerdos hipermagros.

Scientia agropecuaria, 2010

El objetivo de esta investigación fue determinar el grado de competencia alimentaria entre el gua... more El objetivo de esta investigación fue determinar el grado de competencia alimentaria entre el guanaco y el ganado doméstico en la Reserva Nacional de Calipuy. La cobertura vegetal (CV) se determinó con un censo de vegetación y la composición de las dietas mediante la técnica microhistológica de las heces (50 guanacos, 35 vacunos y 25 equinos). La sobreposición dietaria se determinó mediante el Índice de Horn (I), las preferencias alimentarias mediante el índice de Ivlev (E), y la diversidad de la dieta con índice de Shannon-Weaver (D). Se encontró una baja-moderada competencia alimentaria entre el guanaco y el ganado bovino y equino. La sobreposición dietaria fue mayor durante la época lluviosa (I =0. 80 y 0.88) en que la oferta de forraje fue alta (CV= 63%); y menor durante la época seca (I=0.58 y 0.64) en que hubo escasez de alimento (CV=50%). El guanaco fue un consumidor selectivo intermedio. La diversidad dietaria de los adultos aumentó durante la época seca (D = 0.62; p<0.01) incluyendo hasta un 70% de hierbas y arbustos, mostrando una alta flexibilidad alimentaria entre estaciones (I=0.64) y hábitats (I=0.75, p<0.01), lo que le permitió minimizar la competencia con el ganado bovino y equino, que consumió principalmente gramíneas en ambas estaciones (>60%) y no mostró la misma flexibilidad (I=0.90, p<0.01). Los juveniles y los chulengos fueron más sensibles a las variaciones estacionales, consumiendo un menor porcentaje de arbustos pero tuvieron una preferencia marcada por las hierbas bajas.

The 2010 International Power Electronics Conference - ECCE ASIA -, 2010

For material removal in rotor balancing machines, dry Electrical Discharge Machining (EDM) with l... more For material removal in rotor balancing machines, dry Electrical Discharge Machining (EDM) with large working gap is an advantageous alternative to the common mechanical drilling, grinding or laser drilling. This paper presents a novel topology of a power supply required for such an application. It has an increased ignition voltage capability of up to 10 kV compared to standard power supplies with only 300 V, which allows for an increase in working gap distance to millimeters. The control of the current pulse amplitude and length are described. Voltage and current measurements verify the design considerations prove the feasibility of the proposed power supply. I.

International Journal of Pattern Recognition and Artificial Intelligence, 2009

Intelligent surveillance refers to using Artificial Intelligence techniques in order to improve s... more Intelligent surveillance refers to using Artificial Intelligence techniques in order to improve surveillance and deal with semantic information obtained from low-level security devices. In this context, the use of expert knowledge may offer a more realistic solution when dealing with the design of a surveillance system. In this work, a conceptual framework based on normality analysis to detect abnormal behaviors by means of normality concepts is presented. A normality concept specifies how a certain object should ideally behave in a concrete environment depending on such a concept. The definition of the normal path concept is studied in depth in order to analyze behaviors in an outdoor environment.

Communications in Computer and Information Science, 2010

ABSTRACT In this paper, a novel algorithm to carry out the segmentation of moving objects in dyna... more ABSTRACT In this paper, a novel algorithm to carry out the segmentation of moving objects in dynamic cameras is proposed. The developed system distinguishes what actions to execute in function of the environment conditions. In this way, the algorithm can segment objects in static and dynamic scenes and in ideal and noisy conditions. Therefore, the main target of this system is to cover the wider range of ambient situations. The segmentation algorithms have been developed for H.264 compressed domain because it is a modern encoder used in many modern multimedia applications and it can be decoded in real-time. Experimental results show promising performance in standard video sequences.

Scientia Agropecuaria, 2010

El objetivo de esta investigación fue conocer la distribución y organización social del guanaco e... more El objetivo de esta investigación fue conocer la distribución y organización social del guanaco en la Reserva Nacional de Calipuy (RNC), La Libertad, Perú. Se reportaron 430 guanacos con ligera tendencia a la baja (b=-10.21), distribuidos en 114 km 2. Los adultos fueron más numerosos con 73.5 %  (p<0.01), seguido de los juveniles y chulengos con 16.1% y 10.4% respectivamente. El 72 % de la población se encontró en grupos familiares, 18% en tropillas y los solitarios representaron el 10 %. La densidad fue de 5.7 individuos/km 2. La población estuvo en su mayoría concentrada en la zona norte, sobre los 3000 msnm (p<0.01), que además es la más vigilada; alcanzando densidades de 18.9  8.97 guanacos/km 2 y albergando principalmente a grupos familiares. La zona occidental, bajo 3000 msnm y más cercana a la zona ganadera, obtuvo la densidad más baja de 0.24 0.24 guanacos/km 2 , y mantuvo principalmente a solitarios y grupos de machos.

Reumatologia clinica, Jan 11, 2014

To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel ... more To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA). AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID): SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics. The main objective was to assess the coexistence of these diseases and of uveitis, based on the patients' clinical history up to the study entry. A total of 601 patients with SpA (men: 63.1%; women: 36.9%) were enrolled. The specific diagnoses were: ankylosing spondylitis (55.1%),…

Reports of Practical Oncology & Radiotherapy, 2014

This study evaluates the acute toxicity outcome in patients treated with RapidArc for localized p... more This study evaluates the acute toxicity outcome in patients treated with RapidArc for localized prostate cancer. Background: Modern technologies allow the delivery of high doses to the prostate while lowering the dose to the neighbouring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known. Materials and methods: Between December 2009 and May 2012, 45 patients with primary prostate adenocarcinoma were treated using RapidArc. All patients received 1.8 Gy per fraction, the median dose to the prostate gland, seminal vesicles, pelvic lymph nodes and surgical bed was 80 Gy (range, 77.4-81 Gy), 50.4 Gy, 50.4 Gy and 77.4 Gy (range, 75.6-79.2 Gy), respectively. Results: The time between the last session and the last treatment follow up was a median of 10 months (range, 3-24 months). The incidence of grade 3 acute gastrointestinal (GI) and genitourinary (GU) toxicity was 2.2% and 15.5%, respectively. Grade 2 acute GI and GU toxicity occurred in 30% and 27% of patients, respectively. No grade 4 acute GI and GU toxicity were observed. Older patients (>median) or patients with V60 higher than 35% had significantly higher rates of grade ≥2 acute GI toxicity compared with the younger ones. Conclusions: RapidArc in the treatment of localized prostate cancer is tolerated well with no Grade >3 GI and GU toxicities. Older patients or patients with higher V60 had significantly higher rates of grade ≥2 acute GI toxicity. Further research is necessary to assess definitive late toxicity and tumour control outcome.

Transplantation Proceedings, 2007

Background. Cytomegalovirus (CMV) disease is associated with an increased net immunosuppressive s... more Background. Cytomegalovirus (CMV) disease is associated with an increased net immunosuppressive state in solid organ transplant recipients, leading to more bacterial and fungal infections. The release of pro-and anti-inflammatory cytokines could be one of the responsible factors. Methods. We prospectively included all patients undergoing solid organ transplantation between April and November 2004. During follow-up, plasma samples were collected in the immediate postsurgical period, at the first and second months, at the time of maximum antigenemia during CMV disease, and at 6 months posttransplantation. We determine the levels of tumor necrosis factor (TNF)-␣, interleukin (IL)-6, and IL-10. Log-transformed data were compared by a nonparametric Wilcoxon test for related variables. Results. During the study period, we monitored 146 recipients of solid organ transplantation: 77 kidneys, 8 kidney-pancreas, 46 liver, 11 heart, 2 liver-kidney, and 2 heart-kidney. No differences were observed between the TNF-␣ and IL-10 levels in the immediate postsurgical period or during CMV disease. TNF-␣ and IL-10 levels during CMV disease were higher than levels during the first month (mean TNF-␣ first month ϭ 12.71 pg/mL vs CMV disease ϭ 22.71 pg/mL, P ϭ .028; mean IL-10 first month ϭ 3.47 pg/mL vs CMV disease ϭ 19.2 pg/mL, P ϭ .018). Th1/Th2 ratio (measured as TNF-␣/IL-10) was 1.75 in the immediate postsurgical period, 7.5 during the first month, 1.86 at the time of CMV disease, and 4.61 at the sixth month. The difference in Th1/Th2 ratio during CMV disease and in the first month was statistically significant (P ϭ .043). Conclusion. During CMV disease, we observed an increase in TNF-␣ and IL-10 release, which was similar to that during the postsurgical period. An imbalance toward an anti-inflammatory pattern was noted in these two periods. This could reflect a cooperative factor increasing the net state of immunosuppression during CMV disease. C YTOMEGALOVIRUS (CMV) disease is a wellrecognized risk factor for bacterial and fungal superinfections due to increased immunosuppression of a solid organ transplantation recipients. Moreover, CMV has been shown to be an independent factor associated with mortality among liver transplant recipients, due to an increased incidence of bacterial infections. 1 During CMV disease, several cytokines, chemokines, and adhesion molecules are

Transplantation Proceedings, 2007

Background. Mutiresistant bacterial infections are an emerging problem in the nosocomial setting.... more Background. Mutiresistant bacterial infections are an emerging problem in the nosocomial setting. Our objectives were to describe the incidence, outcome, and risk factors for acquisition of multiresistant bacteria among renal transplant recipients. Methods. We prospectively followed patients undergoing kidney transplantation over a 3-year period. We collected demographic features, underlying chronic diseases, and main transplant characteristics and complications. Multiple antibiotic resistance was defined for the most important bacteria: Enteric gram-negative bacilli resistant to betalactamics, cephalosporins, and quinolones; Staphylococcus aureus resistant to methicillin, cotrimoxazole, and clindamcin; Enterococcus spp resistant to ampicillin and quinolones; nonfermentator bacilli resistant to all antibiotics except aminoglycosides and collistin. Results. Overall, 416 patients included 65 double transplants (62 kidney-pancreas and three kidney-liver) of mean age 48.5 years, and 57% men. Infection with multiresistant bacteria was observed in 58 patients (14%). Most frequent multiresistant bacteria were: Escherichia coli (n ϭ 33), Klebsiella spp (n ϭ 15), Citrobacter spp (n ϭ 8), Enterobacter spp (n ϭ 5), Morganella morganii (n ϭ 2), Pseudomonas aeruginosa (n ϭ 16), Acinetobacter baumanii (n ϭ 2), Enterococcus spp (n ϭ 9) and methicillin-resistant S. aureus (MRSA, n ϭ 2). Age greater than 50 years, hepatitis C virus infection, double kidney-pancreas transplantation, requirement for posttransplant hemodialysis, surgical reoperation, and requirement for nephrostomy were independent variables associated with multiresistant bacterial infection. Most used antibiotics for treatment were: carbapenems (65%), amikacin (12%), linezolid, piperacillin-tazobactam, vancomycin, collistin, and fosfomycin. Infection with multiresistant bacteria was associated with a worse prognosis (graft loss or death, 19% vs 8%, P ϭ .009). Conclusions. The incidence of infection with multiresistant bacteria in our renal transplant cohort was high, being most frequently cephalosporin-resistant enteric gramnegative bacilli and multiresistant P aeruginosa. Methicillin-resistant S. aureus incidence was low. Infection with multiresistant bacteria conferred a worse prognosis.

Seminars in Oncology, 2003

Local control of carcinoma of the prostate, when treated with radiation therapy, is dose related.... more Local control of carcinoma of the prostate, when treated with radiation therapy, is dose related. It is well documented that higher radiation doses can produce definitive improvement but not without an increased risk of developing gastrointestinal and/or genitourinary toxicities. Radioprotective agents, such as amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD), have been proven to reduce radiotherapy-induced toxicities to normal tissue in patients with head and neck, thoracic, and pelvic tumors. Based on this information, and in an effort to determine the effectiveness of radioprotective agents in patients with prostate cancer, our institution developed a protocol involving use of amifostine in patients with prostate cancer treated with external beam radiation to a total dose of 45 Gy and/or high-dose rate brachytherapy. High-dose rate doses are 6 Gy times three fractions for combined therapy and 9.3 Gy times four fractions for the monotherapy group. To date, 13 patients have been treated, with preliminary results indicating an acceptably low incidence of gastrointestinal and genitourinary toxicities, including no acute blood pressure changes or skin reactions. However, there have been three cases of severe cardiopulmonary events, which are discussed in detail.

Rheumatology, 2011

Objectives. Etanercept 50 mg a week is approved in the treatment of AS. Increasing the etanercept... more Objectives. Etanercept 50 mg a week is approved in the treatment of AS. Increasing the etanercept dose to 100 mg/week improves efficacy in cutaneous psoriasis, a clinical manifestation related to the spondylarthritis family, while maintaining its safety profile. The purpose of this study was to evaluate the efficacy and safety of etanercept 100 vs 50 mg/week in patients with AS. Methods. Adult patients with AS were randomized to receive etanercept 50 mg twice a week (biw), or etanercept 50 mg once a week (qw) for 12 weeks. The primary efficacy endpoint was Ankylosing Spondylitis Assessment Study (ASAS20) response at Week 12; secondary endpoints included ASAS40, ASAS50, ASAS70 and ASAS5/6 responses, partial remission and quality of life. Safety was assessed until 15 days after the last visit. Results. A total of 108 patients were randomly selected and treated, 54 in each arm. At 12 weeks, ASAS20 response was achieved by 34 (71%) out of 48 patients of the etanercept 50 mg biw group and by 37 (76%) out of 49 patients of the etanercept 50 mg qw group (not statistically significant differences). Other efficacy variables improved significantly over time, but not between treatment groups. Fifty-six patients experienced at least one adverse event (generally, infections and infestations, gastrointestinal disorders and injection site reactions), most of them mild or moderate. Conclusions. High-dose (100 mg/week) etanercept in the treatment of AS for 12 weeks is as safe as the standard dose (50 mg/week). However, it does not significantly increase its efficacy. Trial Registration. Clinicaltrials.gov, http://clinicaltrials.gov/, NCT00873730.

The Journal of Immunology

Osteosarcoma (OS) and Ewing tumor (ET) together account for the majority of musculoskeletal sarco... more Osteosarcoma (OS) and Ewing tumor (ET) together account for the majority of musculoskeletal sarcomas diagnosed in patients of all ages and nearly 90% of those occurring in children and adolescents. Natural IgM antibodies to tumor antigen have been reported in patients with early-stage cancer, and a panel of serum antibodies can detect cancer many years prior to imaging detection. Circulating immune complexes formed by tumor antigens and immunoglobulin M (IgM) represent a novel class of biomarkers with diagnostic value for early cancer detection. In the present study, we investigated the presence of ANG-IgM, VEGF-IgM, bFGF-IgM, PDGF-IgM in the sera of children with bone tumors. The study included 174 pediatric patients with newly diagnosed bone tumors. Express ELISA techniques have been developed to quantify immune complexes in INR. Serum samples from all patients were analyzed for the presence of biomarker-IgM immune complexes. We compared the serum level of angiogenic factors and i...

Proceedings of the Ninth International Conference on Enterprise Information Systems, 2007

The rendering process allows the developer to obtain a raster 2D image from the definition of a 3... more The rendering process allows the developer to obtain a raster 2D image from the definition of a 3D scene. This process is computationally intensive if the source scene has a certain complexity or high-quality images are required. Therefore, a lot of time is spent and many computational resources are needed. In this paper, a novel approach called QUEKARO (standing for a QUalitative Expert Knowledge Approach to Rendering Optimization) is presented for adjusting some relevant parameters involved in the rendering process by using expert systems. This way, the developer can obtain optimized results which reduce the time spent in the rendering process and, in most cases, do not affect the final quality of the raster 2D image. These results will be exposed on the result section, in which different optimizations will be studied. As we discuss on the final section of this paper, the use of expert systems in the rendering process involves a novel approach which reduces drastically the resources used and provides us with a high-scalable system. Using these arguments, we will justify the inclusion of expert systems in this area and will study future works.

Proceedings of the International Conference on Agents and Artificial Intelligence, 2009

Nowadays, the design and development of intelligent surveillance systems is a hot research topic ... more Nowadays, the design and development of intelligent surveillance systems is a hot research topic thanks to the recent advances in related fields such as computer perception, artificial intelligence, and distributed devices infrastructures. These systems are gradually going from the classic CCTV passive surveillance systems towards systems which are capable of offering automatic interpretation of the events occurred in a monitored environment and decision support information based on the data obtained from a number of heterogeneous perception devices. In this work, we introduce the formal definition of an intermediate layer in the architecture of an intelligent surveillance system, of which purpose is to provide the components responsible for performing the reasoning processes with the data from the environment they need. Such data is provided by means of environment views, which are data objects that contain not only data from different sensors, but also associated semantics which depends on the particular context in which the analysis of the normality of a concept is performed.

Proceedings of the 11th International Conference on Enterprise Information, 2009

Recently, there is a growing interest in the development and deployment of intelligent surveillan... more Recently, there is a growing interest in the development and deployment of intelligent surveillance systems capable of finding out and analyzing simple and complex events that take place on scenes monitored by cameras. Within this context, the use of expert knowledge may offer a realistic solution when dealing with the design of a surveillance system. In this paper, we briefly describe the architecture of an intelligent surveillance system based on normality components and expert knowledge. These components specify how a certain object must ideally behave according to one concept. A specific normality component which analyzes the trajectories followed by objects is studied in depth in order to analyze behaviors in an outdoor environment. The analysis of trajectories in the surveillance context is an interesting issue because any moving object has always a goal in an environment, and it usually goes towards one destination to achieve it.

AIP Conference Proceedings, 2004

In this work we study the strange quark matter in an extented version of the Chromodielectric Mod... more In this work we study the strange quark matter in an extented version of the Chromodielectric Model (CDM) with a BCS quark pairing implemented, and analyze the superconducting color flavor locked (CFL) phase. We compare the equation of state and the stability of the strange quark matter from QCD in the CFL phase with the superconducting version of the CDM. In the CDM there is a confining potential which originates a dynamical bag constant in the sense that its value depends on the density. Our results indicate that the inclusion in the energy density of the pairing quark interaction allows for an absolutely stable quark matter state even for large potential energies, preventing the metastability of quark matter found in the CDM at high densities.

Una Perspectiva De La Inteligencia Artificial En Su 50 Aniversario Campus Multidisciplinar En Percepcion E Inteligencia Cmpi 2006 Albacete Espana 10 14 De Julio Del 2006 Actas Vol 2 2006 Isbn 84 689 9562 2 Pags 763 768, 2006

Scientia agropecuaria, 2011

Resumen El objetivo de la presente revisión científica fue sistematizar información bibliográfica... more Resumen El objetivo de la presente revisión científica fue sistematizar información bibliográfica actualizada, concerniente a los aspectos genéticos, morfológicos, zootécnicos y potencial carnicero de los cerdos criollos de Latinoamérica encontró una población de 73 millones de cerdos criollos en Latinoamérica, la mayoría de ellos criados bajo sistemas de producción extensivos, semiextensivos y agro pastoriles. Dado su origen europeo, la adaptación a los diferentes ecosistemas del continente y la introducción de razas ha devenido en una gran diversidad de cerdos criollos, lo que ha dado origen al aumento de variabilidad genética de los cerdos criollos latinos beneficiando su rusticidad, que involucra una mayor eficiencia del sistema inmunológico. De la misma manera, su calidad de omnívoro le permitió una buena adaptación a regímenes alimentarios variados. Los cerdos criollos manifiestan un comportamiento reproductivo aceptable, tomando como referencia los indicadores de producción intensiva, precocidad sexual y alta viabilidad de los lechones al destete; sin embargo, su crecimiento es lento y su periodo de lactancia es largo. Con respecto a la calidad de sus cortes cárnicos, tomando en cuenta criterios subjetivos como la terneza y el valor nutricional, el cerdo criollo tiene mayor valor económico aventajando a los cerdos hipermagros.

Scientia agropecuaria, 2010

El objetivo de esta investigación fue determinar el grado de competencia alimentaria entre el gua... more El objetivo de esta investigación fue determinar el grado de competencia alimentaria entre el guanaco y el ganado doméstico en la Reserva Nacional de Calipuy. La cobertura vegetal (CV) se determinó con un censo de vegetación y la composición de las dietas mediante la técnica microhistológica de las heces (50 guanacos, 35 vacunos y 25 equinos). La sobreposición dietaria se determinó mediante el Índice de Horn (I), las preferencias alimentarias mediante el índice de Ivlev (E), y la diversidad de la dieta con índice de Shannon-Weaver (D). Se encontró una baja-moderada competencia alimentaria entre el guanaco y el ganado bovino y equino. La sobreposición dietaria fue mayor durante la época lluviosa (I =0. 80 y 0.88) en que la oferta de forraje fue alta (CV= 63%); y menor durante la época seca (I=0.58 y 0.64) en que hubo escasez de alimento (CV=50%). El guanaco fue un consumidor selectivo intermedio. La diversidad dietaria de los adultos aumentó durante la época seca (D = 0.62; p<0.01) incluyendo hasta un 70% de hierbas y arbustos, mostrando una alta flexibilidad alimentaria entre estaciones (I=0.64) y hábitats (I=0.75, p<0.01), lo que le permitió minimizar la competencia con el ganado bovino y equino, que consumió principalmente gramíneas en ambas estaciones (>60%) y no mostró la misma flexibilidad (I=0.90, p<0.01). Los juveniles y los chulengos fueron más sensibles a las variaciones estacionales, consumiendo un menor porcentaje de arbustos pero tuvieron una preferencia marcada por las hierbas bajas.

The 2010 International Power Electronics Conference - ECCE ASIA -, 2010

For material removal in rotor balancing machines, dry Electrical Discharge Machining (EDM) with l... more For material removal in rotor balancing machines, dry Electrical Discharge Machining (EDM) with large working gap is an advantageous alternative to the common mechanical drilling, grinding or laser drilling. This paper presents a novel topology of a power supply required for such an application. It has an increased ignition voltage capability of up to 10 kV compared to standard power supplies with only 300 V, which allows for an increase in working gap distance to millimeters. The control of the current pulse amplitude and length are described. Voltage and current measurements verify the design considerations prove the feasibility of the proposed power supply. I.

International Journal of Pattern Recognition and Artificial Intelligence, 2009

Intelligent surveillance refers to using Artificial Intelligence techniques in order to improve s... more Intelligent surveillance refers to using Artificial Intelligence techniques in order to improve surveillance and deal with semantic information obtained from low-level security devices. In this context, the use of expert knowledge may offer a more realistic solution when dealing with the design of a surveillance system. In this work, a conceptual framework based on normality analysis to detect abnormal behaviors by means of normality concepts is presented. A normality concept specifies how a certain object should ideally behave in a concrete environment depending on such a concept. The definition of the normal path concept is studied in depth in order to analyze behaviors in an outdoor environment.

Communications in Computer and Information Science, 2010

ABSTRACT In this paper, a novel algorithm to carry out the segmentation of moving objects in dyna... more ABSTRACT In this paper, a novel algorithm to carry out the segmentation of moving objects in dynamic cameras is proposed. The developed system distinguishes what actions to execute in function of the environment conditions. In this way, the algorithm can segment objects in static and dynamic scenes and in ideal and noisy conditions. Therefore, the main target of this system is to cover the wider range of ambient situations. The segmentation algorithms have been developed for H.264 compressed domain because it is a modern encoder used in many modern multimedia applications and it can be decoded in real-time. Experimental results show promising performance in standard video sequences.

Scientia Agropecuaria, 2010

El objetivo de esta investigación fue conocer la distribución y organización social del guanaco e... more El objetivo de esta investigación fue conocer la distribución y organización social del guanaco en la Reserva Nacional de Calipuy (RNC), La Libertad, Perú. Se reportaron 430 guanacos con ligera tendencia a la baja (b=-10.21), distribuidos en 114 km 2. Los adultos fueron más numerosos con 73.5 %  (p<0.01), seguido de los juveniles y chulengos con 16.1% y 10.4% respectivamente. El 72 % de la población se encontró en grupos familiares, 18% en tropillas y los solitarios representaron el 10 %. La densidad fue de 5.7 individuos/km 2. La población estuvo en su mayoría concentrada en la zona norte, sobre los 3000 msnm (p<0.01), que además es la más vigilada; alcanzando densidades de 18.9  8.97 guanacos/km 2 y albergando principalmente a grupos familiares. La zona occidental, bajo 3000 msnm y más cercana a la zona ganadera, obtuvo la densidad más baja de 0.24 0.24 guanacos/km 2 , y mantuvo principalmente a solitarios y grupos de machos.

Reumatologia clinica, Jan 11, 2014

To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel ... more To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA). AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID): SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics. The main objective was to assess the coexistence of these diseases and of uveitis, based on the patients' clinical history up to the study entry. A total of 601 patients with SpA (men: 63.1%; women: 36.9%) were enrolled. The specific diagnoses were: ankylosing spondylitis (55.1%),…

Reports of Practical Oncology & Radiotherapy, 2014

This study evaluates the acute toxicity outcome in patients treated with RapidArc for localized p... more This study evaluates the acute toxicity outcome in patients treated with RapidArc for localized prostate cancer. Background: Modern technologies allow the delivery of high doses to the prostate while lowering the dose to the neighbouring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known. Materials and methods: Between December 2009 and May 2012, 45 patients with primary prostate adenocarcinoma were treated using RapidArc. All patients received 1.8 Gy per fraction, the median dose to the prostate gland, seminal vesicles, pelvic lymph nodes and surgical bed was 80 Gy (range, 77.4-81 Gy), 50.4 Gy, 50.4 Gy and 77.4 Gy (range, 75.6-79.2 Gy), respectively. Results: The time between the last session and the last treatment follow up was a median of 10 months (range, 3-24 months). The incidence of grade 3 acute gastrointestinal (GI) and genitourinary (GU) toxicity was 2.2% and 15.5%, respectively. Grade 2 acute GI and GU toxicity occurred in 30% and 27% of patients, respectively. No grade 4 acute GI and GU toxicity were observed. Older patients (>median) or patients with V60 higher than 35% had significantly higher rates of grade ≥2 acute GI toxicity compared with the younger ones. Conclusions: RapidArc in the treatment of localized prostate cancer is tolerated well with no Grade >3 GI and GU toxicities. Older patients or patients with higher V60 had significantly higher rates of grade ≥2 acute GI toxicity. Further research is necessary to assess definitive late toxicity and tumour control outcome.

Transplantation Proceedings, 2007

Background. Cytomegalovirus (CMV) disease is associated with an increased net immunosuppressive s... more Background. Cytomegalovirus (CMV) disease is associated with an increased net immunosuppressive state in solid organ transplant recipients, leading to more bacterial and fungal infections. The release of pro-and anti-inflammatory cytokines could be one of the responsible factors. Methods. We prospectively included all patients undergoing solid organ transplantation between April and November 2004. During follow-up, plasma samples were collected in the immediate postsurgical period, at the first and second months, at the time of maximum antigenemia during CMV disease, and at 6 months posttransplantation. We determine the levels of tumor necrosis factor (TNF)-␣, interleukin (IL)-6, and IL-10. Log-transformed data were compared by a nonparametric Wilcoxon test for related variables. Results. During the study period, we monitored 146 recipients of solid organ transplantation: 77 kidneys, 8 kidney-pancreas, 46 liver, 11 heart, 2 liver-kidney, and 2 heart-kidney. No differences were observed between the TNF-␣ and IL-10 levels in the immediate postsurgical period or during CMV disease. TNF-␣ and IL-10 levels during CMV disease were higher than levels during the first month (mean TNF-␣ first month ϭ 12.71 pg/mL vs CMV disease ϭ 22.71 pg/mL, P ϭ .028; mean IL-10 first month ϭ 3.47 pg/mL vs CMV disease ϭ 19.2 pg/mL, P ϭ .018). Th1/Th2 ratio (measured as TNF-␣/IL-10) was 1.75 in the immediate postsurgical period, 7.5 during the first month, 1.86 at the time of CMV disease, and 4.61 at the sixth month. The difference in Th1/Th2 ratio during CMV disease and in the first month was statistically significant (P ϭ .043). Conclusion. During CMV disease, we observed an increase in TNF-␣ and IL-10 release, which was similar to that during the postsurgical period. An imbalance toward an anti-inflammatory pattern was noted in these two periods. This could reflect a cooperative factor increasing the net state of immunosuppression during CMV disease. C YTOMEGALOVIRUS (CMV) disease is a wellrecognized risk factor for bacterial and fungal superinfections due to increased immunosuppression of a solid organ transplantation recipients. Moreover, CMV has been shown to be an independent factor associated with mortality among liver transplant recipients, due to an increased incidence of bacterial infections. 1 During CMV disease, several cytokines, chemokines, and adhesion molecules are

Transplantation Proceedings, 2007

Background. Mutiresistant bacterial infections are an emerging problem in the nosocomial setting.... more Background. Mutiresistant bacterial infections are an emerging problem in the nosocomial setting. Our objectives were to describe the incidence, outcome, and risk factors for acquisition of multiresistant bacteria among renal transplant recipients. Methods. We prospectively followed patients undergoing kidney transplantation over a 3-year period. We collected demographic features, underlying chronic diseases, and main transplant characteristics and complications. Multiple antibiotic resistance was defined for the most important bacteria: Enteric gram-negative bacilli resistant to betalactamics, cephalosporins, and quinolones; Staphylococcus aureus resistant to methicillin, cotrimoxazole, and clindamcin; Enterococcus spp resistant to ampicillin and quinolones; nonfermentator bacilli resistant to all antibiotics except aminoglycosides and collistin. Results. Overall, 416 patients included 65 double transplants (62 kidney-pancreas and three kidney-liver) of mean age 48.5 years, and 57% men. Infection with multiresistant bacteria was observed in 58 patients (14%). Most frequent multiresistant bacteria were: Escherichia coli (n ϭ 33), Klebsiella spp (n ϭ 15), Citrobacter spp (n ϭ 8), Enterobacter spp (n ϭ 5), Morganella morganii (n ϭ 2), Pseudomonas aeruginosa (n ϭ 16), Acinetobacter baumanii (n ϭ 2), Enterococcus spp (n ϭ 9) and methicillin-resistant S. aureus (MRSA, n ϭ 2). Age greater than 50 years, hepatitis C virus infection, double kidney-pancreas transplantation, requirement for posttransplant hemodialysis, surgical reoperation, and requirement for nephrostomy were independent variables associated with multiresistant bacterial infection. Most used antibiotics for treatment were: carbapenems (65%), amikacin (12%), linezolid, piperacillin-tazobactam, vancomycin, collistin, and fosfomycin. Infection with multiresistant bacteria was associated with a worse prognosis (graft loss or death, 19% vs 8%, P ϭ .009). Conclusions. The incidence of infection with multiresistant bacteria in our renal transplant cohort was high, being most frequently cephalosporin-resistant enteric gramnegative bacilli and multiresistant P aeruginosa. Methicillin-resistant S. aureus incidence was low. Infection with multiresistant bacteria conferred a worse prognosis.

Seminars in Oncology, 2003

Local control of carcinoma of the prostate, when treated with radiation therapy, is dose related.... more Local control of carcinoma of the prostate, when treated with radiation therapy, is dose related. It is well documented that higher radiation doses can produce definitive improvement but not without an increased risk of developing gastrointestinal and/or genitourinary toxicities. Radioprotective agents, such as amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD), have been proven to reduce radiotherapy-induced toxicities to normal tissue in patients with head and neck, thoracic, and pelvic tumors. Based on this information, and in an effort to determine the effectiveness of radioprotective agents in patients with prostate cancer, our institution developed a protocol involving use of amifostine in patients with prostate cancer treated with external beam radiation to a total dose of 45 Gy and/or high-dose rate brachytherapy. High-dose rate doses are 6 Gy times three fractions for combined therapy and 9.3 Gy times four fractions for the monotherapy group. To date, 13 patients have been treated, with preliminary results indicating an acceptably low incidence of gastrointestinal and genitourinary toxicities, including no acute blood pressure changes or skin reactions. However, there have been three cases of severe cardiopulmonary events, which are discussed in detail.

Rheumatology, 2011

Objectives. Etanercept 50 mg a week is approved in the treatment of AS. Increasing the etanercept... more Objectives. Etanercept 50 mg a week is approved in the treatment of AS. Increasing the etanercept dose to 100 mg/week improves efficacy in cutaneous psoriasis, a clinical manifestation related to the spondylarthritis family, while maintaining its safety profile. The purpose of this study was to evaluate the efficacy and safety of etanercept 100 vs 50 mg/week in patients with AS. Methods. Adult patients with AS were randomized to receive etanercept 50 mg twice a week (biw), or etanercept 50 mg once a week (qw) for 12 weeks. The primary efficacy endpoint was Ankylosing Spondylitis Assessment Study (ASAS20) response at Week 12; secondary endpoints included ASAS40, ASAS50, ASAS70 and ASAS5/6 responses, partial remission and quality of life. Safety was assessed until 15 days after the last visit. Results. A total of 108 patients were randomly selected and treated, 54 in each arm. At 12 weeks, ASAS20 response was achieved by 34 (71%) out of 48 patients of the etanercept 50 mg biw group and by 37 (76%) out of 49 patients of the etanercept 50 mg qw group (not statistically significant differences). Other efficacy variables improved significantly over time, but not between treatment groups. Fifty-six patients experienced at least one adverse event (generally, infections and infestations, gastrointestinal disorders and injection site reactions), most of them mild or moderate. Conclusions. High-dose (100 mg/week) etanercept in the treatment of AS for 12 weeks is as safe as the standard dose (50 mg/week). However, it does not significantly increase its efficacy. Trial Registration. Clinicaltrials.gov, http://clinicaltrials.gov/, NCT00873730.